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Kinases and their inhibitors |
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Cohen P, Goedert M. GSK3 inhibitors: development and therapeutic potential. Nat Rev Drug Discov. 2004 3(6):479-87. PMID: 15173837. |
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Kinase |
PfID |
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Annotation |
Inhibitor |
Link |
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PfPI4Kβ |
PF3D7_0509800 |
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phosphatidylinositol 4-kinase beta |
KDU691 |
https://pubchem.ncbi.nlm.nih.gov/compound/90157166 |
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MMV390048 |
https://pubchem.ncbi.nlm.nih.gov/compound/53311393 |
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UCT943 |
https://pubchem.ncbi.nlm.nih.gov/compound/71711915 |
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PfPKG |
PF3D7_1436600 |
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cGMP-dependent protein kinase |
MMV030084 |
https://pubchem.ncbi.nlm.nih.gov/compound/22185475 |
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ML10 |
https://pubchem.ncbi.nlm.nih.gov/compound/137553160 |
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PfGSK3 |
PF3D7_0809800 |
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conserved Plasmodium protein, unknown function |
thienopyridine |
https://pubchem.ncbi.nlm.nih.gov/compound/12210218 |
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4h |
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23d |
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PfPK6 |
PF3D7_1337100 |
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protein kinase 6 |
compound 79 |
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TCMDC-135051 |
https://pubchem.ncbi.nlm.nih.gov/compound/146026063 |
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PfCLK3 |
PF3D7_1114700 |
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cyclin-dependent-like kinase clk3 |
7-azaindole TCMDC-135051 |
https://pubchem.ncbi.nlm.nih.gov/compound/139035060 |
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PfCDPK1 |
PF3D7_0217500 |
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Calcium-dependent protein kinases; CDPK1 |
Purfalcamine |
https://pubchem.ncbi.nlm.nih.gov/compound/24762166 |
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compound 41 |
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K252a |
https://pubchem.ncbi.nlm.nih.gov/compound/3035817 |
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imidazopyridazine |
https://pubchem.ncbi.nlm.nih.gov/compound/11029819 |
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staurosporine |
https://pubchem.ncbi.nlm.nih.gov/compound/44259 |
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PfCDPK4 |
PF3D7_0717500 |
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calcium-dependent protein kinase 4, CDPK4 |
BKI-1 |
https://pubchem.ncbi.nlm.nih.gov/compound/135566685 |
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imidazopyridazine |
https://pubchem.ncbi.nlm.nih.gov/compound/11029819 |
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compound 34 |
https://pubchem.ncbi.nlm.nih.gov/compound/86290500 |
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PfPK7 |
PF3D7_0213400 |
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protein kinase 7 |
compound 34 |
https://pubchem.ncbi.nlm.nih.gov/compound/86290500 |
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PfGSK3/PfPK6 |
PF3D7_0312400 |
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glycogen synthase kinase 3 |
CHIR 99021 |
https://pubchem.ncbi.nlm.nih.gov/compound/9956119 |
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