|
Biochemistry
160
|
|
Amino acid metabolism
13
|
|
Aminosugars metabolism
|
|
Arginine and proline metabolism
|
|
Asparagine and Aspartate metabolism
|
|
Glutamate metabolism
|
|
Glycine and Serine metabolism
|
|
Leucine, Isoleucine and Valine metabolism
|
|
Lysine metabolism
|
|
Methionine and Polyamine metabolism
|
|
Models for selenocysteine incorporation
|
|
Nitrogen metabolism
|
|
PfPKG-dependent phosphorylation in schizonts
|
|
Phenylalanine and Tyrosine metabolism
|
|
Selenocysteine biosynthesis
|
|
Carbohydrates
11
|
|
Aminosugars metabolism
|
|
Central Carbon Metabolism
|
|
Enzymes involved in vthe metabolism of various sugar derivatives
|
|
Glycolysis
|
|
Glyoxalase metabolism
|
|
Mannose and Fructose metabolism
|
|
N-glycans biosynthesis
|
|
Pentose Phosphate Cycle
|
|
Pyruvate metabolism
|
|
Subunit composition of the yeast OST (oligosaccharyltransferase) complex
|
|
Sugar nucleotide biosynthesis pathways
|
|
Cofactors & Other Substances
12
|
|
CoA biosynthesis
|
|
Compartmentalization of porphyrin biosynthesis
|
|
Flavin-dependent and - containing enzymes
|
|
Folate biosynthesis
|
|
Nicotinate and nicotinamide metabolism
|
|
One-carbon enzyme systems serine hydroxymethyltransferase and glycine-cleavage complex
|
|
Porphyrin metabolism
|
|
Pyridoxal phosphate (Vitamin B6) metabolism
|
|
Riboflavin metabolism and Flavin-containing proteins
|
|
Shikimate biosynthesis
|
|
Thiamine metabolism
|
|
Ubiquinone metabolism
|
|
Lipid metabolism
25
|
|
a-Linolenic acid (ALA) pathway
|
|
Contribution of precursors to the biosynthesis of major phospholipid types
|
|
Dolichol metabolism
|
|
Domain structures of the putative lipolytic enzymes
|
|
Enzymes involved in glycerophospholipid synthesis
|
|
ER protein VAP establish membrane contact sites
|
|
Fatty acid synthesis in the apicoplast
|
|
Fatty acids elongation in the endoplasmic reticulum
|
|
Glycosylphosphatidylinositol (GPI) anchor biosynthesis
|
|
Inositol Phosphate metabolism
|
|
Isoprenoids metabolism
|
|
Lipolytic enzymes
|
|
LysoPC depletion induces gene activity
|
|
Membranes and compartments of phospholipid synthesis
|
|
Metabolism of reactive lipid aldehydes via detoxification or carbonylation
|
|
Model for cholesterol gradient development in the pRBC
|
|
Model for metabolic compartmentalization of PI biosynthesis
|
|
Phosphatidylcholine metabolism
|
|
Phosphatidylethanolamine and phosphatidylserine metabolism
|
|
Sphingomyelin and ceramide metabolism
|
|
Sterol transport and phosphatidylinositol 4-phosphate transfer between endoplasmic reticulum and Golgi membranes
|
|
Subcellular distribution of phosphoinositides
|
|
Terpenoid metabolism
|
|
Total fatty acids in RBC and iRBC
|
|
Utilization of phospholipids
|
|
Nucleotide metabolism
2
|
|
Purine metabolism
|
|
Pyrimidine metabolism
|
|
Post-translational - Chaperones and protein structure modifications
16
|
|
Cellular responses to endoplasmic reticulum stress
|
|
Chaperone-assisted protein folding
|
|
Chaperones associate with proteins in various iRBC locations
|
|
Genes coding for chaperones and their regulators
|
|
Genes up and down regulated in response to ER stress
|
|
Hsp70 machinery interacts with J-domains
|
|
Hsp90-associated multiprotein complex (R2TP-Hsp90 complex)
|
|
HSP90-R2TP complex (yeast)
|
|
Interactions of HDAC1 with other proteins
|
|
Localization and function of some Hsp40s and Hsp70s
|
|
Location and function of the six HSP70s in infected erythrocytes
|
|
Non-redundant malarial structures in the Protein Data Bank (PDB)
|
|
Organization of chaperone pathways in the cytosol
|
|
Proteins interacting with DnaJ proteins
|
|
The chaperone cycle of Hsp90
|
|
The HSP70 chaperone cycle
|
|
Post-translational - Other protein modifications
17
|
|
A Model for Hrd1-Mediated Retrotranslocation in ERAD
|
|
Activation of eiF5A
|
|
Effect of hyperoxia on gene expression
|
|
Genes coding for GPI-anchored membrane proteins
|
|
Important interacting proteins
|
|
Iron-containing proteins
|
|
Network analysis of drCDC-UNK proteins and their potential protein interactions
|
|
O-GlcNAcylated proteins identified by mass spectrometry
|
|
Possible paths for apoptosis
|
|
Post-translational modification of elongation factor 2
|
|
Programmed cell death pathway
|
|
Protein-protein associations involving proteases
|
|
Proteins of detergent-resistant membranes
|
|
Proteins with ATPase activity
|
|
S-Glutathionylated proteins
|
|
S-nitrosylated proteins
|
|
Total palmitome of Plasmodium falciparum
|
|
Post-translational - Single amino acid modification
31
|
|
14-3-3 protein
|
|
Arginine-methylated proteins
|
|
Calcium – calmodulin activation of protein kinases
|
|
Carbonylated proteins at erythrocytic stages
|
|
Cotranslational cleavage of N-terminal methionine residues and N-terminal acetylation
|
|
Eukaryotic fMet/N-End Rule Pathway
|
|
Interactome of the Ser/Thr Protein Phosphatase type 1
|
|
Lysine acetylated proteins
|
|
Methyl lysine binding modules readers
|
|
Modification of proteins by adenylylation and ADP-ribosylation
|
|
Myristoylated proteins
|
|
N-myristoylation, S-palmitoylation and prenylation of proteins
