Malaria Parasite Metabolic Pathways
Drugs affecting pathway with unknown specific target
| Drug Name | PubMed Articles (year of publication) |
|---|---|
| Docetaxel |
Regulation of spindle microtubule dynamics map details
| PFID | PFID Old | Annotation | Formal Annotation | EC | Transcript |
|---|---|---|---|---|---|
| PF3D7_1026400 | PF10_0261 | Ase1 | cell division cycle protein 20 homolog, putative |
|
|
PF3D7_0422300
|
PFD1050w | a-Tubulin | alpha tubulin 2, transcript expression profile microgametocyte |
|
|
|
PF3D7_0903700
|
PFI0180w | a-Tubulin | alpha tubulin 1 |
|
|
|
PF3D7_1008700
|
PF10_0084 | b-tubulin | tubulin beta chain |
|
|
|
PF3D7_1475700
|
PF14_0725 | b-tubulin | tubulin epsilon chain, putative |
|
|
| PF3D7_1473300 | PF14_0701 | CKK | ckk domain-containing protein, putative |
|
|
| PF3D7_1449100 | PF14_0468 | CLASP | CLASP domain-containing protein, putative |
|
|
| PF3D7_0708000 | MAL7P1.25 | cytoskeleton associated protein, putative | cytoskeleton associated protein, putative |
|
|
| PF3D7_1145300 | PF11_0464a | cytoskeleton associated protein, putative | cysteine-rich PDZ-binding protein, putative |
|
|
|
PF3D7_0729800
|
MAL7P1.161 | Dynein | dynein light chain, putative | ||
|
PF3D7_0729900
|
MAL7P1.162 | Dynein | dynein heavy chain, putative |
|
|
|
PF3D7_0822500
|
MAL8P1.46 | Dynein | leucine-rich repeat protein dynein light chain 1 | ||
| PF3D7_0927500 | PFI1350c | Dynein | dynein light chain, putative |
|
|
| PF3D7_1020300 | PF10_0196 | Dynein | cytoplasmic dynein intermediate chain, putative |
|
|
|
PF3D7_1023100
|
PF10_0224 | Dynein | dynein heavy chain, putative |
|
|
| PF3D7_1037800 | PF10_0371 | Dynein | dynein intermediate chain, putative |
|
|
| PF3D7_1114000 | PF11_0148 | Dynein | dynein light chain Tctex-type, putative |
|
|
|
PF3D7_1122900
|
PF11_0240 | Dynein | dynein heavy chain, putative |
|
|
|
PF3D7_1213600
|
PFL0660w | Dynein | dynein light chain 1, putative |
|
|
| PF3D7_1357300 | PF13_0306 | Dynein | dynein light chain, putative |
|
|
| PF3D7_1426300 | PF14_0243a | Dynein | dynein intermediate chain, putative |
|
|
|
PF3D7_1465800
|
PF14_0626 | Dynein | dynein beta chain, putative |
|
|
| PF3D7_1420800 | PF14_0202 | dynein light chain, putative | dynein light chain, putative |
|
|
|
PF3D7_0307300
|
PFC0305w | EB1 | microtubule-associated protein RP/EB family, putative |
|
|
|
PF3D7_0317500
|
PFC0770c | Eg5 | kinesin-5 |
|
|
|
PF3D7_0803700
|
PF08_0125 | g-TuRC | tubulin gamma chain |
|
|
| PF3D7_1229500 | PFL1425w | g-TuRC | T-complex protein 1 subunit gamma |
|
|
|
PF3D7_0309200
|
PFC0385c | IPL1 | serine/threonine protein kinase ark2, putative | 2.7.11.1 |
|
|
PF3D7_0407900
|
PFD0390c | Katanin | AAA family ATPase, putative |
|
|
| PF3D7_1243800 | PFL2105c | Katanin | WD repeat-containing protein 82, putative |
|
|
|
PF3D7_0111000
|
PFA0535c | Kinesin | kinesin-8b |
|
|
| PF3D7_0319400 | PFC0860w | Kinesin | kinesin-8x |
|
|
| PF3D7_0724900 | PF07_0104 | Kinesin | kinesin-20, putative |
|
|
| PF3D7_0806600 | MAL8P1.132 | Kinesin | kinesin-like protein, putative |
|
|
| PF3D7_1146700 | PF11_0478 | Kinesin | kinesin-x4, putative |
|
|
| PF3D7_1211000 | PFL0545w | Kinesin | kinesin-x3, putative |
|
|
| PF3D7_1245100 | PFL2165w | Kinesin | kinesin-13, putative | ||
| PF3D7_1245600 | PFL2190c | Kinesin | kinesin-15, putative |
|
|
| PF3D7_1144800 | PF11_0460 | KinI | conserved Plasmodium protein, unknown function | ||
| PF3D7_1339800 | PF13_0217 | mitotic-spindle organizing protein | mitotic-spindle organizing protein 1, putative |
|
|
| PF3D7_0813200 | MAL8P1.96 | NudC | CS domain protein, putative |
|
|
| PF3D7_0920200 | PFI0990c | NudC | CS domain protein, putative |
|
|
| PF3D7_0927000 | PFI1325w | NudC | Hsp90 co-chaperone p23 |
|
|
