Polar metabolites pool size
Cobbold SA, V Tutor M, Frasse P, McHugh E, Karnthaler M, Creek DJ, Odom John A, Tilley L, Ralph SA, McConville MJ. Non-canonical metabolic pathways in the malaria parasite detected  by isotope-tracing metabolomics. Mol Syst Biol. 2021 17(4):e10023. PMID: 33821563.
Compound KEGG ID Pubchem ID iRBC / uRBC
2-3-Bisphosphoglycerate C01159 0.002
Gamma-Glutamylcysteine C00669 0.003
fructose-1-6-bisphosphate C00354 0.008
Carnitine C15025 0.015
N-Acetyl-D-fucosamine C15480 0.016
Pyridoxine 5--phosphate C00627 0.022
L-threo-3-Methylaspartate C03618 0.024
Mannitol C00392 0.036
Sorbitol C00794 0.036
Indoleacrylic acid C00331 0.038
D-Glucuronic acid C00191 0.041
L-Histidinol phosphate C01100 0.043
Octulose-1-P 0.047
2-keto-3-deoxy-D-glycero-D-galacto-nononic acid C20934 0.056
Dyspropterin C03684 0.056
(S)-5-amino-3-oxohexanoate C03656 0.059
AMP C00020 0.062
alpha-D-Glucose C00267 0.063
D-Galactose C00124 0.063
alpha;-L-fucose C20835 0.065
Glyceraldehyde-3-phosphate C00661 0.066
S-1-Pyrroline-5-carboxylate C03912 0.069
dihydrolipoate C02147 0.073
2-Keto-3-deoxy-D-gluconic acid C00204 0.074
L-galactono-1-4-lactone C01115 0.075
1-5-Anhydrosorbitol C07326 0.077
Gluconate C00257 0.081
D-Fructose-1-phosphate C01094 0.082
10-Formyltetrahydrofolate C00234 0.087
Ribose C00121 0.088
2,3-Bisphospho-D-glycerate C00236 0.091
Aminoadipic acid C00956 0.091
D-Histidine C00135 0.092
Octulose-8-P 90657269 0.095
5-methyl-tetrahydrofolate C00440 0.097
1-3 Bisphosphoglycerate / 2-3-Bisphosphoglycerate C00236 0.098
3-Keto-beta-D-galactose C05394 0.099
DHAP C00111 0.099
5-deoxy-D-glucuronate C16737 0.101
L-Acetylcarnitine C02571 0.104
D-Tagatose 6-phosphate C01097 0.104
alpha-D-mannose 1-phosphate C00636 0.106
Fructose-1-P C01094 0.106
L-Ornithine C00077 0.110
Octulose-1-8-bisphosphate 130470   0.112
Acetylphenylalanine C03519 0.113
alpha-D-altrose C06464 0.114
Sedoheptulose-7-phosphate C05382 0.116
5-formyl-tetrahydrofolate C03479 0.117
D-(+)-Glucose C00267 0.119
D-Ribonate C01685 0.124
p-Aminobenzoic acid C00568 0.126
Sucrose C00089 0.130
Biopterin C06313 0.135
ADP C00008 0.139
D-Glucosamine C00329 0.144
Phosphoribosyl formamidocarboxamide C04734 0.144
PA(18:0/0:0) C00681 0.146
sphinganine 1-phosphate C01120 0.155
Sedoheptulose-1-7-bisphosphate C00447 0.155
Thr-Ala 7010578   0.167
Itaconic acid C00490 0.175
Acetoacetic acid C00164 0.179
4-hydroxybutyrate C00989 0.180
S-3-hydroxy-isobutyrate C03197 0.180
5--deoxyadenosine C05198 0.182
Fructose-6-phosphate C00085 0.183
Galactose-6-phsphate C01113 0.183
L-Alanine C00041 0.185
3-Hydroxy-2-methylpropanoate C01188 0.187
N-Acetyl-glucosamine 1-phosphate C04256 0.188
dihydroxy-acetone-phosphate C00111 0.189
5-Methyl-THF C00440 0.191
2-keto-D-Gluconic acid C06473 0.204
Tryptophan C00078 0.204
L-1-Pyrroline-3-hydroxy-5-carboxylate C04281 0.210
Hydroxypyruvic acid C00168 0.212
Phosphoenolpyruvate C00074 0.216
S-Pyruvylglutathione 20841753 0.224
2-Hydroxyglutarate C01087 0.226
Mesaconic acid C01732 0.226
D-Sorbitol C00794 0.261
D-(-)-Fructose C02336 0.262
N-Acetylmannosamine C00645 0.262
