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Peptidases and proteases |
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Weißbach T, Golzmann A, Bennink S, Pradel G, Julius Ngwa C. Transcript and protein expression analysis of proteases in the blood stages of Plasmodium falciparum. Exp Parasitol. 2017 180:33-44. PMID: 28351685. |
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Data for MEROPS were taken from (http://merops.sanger.ac.uk/index.htm) with additions. Clans and families are linked to MEROPS. |
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PfID |
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Annotation |
EC |
Transcript |
MEROPS assignment |
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Cysteine proteases |
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Clan |
Family |
MEROPS ID |
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PF3D7_1458000 |
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cysteine proteinase falcipain 1 |
3.4.22.- |
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AA |
A1 |
A01.022 |
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PF3D7_1115700 |
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cysteine proteinase falcipain 2a falcipain 2 |
3.4.22.- |
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AA |
A1 |
A01.023 |
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PF3D7_1115300 |
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falcipain 2' cysteine proteinase falcipain 2b |
3.4.22.- |
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AA |
A1 |
A01.043 |
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PF3D7_1115400 |
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cysteine proteinase falcipain 3 |
3.4.22.- |
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AA |
A1 |
A01.058 |
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PF3D7_1116700 |
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dipeptidyl aminopeptidase 1 cathepsin C, homolog |
3.4.14.1 |
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AA |
A1 |
A01.058 |
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PF3D7_1247800 |
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dipeptidyl aminopeptidase 2 |
3.4.14.1 |
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AA |
A1 |
A01.059 |
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PF3D7_0404700 |
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dipeptidyl aminopeptidase 3 |
3.4.14.4 |
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AA |
A1 |
A01.075 |
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PF3D7_0208000 |
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serine repeat antigen 1 |
3.4.22.- |
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AA |
A1 |
A01.A32 |
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PF3D7_0207900 |
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serine repeat antigen 2 |
3.4.22.- |
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AA |
A1 |
A01.A93 |
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PF3D7_0207800 |
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serine repeat antigen 3 |
3.4.22.- |
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AA |
A1 |
A01.A95 |
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PF3D7_0207700 |
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serine repeat antigen 4 |
3.4.22.- |
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AA |
A1 |
unassigned |
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PF3D7_0207600 |
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serine repeat antigen 5 |
3.4.22.- |
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AA |
A28 |
A28.A07 |
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PF3D7_0207500 |
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serine repeat antigen 6 |
3.4.22.- |
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AD |
A22 |
A22.013 |
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PF3D7_0207400 |
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serine repeat antigen 7 |
3.4.22.- |
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CA |
C1 |
C01.046 |
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PF3D7_0207300 |
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serine repeat antigen 8 |
3.4.22.- |
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CA |
C1 |
C01.063 |
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PF3D7_0902800 |
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serine repeat antigen 9 |
3.4.22.2 |
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CA |
C1 |
C01.077 |
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PF3D7_1362400 |
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calpain |
3.4.22.- |
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CA |
C1 |
C01.124 |
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PF3D7_1117100 |
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ubiquitin carboxyl-terminal hydrolase uch54 |
3.4.19.12 |
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CA |
C1 |
C01.126 |
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PF3D7_0104300 |
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ubiquitin carboxyl-terminal hydrolase 1, putative |
3.4.19.12 |
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CA |
C1 |
C01.169 |
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PF3D7_0403500 |
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ubiquitin specific protease, putative |
3.1.2.15 |
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CA |
C1 |
C01.984 |
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PF3D7_0413900 |
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ubiquitin carboxyl-terminal hydrolase 13, putative |
3.4.19.12 |
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CA |
C1 |
C01.984 |
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PF3D7_0527200 |
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ubiquitin carboxyl-terminal hydrolase 14 |
3.4.19.12 |
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CA |
C1 |
C01.984 |
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PF3D7_0516700 |
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ubiquitin carboxyl-terminal hydrolase 2, putative |
3.4.19.12 |
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CA |
C1 |
C01.984 |
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PF3D7_0726500 |
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ubiquitin carboxyl-terminal hydrolase, putative |
3.4.19.12 |
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CA |
C1 |
C01.984 |
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PF3D7_0904600 |
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ubiquitin specific protease, putative |
3.4.19.12 |
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CA |
C1 |
C01.984 |
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PF3D7_1317000 |
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U4/U6.U5 tri-snRNP-associated protein 2, putative |
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CA |
C1 |
C01.A64 |
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PF3D7_1414700 |
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ubiquitin carboxyl-terminal hydrolase, putative |
3.4.19.12 |
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CA |
C1 |
non-peptidase homologue |
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PF3D7_1128700 |
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GPI-anchor transamidase |
3.4.13.19 |
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CA |
C1 |
non-peptidase homologue |
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PF3D7_1354800 |
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metacaspase 1 |
3.4.22.- |
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CA |
C1 |
non-peptidase homologue |
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PF3D7_1438400 |
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metacaspase-2 |
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CA |
C1 |
unassigned |
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PF3D7_1233900 |
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sentrin-specific protease 1 |
3.4.22.68 |
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CA |
C1 |
unassigned |
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PF3D7_0801700 |
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sentrin-specific protease 2, putative |
5.3.1.8 |
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CA |
C2 |
C02.029 |
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PF3D7_0627500 |