|
|
Peptidases and proteases
|
|
Peptides with confirmed methylated lysine residues
|
|
Phosphatome - Phosphatases of Plasmodium falciparum
|
|
Phosphopoteome - Wu et al, 2009
|
|
Phosphoproteome
|
|
Phosphoproteome of the merozoite
|
|
Potential Farnesylated proteins
|
|
Potential PKG substrates in schizonts
|
|
Prenylated proteins
|
|
Protein acetylation and lysine aminoacylation
|
|
Protein arginine methylation
|
|
Protein kinase coding genes
|
|
Protein kinase G-dependent phosphorylation in schizonts
|
|
Protein nitrosylation and denitrosylation
|
|
Protein N-terminal acetylation
|
|
Protein phosphorylation
|
|
Protein-lysine methylation and demethylation
|
|
Proteins with conserved phosphatase related superfamily domains
|
|
Schematic representations of protein S-acyl transferases and their salient protein features
|
|
Post-translational - Ubiquitin-dependent processes
23
|
|
Anaphase promoting complex ubiquitin-ligase
|
|
Autophagy and autophagy-related pathways
|
|
Cdc48 is the driving force in the targeting of the ER-substrates to the 26S-proteasome
|
|
Crosstalk between ubiquitination and SUMOylation
|
|
CUL3 ubiquitin ligase is regulated by a calcium-dependent co-adaptor
|
|
Enhanced protein degradation by branched ubiquitin chains
|
|
General roles of deubiquitinases
|
|
Genes coding for components of the proteasome degradation machinery & their timed transcription
|
|
Genes encoding ubiquitin-related reactions
|
|
Mechanism of ubiquitin transfer
|
|
Model for ubiquitin-mediated regulation of Ras
|
|
Model of the Ube2w/CHIP/Ataxin-3 Ubiquitination Cycle
|
|
Models for ubiquitin (Ub) chain amputation and trimming in regulating proteasomal degradation
|
|
Plasmodium ubiquitin-protein conjugates
|
|
Post-translational modification –SUMOylation
|
|
Proteasome-mediated degradation of non-native ER proteins
|
|
Proteasome-mediated proteolysis of ubiquinated proteins
|
|
Putative SUMO substrates
|
|
SCF (Skp1-Cullin-F-box) ubiquitin-ligase
|
|
The ATG autophagic pathway
|
|
The Atg8 and Atg12 ubiquitin-like conjugation systems
|
|
The ubiquitylation machineries of the ER for misfolded secretory proteins
|
|
Transfer of polyubiquinated proteins to the 26S proteasome
|
|
Redox Metabolism
10
|
|
4-hydroxynonenal-modified proteins
|
|
Compartmentation of redox metabolism
|
|
Glutathione metabolism
|
|
Lipoic acid metabolism
|
|
Mitochondrial antioxidant system
|
|
Oxidative protein folding in the endoplasmic reticulum
|
|
Proteins targeted by the thioredoxin superfamily enzymes
|
|
Reactions and transformations of the superoxide anion
|
|
Redox Metabolism
|
|
Thioredoxin, Glutaredoxin and Peroxiredoxin
|
|
Cell-Cell Interactions
46
|
|
Cytoadherence
8
|
|
Adhesion properties that have been mapped to different PfEMP1
|
|
Characteristics of Plasmodium falciparum export proteins that remodel infected erythrocyte
|
|
Constitutive and inducible receptors
|
|
Interactions between modified host cell membrane and endothelial cell
|
|
Molecular aspects of rosette formation
|
|
PfEMP1 domain architectures
|
|
PfEMP1-endothelial receptor interactions mediate microvascular bed–specific sequestration of P. falciparum infected erythrocytes (Ies)
|
|
Rosette formation between normal and infected RBC
|
|
Invasion
28
|
|
cGMP/PKG signalling in egress/invasion
|
|
Domains of merozoite surface proteins
|
|
Erythrocyte glycophorins as receptors for Plasmodium merozoites
|
|
Functional annotation of merozoite invasion-related proteins
|
|
Merozoite components involved in attachment and initiation of penetration
|
|
Merozoite ligands, their erythrocyte receptors
|
|
Merozoite protein complexes
|
|
Model for merozoite invasion
|
|
Model of lipid and protein uptake into the parasitophorous vacuole
|
|
Morphology of the merozoite
|
|
MSP1 as an anchor in merozoite invasion
|
|
MSPDBL and MSP1 mediate merozoite invasion
|
|
Parasite invasion ligands and human erythrocyte receptors
|
|
Pellicle formation in the merozoite
|
|
Program of malaria parasite egress
|
|
Protein-Protein Interactions between Human Erythrocytes and Plasmodium falciparum
|
|
Proteins released from infected cells during rupture
|
|
Proteolytic processing of the MSP1/6/7 complex
|
|
Rhoptry neck and bulb proteins during and after invasion
|
|
Rhoptry transition during invasion
|
|
Role of the PfRh5/PfRipr/CyRPA Complex during Invasion of Erythrocytes
|
|
Roles of rhoptry neck proteins during invasion
|
|
Schematic depiction of parasite invasion and egress
|
|
Stages of parasite egress program
|
|
Steps of merozoite invasion
|
|
Subcellular localization of proteins involved in invasion
|
|
The apical region of the merozoite
|
|
Time course of invasion
|
|
Motility
10
|
|
Actin and filaments
|
|
Components of the linear motor responsible for merozoite motility in invasion
|
|
Control of microtubule assembly
|
|
Control of the mitotic spindle organization by kinesins
|
|
Different kinesins with different roles
|
|
Kinetochore–microtubule attachment and kinetochore oscillations
|
|
Merozoite egress
|
|
Molecular motor prototypes
|
