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Proteins with ER retention sequences |
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Table compiled by Jude Przyborski |
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C-terminal -xDEL sequences are referred to as "ER retention sequences". These sequences actually cause continual retrieval of these protein from post-ER compartments, leading to their accumulation in the ER lumen. Hence, they are called "ER retrieval sequences". Such sequences mediate ER retrieval of soluble proteins only, the signals for membrane bound proteins are more complex, and not so predictive in value. |
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Gene ID |
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Predicted protein |
C-terminus |
Predicted/ known function |
Transcript |
EC |
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| 8230 |
PF3D7_1108600 |
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endoplasmic reticulum-resident calcium binding protein |
IDEL |
Calcium regulation |
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| 8235 |
PF3D7_1344200 |
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PfHsp70-y |
KDEL |
Protein folding. Apicoplast transit peptide; overlaps with HSP70 domain |
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| 8227 |
PF3D7_0917900 |
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PfHsp70-2 |
SDEL |
Protein folding |
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| 8233 |
PF3D7_1222300 |
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endoplasmin, putative |
SDEL |
Abundant ER resident glycoprotein with calcium binding properties |
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| 8232 |
PF3D7_1115600 |
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peptidyl-prolyl cis-trans isomerase |
SGEL-PL |
Protein folding. |
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5.2.1.8 |
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| 8226 |
PF3D7_0827900 |
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protein disulfide isomerase |
SEEL |
Protein folding/ di-sulphide bond formation. |
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5.3.4.1 |
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| 8236 |
PF3D7_1472600 |
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protein disulfide-isomerase |
YEEL |
Protein folding/ di-sulphide bond formation. |
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5.3.4.1 |
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| 25886 |
PF3D7_1108700 |
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heat shock protein 40, type ii |
Y-DDEL |
DnaJ/Theoredoxin domains. Next to PfERC on chromosome. |
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| 8225 |
PF3D7_0309100 |
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omd protein, putative |
NEEL |
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| 25684 |
PF3D7_1322000 |
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nucleoside-diphosphatase, putative |
SEDL |
Putative nucleoside-diphosphatase, Mig23 domain. |
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3.6.1.6 |
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| 8228 |
PF3D7_1010700 |
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dolichyl-phosphate-mannose-protein mannosyltransferase, putative |
RDEL |
MIR domain containing protein. Possibly involved in calcium regulation. |
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2.4.1.109 |
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| 33886 |
PF3D7_1104400 |
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thioredoxin-like mero protein |
KDEL |
Thioredoxin/PDI domains. Protein folding. Oxidative stress. |
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| 14383 |
PF3D7_1404900 |
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conserved Plasmodium protein, unknown function |
SDEL |
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