Encoded proteins that could be constituents of P-bodies
P-bodies are sites of mRNA decay. In addition to proteins that are involved in mRNA degradation, P-body components include proteins with roles in mRNA surveillance, RNA interference and translational repression. mRNA decapping is an irreversible and therefore highly regulated process that requires the participation of several proteins. all proteins that function in the 5′→3′ mRNA-decay pathway have now been shown to localize to P bodies. Most P-body components are distributed diffusely throughout the cytoplasm as well as being localized in P-bodies. P-body components dynamically exchange with the cytoplasmic pool, which indicates that decay enzymes and co-activators are not confined to P-bodies. There is no evidence that P-bodies are present in Pf. Hence. this table is a suggestion that deserves some experimental verification
Hs or Sc ortholog PfID Formal annotation Transcript EC# Effect of Depletion: or overexpression on P-body integrity
XRN1/Kem1 PF3D7_1106300 5'-3' exoribonuclease 1, putative
3.1.4.1 Depletion: increase in P-body size and numbers
PF3D7_0909400 exoribonuclease, putative
3.1.13.1
DCP1/DCAP-1 PF3D7_1032100
mRNA-decapping enzyme subunit 1, putative
Depletion: increase in P-body size and numbers
DCP2/DCAP-2 PF3D7_1308900
mRNA-decapping enzyme 2, putative
Depletion: increase in P-body size and numbers; overexpression: P-body loss
Lsm1-7 PF3D7_1124400
U6 snRNA-associated Sm-like protein LSm1, putative
PF3D7_0520300 U6 snRNA-associated Sm-like protein LSm2, putative
PF3D7_0819900 U6 snRNA-associated Sm-like protein LSm3, putative Depletion: P-body loss in human but increase in yeast
PF3D7_1443300 U6 snRNA-associated Sm-like protein LSm5, putative
PF3D7_1325000 U6 snRNA-associated Sm-like protein LSm6, putative
PF3D7_1209200
U6 snRNA-associated Sm-like protein LSm7, putative
RAP55/Lsm14 PF3D7_1474900
trailer hitch homolog, putative
Depletion: P-body loss; a marker of P-bodies
RCK/p54/Me31B PF3D7_0320800
ATP-dependent RNA helicase DDX6
3.6.4.13 Depletion: P-body loss; overexpression: P-body loss but increase in size
eIF4E PF3D7_0315100
eukaryotic translation initiation factor 4E
ND
UPF1 PF3D7_1005500
regulator of nonsense transcripts 1, putative
Depletion: no effect
UPF2 PF3D7_0925800
regulator of nonsense transcripts 2, putative
Depletion: increase body size
UPF3 PF3D7_1327700 regulator of nonsense transcripts 3B, putative
Depletion: increase body size
CAF-1 PF3D7_0811300 CCR4-associated factor 1
CAF40 PF3D7_0507600 protein caf40, putative
NOT1 PF3D7_1417200 CCR4-NOT transcription complex subunit not1, putative
NOT1 PF3D7_1103800 CCR4-NOT transcription complex subunit not1-g, putative
NOT2 PF3D7_1128600 CCR4-NOT transcription complex subunit 2, putative
NOT5 PF3D7_1006100 CCR4-NOT transcription complex subunit 5, putative
CCR4 PF3D7_0519500 ccr4 domain-containing protein 1, putative
Depletion: P-body loss
CCR4 PF3D7_0107200
ccr4 domain-containing protein 3, putative Depletion: P-body loss
CCR4 PF3D7_0319200
ccr4 domain-containing protein 4, putative
Depletion: P-body loss
FAST PF3D7_0217500
Calcium-dependent protein kinases; CDPK1
2.7.11.1 ND
Rbp1 PF3D7_0414500 RNA-binding protein, putative
ND
Rbp4 PF3D7_0205500 DNA-directed RNA polymerase II 16 kDa subunit, putative
2.7.7.6 ND
Rbp4 PF3D7_1404000 DNA-directed RNA polymerase II subunit RPB4, putative
2.7.7.6
Sbp1 PF3D7_0419600 ran-specific GTPase-activating protein 1, putative
Dcs2 PF3D7_1436900
histidine triad protein, putative
3.6.1.29 ND
APOBEC3G PF3D7_1349400 cytidine and deoxycytidylate deaminase, putative
3.5.4.5 ND
Compounds involved in the stabilization of mRNA in cytoplasm
Dhh1 PF3D7_0320800
ATP-dependent RNA helicase DDX6
3.6.4.13
Dhh1 PF3D7_0807100
parasite specific helicase 3
3.6.4.13
DDX6 PF3D7_0320800
ATP-dependent RNA helicase DDX6
3.6.4.13
CITH PF3D7_1474900
trailer hitch homolog, putative
Poly(A) binding protein PF3D7_1224300
polyadenylate-binding protein 1, putative
RNA binding protein Bruno, PF3D7_1409800 CUGBP Elav-like family member 2
RNA-binding protein musashi PF3D7_0916700 RNA-binding protein musashi, putative
DNA/RNA-binding protein Alba, putative PF3D7_0814200
DNA/RNA-binding protein Alba 1
DNA/RNA-binding protein Alba, putative PF3D7_1347500
DNA/RNA-binding protein Alba 4
DNA/RNA-binding protein Alba, putative PF3D7_1006200
DNA/RNA-binding protein Alba 3
DNA/RNA-binding protein Alba, putative PF3D7_1346300
DNA/RNA-binding protein Alba 2
phosphoglycerate mutase PF3D7_0310300 phosphoglycerate mutase, putative
5.4.2.11
Poly(A)-specific ribonuclease PARN PF3D7_1443500 poly(A)-specific ribonuclease PARN, putative 3.1.13.4
Online articles related to Encoded proteins that could be constituents of P-bodies retrieved from PubMed