Biosynthesis of Fe-S proteins in the apicoplast

Online articles related to Biosynthesis of Fe-S proteins in the apicoplast retrieved from PubMed

Drugs affecting pathway with unknown specific target

Drug Name	PubMed Articles (year of publication)
(3R,4R)-3-butoxy-N-butyl-3-methoxy-6,6-dimethyl-dioxane-4-carboxamide	Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity
(3R,4R,6R)-3-methoxy-4-(methoxymethyl)-6-methyl-3,6-dipentyl-dioxane	Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity
[4-[12'-carboxy-6-(cyclohexa-2,4-dien-1-ylcarbamoyl)-13'-methyl-spiro[1,2,4,5-tetraoxane-3,3'-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene]-17'-yl]pentanoylamino];methanol	Tetraoxane antimalarials and their reaction with Fe(II)
1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one	Inhibitory effect of novel iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green tea extract on growth of Plasmodium falciparum
17'-(4-amino-1-methyl-4-oxo-butyl)-6-carbamoyl-13'-methyl-spiro[1,2,4,5-tetraoxane-3,3'-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene]-12'-carboxylic acid;methanol	Tetraoxane antimalarials and their reaction with Fe(II)
2,2’-bipyridyl	Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
3-hydroxypyridin-4-one	Basic 3-hydroxypyridin-4-ones: potential antimalarial agents
4-[(E)-(1,3-benzothiazol-2-ylhydrazono)methyl]benzene-1,2-diol	Antimalarial Activity of Small-Molecule Benzothiazole Hydrazones
4-aminoquinoline	Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators
4-oxocyclohexanecarboxylic acid	Tetraoxane antimalarials and their reaction with Fe(II)
5-[(E)-(1,3-benzothiazol-2-ylhydrazono)methyl]benzene-1,3-diol	Antimalarial Activity of Small-Molecule Benzothiazole Hydrazones
6-(2-hydroxyethylcarbamoyl)-17'-[4-(3-hydroxypropylamino)-1-methyl-4-oxo-butyl]-13'-methyl-spiro[1,2,4,5-tetraoxane-3,3'-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene]-12'-carboxylic acid;methanol	Tetraoxane antimalarials and their reaction with Fe(II)
Aroylhydrazone	Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool
Benzylethene	Antimalarial iron chelator FBS0701 blocks transmission by Plasmodium falciparum gametocyte activation inhibition
Catecholate siderophore	In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum
Cholic acid	Tetraoxane antimalarials and their reaction with Fe(II)
Daphnetin	In vitro antimalarial effect of daphnetin relating to its iron-chelating activity
deferasirox	Inhibitory effect of novel iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green tea extract on growth of Plasmodium falciparum
deferiprone	Inhibitory effect of novel iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green tea extract on growth of Plasmodium falciparum Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
Deferoxamine	Antimalarial Activity of Small-Molecule Benzothiazole Hydrazones
Desferrioxamine	In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum Inhibitory effect of novel iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green tea extract on growth of Plasmodium falciparum
Dicatecholate	Iron chelators as antimalarial agents: in vitro activity of dicatecholate against Plasmodium falciparum
Doxycycline	In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum
E-64	Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool
Mmv007384	Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines
Mmv665805	Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines
Mmv666023	Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines
Phenyl benzamide	Antimalarial iron chelator FBS0701 blocks transmission by Plasmodium falciparum gametocyte activation inhibition
plakortin	Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity

Biosynthesis of Fe-S proteins in the apicoplast map details

PFID	PFID Old	Annotation	Formal Annotation	EC
PF3D7_1139700	PF11_0407	Adrenoredoxin reductase, putative	adrenodoxin reductase, putative	1.18.1.2
PF3D7_0302700	PFC0126c	CDGSH	CDGSH iron-sulfur domain-containing protein, putative
PF3D7_0416700	PFD0807c	CDGSH	CDGSH iron-sulfur domain-containing protein, putative
PF3D7_1022900	PF10_0222	CDGSH	COX13 CDGSH iron-sulfur domain-containing protein, putative
PF3D7_0716600	PF07_0068	Cysteine desulfurase	cysteine desulfurase	2.8.1.7
PF3D7_0727200	MAL7P1.150	Cysteine desulfurase	cysteine desulfurase ISCS	2.8.1.7
PF3D7_1318100	MAL13P1.95	ferredoxin	ferredoxin, putative
PF3D7_0720400	PF07_0085	Ferredoxin reductase-like protein; Rieske [2Fe=2S] domain	ferrodoxin reductase-like protein	1.18.1.2
PF3D7_0623200	PFF1115w	Ferredoxin-NADP+ reductase	ferredoxin--NADP reductase	1.18.1.2
PF3D7_API04700	PF3D7_API04700	Fe-S cluster assembly protein SUFB	iron-sulfur cluster assembly protein SUFb
PF3D7_1435300	PF14_0334	glutamate synthase [NADH], putative	glutamate synthase [NADH], putative	1.4.1.14
PF3D7_1128500	PF11_0296	HCF101	Fe-S cluster assembly factor hcf101, putative
PF3D7_0823600	MAL8P1.37	Lipoate protein ligase	lipoate-protein ligase B, FTO	2.3.1.181
PF3D7_0921400	PFI1050c	NiFU	NifU-like scaffold protein
PF3D7_0522700	PFE1135w	SUFA	iron-sulfur cluster assembly protein SUFA
PF3D7_1103400	PF11_0044	SufB/D	sulfur cluster assembly protein SufD
PFC10_API0012	PFC10_API0012	SufB/D	SufB protein, putative (sufB)
PF3D7_1413500	PF14_0133	SufC	ABC transporter I family member 1 FeS assembly ATPase SufC
PF3D7_0206100	PFB0270w	SufE	cysteine desulfuration protein SufE
PF3D7_0716600	PF07_0068	SufS	cysteine desulfurase	2.8.1.7
PF3D7_1242000	PFL2020c	sulfhydryl oxidase	sulfhydryl oxidase, putative	1.8.3.2

Total number of related proteins: 1

#	PFID	Formal Name
1	PFB0270w	cysteine desulfuration protein SufE

Total number of related proteins: 3

#	PFID	Formal Name
1	PFC0126c	CDGSH iron-sulfur domain-containing protein, putative
2	PFD0807c	CDGSH iron-sulfur domain-containing protein, putative
3	PF10_0222	COX13 CDGSH iron-sulfur domain-containing protein, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PFE1135w	iron-sulfur cluster assembly protein SUFA

Total number of related proteins: 1

#	PFID	Formal Name
1	PFF1115w	ferredoxin--NADP reductase

Total number of related proteins: 2

#	PFID	Formal Name
1	PF07_0068	cysteine desulfurase
2	MAL7P1.150	cysteine desulfurase ISCS

Total number of related proteins: 1

#	PFID	Formal Name
1	PF07_0068	cysteine desulfurase

Total number of related proteins: 1

#	PFID	Formal Name
1	PF07_0085	ferrodoxin reductase-like protein

Total number of related proteins: 1

#	PFID	Formal Name
1	MAL8P1.37	lipoate-protein ligase B, FTO

Total number of related proteins: 1

#	PFID	Formal Name
1	PFI1050c	NifU-like scaffold protein

Total number of related proteins: 2

#	PFID	Formal Name
1	PF11_0044	sulfur cluster assembly protein SufD
2	PFC10_API0012	SufB protein, putative (sufB)

Total number of related proteins: 1

#	PFID	Formal Name
1	PF11_0296	Fe-S cluster assembly factor hcf101, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PF11_0407	adrenodoxin reductase, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PFL2020c	sulfhydryl oxidase, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	MAL13P1.95	ferredoxin, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0133	ABC transporter I family member 1 FeS assembly ATPase SufC

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0334	glutamate synthase [NADH], putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PF3D7_API04700	iron-sulfur cluster assembly protein SUFb

Malaria Parasite Metabolic Pathways

Drugs affecting pathway with unknown specific target

Biosynthesis of Fe-S proteins in the apicoplast map details

Total number of related proteins: 1

Total number of related proteins: 3

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 2

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 2

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1