|
Role of perforin 1 in merozoite egress
|
|
Tubulin and microtubules
|
|
Drug
51
|
|
Mode of action
30
|
|
Antimalarial activity of plant metabolites
|
|
Antimalarial drugs and associated markers of resistance in asexual blood stage parasites
|
|
Antiplasmodial activities of compounds isolated from terrestrial plants
|
|
Approved drugs with anti-malarial activity and their possible targets
|
|
Artemisinin - effect of drug on gene transcription
|
|
Atovaquone - effect of drug on gene transcription
|
|
Chloramphenicol - effect of drug on gene transcription
|
|
Chloroquine - effect of drug on gene transcription
|
|
Current anti-malarial agents
|
|
Differential proteome analysis under drug treatment
|
|
Doxycycline - effect of drug on gene transcription
|
|
Drug targets
|
|
Drug-target associations predicted for P. falciparum
|
|
Fungal compounds with antimlarial action
|
|
Geldanamycin - effect of drug on gene transcription
|
|
Malaria merozoite invasion of the RBC and its inhibition
|
|
Methotrexate - effect of drug on gene transcription
|
|
Methyl Methanesulfonate - effect of drug on gene transcription
|
|
Natural products with antimalarial activity
|
|
New antimalarial drugs in the pipeline
|
|
Parasite proteins that form complexes with natural products
|
|
Postulated artemisinins’ modes of action
|
|
Prenylation dependence in delayed-death
|
|
Primaquine mode of action
|
|
Proguanil - effect of drug on gene transcription
|
|
Proposed mechanism of delayed death
|
|
Redox-proteome changes induced by chloroquine across the intraerythrocytic stages of P. falciparum Dd2
|
|
Synergy between antimalarial compounds
|
|
Tafenoquine - effect of drug on gene transcription
|
|
The ART proteome
|
|
Resistance
21
|
|
Associated clinical and molecular markers of resistance to antimalarial drugs
|
|
Cumulative frequency of kelch13 mutations (A) and haplogroups (B)
|
|
Drug resistance and fitness cost
|
|
Emergence and spread of P. falciparum resistance to CQ, pyrimethamine and ART derivatives
|
|
Evolution of parasite resistance to antifolates
|
|
Gene expression affected by lumefantrine
|
|
Genetic polymorphisms in target-genes at and surrounding resistant linked mutations
|
|
In vitro resistance to experimental antimalarials
|
|
Isocryptolepine - effect of drug on gene transcription
|
|
K13-mediated resistance to artemisinins in mutated K13
|
|
Kelch13 propeller mutations are correlated with resistance to artemisinin
|
|
Mechanism of resistance to artemisinin
|
|
Model of CNV development and selection
|
|
Molecular markers of resistance to antimalarial drugs
|
|
Molecular targets of and mechanisms of resistance to major antimalarial drugs
|
|
Mutant genotypes associated with high levels of anti-folate resistance
|
|
Non-Genetic or Missed Genetic Variation
|
|
Polymorphisms associated with Plasmodium sensitivity to artemisinins
|
|
Resistance mechanisms for clinically important antimalarial drugs
|
|
Resistance to experimental antimalarials generated in vitro
|
|
Schematic overview of drug resistance mechanisms
|
|
Genetic Information Processing
164
|
|
Chromosome structure (Mitosis and Chromosome Separation)
26
|
|
Apicomplexa divide by closed mitosis
|
|
Cell cycle compartment assocation between P. falciparum cell cycle perturbed transcriptomes
|
|
Centriole proteins
|
|
Centrosome proteins
|
|
Chromatin dynamics controlling temporal regulation of var gene expression
|
|
Chromatin-associated protein degradation (CAD) regulated by CDC48–Ufd1–Npl4
|
|
Chromosome dynamics in cell cycle that lead to anaphase
|
|
Effect of different motors on spindle length
|
|
Functional orthologs of known cell cycle proteins in E. coli
|
|
Heterochromatin structure of the telomeric and subtelomeric regions
|
|
High-resolution display of gene families in the subtelomeric compartment
|
|
Kinetochores power chromosome movements in mitosis
|
|
Microtubule organization at the centrosome
|
|
Nuclear organization in Plasmodium
|
|
Nucleosome assembly and regulation
|
|
Potential models for lncRNA-TARE at chromosome ends
|
|
Proteins involved in steps during passage through prophase
|
|
Proteins predicted to be involved in cell cycle regulatory network
|
|
Putative organization of the kinetochore
|
|
Regulation of spindle microtubule dynamics
|
|
Schematics of the Apicomplexan cell cycle
|
|
Structure and organization of centromeric chromatin
|
|
Structure of telomere and sub-telomeric regions
|
|
Structure of the mitotic centrosome
|
|
Telomerase and some telomerase associated proteins
|
|
The mitotic spindle of P. falciparum
|
|
Epigenetics
2
|
|
Epigenetic mechanisms in Plasmodium
|
|
Epigenetic regulation of specific genes and gene families in Plasmodium falciparum
|
|
Histones and their modifications
23
|
|
Acetylation recognition by the bromodomain and other modules
|
|
ATP-dependent chromatin remodeling complexes
|
|
Binding modes of methyllysine readers
|
|
Chaperone-mediated modulation of nucleosome-histone interactions
|
|
Chromatin modifying proteins
|
|
Distinct H3/H4 – histone chaperone complexes are marked by specific H3/H4 posttranslational modifications
