Total fatty acids in RBC and iRBC
Wein S, Ghezal S, Buré C, Maynadier M, Périgaud C, Vial HJ, Lefebvre-Tournier I, Wengelnik K, Cerdan R. Contribution of the precursors and interplay of the pathways in the phospholipid metabolism of the malaria parasite. J Lipid Res. 2018 59(8):1461-1471. PMID: 29853527
pfpmtD =D phosphoethanolamine N-methyltransferase PF3D7_1343000.
fatty acid in different phospholipids RBC 3D7 P. f.-iRBC pfpmtD
(% of total PC) (% of total PC) (% of total PC)
Phosphatidyl choline Mean s.e.m. (n=3) Mean s.e.m. (n=7) Mean s.e.m. (n=3)
PC 14:0-16:1 3.67 0.56 0.92 0.16 0.66 0.11
PC 16:0/16:0 4.28 0.11 13.01 1.29 15.39 1.27
PC 14:0-18:1 1.11 0.24 1.96 0.48 1.25 0.05
PC 14:0-18:2 0.16 0.01 0.28 0.05 0.17 0.01
PC 16:0-18:0 5.78 2.31 11.7 3.22 9.12 1.4
PC 16:0-18:1 22.57 1.21 32.42 1.94 29.6 0.81
PC 16:0-18:2 22.91 0.49 14.99 0.89 13.95 0.79
PC 18:0-18:1 5.46 0.55 6.12 0.33 6.52 0.54
PC 18:0-18:2 + 10.75 1.02 5.89 0.33 5.71 0.39
PC 18:1/18:1
PC 16:0-20:3 + 6.46 0.37 3.21 0.19 3.71 0.36
PC 18:1-18:2
PC 16:1-20:3 + 7.41 0.73 4.28 0.3 6.73 1.12
PC 16:0-20:4 +
PC 18:2/18:2
PC 38:3 1.17 0.16 0.69 0.06 0.97 0.01
PC 18:0-20:4 + 3.69 0.08 1.73 0.15 2.51 0.23
PC 18:1-20:3
PC 38:5 1.91 0.27 1.15 0.1 1.61 0.15
PC 16:0-22:6 2.15 0.24 1.3 0.1 1.78 0.19
PC 40:4 0.15 0.01 0.07 0.01 0.1 0.01
PC 40:5 0.34 0.07 0.17 0.02 0.24 0.01
Phosphatidyl ethanolamine RBC 3D7 P. f.-iRBC pfpmtD P. f.-iRBC
(% of total PE) (% of total PE) (% of total PE)
Species Mean s.e.m. (n=3) Mean s.e.m. (n=3) Mean s.e.m. (n=3)
PE 14:0/18:1 0.22 0.03 0.55 0.12 0.47 0.05
PE 14:0/18:2 0.09 0.01 0.5 0.14 0.47 0.08
PE 16:0/16:0 0.77 0.12 2.39 0.48 2.24 0.83
PE 16:0/18:0 0.24 0.01 0.43 0.14 1.05 0.34
PE 16:0/18:1 23.49 0.68 29.14 1.04 27.46 0.8
PE 16:0/18:2 8.17 0.38 26.9 0.91 24.6 1.49
PE 16:0/20:1 0.23 0.01 0.14 0.06 0.21 0.03
PE 16:0/20:3 0.39 0.2 0.42 0.12 0 0
PE 16:0/20:4 12.54 1.16 9.92 0.9 13.35 0.83
PE 16:0/22:4 3.84 0.12 0.83 0.09 0.64 0.06
PE 16:0/22:5 2.24 0.21 0.69 0.16 1.17 0.02
PE 16:0/22:6 2.58 0.39 1.12 0.12 1.13 0.06
PE 18:0/18:1 6.85 0.27 4.82 0.64 5.88 0.4
PE 18:0/18:2 2.25 0.15 3.32 0.25 4.89 0.43
PE 18:0/20:3 0.59 0.3 0.78 0.18 1.24 0.27
PE 18:0/20:4 9.02 0.38 4.11 0.38 4.72 0.71
PE 18:0/22:4 1.3 0.09 0.27 0.07 0.24 0.01
PE 18:1/18:1 7.57 0.55 3.23 0.46 2.87 0.34
PE 18:1/18:2 7.3 0.38 2.92 0.68 4.06 0.26
PE 18:1/20:3 0.93 0.07 0.12 0.06 0 0
PE 18:1/20:4 7.66 0.4 1.6 0.12 1.61 0.11
PE 18:1/22:4 1.08 0.09 0.1 0.04 0.12 0.01
PE 18:2/18:2 0.66 0.02 0.61 0.3 1.57 0.13
Phosphatidyl ethanolamine RBC 3D7 P. f.-iRBC pfpmtD P. f.-iRBC
(% of total PS) (% of total PS) (% of total PS)
Species Mean s.e.m. (n=3) Mean s.e.m. (n=7) Mean s.e.m. (n=3)
PS 16:0-18:0 3.85 0.77 3.54 0.63 4.25 0.53
