LysoPC depletion induces gene activity
Brancucci NMB, Gerdt JP, Wang C, De Niz M, Philip N, Adapa SR, Zhang M, Hitz E, Niederwieser I, Boltryk SD, Laffitte MC, Clark MA, Grüring C, Ravel D, Blancke Soares A, Demas A, Bopp S, Rubio-Ruiz B, Conejo-Garcia A, Wirth DF, Gendaszewska-Darmach E, Duraisingh MT, Adams JH, Voss TS, Waters AP, Jiang RHY, Clardy J, Marti M. Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum. Cell. 2017 Nov 2. pii: S0092-8674(17)31242-4. PMID: 29129376.
GO-classified PfID Annotation Induction score E.C Transcript
PC biosynthesis PF3D7_1343000
phosphoethanolamine N-methyltransferase 5.92 2.1.1.103
PF3D7_0922200
S-adenosylmethionine synthetase 4.72 2.5.1.6
PF3D7_0520900
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase 4.17 3.3.1.1
PF3D7_1124600
ethanolamine kinase 3.13 2.7.1.82
PF3D7_1332500 SAM-dependent RNA methyltransferase, putative 2.15 2.1.1.220
PF3D7_0935400
gametocyte development protein 1 4.10
PF3D7_1328800
transcriptional regulatory protein sir2a 1.51 3.5.1.98
PF3D7_1114700
cyclin-dependent-like kinase clk3 1.44 2.7.11.1
DNA replication PF3D7_0309200
serine/threonine protein kinase ark2, putative 3.99 2.7.11.1
PF3D7_1227500 protein soc2, putative 3.43
PF3D7_0509100
structural maintenance of chromosomes protein 4 3.19
PF3D7_0625300
mitochondrial DNA polymerase 2.62 2.7.7.7
PF3D7_1211300 DNA helicase MCM8, putative 2.06 3.6.4.12
PF3D7_0111300
p-loop containing nucleoside triphosphate hydrolase, putative 1.95
PF3D7_1203000
origin recognition complex subunit 1 1.48
PF3D7_0928800 serine/threonine protein kinase, putative 2.57 2.7.11.1
PF3D7_0926100 protein kinase, putative 2.43 2.7.11.1
PF3D7_0211700
tyrosine kinase-like protein, putative 2.24 2.7.11.1
PF3D7_1121300
tyrosine kinase-like protein 2.15 2.7.10.2
PF3D7_0705000 mrna cap guanine-n7 methyltransferase, putative 2.43 2.1.1.56
PF3D7_1008000
histone deacetylase 2 2.15 3.5.1.98
PF3D7_1211600
lysine-specific histone demethylase 1, putative 2.03 1.14.11.27
PF3D7_1233700 homocysteine S-methyltransferase, putative 1.93 2.1.1.10
Macromolecules modification PF3D7_1123100
calcium-dependent protein kinase 7 3.46 2.7.11.17
PF3D7_1431500
mitogen-activated protein kinase 1 2.77 2.7.11.24
PF3D7_0419900
phosphatidylinositol 4-kinase, putative 2.10 2.7.1.67
PF3D7_1145200 serine/threonine protein kinase, putative 2.09 2.7.11.1
PF3D7_1316100 inositol polyphosphate kinase, putative 1.88 2.7.1.151
PF3D7_1247500
serine/threonine protein kinase, putative 2.23 2.7.11.1
PF3D7_0705300
mediator of RNA polymerase ii transcription subunit 10, putative 3.41
PF3D7_0919900
regulator of chromosome condensation, putative 2.50
PF3D7_0615500
cdc2-related protein kinase 5 2.33 2.7.11.22
PF3D7_1227600 kinetochore protein SPC24, putative 2.07
PF3D7_0317200
cdc2-related protein kinase 4 1.62 2.7.11.22
PF3D7_1222600
AP2 domain transcription factor AP-G 7.54
PF3D7_1221000
histone-lysine N-methyltransferase, H3 lysine-4 specific 2.55 2.1.1.43
PF3D7_0827800
SET domain protein, putative 2.19 2.1.1.43
The expression of more than 300 genes was found to be modified by LysoPC  deprivation
Online articles related to LysoPC depletion induces gene activity retrieved from PubMed