|
|
Domains binding modified histones
|
|
Histone acetylation
|
|
Histone chaperones
|
|
Histone lysine methylation
|
|
Histone modification cross-talk
|
|
Histone post-translational modifications landscape
|
|
Hypothetical routes to sexual differentiation
|
|
Model of reaction schemes showing possible ADP-ribosylation and deacetylation outcomes of the sirtuin reaction
|
|
Plasmodium falciparum chromatin landscape
|
|
Plasmodium falciparum histone acetylation and methylation
|
|
Post-translational modifications identified of histones
|
|
Proteins containing histone post translational modification-binding modules
|
|
Proteins interacting with histone deacetylase
|
|
Regulation of Sexual Commitment
|
|
Role of histone exchange in transcription elongation
|
|
Structure and organization of centromeric chromatin
|
|
Synergism between SWR1, HIRA and FACT in histone variant exchange
|
|
Replication
22
|
|
A model for global single-strand break (SSB) repair
|
|
A model for UbpX function in the regulation of PCNA deubiquitylation
|
|
Base excision repair of AP sites
|
|
DNA mismatch repair system
|
|
DNA Replication
|
|
DNA–protein crosslink repair
|
|
Double strand break repair and homologous recombination
|
|
Epigenetic switching mechanisms
|
|
Genes coding for enzymes/proteins involved in DNA replication
|
|
Genes involved in DNA repair
|
|
Helicases
|
|
HP1 enrichment values
|
|
Mechanisms of crosstalk between autophagy and double-strand break repair
|
|
Model for translesion DNA synthesis
|
|
Nucleotide excision repair
|
|
Origin, repair and biological consequences of spontaneous AP sites
|
|
P. falciparum genes harboring G-quadruplexes
|
|
Predicted protein-protein interactions of plausible stress helicases
|
|
Pre-replicative complex formation and transition to replication
|
|
Processing or protecting stalled replication forks
|
|
Roles of RecQ helicases
|
|
Single Gene/enzyme deletions predicted to cause impairment of metabolic networks
|
|
Transcription- Biogenesis of RNA
39
|
|
Alternative splicing
|
|
Alternative splicing events confirmed by RNA-Seq
|
|
Architecture, Dynamic Formation, and Processing of the 90S Pre-ribosome during Early Ribosome Biogenesis
|
|
Assembly and recycling of spliceosome components with respect to Prp8
|
|
CCR4 – NOT complex
|
|
Cleavage and polyadenylation of pre-mRNA
|
|
Compartmentalization of transcription site in the nucleus
|
|
Cooperation and competition of splicing factors in regulated splicing
|
|
DNA binding proteins with AP2 domain(s)
|
|
Exon definition during the earliest stages of spliceosome assembly
|
|
Gene gating and mRNA export
|
|
Genomic landscape of splicing regulators
|
|
Highest expressed genes based on mRNA abundance
|
|
Lsm proteins and RNA processing
|
|
Maturation and export of 60S and 40S ribosomal subunits
|
|
Mechanisms of alternative splicing by splice site selection
|
|
Mechanisms of alternative splicing regulation at the transition from exon definition to intron definition
|
|
Model of RNA Pol II biogenesis
|
|
Nuclear export of tRNA
|
|
Pathway for Cytoplasmic 40S maturation
|
|
Pathway for Cytoplasmic 60S maturation
|
|
Pre-ribosomal particles along the 40S assembly pathway
|
|
Pre-ribosomal particles along the 60S assembly pathway
|
|
Protein composition of affinity-purified exon and B-like complexes
|
|
Protein factors in pre-mRNA 3’-end processing
|
|
Regulators of alternative splicing
|
|
RNA polymerase I transcribes rRNA
|
|
RNA polymerase II transcribes mRNA
|
|
RNA polymerase III transcribes tRNA and 5S rRNA
|
|
Schematic representation of the spliceosome pathway in yeast
|
|
Secondary structure of spliceosomal RNAs
|
|
Spliceosome dynamics during the catalytic steps
|
|
Splicing of pre-mRNA
|
|
SR (Ser–Arg) proteins
|
|
Structure and processing of pre rRNA
|
|
The different RNA export pathways
|
|
The structures of RNA polymerases
|
|
Transcription related proteins encoding genes
|
|
Transcriptional mediator complex
|
|
Transcription - RNA modification and degradation
21
|
|
Encoded proteins that could be constituents of P-bodies
|
|
Histone mRNA degradation
|
|
m6A Effectors: Writers, Erasers, and Readers
|
|
Modification of the wobble position uridine (U34) in Lys, Glu, Gln, Leu and Arg tRNAs
|
|
mRNA 5' capping
|
|
mRNA degradation
|
|
mRNA-binding proteins in trophozoite and schizonts
|
|
Potential roles of tRNA modifications in asexual blood stage development
|
|
Quality control in mRNA biogenesis
|
|
Recruitment of the exosome to mRNA substrates
|
|
Regulated splicing through controlling the assembly of the core splicing machinery
|
|
RNA binding proteins
|
|
RNA Channeling in the Exosome-Ski Assembly during mRNA degradation
|
|
RNA Degradation Factors
|
|
Schematic depiction of pseudouridylation
|
|
Splicing and non-sense-mediated decay factors
|
|
Transcription associated proteins implicated in the transcriptional machinery
|
|
tRNA modifications
|
|
tRNA thiolation
|
|
tRNA-wybutosine biosynthesis
|
|
Various features of C/D and H/ACA snoRNAs
|
|
Transcription - snRNP assembly
4
|
|