PS 16:0-18:1 0.81 0.16 10.62 1.41 12.85 1.42
PS 16:0-18:2 0 0 4.56 0.89 5.9 0.94
PS 16:0-20:1 0 0 0.19 0.16 0 0
PS 16:0-22:4 0.15 0.1 0 0 0 0
PS 16:0-22:5 0 0 0.03 0.03 0 0
PS 16:0-22:6 0 0 0.39 0.3 0 0
PS 18:0-18:1 9.44 0.69 14.96 0.93 16.36 1.46
PS 18:0-18:2 2.85 0.12 9.26 0.51 11.28 0.2
PS 18:0-20:3 6.6 0.37 4.83 0.69 5.33 0.26
PS 18:0-20:4 63.11 1.97 32.72 2.45 29.04 1.61
PS 18:0-22:4 8.58 0.76 4.66 0.86 3.17 0.39
PS 18:1/18:1 0.79 0.07 5.83 1.02 3.91 0.15
PS 18:1-18:2 0.16 0.03 3.41 0.63 3.47 0.12
PS 18:1-20:3 0.4 0.11 0.5 0.19 0 0
PS 18:1-20:4 3.86 1.02 3.8 0.39 4.44 0.43
PS 18:1-22:4 0.29 0.15 0 0 0 0
PS 18:2/18:2 0 0 0.24 0.12 0 0
Fatty acids labelling in 3D7
Phosphtidyl choline Unlabeled PC PC-d3 PC-d4
mean (%) s.e.m (%) mean (%) s.e.m (%) mean (%) s.e.m (%)
PC 14:0-16:1 0.64 0.19 0 0 0.06 0.04
PC 16:0/16:0 12.05 1.46 13.01 0.99 12.78 1.72
PC 14:0-18:1 2.26 0.67 1.15 0.39 2.53 0.62
PC 14:0-18:2 0.32 0.07 0.07 0.07 0.24 0.08
PC 16:0-18:0 13.04 3.29 4.87 2.14 3.7 0.98
PC 16:0-18:1 32.67 3.07 43.45 5.35 40.22 1.22
PC 16:0-18:2 14.76 1.12 17.59 2.21 16.76 1.36
PC 18:0-18:1 5.87 0.29 5.89 0.41 5.81 0.71
PC 18:0-18:2 + PC 18:1/18:1
 5.82 0.54 4.91 1.86 5.76 0.16
PC 16:0-20:3 + PC 18:1-18:2
 3.27 0.43 2.58 0.89 3.29 0.16
PC 16:1-20:3 + PC 16:0-20:4 + 4.15 0.44 3.04 1.25 4.51 0.18
PC 18:2/18:2
PC 36:8 0.18 0 0 0 0.19 0
PC 38:3 0.65 0.08 0.14 0.14 0.4 0.15
PC 18:0-20:4 + 1.66 0.29 1.31 0.58 1.39 0.18
PC 18:1-20:3
PC 38:5 1.23 0.23 0.56 0.42 0.92 0.33
PC 16:0-22:6 1.35 0.22 0.84 0.5 1.38 0.26
PC 40:4 0.06 0.02 0 0 0.05 0.02
PC 40:5 0.16 0.04 0 0 0.14 0.06
Total 100% 100% 100%
Phosphatidyl ethanolamine Unlabeled PE PE-d3 PE-d4
mean (%) s.e.m (%) mean (%) s.e.m (%) mean (%) s.e.m (%)
PE 14:0-18:1 0.64 0.1 0.47 0.24 0.6 0.17
PE 14:0-18:2 0.48 0.09 0.5 0.32 0.51 0.21
PE 16:0/16:0 1.97 0.52 2.17 0.61 2.03 0.54
PE 16:0-18:0 0.59 0.19 0.07 0.07 0.48 0.14
PE 16:0-18:1 30.25 0.94 31.01 2.12 31.8 1.51
PE 16:0-18:2 24.51 1.47 24 1.41 31.43 1.98
PE 16:0-20:1 0.18 0.08 0.05 0.05 0.12 0.07
PE 16:0-20:3 0.55 0.19 0.73 0.73 0.4 0.23
PE 16:0-20:4 9.38 0.79 10.55 2.02 9.5 1.09
PE 16:0-22:4 1.3 0.08 0.43 0.16 0.77 0.2
PE 16:0-22:5 0.76 0.27 0.25 0.14 0.44 0.17
PE 16:0-22:6 1.25 0.16 0.76 0.57 1.19 0.35
PE 18:0-18:1 6.57 0.81 7.26 0.16 4.57 0.41
PE 18:0-18:2 4.01 0.64 4.24 1.03 2.92 0.53
PE 18:0-20:3 0.91 0.09 0.22 0.13 0.84 0.3
PE 18:0-20:4 4.97 0.33 4.56 2.53 3 0.48
PE 18:0-22:4 0.53 0.05 0.05 0.05 0.19 0.04
PE 18:1/18:1 4.83 1.01 5.86 1.24 2.52 0.4
PE 18:1-18:2 3.18 0.14 4.32 0.31 4.13 2.57
PE 18:1-20:3 0.33 0.11 0.08 0.05 0.2 0.11
PE 18:1-20:4 2.07 0.16 1.73 0.32 1.03 0.25
PE 18:1-22:4 0.25 0.05 0.01 0.01 0 0
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