Post-translational modifications - 2- hydroxyisobutyrylation, acetylation and crotonylation
Wang J, Jiang N, Sang X, Yang N, Feng Y, Chen R, Wang X, Chen Q. Protein modification characteristics of the malaria parasite Plasmodium falciparum and the infected erythrocytes. Mol Cell Proteomics. 2020 Nov 4:mcp.RA120.002375. PMID: 33148788.
Modification Plasmo ID Annotation Position Amino acid EC Transcript
2- hydroxyisobutyrylation
PF3D7_0102200
ring-infected erythrocyte surface antigen 710 K
PF3D7_0108000 proteasome subunit beta type-3, putative 117 K 3.4.25.1
PF3D7_0205900 26S proteasome regulatory subunit RPN1, putative 138 K
PF3D7_0207600
serine repeat antigen 5 701 K 3.4.22.-
PF3D7_0207600
serine repeat antigen 5 692 K 3.4.22.-
PF3D7_0207600
serine repeat antigen 5 488 K 3.4.22.-
PF3D7_0220500 Plasmodium exported protein (hyp2), unknown function 181 K
PF3D7_0302000 pre-mRNA-splicing factor PRP46, putative 265 K
PF3D7_0302200
cytoadherence linked asexual protein 3.2 791 K
PF3D7_0306300
glutaredoxin 1 72, 99 K 1.8.4.2
PF3D7_0306900 40S ribosomal protein S23, putative 50 K
PF3D7_0307100 40S ribosomal protein S12, putative 30 K
PF3D7_0307200 60S ribosomal protein L7, putative 32 K
PF3D7_0313500
ras-like g protein 448 K
PF3D7_0316300 inorganic pyrophosphatase 236 K 3.6.1.1
PF3D7_0317100 6-cysteine protein 679 K
PF3D7_0317600 40S ribosomal protein S11, putative 32 K
PF3D7_0322000
peptidyl-prolyl cis-trans isomerase 51 K 5.2.1.8
PF3D7_0402000
Plasmodium exported protein (PHISTa), unknown function 163 K
PF3D7_0406900 conserved Plasmodium protein, unknown function 900, 907, 899 K
PF3D7_0415900 60S ribosomal protein L15, putative 83, 85, 91, 170, 178, 184 K
PF3D7_0418200 eukaryotic translation initiation factor 3 subunit m, putative 233 K
PF3D7_0422400 40S ribosomal protein S19 46, 105 K
PF3D7_0500800
erythrocyte membrane protein 2 mature parasite-infected erythrocyte surface antigen 226 K
PF3D7_0501000 Plasmodium exported protein, unknown function 196 K
PF3D7_0501200
parasite-infected erythrocyte surface protein 320 K
PF3D7_0501600
rhoptry-associated protein 2 303, 390 K
PF3D7_0501700 anaphase-promoting complex subunit 3, putative 329, 333, 335 K
PF3D7_0503800 60S ribosomal protein L31 55 K
PF3D7_0507100 60S ribosomal protein L4 377 381 K
PF3D7_0508000
6-cysteine protein 74 K
PF3D7_0511000
translationally-controlled tumor protein homolog 85 97 K
PF3D7_0511800
inositol-3-phosphate synthase 17 K 5.5.1.4
PF3D7_0512600 ras-related protein Rab-1B 172 K 3.6.5.2
PF3D7_0513300
purine nucleoside phosphorylase 48 55 K 2.4.2.1
PF3D7_0517000 60S ribosomal protein L12, putative 41 99 126 K
PF3D7_0520900
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase 186 K 3.3.1.1
PF3D7_0532300 Plasmodium exported protein (PHISTb), unknown function 312 K
PF3D7_0608800
ornithine aminotransferase 36 125 132 335 381 K 2.6.1.13
PF3D7_0610400
histone H3 28 K
PF3D7_0610400
histone H3 123 K
PF3D7_0610400