Assisted assembly of Sm-class snRNPs
|
|
Maturation of snRNAs requires nuclear and cytoplasmic regulatory steps
|
|
Transcription and processing of snRNAs
|
|
U6 snRNP role in pre-mRNA splicing
|
|
Translation
27
|
|
80S ribosomes
|
|
Assembly factors and their roles in quality control during ribosome maturation
|
|
Co-inhibition of S-adenosylmethionine decarboxylase/ornithine decarboxylase effect on gene expression
|
|
Co-translational capturing of selected ribosomal proteins by their dedicated chaperones
|
|
eIF5A Functions globally in translation elongation and termination
|
|
ER Sec61 translocon
|
|
Essential metabolic genes
|
|
Essential, Non-mutable genes
|
|
Genes coding for components involved in ribosome assembly
|
|
Genes whose expression is highly positively or negatively correlated with pfcrt or pfmdr1
|
|
Initiation of translation
|
|
Involvement of GTP-binding proteins and ribosomes in amino acid shortage
|
|
Localization of aminoacyl-tRNA ligases in the three protein translational compartments
|
|
PfWDR genes
|
|
Posttranslational translocation in eukaryotes
|
|
Protein biosynthesis
|
|
Ribosomal structure
|
|
Ribosome recycling and mRNA surveillance
|
|
Ribosome-associated protein quality control
|
|
Signal recognition particle-mediated targeting of membrane and secretory proteins
|
|
SRP independent translocation of GPI anchored proteins
|
|
SRP-mediated targeting of membrane and secretory proteins – functional cycle
|
|
The 35 most abundant proteins
|
|
The structure of translation initiation factor 3
|
|
Transcripts translationally regulated in asexual blood stages
|
|
WD40 proteins as platforms of protein-protein interactions
|
|
Working model for recognition of a stalled ribosome by recycling factors
|
|
Morphology and Pathology
86
|
|
Immunity
13
|
|
Antibody-mediated immunity to malaria
|
|
Anti-parasite immunity
|
|
B cell subsets and CD4 follicular helper T cell interactions during infection
|
|
Dendritic cells and T cells during blood-stage infections
|
|
Dendritic cells link innate and adaptive arms of the immune system
|
|
Gamma-Delta T cells immunity during blood stage infections
|
|
Innate sensors of Plasmodium PAMPs and malaria DAMPs
|
|
Links between innate and adaptive immune responses to the blood stage parasite
|
|
Localization and phenotype of splenic MF subsets and their role in malaria
|
|
Natural Killer cell cytotoxicity during blood-stage infections
|
|
Pattern recognition receptors and the pathophysiology of malaria
|
|
Potential immunopathological roles of monocytes and macrophages
|
|
Proposed Antibody-mediated Mechanisms in Immunity to Blood-Stages
|
|
Models for extracellular transport
3
|
|
Models for protein transport to the membrane of P. falciparum-infected erythrocytes
|
|
Putative traffic mechanisms in Plasmodium falciparum-infected erythrocytes - II
|
|
Putative trafficking pathways in P. falciparum-infected erythrocytes I - Diagrammatic representation
|
|
Morphological development of blood forms
16
|
|
3D reconstruction of a late schizont stage-iRBC
|
|
Merozoite
|
|
Merozoites in segmenters
|
|
Ring Stage
|
|
Schizont
|
|
Schizont stage parasite – EM
|
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Serial block-face scanning electron microscopy of ring and trophozoite stages
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The 3D ultrastructure of an infected erythrocyte
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Three-dimensional structured illumination microscopy and immuno-electron microscopy (EM) of infected red blood cells
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Trophozoite
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Ultrastructural features of a intraerythrocytic Plasmodium falciparum – merozoite and ring
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Ultrastructural features of a intraerythrocytic Plasmodium falciparum – trophozoite and schizont
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Ultrastructure of the exomembrane system
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Ultrastructure of the merozoite - EM
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Ultrastructure of the ring stage EM
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Whole cycle
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Morphology of sub-cellular organelles
18
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Apicoplast division precedes mitochondrial division during schizogony
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Apicoplast ultrastructure in Plasmodium falciparum merozoites
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Digestive vacuole
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Fluorescence visualization of mitochondrion and plastid in a living schizont
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Golgi apparatus – development throughout the asexual life cycle
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Hemozoin structure
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Maurer’s clefts
