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Myristoylated proteins |
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Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nat Chem. 2014 6(2):112-21. PMID: 24451586 |
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Function |
PfID |
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Annotation |
Transcript |
EC |
N-terminal residue other than glycine |
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| 12144 |
Transcription and RNA metabolism |
PF3D7_0423200 |
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BSD-domain protein, putative |
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| 12171 |
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PF3D7_1328800 |
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transcriptional regulatory protein sir2a |
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3.5.1.98 |
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| 12163 |
Translation |
PF3D7_1204300 |
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eukaryotic translation initiation factor 5A |
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√ |
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| 12179 |
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PF3D7_1457000 |
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signal peptide peptidase |
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3.4.21.89 |
√ |
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| 12174 |
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PF3D7_1365900 |
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ubiquitin-60S ribosomal protein L40 |
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√ |
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| 12160 |
Amino acid metabolism |
PF3D7_1129000 |
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spermidine synthase |
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2.5.1.16 |
√ |
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| 23455 |
Cofactors metabolism |
PF3D7_1437400 |
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pantothenate kinase 2 |
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2.7.1.33 |
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| 12175 |
Hemoglobin digestion |
PF3D7_1408100 |
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plasmepsin III histo-aspartic protease |
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3.4.23.- |
√ |
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| 12180 |
Invasion and motility |
PF3D7_1460600 |
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inner membrane complex sub-compartment protein 3 |
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| 12155 |
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PF3D7_1011000 |
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inner membrane complex sub-compartment protein 1 |
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| 12164 |
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PF3D7_1222700 |
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glideosome-associated protein 45 |
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| 12153 |
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PF3D7_0929600 |
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G2 protein, putative |
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| 12172 |
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PF3D7_1335100 |
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merozoite surface protein 7 |
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√ |
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| 12143 |
Mitosis and chromosome separation |
PF3D7_0414900 |
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armadillo-domain containing rhoptry protein |
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| 12158 |
Organellar functions |
PF3D7_1025600 |
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COX17 cytochrome c oxidase copper chaperone, putative |
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| 12145 |
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PF3D7_0524700 |
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mitochondrial import receptor subunit TOM22, putative |
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| 12154 |
Post-translational modifications |
PF3D7_1008400 |
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26S protease regulatory subunit 4, putative |
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3.6.4.8 |
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| 12138 |
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PF3D7_0205900 |
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26S proteasome regulatory subunit RPN1, putative |
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√ |
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| 23963 |
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PF3D7_1311500 |
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26S protease regulatory subunit 7, putative; 26S proteasome AAA-ATPase subunit RPT1, putative |
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3.6.4.8 |
√ |
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| 23883 |
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PF3D7_1306400 |
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26S protease regulatory subunit 10B, putative; 26S proteasome AAA-ATPase subunit RPT4, putative |
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3.6.4.8 |
√ |
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| 23967 |
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PF3D7_1248900 |
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26S protease regulatory subunit 8, putative |
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3.6.4.8 |
√ |
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| 12162 |
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PF3D7_1138500 |
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protein phosphatase 2C protein phosphatase PPM2 |
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3.1.3.16 |
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| 12149 |
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PF3D7_0810300 |
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protein phosphatase PPM5, putative |
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3.1.3.16 |
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| 12178 |
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PF3D7_1451700 |
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calcineurin subunit B |
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| 12140 |
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PF3D7_0217500 |
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Calcium-dependent protein kinases; CDPK1 |
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2.7.11.1 |
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| 12147 |
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PF3D7_0717500 |
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calcium-dependent protein kinase 4, CDPK4 |
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2.7.11.1 |
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| 12177 |
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PF3D7_1450000 |
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serine/threonine protein kinase, putative |
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2.7.11.17 |
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| 12165 |
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PF3D7_1223100 |
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cAMP-dependent protein kinase regulatory subunit |
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2.7.11.11 |
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| 12146 |
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PF3D7_0601600 |
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tetratricopeptide repeat protein, putative |
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| 12139 |
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PF3D7_0215100 |
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RING zinc finger protein, putative |
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| 12148 |
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PF3D7_0805000 |
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alpha/beta hydrolase, putative |
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| 12141 |
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PF3D7_0403800 |
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alpha/beta hydrolase, putative |
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| 12157 |
Protein trafic |
PF3D7_1020900 |
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ADP-ribosylation factor 1 |
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| 12159 |
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PF3D7_1034700 |
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ADP-ribosylation factor, putative |
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| 12152 |
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PF3D7_0920500 |
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ADP-ribosylation factor, putative |
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| 12173 |
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PF3D7_1359800 |
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ADP-ribosylation factor, putative |
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√ |
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| 12156 |
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PF3D7_1017300 |
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golgi re-assembly stacking protein 2 |
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| 12151 |
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PF3D7_0906100 |
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vacuolar protein sorting-associated protein 46, putative |
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| 12150 |
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PF3D7_0816200 |
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vacuolar protein sorting-associated protein 2, putative |
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| 12169 |
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PF3D7_1310600 |
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ras-related protein Rab-5B secretory complex protein 61 alpha |
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3.6.5.2 |
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| 20774 |
Unknown function |
PF3D7_1137300 |
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Clptm1 domain-containing protein, putative |
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| 12166 |
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PF3D7_1237700 |
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conserved protein, unknown function |
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| 23510 |
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PF3D7_0414600 |
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acylated pleckstrin-homology domain-containing protein, putative |
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| 14603 |
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PF3D7_0913800 |
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conserved Plasmodium protein, unknown function |
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*Green: experimentally validated/very high confidence; White: high confidence substrates based on available data; Yellow: possible false positive, requires further proof. Data kindly provided by Edward Tate and Megan Wright |
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