Malaria Parasite Metabolic Pathways
Drugs affecting pathway with unknown specific target
| Drug Name | PubMed Articles (year of publication) |
|---|---|
| (±)-Benzyl 5-[3-(6-Amino-5-cyano-3-methyl-4-isopropyl-2,4- dihydropyrano[2,3-c]pyrazol-4-yl)-5-cyanophenyl]thiophene- 2-carboxylate ((±)-8) and (±)-Methyl 5-[3-(6-Amino-5-cyano-4- isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazol-4-yl)-5- cyanophenyl]thiophene-2-carboxylate | |
| 1,12-Dodecamethylenebis(N-methylpyrrolidinium) Dibromide | |
| 1,16-Hexadecamethylenebis(N-methylpyrrolidinium) Dibromide | |
| 16-hexamethylene bis (N-methyl pyrrolidinium) dibromide | |
| Choline | |
| G25 | |
| isothiazolium | |
| M73 | |
| N,N,N,N',N',N'-Hexaethyl-1,16-hexadecanediaminium Dibromide | |
| N,N,N,N',N',N'-Hexamethyl-1,16-hexadecanediaminium Dibromide | |
| N,N,N',N'-Tetraethyl-N,N'-di(2-hydroxyethyl)-1,16-hexadecanediaminium Dibromide | |
| N,N,N',N'-Tetramethyl-N,N'-di(2-propenyl)-1,12-dodecanediaminium Dibromide | |
| N,N,N-Trimethyl-1-(8-phenyl)octanaminium Chloride | |
| N'N'N' triethyl 1,12-dodecamethylenebisammonim bromide | |
| NNN, N'N'N' triethyl 1,12-dodecamethylenebisammonim bromide | |
| Quaternary ammonium compounds | |
| T16 | |
| T4 | |
| Thiazolium | |
| Triethyldodecylammonium bromide | |
| Tripropyldodecylammonium bromide | |
| Triquaternary ammonium |
Phosphatidylcholine metabolism map details
| PFID | PFID Old | Annotation | Formal Annotation | EC | Transcript |
|---|---|---|---|---|---|
PF3D7_1401800
|
PF14_0020 | Choline kinase | choline kinase | 2.7.1.32 |
|
|
PF3D7_1316600
|
MAL13P1.86 | CTP:phosphocholine cytidylyltransferase | CTP:phosphocholine cytidylyltransferase | 2.7.7.15 |
|
|
PF3D7_0628300
|
PFF1375c | Diacylglycerol choline phosphotransferase | choline/ethanolaminephosphotransferase, putative | 2.7.8.2 |
|
|
PF3D7_1406300
|
PF14_0060 | Glycerophosphodiester phosphodiesterase | glycerophosphodiester phosphodiesterase | 3.1.4.46 |
|
| PF3D7_0102400 | PFA0120c | Lysohospholipase | lysophospholipase, putative, pseudogene | 3.1.1.5 | |
|
PF3D7_0702200
|
PF07_0005 | Lysohospholipase | lysophospholipase lpl20 | 3.1.1.5 |
|
| PF3D7_0937200 | PFI1800w | Lysohospholipase | lysophospholipase, putative | 3.1.1.5 |
|
|
PF3D7_1476700
|
PF14_0737 | Lysohospholipase | lysophospholipase lpl1, lpl1 | 3.1.1.5 |
|
|
PF3D7_1476800
|
PF14_0738 | Lysohospholipase | lysophospholipase, putative | 3.1.1.5 |
|
| PF3D7_1120400 | PF11_0211 | lysophospholipase | alpha/beta hydrolase fold domain containing protein, putative |
|
|
|
PF3D7_0209100
|
PFB0410c | patatin-like phospholipase, putative | patatin-like phospholipase 1; PNPLA1 | 3.1.1.4 |
|
|
PF3D7_0629900
|
PFF1450w | Phosphatidylcholine transfer Protein Sec14 | cral/trio domain-containing protein, putative |
|
|
|
PF3D7_1343000
|
MAL13P1.214 | phosphoethanolamine N-methyltransferase | phosphoethanolamine N-methyltransferase | 2.1.1.103 |
|
| PF3D7_0218600 | PFB0870w | Phospholipase A2 | patatin-like phospholipase, putative | 3.1.1.4 |
|
|
PF3D7_0924000
|
PFI1180w | Phospholipase A2 | patatin-like phospholipase, putative | 3.1.1.4 |
|
|
PF3D7_1358000
|
MAL13P1.285 | Phospholipase A2 | patatin-like phospholipase, putative | 3.1.1.4 |
|
|
PF3D7_1013500
|
PF10_0132 | Phospholipase C | phosphoinositide-specific phospholipase C | 3.1.4.11 |
|
| PF3D7_1463600 | PF14_0604a | phospholipd transfer protein | conserved Plasmodium protein, unknown function |
|
|
|
PF3D7_0104200
|
PFA0210c | phospholipid transfer protein | StAR-related lipid transfer protein |
|
|
| PF3D7_0911100 | PFI0540w | Phospholipid transfer protein | start domain-containing protein, putative |
|
|
| PF3D7_1343800 | MAL13P1.380 | phospholipid transfer protein | vps13 domain-containing protein, putative |
|
Total number of related proteins: 5
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFA0120c | lysophospholipase, putative, pseudogene |
| 2 |
PF07_0005
|
lysophospholipase lpl20 |
| 3 | PFI1800w | lysophospholipase, putative |
| 4 |
PF14_0737
|
lysophospholipase lpl1, lpl1 |
| 5 |
PF14_0738
|
lysophospholipase, putative |
Total number of related proteins: 3
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFA0210c
|
StAR-related lipid transfer protein |
| 2 | PFI0540w | start domain-containing protein, putative |
| 3 | MAL13P1.380 | vps13 domain-containing protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFB0410c
|
patatin-like phospholipase 1; PNPLA1 |
Total number of related proteins: 3
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFB0870w | patatin-like phospholipase, putative |
| 2 |
PFI1180w
|
patatin-like phospholipase, putative |
| 3 |
MAL13P1.285
|
patatin-like phospholipase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFF1375c
|
choline/ethanolaminephosphotransferase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFF1450w
|
cral/trio domain-containing protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF10_0132
|
phosphoinositide-specific phospholipase C |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF11_0211 | alpha/beta hydrolase fold domain containing protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
MAL13P1.86
|
CTP:phosphocholine cytidylyltransferase |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
MAL13P1.214
|
phosphoethanolamine N-methyltransferase |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF14_0020
|
choline kinase |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF14_0060
|
glycerophosphodiester phosphodiesterase |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF14_0604a | conserved Plasmodium protein, unknown function |