Xylulose C00310 0.263
Ornithine C00077 0.271
Ribulose C00309 0.279
D-Mannitol C00392 0.279
Pantothenic acid C00864 0.279
Histidine C00135 0.334
(S)-3-amino-2-methylpropanoate C03284 0.337
GDP-D-fucose C00325 0.341
N-Acetylornithine C00437 0.344
Dimethylglycine C01026 0.349
Hypoxanthine C00262 0.351
Pyridoxine C00314 0.383
4-hydroxytoluene C01468 0.384
4-Amino-4-deoxychorismate C11355 0.389
alpha-L-arabinofuranose C06115 0.412
sphingo-myelin C00550 0.421
Adenosine C00212 0.434
Stearoyl-CoA C00412 0.437
Hydroxypropionic acid C01013 0.449
Sorbitol 6-phosphate C01096 0.479
5-10-Methenyltetrahydrofolic acid C00445 0.480
Xanthine C00385 0.480
2-Aminobenzoic acid C00108 0.482
4-Oxoproline C01877 0.518
2-Phenylacetamide C02505 0.539
Glutathione C00051 0.542
Glycerol-1-phosphate C00623 0.546
sn-Glycerol 3-phosphate C00093 0.546
Dehydroascorbic acid C00425 0.570
2-C-Methyl-D-erythritol 4-phosphate C11434 0.575
Mevalonic acid C00418 0.576
D-(+)-Xylose C00181 0.586
Glycine C00037 0.597
Orotidine 92751   0.662
D-Gluconic acid C00257 0.662
nicotinamide mononucleotide C00455 0.664
myo-Inositol C00137 0.668
D-Galactitol C01697 0.671
L-Cystathionine C02291 0.677
Urate D-ribonucleotide C03312 0.679
Methionine C00073 0.686
PS-Lipid C02737 0.688
Pyrophosphate C00013 0.720
Phosphate C00009 0.726
3-7-11-Trimethyl-6E-10-dodecadien-1-ol 5280341  0.733
L-Citrulline C00327 0.734
L-Homoserine C00263 0.735
Dodecanoic acid C02679 0.744
ATP C00002 0.745
Uridine diphosphate glucuronic acid C00167 0.756
Glu Met Met Trp 0.759
Serine C00065 0.759
ferriprotoporphyrin IX C06767 0.764
Glutathione disulfide C00127 0.766
dIMP C06196 0.788
(-)-jasmonic acid methyl ester C11512 0.794
2-Hydroxyethanesulfonate C05123 0.799
2-S-Glutathionyl acetate C14862 0.821
octanoate C02838 0.822
Tetradecanoic acid C06424 0.822
5-Aminolevulinic acid C00430 0.826
malonate semialdehyde C00222 0.835
2-Phenylaminoadenosine 6917803 0.840
Octanoic acid C06423 0.844
2E-Octadecenoyl-CoA C16218 0.864
Isoleucine C00407 0.867
3-Sulfinylpyruvic acid C05527 0.877
Asp Phe His Trp 0.891
Palmitic acid C00249 0.901
DL-Tyrosine C00082 0.904
4-hydroxyphenylpyruvate C01179 0.908
phenylpyruvate C00166 0.917
2-hydroxycinnamic acid C01772 0.923
Proline C00148 0.979
gamma-L-Glutamyl-D-alanine C03740 1.000
Oleyl-CoA C00510 1.003
Methionine sulfoxide C02989 1.008
Citrate C00158 1.017
Shikimate 3-phosphate C03175 1.024
D-Phenylalanine C00079 1.033
4-Hydroxycinnamyl aldehyde C05608 1.044
D-(+)-Mannose C02209 1.057
12-13(S)-epoxylinolenate C14826 1.069
Cysteine C00097 1.070
Ala Ala Pro Gln 1.070
Leucine C00123 1.073
N-Methylhydantoin C02565 1.077
Cholesterol C00187 1.083
2-Oxobutanoate C00109 1.087
L-Glutamine C00064 1.093
L-Octanoylcarnitine C02838 1.093
D-Ribulose-5-phosphate C00199 1.099
9Z-Hexadecenoic acid C08362 1.102
Ascorbic acid C00072 1.107
Glycerol-3-phosphate C00093 1.149
Guanine C00242 1.156
LL-2-6-Diaminopimelate C00666 1.177
7-8-dihydroneopterin phosphate C05925 1.196
Octadecanoic acid C01530 1.216
DL-Glutamate C00025 1.233
Asparaginyl-Proline  9920984   1.239
D-Erythrose C01796 1.270
