Malaria Parasite Metabolic Pathways
Drugs affecting pathway with unknown specific target
| Drug Name | PubMed Articles (year of publication) |
|---|---|
| 4-(1,5,8,12-tetrazacyclotetradec-1-yl) | |
| 5,7-dihydroxy- 3,3' ,4' ,5' ,6-pentamethoxyflavone | |
| Blahone epb | |
| colchicine | |
| Docetaxel | |
| Omeprazole | |
| oryzalin | |
| paclitaxel | |
| Phenoxyoxazaphosphinane | |
| Phenoxyoxazaphospholidine | |
| Santin | |
| Suggested target | |
| Taxol | |
| Triclosan | |
| Trimethoprim | |
| Vinblastine | |
| Vincristine |
Tubulin and microtubules map details
| PFID | PFID Old | Annotation | Formal Annotation | EC | Transcript |
|---|---|---|---|---|---|
PF3D7_0422300
|
PFD1050w | a-tubulin | alpha tubulin 2, transcript expression profile microgametocyte |
|
|
|
PF3D7_0903700
|
PFI0180w | a-tubulin | alpha tubulin 1 |
|
|
|
PF3D7_0924900
|
PFI1220w | a-tubulin acetylase | alpha-tubulin N-acetyltransferase, putative | 2.3.1.108 |
|
|
PF3D7_1008700
|
PF10_0084 | b-tubulin | tubulin beta chain |
|
|
|
PF3D7_0717500
|
PF07_0072 | CDPK4 | calcium-dependent protein kinase 4, CDPK4 | 2.7.11.1 |
|
|
PF3D7_1015600
|
PF10_0153 | Cytosolic chaperonin | heat shock protein 60 |
|
|
|
PF3D7_0517800
|
PFE0890c | doublecortin | apicortin |
|
|
| PF3D7_0933800 | PFI1635w | d-tubulin | tubulin delta chain, putative |
|
|
| PF3D7_1475700 | PF14_0725 | e-tubulin | tubulin epsilon chain, putative |
|
|
|
PF3D7_0803700
|
PF08_0125 | g-tubulin | tubulin gamma chain |
|
|
| PF3D7_0613500 | PFF0655c | Other gTuRC proteins | AP-3 complex subunit beta, putative |
|
|
| PF3D7_1138600 | PF11_0397 | Other gTuRC proteins | beta-catenin-like protein 1, putative |
|
|
|
PF3D7_1328800
|
PF13_0152 | Sirtuin | transcriptional regulatory protein sir2a | 3.5.1.98 |
|
| PF3D7_1451400 | PF14_0489 | Sirtuin | transcriptional regulatory protein sir2b | 3.5.1.98 |
|
| PF3D7_1227500 | PFL1330c | SOC2 | protein soc2, putative |
|
|
| PF3D7_0303500 | PFC0165w | SPC97 and SPC98 homologues | spindle pole body protein, putative |
|
|
| PF3D7_0933500 | PFI1620c | SPC97 and SPC98 homologues | gamma-tubulin complex component, putative |
|
|
|
PF3D7_0109400
|
PFA0460c | TBCA | tubulin-specific chaperone a, putative |
|
|
| PF3D7_0906910 | PFI0335w | TBCB | tubulin-specific chaperone, putative |
|
|
| PF3D7_1015700 | PF10_0153a | TBCB | tubulin binding cofactor c, putative |
|
|
| PF3D7_1015700 | PF10_0153a | TBCC | tubulin binding cofactor c, putative |
|
|
| PF3D7_1203300 | PFL0165c | TBCC | tbcc domain-containing protein, putative |
|
|
| PF3D7_1337500 | PF13_0210 | TBCE | conserved Plasmodium protein, unknown function |
|
|
| PF3D7_1452100 | PF14_0496 | TBCE | leucine-rich repeat protein |
|
|
| PF3D7_0906910 | PFI0335w | TCBD | tubulin-specific chaperone, putative |
|
|
| PF3D7_1015700 | PF10_0153a | TCBD | tubulin binding cofactor c, putative |
|
|
| PF3D7_1322200 | MAL13P1.124 | TOG | tog domain-containing protein, putative |
|
|
| PF3D7_0514000 | PFE0700c | tubulin-tyrosine ligase, putative | tubulin--tyrosine ligase, putative | 6.3.2.25 |
|
| PF3D7_1009700 | PF10_0094 | tubulin-tyrosine ligase, putative | tubulin--tyrosine ligase, putative | 6.3.2.25 |
|
| PF3D7_1147200 | PF11_0481 | tubulin-tyrosine ligase, putative | tubulin--tyrosine ligase, putative | 6.3.2.25 |
|
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFA0460c
|
tubulin-specific chaperone a, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFC0165w | spindle pole body protein, putative |
| 2 | PFI1620c | gamma-tubulin complex component, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFD1050w
|
alpha tubulin 2, transcript expression profile microgametocyte |
| 2 |
PFI0180w
|
alpha tubulin 1 |
Total number of related proteins: 3
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFE0700c | tubulin--tyrosine ligase, putative |
| 2 | PF10_0094 | tubulin--tyrosine ligase, putative |
| 3 | PF11_0481 | tubulin--tyrosine ligase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFE0890c
|
apicortin |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFF0655c | AP-3 complex subunit beta, putative |
| 2 | PF11_0397 | beta-catenin-like protein 1, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF07_0072
|
calcium-dependent protein kinase 4, CDPK4 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF08_0125
|
tubulin gamma chain |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFI0335w | tubulin-specific chaperone, putative |
| 2 | PF10_0153a | tubulin binding cofactor c, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFI0335w | tubulin-specific chaperone, putative |
| 2 | PF10_0153a | tubulin binding cofactor c, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFI1220w
|
alpha-tubulin N-acetyltransferase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFI1635w | tubulin delta chain, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF10_0084
|
tubulin beta chain |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF10_0153
|
heat shock protein 60 |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF10_0153a | tubulin binding cofactor c, putative |
| 2 | PFL0165c | tbcc domain-containing protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFL1330c | protein soc2, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | MAL13P1.124 | tog domain-containing protein, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF13_0152
|
transcriptional regulatory protein sir2a |
| 2 | PF14_0489 | transcriptional regulatory protein sir2b |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF13_0210 | conserved Plasmodium protein, unknown function |
| 2 | PF14_0496 | leucine-rich repeat protein |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF14_0725 | tubulin epsilon chain, putative |