Possible reasons for increased permeability of host cell membrane

Online articles related to Possible reasons for increased permeability of host cell membrane retrieved from PubMed

Drugs affecting pathway with unknown specific target

Drug Name	PubMed Articles (year of publication)
(E)-3-((13S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-2-yl)-1-phenylprop-2-en-1-one	Antiplasmodial activity of steroidal chalcones: evaluation of their effect on hemozoin synthesis and the new permeation pathway of Plasmodium falciparum-infected erythrocyte membrane
2-(3,3-diphenylpropylamino)-5-nitro-benzoic acid	In search of a selective inhibitor of the induced transport of small solutes in Plasmodium falciparum-infected erythrocytes: effects of arylaminobenzoates
2-(4-methoxyphenyl)-5H-thiazolo[4,5-c]quinolin-4-one	Synergistic Malaria Parasite Killing by Two Types of Plasmodial Surface Anion Channel Inhibitors
2-[2-(4-methoxyphenyl)ethylamino]-5-nitro-benzoic acid	In search of a selective inhibitor of the induced transport of small solutes in Plasmodium falciparum-infected erythrocytes: effects of arylaminobenzoates
2-amino-1-((2-amino-3-oxobutyl)disulfaneyl)-5-((7-chloroquinolin-4-yl)amino)pentan-3-one	Insights into the Membranolytic Activity of Antimalarial Drug-Cell Penetrating Peptide Conjugates
2-butyl-5-imino-6-{[5-(4-nitrophenyl)-2-furyl]methylene}-5,6-dihydro-7h-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one	Solute-inhibitor interactions in the plasmodial surface anion channel reveal complexities in the transport process
3-(4-phenylpiperazine-1-carbonyl)-5H-benzo[b][1,4]benzothiazepin-6-one	Synergistic Malaria Parasite Killing by Two Types of Plasmodial Surface Anion Channel Inhibitors
3-[(1-naphthylmethylamino)methyl]-4-phenyl-5-sulfinamoyl-benzoic acid	Furosemide analogues as potent inhibitors of the new permeability pathways of Plasmodium falciparum-infected human erythrocytes
3-[3-(2-naphthyl)propyl]-4-phenyl-5-sulfinamoyl-benzoic acid	Furosemide analogues as potent inhibitors of the new permeability pathways of Plasmodium falciparum-infected human erythrocytes
3-[5-[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl-2-thienyl]-1H-pyridazin-6-one	Synergistic Malaria Parasite Killing by Two Types of Plasmodial Surface Anion Channel Inhibitors
3-{3-[4-(7-Chloro-quinolin-4-yl)-piperazin-1-ylmethyl]-4-hydroxy-5- methoxyphenyl}-1-(2,4-dimethoxy-phenyl)-propenone	Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies
4-(4-((4-(3-methylpyrazin-2-yl)piperazin-1-yl)sulfonyl)cyclopenta-1,3-dien-1-yl)cyclohexa-2,4-dien-1-one	Optimized pyridazinone nutrient channel inhibitors are potent and specific antimalarial leads
4-(4-((4-(o-tolyl)piperazin-1-yl)sulfonyl)cyclopenta-1,3-dien-1-yl)cyclohexa-2,4-dien-1-one	Optimized pyridazinone nutrient channel inhibitors are potent and specific antimalarial leads
4,4 -diisothiocyanostilbene- 2,2 -disulfonic acid	A biotin derivative blocks parasite induced novel permeation pathways in Plasmodium falciparum-infected erythrocytes
4-chloro-5-nitro-2-(3-phenylpropylamino)benzoic acid	Furosemide analogues as potent inhibitors of the new permeability pathways of Plasmodium falciparum-infected human erythrocytes
4-methyl-3-[(1-naphthylmethylamino)-(2-thienyl)methyl]-5-sulfinamoyl-benzoic acid	Furosemide analogues as potent inhibitors of the new permeability pathways of Plasmodium falciparum-infected human erythrocytes
5-nitro-2-(3-phenylpropylamino)benzoate	Solute-inhibitor interactions in the plasmodial surface anion channel reveal complexities in the transport process
5-nitro-2-(3-phenylpropylamino)benzoic acid	In search of a selective inhibitor of the induced transport of small solutes in Plasmodium falciparum-infected erythrocytes: effects of arylaminobenzoates A biotin derivative blocks parasite induced novel permeation pathways in Plasmodium falciparum-infected erythrocytes
5-nitro-2-(4-phenylbutylamino)benzoic acid	In search of a selective inhibitor of the induced transport of small solutes in Plasmodium falciparum-infected erythrocytes: effects of arylaminobenzoates
7-methyl-N-(m-tolyl)-N-propyl-furo[2,3-b]quinoline-2-carboxamide	Synergistic Malaria Parasite Killing by Two Types of Plasmodial Surface Anion Channel Inhibitors
8-oh-dpat	5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel
Alkoxylated chalcones	Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes
Artemisinin	Artemisinin inhibits cation currents in malaria-infected human erythrocytes
Arvanil	Conditional permeabilization of the P. falciparum plasma membrane in infected cells links cation influx to reduced membrane integrity
Asp-Arg-Asp-Val-Lys-Tyr-Ile-His-Pro-Phe	Evidences for the action mechanism of angiotensin II and its analogs on Plasmodium sporozoite membranes
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe	Evidences for the action mechanism of angiotensin II and its analogs on Plasmodium sporozoite membranes
Benzylthiazolium	Selective killing of the human malaria parasite Plasmodium falciparum by a benzylthiazolium dye
Blasticidin s	A blasticidin S-resistant Plasmodium falciparum mutant with a defective plasmodial surface anion channel Altered plasmodial surface anion channel activity and in vitro resistance to permeating antimalarial compounds
Bradikynin	Anti-plasmodial activity of bradykinin and analogs
Dantrolene	Malaria parasites are rapidly killed by dantrolene derivatives specific for the plasmodial surface anion channel Specific inhibition of the plasmodial surface anion channel by dantrolene
D-Asp-D-Arg-D-Asp-D-Val-D-Lys-D-Tyr-D-Ile-D-His-D-Pro-D-Phe	Evidences for the action mechanism of angiotensin II and its analogs on Plasmodium sporozoite membranes
D-Asp-D-Arg-D-Val-D-Tyr-D-Ile-D-His-D-Pro-D-Phe	Evidences for the action mechanism of angiotensin II and its analogs on Plasmodium sporozoite membranes
Furoquinoline	A cell-based high-throughput screen validates the plasmodial surface anion channel as an antimalarial target
Furosemide	A biotin derivative blocks parasite induced novel permeation pathways in Plasmodium falciparum-infected erythrocytes Furosemide analogues as potent inhibitors of the new permeability pathways of Plasmodium falciparum-infected human erythrocytes Solute-inhibitor interactions in the plasmodial surface anion channel reveal complexities in the transport process Plasmodium falciparum transfected with ultra bright NanoLuc luciferase offers high sensitivity detection for the screening of growth and cellular trafficking inhibitors Synergistic Malaria Parasite Killing by Two Types of Plasmodial Surface Anion Channel Inhibitors
Glybenclamide	A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite Solute-inhibitor interactions in the plasmodial surface anion channel reveal complexities in the transport process
Hydroxylated chalcones	Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes
Ispa-28	Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells Solute restriction reveals an essential role for clag3-associated channels in malaria parasite nutrient acquisition
Lauryl-lysine	Antiplasmodial activity of lauryl-lysine oligomers
Leupeptin	Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes Altered plasmodial surface anion channel activity and in vitro resistance to permeating antimalarial compounds
Mmv007384	Bilayer Effects of Antimalarial Compounds
N-(1-benzylpropyl)-6-oxo-5H-benzo[b][1,4]benzothiazepine-3-carboxamide	Synergistic Malaria Parasite Killing by Two Types of Plasmodial Surface Anion Channel Inhibitors
N-benzyl-N-ethyl-6-oxo-5H-benzo[b][1,4]benzothiazepine-3-carboxamide	Synergistic Malaria Parasite Killing by Two Types of Plasmodial Surface Anion Channel Inhibitors
N-butyl-N-ethyl-7-methyl-furo[2,3-b]quinoline-2-carboxamide	Synergistic Malaria Parasite Killing by Two Types of Plasmodial Surface Anion Channel Inhibitors
Niflumate	A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite
Nk-2, a peptide representing the cationic core region of the lymphocytic effector protein nk-lysin	The antimicrobial peptide NK-2, the core region of mammalian NK-lysin, kills intraerythrocytic Plasmodium falciparum
Nppb	A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite The Plasmodium falciparum-induced anion channel of human erythrocytes is an ATP-release pathway Organic osmolyte channels in malaria-infected erythrocytes
Phe-Pro-His-Ile-Tyr-Val-Arg-Asp	Evidences for the action mechanism of angiotensin II and its analogs on Plasmodium sporozoite membranes
Phloretin-2-beta-glucoside	On the mode of action of phlorizin as an antimalarial agent in in vitro cultures of Plasmodium falciparum
Phosphinic acid	A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite Plasmodial surface anion channel-independent phloridzin resistance in Plasmodium falciparum
P-nitrophenyl phosphate	A biotin derivative blocks parasite induced novel permeation pathways in Plasmodium falciparum-infected erythrocytes
RPGLPVRFESPL-NH2	Anti-plasmodial activity of bradykinin and analogs
STAD-2	The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism
Succinimidyl-6-(biotinamido)hexanoate	A biotin derivative blocks parasite induced novel permeation pathways in Plasmodium falciparum-infected erythrocytes
Sulfo-nhs-lc-biotin	A biotin derivative blocks parasite induced novel permeation pathways in Plasmodium falciparum-infected erythrocytes