Maleamate C01596 1.276
5-Phosphoribosylamine C03090 1.300
Pyroglutamic acid C01879 1.300
13S-HODE C14762 1.301
dCDP C00705 1.301
4-Aminobutyric acid C00334 1.307
UDP-N-acetyl-D-glucosamine C00043 1.308
Asparaginyl-Methionine 9813901 1.308
Cysteinylglycine C01419 1.311
D-Ribose-5-phosphate C00103 1.348
CMP-trimethyl-aminoethylphsphonate C05674 1.358
Asp Glu Pro Pro 1.358
5-Methyldeoxycytidine diphosphate C04187 1.365
Methacrylyl-CoA C03460 1.366
Glycerol-2-phosphate C02979 1.374
D-Fructose-6-phosphate C00085 1.392
5-Oxo-proline C01879 1.400
Phenylalanine C00079 1.425
3-Phosphoglycerate C00197 1.447
2--hydroxygenistein C12134 1.459
4-Phosphopantothenoylcysteine C04352 1.461
Glycerate C00258 1.471
Threonine C00188 1.472
Asparagine C00152 1.498
Thymine C00178 1.513
Glutamate C00025 1.520
Threonate C01620 1.530
2-Phospho-D-glycerate C00631 1.541
Uracil C00106 1.567
5S-HETE C04805 1.578
N-Acetylproline 66141   1.588
5S-HPETE C05356 1.591
XMP C00655 1.614
Deoxycytidine C00881 1.627
5-amino-6-(5-phospho-D-ribosylamino)uracil C01268 1.638
Arginine C00062 1.669
octanal C01545 1.729
Oleate C00712 1.818
D-Mannose-6-phosphate C00275 1.837
alpha-linolenate C06427 1.947
Pro Arg Trp Tyr 1.962
Valine C00183 1.978
ARGININO-SUCCINATE C03406 1.979
2-Octaprenyl-3-methyl-6-methoxy-14-benzoquinone C05814 2.012
NADH C00004 2.066
cis-Aconitic acid C00417 2.067
(cis)-aconitate C00417 2.081
S-(2-Succinyl)glutathione 439932   2.144
Glucosamine-1P C06156 2.149
Cytosine C00380 2.156
Al-Al-Glu Al-Al-Glu 2.159
N-Acetyl-aspartate C01042 2.172
Palmityl-CoA C00154 2.187
Citrulline C00327 2.236
L-gamma-glutamyl-L-Leucine 151023 2.243
Lys Met Pro Trp 2.255
15S-15-Hydroxy-5811-cis-13-trans-eicosatetraenoate C04742 2.333
Allantoate C00499 2.365
GDP-L-galactose C02280 2.370
GDP-L-gulose C15925 2.370
GDP-glucose C00394 2.383
GDP-mannose C00096 2.383
Linoleate C01595 2.414
sn-glycero-3-Phosphoethanolamine 444183  2.474
Nicotinamide C00153 2.511
Dihydrofolic acid C00415 2.517
Cytidine C00475 2.534
N-Acetyl-D-mannosamine 6-phosphate C04257 2.580
UDP-D-galactose C00052 2.596
UDP-D-glucose C00029 2.596
CMP-2-aminoethylphosphonate C05673 2.711
D-Ribose 1-phosphate C00620 2.755
6-Phospho-D-gluconate C00345 2.779
Alanine C00041 2.800
IMP C00130 2.867
Aspartate C00049 2.877
P1P4-Bis5-xanthosyl tetraphosphate C04392 2.914
Tyrosine C00082 2.918
D-Xylulose 5-phosphate C00231 2.949
Ribose-1-Phosphate C00620  2.949
L-Aspartate C00049 3.114
Adenine C00147 3.159
Asp Lys Lys Met 3.197
S-Methyl GSH C11347 3.253
3-octaprenyl-4-hydroxybenzoate C05809 3.286
Pseudouridine 5--phosphate C01168 3.357
Gamma-glutamyl-L-putrescine C15699 3.386
6-hydroxymethyl-7-8-dihydropterin C01300 3.549
Inosine C00294 3.641
4-Methyl-5-2-phosphooxyethylthiazole C04327 3.663
GDP-4-Dehydro-6-deoxy-D-mannose C01222 3.771
GDP C00035 3.832
Guanosine diphosphate C00035 3.832
Oxalic acid C00209 4.019
Linoleoyl-CoA C02050 4.109
Glucose-6-phosphate C00092 4.265
D-myo-Inositol-3-phosphate C04006 4.413
Arg Thr Arg Pro 4.448
gamma-L-Glutamyl-L-cysteine C00669 4.646
L-3-aminobutyryl-CoA C05231 4.819
Glu Gln Gln Trp 4.991
