PfPDI8 and PfPDI11 are redox-active ER proteins. A) PfJ2apt-PDI8glmS and PfJ2apt-PDI11glmS parasites were fixed and stained with DAPI (blue) and with antibodies against HA (green) and V5 (red). Ring (R), Trophozoite (T), and Schizont (S) stage parasites are shown. Z-stack Images were deconvoluted and shown as a single, maximum intensity projection. Scale bar represents 5 μm. The subcellular localizations of PfPDI8 and -11 were determined by IFA, and both proteins were found to co-localize with PfJ2 in the ER.
Cobb DW, Kudyba HM, Villegas A, Hoopmann MR, Baptista RP, Bruton B, Krakowiak M, Moritz RL, Muralidharan V. A redox-active crosslinker reveals an essential and inhibitable oxidative folding network in the endoplasmic reticulum of malaria parasites. PLoS Pathog. 2021 7(2):e1009293.
Other associated proteins
|PF3D7_0827900||protein disulfide isomerase|
|PF3D7_1108700||heat shock protein 40, type ii|