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Maurer’s clefts complex morphology
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Morpholgy of developing P. falciparum apicoplast
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Morpholgy of developing P. falciparum mitochondrion
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Morphology of the ER during the asexual cycle of P. falciparum
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Putative flagellar proteins
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The fate of the parasitophorous vacuolar membrane
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The mitochondrion ultrastructure
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The relationship between the apicoplast and the mitochondrion throughout the intraerythrocytic cycle
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Ultrastructure of knobs - electronmicrograph
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Ultrastructure of the apicoplast EM
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Ultrastructure of the mitochondrion
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Pathology
36
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A proposed mechanism of malaria fever induction
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a-Thalassemia – pathogenesis and clinical presentations
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Candidate genes related to virulence
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Causes of anemia in malarial infection
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Cerebral malaria
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Cytoadherence is tissue-specific
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Endothelial activation and chemokine secretion
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Endothelial permeability and neuroinflammation
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G6PD deficiency and malaria
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Genes differentially expressed in severe malaria
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Genes for which expression is significantly correlated with coma score
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Hemoglobinopathies and their effect on parasite growth
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Human genes that protect against malaria
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Induction of endothelial proinflammatory response and barrier dysfunction by P. falciparum
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Inflammation and loss of barrier integrity
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Innate immune response to Plasmodium blood stage infection in the spleen
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Malaria during pregnancy
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Malaria infection disrupts nitric oxide metabolism
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Malaria-associated syndromes
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Mechanisms for Cerebral malaria pathogenesis
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Mechanisms involved in protection against malaria by monocytes and macrophages
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Mechanisms underlying protection by sickle trait (AS) RBC against falciparum malaria
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Model for the regulation of commitment and gametocytogenesis
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Modulators of endothelial cell that may be relevant in BBB disruption during CM
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Multifactorial roles of platelets in malaria pathogenesis
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Oxidative events in the bone marrow and circulation
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Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
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Oxidative stress in ß-thalassaemia and sickle cell disease
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Pathogenic events that contribute to severe malaria
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Pathophysiology of BBB leakage in CM
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Pathophysiology of ß-thalassemia
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Pitting of infected cells
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Possible regulators of gene regulation during commitment and gametocytogenesis
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Severe malaria in children
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Symptoms of malaria
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The spleen and protection of Sickle-cell trait severe malaria
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Physiology
140
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Apicoplast functions
12
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Apicoplast DNA
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Apicoplast Kae1api-protein interactions