2-Keto-6-aminocaproic acid C05825 4.997
Lauroyl-CoA C01832 5.383
dATP C00131 5.596
Cadaverine C01672 5.701
Riboflavin C00255 5.989
Flavin Mononucleotide C00061 6.031
PE(16:0/0:0) C04438 6.203
Propanoyl phosphate C02876 7.006
N-Acetyl-L-glutamate C00624 7.025
D-Glucose-6-phosphate C00668 7.072
pyruvate C00022 7.108
CoA C00010 7.146
Nicotinic acid mononucleotide C01185 7.243
Acetyl-CoA C00024 7.466
1-Deoxy-D-xylulose 5-phosphate C11437 7.796
2-deoxyribose-5-P C00673 7.796
D-Ribose C00121 8.034
Acetylphosphate C00227 8.124
Ile Pro Ile Thr Arg 8.138
P1P4-Bis5-adenosyltetraphosphate C01260 8.521
NADP+ C00006 8.629
Cyclic GMP C00942 8.711
Asp Asn Pro Ser 8.892
Folic acid C00504 9.124
3-Dehydrosphinganine C02934 9.145
Sphingosine C00319 9.145
LysoPE(0:0/20:4) C04438 9.267
Deoxyuridine C00526 9.536
Isoleucyl-Valine 449407   9.703
Hydroxyacetone phosphate C03505 9.778
PS(18:0/0:0) C18125 10.126
D-Erythrose 4-phosphate C00279 10.185
Orotidine 5-phosphate C01103 10.417
N2-Acetyl-L-aminoadipate C12986 10.451
Lactate C00186 10.619
D-Lactic acid C00256 10.772
L-Lactic acid C00186 10.772
Leu Glu Gly 145456413   11.064
5-methyltetrahydropteroyltri-L-glutamate C04489 11.348
2-Phosphinomethylmalate C17947 11.396
Propionyl-CoA C00100 11.506
Spermidine C00315 11.525
Acetyllysine C12989 11.963
CDP-N-methylethanolamine C03486 12.227
dTDP C00363 12.269
octanoyl-CoA C01944 12.411
N-Formyl-L-methionine C03145 12.527
Dephospho-CoA C00882 12.718
N-Acetyl-L-methionine C02712 12.987
Fumarate C00122 13.180
VS C00107 13.334
tetrahydropteroyl tri-L-glutamate C04144 13.352
Dihydroorotate C00337 14.026
Phosphoribosyl-AMP C02741 14.476
Acetyl-alanine C00430 14.895
Sarcosine C00213 15.101
Uridine C00299 15.348
Glu-Al-Gln 15.359
4-(glutamylamino) butanoate C15767 15.382
N-Carbamoyl-L-aspartate C00438 15.606
Porphobilinogen C00931 15.690
Ala Ala Ala Asp 15.737
4-Methylene-L-glutamate C00651 15.753
FAD C00016 15.946
(R)-S-Lactoylglutathione C03451 17.244
Malate C00149 17.540
lysine C00047 17.735
Tetrahydrodipicolinate C03972 17.925
cis-zeatin C00371 17.944
S-Methyl-5-thio-D-ribose 1-phosphate C04188 18.186
LysoPE(0:0/18:3) C04438 18.260
NADPH C00005 18.528
Putrescine C00134 18.878
GTP C00044 18.962
Succinoadenosine C03794 19.397
N-N--Diacetylhydrazine C16622 19.628
2--Deoxy-5-hydroxymethylcytidine-5--diphosphate C11038 19.892
Gln-Al C00107 20.917
Glycerophosphoglycerol C03274 21.095
1-Pyrroline-5-carboxylic acid C04322 21.271
Farnesyl pyrophosphate C00448 21.675
dTMP C00364 21.841
CDP-choline C00307 21.863
2-Oxoglutarate C00026 22.142
Succinate C00042 22.993
dimethylallyl diphosphate C00235 23.303
Isopentenyl pyrophosphate C00129 23.303
S-Adenosyl-L-methionine C00019 23.884
O-Succinyl-L-homoserine C01118 24.783
Geranylgeranyl-PP C00353 24.786
Pipecolic acid C00386 25.076
thymidine monophosphate C00364 26.032
Pantetheine 4--phosphate C01134 26.342
Ophthalmic acid 7018721 26.477
L-Glutamic gamma-semialdehyde C01165 26.642
L-2-3-Dihydrodipicolinate C03340 27.134
Asn Ser Thr Tyr 27.799
Asp Asp Pro Pro 27.940
S-(2-Hydroxyethyl)glutathione C14875 29.904
