FIKKs are localized to different subcellular compartments. Localization pattern of additional FIKK kinases using antibodies against the C-terminal HA-tag fused to each FIKK kinase. DAPI was used for nuclear staining. The experiment was repeated at least 3 times independently for each FIKK with similar results. Scale bar - 5 μm. Several FIKKs were clearly exported into the host cell, with some additional staining observed in the parasite. Surprisingly, FIKK3 and FIKK5 did not seem to be exported, with FIKK5 localizing to merozoites. FIKK1, FIKK10.1 and FIKK10.2 co-localized with the Maurer’s cleft, whereas FIKK4.1, FIKK4.2 and FIKK11 localized to the RBC periphery.
Davies H, Belda H, Broncel M, et al. An exported kinase family mediates species-specific erythrocyte remodelling and virulence in human malaria Nat Microbiol. 2020;10.1038/s41564-020-0702-4.
Other associated proteins
|PF3D7_0102600||serine/threonine protein kinase, FIKK family|
|PF3D7_0301200||serine/threonine protein kinase, FIKK family|
|PF3D7_0424500||serine/threonine protein kinase, FIKK family|
|PF3D7_0805700||serine/threonine protein kinase, FIKK family|
|PF3D7_1149300||serine/threonine protein kinase, FIKK family|