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protein DJ-1 |
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CA |
C12 |
C12.010 |
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PF3D7_0309500 |
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asparagine synthetase [glutamine-hydrolyzing], putative |
6.3.5.4 |
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CA |
C12 |
C12.A12 |
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PF3D7_0809600 |
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peptidase family C50, putative separase, putative |
3.4.22.49 |
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CA |
C19 |
C19.A74 |
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PF3D7_0919200 |
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PPPDE peptidase, putative |
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CA |
C19 |
C19.A75 |
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PF3D7_0922400 |
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para-aminobenzoic acid synthetase |
2.6.1.85 |
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CA |
C19 |
C19.A76 |
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PF3D7_1006900 |
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PPPDE peptidase, putative |
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CA |
C19 |
C19.A77 |
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PF3D7_1012600 |
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GMP synthase [glutamine-hydrolyzing] |
6.3.5.2 |
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CA |
C19 |
C19.A78 |
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PF3D7_1025100 |
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glutamine--fructose-6-phosphate aminotransferase [isomerizing], putative |
2.6.1.16 |
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CA |
C19 |
C19.A79 |
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PF3D7_1031400 |
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OTU-like cysteine protease |
3.4.22.- |
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CA |
C19 |
C19.A80 |
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PF3D7_1111900 |
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Josephin domain-containing protein, putative |
3.4.19.12 |
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MA |
M3 |
unassigned |
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PF3D7_1116200 |
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pyridoxine biosynthesis protein PDX2 |
1.4.3.5 |
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MA |
M100 |
M100.UPW |
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PF3D7_1217900 |
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PPPDE peptidase domain-containing protein, putative |
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MA |
M41 |
M41.A13 |
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PF3D7_1226800 |
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ataxin-3, putative |
3.4.19.12 |
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MA |
M41 |
M41.A21 |
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PF3D7_1308200 |
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carbamoyl phosphate synthetase |
6.3.5.5 |
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MA |
M41 |
unassigned |
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PF3D7_1410200 |
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CTP synthase |
6.3.4.2 |
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MA |
M76 |
M76.A01 |
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PF3D7_1460400 |
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ubiquitin carboxyl-terminal hydrolase isozyme L3 |
3.4.19.12 |
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MA |
M80 |
unassigned |
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Aspartic proteases |
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PF3D7_1407900 |
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plasmepsin I |
3.4.23.38 |
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AA |
A1 |
A01.022 |
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PF3D7_1408000 |
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plasmepsin II |
3.4.23.39 |
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AA |
A1 |
A01.023 |
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PF3D7_1408100 |
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plasmepsin III histo-aspartic protease |
3.4.23.- |
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AA |
A1 |
A01.023 |
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PF3D7_1407800 |
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plasmepsin IV |
3.4.23.- |
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NA |
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PF3D7_1323500 |
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PEXEL protease plasmepsin V |
3.4.23.- |
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AA |
A1 |
A01.075 |
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PF3D7_0311700 |
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plasmepsin VI |
3.4.23.- |
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AA |
A1 |
A01.058 |
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PF3D7_1033800 |
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plasmepsin VII |
3.4.23.- |
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AA |
A1 |
A01.A32 |
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PF3D7_1465700 |
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plasmepsin viii, putative |
3.4.17.4 |
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AA |
A1 |
A01.058 |
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PF3D7_1430200 |
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plasmepsin IX |
3.4.23.- |
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AA |
A1 |
A01.A32 |
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PF3D7_0808200 |
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plasmepsin X |
3.4.23.1 |
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NA |
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PF3D7_1234400 |
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microgamete surface protein migs, putative |
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PF3D7_1409300 |
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DNA damage-inducible protein 1 |
3.4.23.- |
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AA |
A28 |
A28.A07 |
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PF3D7_1457000 |
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signal peptide peptidase |
3.4.21.89 |
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AD |
A22 |
A22.013 |
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Serine proteases |
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PF3D7_0807700 |
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serine protease DegP |
3.4.21.- |
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PA |
S1 |
S01.B87 |
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PF3D7_0321500 |
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peptidase, putative |
3.4.21.26 |
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SC |
S9 |
S09.A66 |
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PF3D7_0307400 |
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ATP-dependent Clp protease proteolytic subunit |
3.4.21.92 |
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SK |
S14 |
S14.011 |
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PF3D7_1436800 |
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ATP-dependent Clp protease proteolytic subunit |
3.4.21.92 |
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SK |
S14 |
non-peptidase homologue |
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PF3D7_0816600 |
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chaperone protein ClpB1 |
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NA |
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PF3D7_1406600 |
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ATP-dependent Clp protease regulatory subunit Clpc, putative |
3.4.21.92 |
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NA |
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PF3D7_1116800 |
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heat shock protein 101 chaperone protein ClpB2 |
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NA |
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PF3D7_1414900 |
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ATP-dependent protease, putative |