S-Inosyl-L-homocysteine C03431 33.837
GMP C00144 35.729
Ser Asp Tyr 58753253  36.785
2-Methyl-3-oxopropanoic acid C00349 37.280
Succinic acid semialdehyde C00232 37.280
4-Oxoglutaramate C05572 37.681
Gly-Glu-Arg 10133134 38.909
myristoyl-CoA C02593 39.515
Ala Cys Glu Phe 39.685
a-ketoglutarate C00026 41.024
Ala Ala Gln Thr 41.746
IDP C00104 42.325
cyclic-AMP C00575 42.789
Heme C00032 44.856
CDP C00112 44.955
UDP C00015 46.778
O-phosphoethanolamine C00346 48.002
2-octaprenylphenol C05810 48.747
Ala Ala Pro Thr 49.055
Ala-Trp-OH C00107                       49.786
succinyl-L-glutamate 5-semialdehyde C05932 54.090
GABA C00334 54.298
Glutamyl-Glutamate 52940163 54.430
Ε-(gamma-Glutamyl)-lysine 471584   58.504
Pro Glu Phe  71550824   61.953
N-Succinyl-L-L-2-6-diaminopimelate C04421 65.004
adenosine-3--5--bisphosphate C00054 66.034
Ala Asp Glu Lys 70.641
2-Oxoglutaramate C00940 73.494
Asp Phe Asn Gln 74.183
Lyso PS C18125 77.041
5-Methylthioadenosine C00170 78.383
S-Adenosyl-L-homocysteine C00021 78.476
2-3-6-Trihydroxypyridine C03458 83.013
dCTP C00458 84.296
Ala Ala Ala Ala 85.543
Ala Cys Phe Pro 89.748
ADP-ribose C00301 95.494
N2-Succinyl-L-ornithine C03415 96.313
Phosphonoacetaldehyde C03167 97.173
Phosphodimethylethanolamine C13482 97.188
Orotate C00295 98.888
NAD+ C00003 102.079
Cyclic ADP-ribose C13050 102.185
Aspartyl-Glutamine Aspartyl-Glutamine 471584  102.768
Gly-Gly C02037 105.195
Glu-Ile Glu-Ile 9813855   105.711
Gly-Val-Thr 87521207   106.125
Serinyl-Threonine C00107                       107.253
Gly-Pro-Glu 3080768   110.889
L-2-Amino-3-oxobutanoic acid C03508 112.189
myo-inositol-3-P C04006 113.832
CTP C00063 130.860
Gly-Asp Gly-Asp 97363   135.318
Pro Ser Asp  145457568   155.000
Asn Cys Trp His 160.224
Ala Ala Trp Trp 161.746
γ-D-Glutamylglycine C00107 163.465
Glu-Lys-Gln 15431731   168.231
O-Acetyl-L-serine C00979 169.088
Glutamyl-lysine  7015704   172.441
Nα-Acetyl-L-glutamine 182230   179.258
Cys Phe Phe Gln 182.403
CDP-ethanolamine C00570 192.235
5-Formiminotetrahydrofolate C00664 208.471
N-Formimino-L-glutamate C00439 211.848
Phosphocholine C00588 211.968
L-Pipecolate C00408 223.284
Pro-Ser 7408258   248.576
N-Acetylaspartylglutamic acid C12270 256.280
Glu Thr 6998031   296.795
N-acetyl-Aspartyl-glutamate C12270 308.799
dTTP C00459 351.776
CMP C00055 364.423
LysoPG(18:0/0:0) C18126 387.044
D-4--Phosphopantothenate C03492 475.553
Ethanolamine phosphate C00346 492.321
N-Succinyl-L-glutamate C05931 500.733
L-beta-aspartyl-L-threonine 53480674   502.178
2-C-Methyl-D-erythritol 2-4-cyclodiphosphate C11453 654.232
UTP C00075 787.487
Ala Asp Ile Thr 809.470
Gly Glu Glu 13233357   868.289
gamma-Glutamyl-S-(1-propenyl)cysteine sulfoxide 18410556   965.977
UMP C00105 1337.086
Pro-Thr 18218237   2181.343
6-7-dimethyl-8-(1-D-ribityl)lumazine C04332 2708.469
Glu-Glu 439500  4114.469
L-alpha-Aspartyl-L-hydroxyproline  53480671   5096.315
Glu Thr Glu  145455508   7545.386
L-beta-aspartyl-L-glutamic acid 25207301   13789.162
Online articles related to Polar metabolites pool size retrieved from PubMed

Related Maps