Possible reasons for increased permeability of host cell membrane map details

PFID	PFID Old	Annotation	Formal Annotation	EC
PF3D7_0302500	PFC0120w	CLAG3.1	cytoadherence linked asexual protein 3.1
PF3D7_0302200	PFC0110w	CLAG3.2	cytoadherence linked asexual protein 3.2
PF3D7_1439000	PF14_0369	CTR1	copper transporter, CTR1
PF3D7_0904900	PFI0240c	CuTP	copper-transporting ATPase	3.6.3.4
PF3D7_1455400	PF14_0528	HlyIII	hemolysin III
PF3D7_0929400	PFI1445w	RhopH2	high molecular weight rhoptry protein 2
PF3D7_0905400	PFI0265c	RhopH3	high molecular weight rhoptry protein 3

Total number of related proteins: 1

#	PFID	Formal Name
1	PFC0110w	cytoadherence linked asexual protein 3.2

Total number of related proteins: 1

#	PFID	Formal Name
1	PFC0120w	cytoadherence linked asexual protein 3.1

Total number of related proteins: 1

#	PFID	Formal Name
1	PFI0240c	copper-transporting ATPase

Total number of related proteins: 1

#	PFID	Formal Name
1	PFI0265c	high molecular weight rhoptry protein 3

Total number of related proteins: 1

#	PFID	Formal Name
1	PFI1445w	high molecular weight rhoptry protein 2

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0369	copper transporter, CTR1

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0528	hemolysin III

Malaria Parasite Metabolic Pathways

Drugs affecting pathway with unknown specific target

Possible reasons for increased permeability of host cell membrane map details

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1