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Apicoplast putative membrane proteins
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Biosynthesis of Fe-S proteins in the apicoplast
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Components of translation machinery in apicoplast
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Fatty acid synthesis in the apicoplast
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Genes coding for apicoplast ribosome subunits
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Genes of the apicoplast genome
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Integrated metabolism of the apicoplast
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KEOPS complex
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Nuclear genes with apicoplast signal sequences
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The proteome of the apicoplast
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Common for mitochondrion and apicoplast
9
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Compartmentalization of porphyrin biosynthesis
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Lipoic acid metabolism
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Organellar distribution of translation components
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Organellar ribosomal proteins
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Organellar ribosome assembly proteins and their predicted targeting
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Replication in prokaryotes – a model for apicoplast and mitochondion DNA replication
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Transcription in prokaryotes
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Translation in prokaryotes – a template for apicoplast and mitochondrion
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Transporters of the mitochondrial and apicoplast membranes
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Hemoglobin digestion in the food vacuole
5
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Crystallization of Hemozoin and its Inhibition by Antimalarial Drugs
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Endocytosis of host cell cytosol
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Hemoglobin digestion
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Hemozoin and b-hematin formation
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Phosphatidylinositol 3-kinase (PI3K)-controlled endocytosis of host cell hemoglobin
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Intracellular traffic
26
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ADP ribosylation factors functions in the secretory pathway
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Assembly of the retromer complex
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Classical clathrin-mediated vesicular transport
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Classical COPII-mediated vesicular transport
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Classical COPI-mediated vesicular transport
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Endosome maturation
|
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ER-to Golgi, translocation and quality control
|
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GARP (Golgi-associated retrograde protein) complex
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gp78 and Hrd1-mediated ERAD pathways
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Intracellular distribution of phosphoinositides and small GTPases involved in membrane traffic
|
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Large Tethering Complexes that Act in the Secretory and Endocytic Pathways
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Phosphoinositides and membrane traffic
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Proteins and complexes that are involved in protein transport into the endoplasmic reticulum
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Proteins of the parasitophorous vacuolar membrane
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Proteins with ER retention sequences
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Proteome of the parasitophorous vacuole
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Putative Golgi disassembly and reassembly mechanisms
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Rab and other proteins involved in intracellular traffic
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Rab cycle
|
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Rab GTPase regulation of membrane identity
|
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Rab proteins
|
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Shared themes in cascading Rab and phosphoinositide pathways
|
|
SNAREs and their accessories
|
|
SNAREs are traffic-specific
|
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Subcellular location of adaptor proteins
|
|
Vacuole biogenesis and ER proliferation