3.4.21.53 |
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SJ |
S16 |
S16.A14 |
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PF3D7_1320400 |
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type I signal peptidase |
3.4.21.89 |
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SF |
S26 |
non-peptidase homologue |
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PF3D7_1331300 |
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signal peptidase complex catalytic subunit SEC11 |
3.4.21.89 |
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SF |
S26 |
S26.010 |
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PF3D7_0507500 |
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subtilisin-like protease 1 |
3.4.21.62 |
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SB |
S8 |
S08.013 |
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PF3D7_1136900 |
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subtilisin-like protease 2 |
3.4.21.62 |
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SB |
S8 |
S08.013 |
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PF3D7_0507200 |
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subtilisin-like protease 3 |
3.4.21.62 |
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SB |
S8 |
non-peptidase homologue |
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PF3D7_1114100 |
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rhomboid protease ROM1 |
3.4.21.105 |
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ST |
S54 |
S54.018 |
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PF3D7_0828000 |
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rhomboid protease ROM3 |
3.4.21.105 |
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ST |
S54 |
S54.021 |
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PF3D7_0506900 |
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rhomboid protease ROM4 |
3.4.21.105 |
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ST |
S54 |
S54.017 |
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PF3D7_1345200 |
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rhomboid protease ROM6, putative |
3.4.21.105 |
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ST |
S54 |
unassigned |
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PF3D7_1358300 |
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rhomboid protease ROM7 |
3.4.21.105 |
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ST |
S54 |
unassigned |
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PF3D7_1411200 |
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rhomboid protease ROM8 |
3.4.21.105 |
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ST |
S54 |
S54.A13 |
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PF3D7_0515100 |
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rhomboid protease ROM9 |
3.4.21.105 |
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ST |
S54 |
unassigned |
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PF3D7_0618600 |
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rhomboid protease ROM10 |
3.4.21.105 |
ST |
S54 |
non-peptidase homologue |
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PF3D7_0826200 |
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alpha/beta hydrolase, putative |
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SC |
S33 |
S33.B16 |
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PF3D7_0812200 |
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trypsin-like serine protease, putative |
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NA |
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PF3D7_0805000 |
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alpha/beta hydrolase, putative |
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NA |
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PF3D7_0812220 |
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GTP-binding protein YihA3 |
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NA |
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PF3D7_1032500 |
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DER1-like protein, putative |
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ST |
S54 |
non-peptidase homologue |
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PF3D7_1401300 |
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proline aminopeptidase |
3.4.11.5 |
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SC |
S33 |
unassigned |
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PF3D7_1410100 |
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alpha/beta hydrolase, putative |
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NA |
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PF3D7_1468500 |
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derlin-1 |
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ST |
S54 |
non-peptidase homologue |
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PF3D7_1001400 |
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exported lipase 1 |
3.1.1.5 |
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SC |
S33 |
S33.B17 |
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PF3D7_0731800 |
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alpha/beta hydrolase, putative gametocyte exported protein 8 |
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SC |
S33 |
S33.B17 |
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PF3D7_0403800 |
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alpha/beta hydrolase, putative |
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SC |
S9 |
S09.A95 |
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PF3D7_0301300 |
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epoxide hydrolase 1 |
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SC |
S33 |
unassigned |
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Threonine proteases |
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PF3D7_1474800 |
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proteasome subunit alpha type-1, putative |
3.4.25.1 |
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PB |
T1 |
T01.A16 |
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PF3D7_0608500 |
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proteasome subunit alpha type-2, putative |
3.4.25.1 |
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PB |
T1 |
T01.972 |
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PF3D7_0317000 |
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proteasome subunit alpha type-3, putative |
3.4.25.1 |
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PB |
T1 |
unassigned |
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PF3D7_1353800 |
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proteasome subunit alpha type-4, putative |
3.4.25.1 |
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PB |
T1 |
T01.973 |
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PF3D7_0727400 |
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proteasome subunit alpha type-5, putative |
3.4.25.1 |
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PB |
T1 |
unassigned |
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PF3D7_0807500 |
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proteasome subunit alpha type-6, putative |
3.4.25.1 |
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PB |
T1 |
unassigned |
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PF3D7_1353900 |
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proteasome subunit alpha type-7, putative |
3.4.25.1 |
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PB |
T1 |
T01.974 |
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PF3D7_0518300 |
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proteasome subunit beta type-1, putative |
3.4.25.1 |
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PB |
T1 |
T01.A14 |
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PF3D7_0803800 |
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proteasome subunit beta type-4 |
3.4.25.1 |
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PB |
T1 |
unassigned |
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PF3D7_0108000 |
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proteasome subunit beta type-3, putative |
3.4.25.1 |
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NA |
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PF3D7_1470900 |
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proteasome subunit beta type-2, putative |
3.4.25.1 |
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