| PF3D7_1336800 | PF13_0204 | NudC | nuclear movement protein, putative |
|
|
| PF3D7_1416100 | PF14_0159 | SEY1 | protein SEY1, putative |
|
|
| PF3D7_0803200 | MAL8P1.146 | SF-assemblin | filament assembling protein, putative |
|
|
| PF3D7_1432900 | PF14_0311 | SF-assemblin | SF-assemblin, putative |
|
|
| PF3D7_1023400 | PF10_0227 | Spindle assembly checkpoint protein mad2 | HORMA domain protein, putative | ||
| PF3D7_1309400 | PF13_0050 | Spindle assembly checkpoint protein mad2 | HORMA domain protein, putative |
|
Total number of related proteins: 8
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFA0535c
|
kinesin-8b |
| 2 | PFC0860w | kinesin-8x |
| 3 | PF07_0104 | kinesin-20, putative |
| 4 | MAL8P1.132 | kinesin-like protein, putative |
| 5 | PF11_0478 | kinesin-x4, putative |
| 6 | PFL0545w | kinesin-x3, putative |
| 7 | PFL2165w | kinesin-13, putative |
| 8 | PFL2190c | kinesin-15, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFC0305w
|
microtubule-associated protein RP/EB family, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFC0385c
|
serine/threonine protein kinase ark2, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFC0770c
|
kinesin-5 |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFD0390c
|
AAA family ATPase, putative |
| 2 | PFL2105c | WD repeat-containing protein 82, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFD1050w
|
alpha tubulin 2, transcript expression profile microgametocyte |
| 2 |
PFI0180w
|
alpha tubulin 1 |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | MAL7P1.25 | cytoskeleton associated protein, putative |
| 2 | PF11_0464a | cysteine-rich PDZ-binding protein, putative |
Total number of related proteins: 13
| # | PFID | Formal Name |
|---|---|---|
| 1 |
MAL7P1.161
|
dynein light chain, putative |
| 2 |
MAL7P1.162
|
dynein heavy chain, putative |
| 3 |
MAL8P1.46
|
leucine-rich repeat protein dynein light chain 1 |
| 4 | PFI1350c | dynein light chain, putative |
| 5 | PF10_0196 | cytoplasmic dynein intermediate chain, putative |
| 6 |
PF10_0224
|
dynein heavy chain, putative |
| 7 | PF10_0371 | dynein intermediate chain, putative |
| 8 | PF11_0148 | dynein light chain Tctex-type, putative |
| 9 |
PF11_0240
|
dynein heavy chain, putative |
| 10 |
PFL0660w
|
dynein light chain 1, putative |
...
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Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | MAL8P1.146 | filament assembling protein, putative |
| 2 | PF14_0311 | SF-assemblin, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF08_0125
|
tubulin gamma chain |
| 2 | PFL1425w | T-complex protein 1 subunit gamma |
Total number of related proteins: 4
| # | PFID | Formal Name |
|---|---|---|
| 1 | MAL8P1.96 | CS domain protein, putative |
| 2 | PFI0990c | CS domain protein, putative |
| 3 | PFI1325w | Hsp90 co-chaperone p23 |
| 4 | PF13_0204 | nuclear movement protein, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF10_0084
|
tubulin beta chain |
| 2 |
PF14_0725
|
tubulin epsilon chain, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF10_0227 | HORMA domain protein, putative |
| 2 | PF13_0050 | HORMA domain protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF10_0261 | cell division cycle protein 20 homolog, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF11_0460 | conserved Plasmodium protein, unknown function |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF13_0217 | mitotic-spindle organizing protein 1, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF14_0159 | protein SEY1, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF14_0202 | dynein light chain, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF14_0468 | CLASP domain-containing protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF14_0701 | ckk domain-containing protein, putative |