|
|
Mitochondrial functions
24
|
|
Acetyl-CoA production in the mitochondrion
|
|
Biogenesis and functions of mitochondrial cytochrome c
|
|
Biogenesis of cytochrome oxidase
|
|
Chaperone network and protein quality control of the mitochondrion
|
|
Enzyme involved in protein degradation within mitochondria
|
|
Functions of the ER–Mitochondrial contacts
|
|
Genes coding for Fe-S containing proteins
|
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Genes coding for mitochondrial ribosome subunits
|
|
Import of proteins into the mitochondrion
|
|
Maturation of cytosolic and nuclear Fe-S proteins
|
|
Mechanism of Fe–S-protein biogenesis
|
|
Mitochondrial antioxidant system
|
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Mitochondrial copper transport pathways to cytochrome C oxidase subunits
|
|
Mitochondrial disulfide relay system
|
|
Mitochondrial division
|
|
Mitochondrial electron flow
|
|
Mitochondrial LSU rRNA secondary structure
|
|
Mitochondrial TCA cycle
|
|
Models for TCA metabolism under various conditions
|
|
Nuclear genes with mitochondrial signal sequences
|
|
Pathways of peptide export from the mitochondrion
|
|
Schematic map of the mitochondrial genome
|
|
Topogenesis of the Rieske FeS protein
|
|
Translation in mitochondrion
|
|
Other functional processes
13
|
|
Activation of the calcium and cAMP signaling pathway by melatonin
|
|
Catabolism of polyphosphates
|
|
Cell apoptosis in malaria
|
|
Differentially expressed genes in 3D7 strain treated for 5h with melatonin
|
|
Differentially expressed genes in different stages treated with cAMP
|
|
Generation of polyphosphates
|
|
Localization of the key cyclic nucleotide signaling components in a merozoite prior to egress
|
|
pH regulation in the parasite cytosol
|
|
Putative role of PfSR25 in activation of Ca2+ signaling and stress survival
|
|
Signaling machinery in malaria parasites
|
|
Stage-specific involvement of cyclic nucleotide signaling components and calcium-dependent protein kinases
|
|
The homeostasis of Ca2+ in malaria parasites
|
|
Transcriptomic response of dihydroartemisinin (DHA) treated K1 strain trophozoites
|
|
Other organelles
6
|
|
Food vacuole proteome
|
|
Nuclear proteome
|
|
Oxysterol binding protein (OSBP) structure and function
|
|
Parasitophorous vacuole proteins
|
|
Peroxidase active organelles
|
|
The acidocalcisome
|
|
Permeability of the membrane of the infected RBC
6
|
|
Malaria parasite infection perturbs Na+ and K+ homeostasis in human erythrocytes
|
|
Possible reasons for increased permeability of host cell membrane
|
|
Sequential and parallel solute transport pathways
|
|
Solutes permeating through NPPs
|
|
Transport systems in normal and parasitized RBC
|
|
Volume and ion homeostasis of infected red blood cells during the intraerythrocytic cycle of the parasite
|
|
Protein Export
29
|
|
Alternative protein export pathways
|
|
Biogenesis of Maurer’s clefts
|
|
Characteristics of Plasmodium falciparum export proteins that remodel infected erythrocyte
|
|
Clp proteases and the translocon of exported proteins
|
|
Components of exosomes
|
|
Established and putative Maurer’s clefts proteins
|
|
Exported parasite proteins associated with Maurer’s clefts
|
|
Exported proteins containing a PHIST domain
|
|
Exported proteins of Plasmodium falciparum with confirmed location
|
|
Exportome - compiled from various sources
|
|
Extracellular vesicle involvement in malaria disease
|
|
Genes coding for protein traffic related proteins
|
|
Key steps and compartments in the protein export pathway
|
|
Location of lipid raft-associated proteins
|
|
Model of PfEMP1 export
|
|
Models for protein transport to the membrane of P. falciparum-infected erythrocytes
|
|
Models of PEXEL and PNEP export
|
|
Molecular model of vesicle exocytosis
|
|
Parasite encoded proteins associated with the membrane of infected erythrocytes
|
|
Parasite proteins co-exported with Hsp70x
|
|
Phosphatidylinositol-3-phosphate-dependent and -independent export from the endoplasmic reticulum
|
|
Properties of proteins exported to erythrocyte
|
|
Proteins of erythrocyte-derived microvesicles
|
|
Putative trafficking pathways in P. falciparum-infected erythrocytes I - Diagrammatic representation
|
|
Signal-peptide-containing exported proteins
|
|
Subcellular localization of exported proteins
|
|
Subcellular location of exported proteins
|
|
Top ranked surface exposed proteins
|
|
Translocon of exported proteins (PTEX)
|
|
The parasite cell membrane
3
|
|
Genes coding for transport proteins
|
|
Physiology and biochemistry of the parasite as affected by inhibition of PfATP4
|
|
Transporters of the plasma membrane
|
|
Transport through the nuclear pore
4
|
|
Bulk mRNA transport through the nuclear pore
|
|
Import and export through the nuclear pore
|
|
Karyopherin/exportin-mediated nuclear export pathways
|
|
Structure of the nuclear pore
|
|
Transporters of intracellular membranes
3
|
|
ATP synthase complex
|
|
Transporters of the ER/Golgi and digestive vacuole membranes
|
|
Transporters of the mitochondrial and apicoplast membranes
|