LysoPC depletion induces gene activity
Brancucci NMB, Gerdt JP, Wang C, De Niz M, Philip N, Adapa SR, Zhang M, Hitz E, Niederwieser I, Boltryk SD, Laffitte MC, Clark MA, Grüring C, Ravel D, Blancke Soares A, Demas A, Bopp S, Rubio-Ruiz B, Conejo-Garcia A, Wirth DF, Gendaszewska-Darmach E, Duraisingh MT, Adams JH, Voss TS, Waters AP, Jiang RHY, Clardy J, Marti M. Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum. Cell. 2017 Nov 2. pii: S0092-8674(17)31242-4. PMID: 29129376.
GO-classified PfID Annotation Induction score E.C Transcript
27351 PC biosynthesis PF3D7_1343000
phosphoethanolamine N-methyltransferase 5.92 2.1.1.103
27329 PF3D7_0922200
S-adenosylmethionine synthetase 4.72 2.5.1.6
27322 PF3D7_0520900
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase 4.17 3.3.1.1
27337 PF3D7_1124600
ethanolamine kinase 3.13 2.7.1.82
27350 PF3D7_1332500 SAM-dependent RNA methyltransferase, putative 2.15 2.1.1.220
27332 PF3D7_0935400
gametocyte development protein 1 4.10
27349 PF3D7_1328800
transcriptional regulatory protein sir2a 1.51 3.5.1.98
27334 PF3D7_1114700
cyclin-dependent-like kinase clk3 1.44 2.7.11.1
27318 DNA replication PF3D7_0309200
serine/threonine protein kinase ark2, putative 3.99 2.7.11.1
27344 PF3D7_1227500 protein soc2, putative 3.43
27321 PF3D7_0509100
structural maintenance of chromosomes protein 4 3.19
27324 PF3D7_0625300
mitochondrial DNA polymerase 2.62 2.7.7.7
27340 PF3D7_1211300 DNA helicase MCM8, putative 2.06 3.6.4.12
27316 PF3D7_0111300
p-loop containing nucleoside triphosphate hydrolase, putative 1.95
27339 PF3D7_1203000
origin recognition complex subunit 1 1.48
27331 PF3D7_0928800 serine/threonine protein kinase, putative 2.57 2.7.11.1
27330 PF3D7_0926100 protein kinase, putative 2.43 2.7.11.1
27317 PF3D7_0211700
tyrosine kinase-like protein, putative 2.24 2.7.11.1
27335 PF3D7_1121300
tyrosine kinase-like protein 2.15 2.7.10.2
27325 PF3D7_0705000 mrna cap guanine-n7 methyltransferase, putative 2.43 2.1.1.56
27333 PF3D7_1008000
histone deacetylase 2 2.15 3.5.1.98
27341 PF3D7_1211600
lysine-specific histone demethylase 1, putative 2.03 1.14.11.27
27346 PF3D7_1233700 homocysteine S-methyltransferase, putative 1.93 2.1.1.10
27336 Macromolecules modification PF3D7_1123100
calcium-dependent protein kinase 7 3.46 2.7.11.17
27352 PF3D7_1431500
mitogen-activated protein kinase 1 2.77 2.7.11.24
27320 PF3D7_0419900
phosphatidylinositol 4-kinase, putative 2.10 2.7.1.67
27338 PF3D7_1145200 serine/threonine protein kinase, putative 2.09 2.7.11.1
27348 PF3D7_1316100 inositol polyphosphate kinase, putative 1.88 2.7.1.151
27347 PF3D7_1247500
serine/threonine protein kinase, putative 2.23 2.7.11.1
33708 PF3D7_0705300
mediator of RNA polymerase ii transcription subunit 10, putative 3.41
27328 PF3D7_0919900
regulator of chromosome condensation, putative 2.50
27323 PF3D7_0615500 cdc2-related protein kinase 5 2.33 2.7.11.22
27345 PF3D7_1227600 kinetochore protein SPC24, putative 2.07
27319 PF3D7_0317200
cdc2-related protein kinase 4 1.62 2.7.11.22
27343 PF3D7_1222600
AP2 domain transcription factor AP-G 7.54
27342 PF3D7_1221000
histone-lysine N-methyltransferase, H3 lysine-4 specific 2.55 2.1.1.43
27327 PF3D7_0827800
SET domain protein, putative 2.19 2.1.1.43
The expression of more than 300 genes was found to be modified by LysoPC  deprivation
Online articles related to LysoPC depletion induces gene activity retrieved from PubMed