PF3D7_1471100 exported protein 2

AP-2m-KO severely disrupts schizont maturation. (A) Antibodies against the ER (PMV), Golgi apparatus (ERD2), PVM (EXP2), PPM (MSP1), IMC (GAP45, GAP50), apicoplast (CDC48), micronemes (AMA1), rhoptries (RON4), episomal K13 (GFP), and AP-2m (HA) were used to stain 3D7-AP-2m-floxed-3xHA schizonts with rap treatment (KO) or without (wt). All organelle markers have been false colored green regardless of fluorophore-conjugated secondary antibody used for clarity. Nuclei have been false colored blue. IMC-TM, transmembrane component of inner membrane complex. Scale bar, 2 mm.

Henrici RC, Edwards RL, Zoltner M, van Schalkwyk DA, Hart MN, Mohring F, Moon RW, Nofal SD, Patel A, Flueck C, Baker DA, Odom John AR, Field MC, Sutherland CJ. The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation. mBio. 2020 Feb 25;11(1). pii: e02918-19.

Other associated proteins

PFID Formal Annotation
PF3D7_0711000 AAA family ATPase, CDC48 subfamily
PF3D7_0918000 glideosome-associated protein 50 secreted acid phosphatase
PF3D7_0930300 merozoite surface protein 1
PF3D7_1116000 rhoptry neck protein 4
PF3D7_1133400 apical membrane antigen 1
PF3D7_1218300 AP-2 complex subunit mu
PF3D7_1222700 glideosome-associated protein 45
PF3D7_1323500 PEXEL protease plasmepsin V
PF3D7_1343700 kelch protein K13
PF3D7_1353600 ER lumen protein retaining receptor