histone H3 57 80 K
PF3D7_0617100
AP-2 complex subunit alpha, putative 299 300 K
PF3D7_0617800
histone H2A 21 K
PF3D7_0618300 60S ribosomal protein L27a, putative 125 K
PF3D7_0624000
hexokinase 118 K 2.7.1.1
PF3D7_0626800
pyruvate kinase 116 477 K 2.7.1.40
PF3D7_0627100 ankyrin-repeat protein, putative 1643 1646 K
PF3D7_0627500
protein DJ-1 135 K
PF3D7_0708400
heat shock protein 90 166 196 298 462 465 K
PF3D7_0714000
histone H2B variant 43 113 K
PF3D7_0727400
proteasome subunit alpha type-5, putative 224 K 3.4.25.1
PF3D7_0803800
proteasome subunit beta type-4 71 K 3.4.25.1
PF3D7_0813300 npl domain-containing protein, putative 298 K
PF3D7_0813900 40S ribosomal protein S16, putative 103 K
PF3D7_0818200
14-3-3 protein 19 91 119 154 257 K
PF3D7_0818900
heat shock protein 70 67 82 88 124 138 149 268 341 342 436 510 539 570 602 K
PF3D7_0821700 60S ribosomal protein L22, putative 127 K
PF3D7_0824400
nucleoside transporter 2, NT2 260 K
PF3D7_0827900
protein disulfide isomerase 117 182 K 5.3.4.1
PF3D7_0831700
heat shock protein 70 454 528 557 K
PF3D7_0905400
high molecular weight rhoptry protein 3 295 K
PF3D7_0907200 GTPase-activating protein, putative 982 988 991 997 K
PF3D7_0913200 elongation factor 1-beta 51 K
PF3D7_0917900
heat shock protein 70 95 161 211 341 442 549 575 577 587 K
PF3D7_0922200
S-adenosylmethionine synthetase 69 81 90 95 230 391 397 K 2.5.1.6
PF3D7_0922500
phosphoglycerate kinase 106 130 138 143 219 245 K 2.7.2.3
PF3D7_0928500 conserved Plasmodium protein, unknown function 148 150 153 K
PF3D7_0929400
high molecular weight rhoptry protein 2 70 85 1285 K
PF3D7_0930300
merozoite surface protein 1 144 282 361 368 456 492 563 583  586 616 1023 1139 1160 1190 1214 1463 K
PF3D7_0936800
Plasmodium exported protein (PHISTc), unknown function 127 281 K
PF3D7_1003500 40S ribosomal protein S20e, putative 13 K
PF3D7_1004000 60S ribosomal protein L13, putative 93 164 170 K
PF3D7_1012400
hypoxanthine-guanine phosphoribosyltransferase 37 62 103 138 K 2.4.2.8
PF3D7_1013500
phosphoinositide-specific phospholipase C 901 K 3.1.4.11
PF3D7_1015900
enolase 62 66 109 247 272 324 419 K 4.2.1.11
PF3D7_1016300
glycophorin binding protein 247 347 K
PF3D7_1027300
peroxiredoxin merozoite capping protein 1 66 212 K 1.11.1.15
PF3D7_1027800 60S ribosomal protein L3 97 288 K
PF3D7_1029600
adenosine deaminase 196 359 K 3.5.4.4
PF3D7_1105000
histone H4 13 78 80 K
PF3D7_1105100
histone H2B 39 109 K
PF3D7_1108600
endoplasmic reticulum-resident calcium binding protein 142 K
PF3D7_1113000 conserved Plasmodium protein, unknown function 878 880 K
PF3D7_1120100
phosphoglycerate mutase, putative 43 100 106 248 K 5.4.2.11
PF3D7_1121600
parasitophorous vacuole membrane antigen QF 116 exported protein 1 circumsporozoite-related antigen 69 K
PF3D7_1124600
ethanolamine kinase 253 K 2.7.1.82
PF3D7_1129100
parasitophorous vacuolar protein 1 195 K
PF3D7_1129300 conserved Plasmodium protein, unknown function 923 926 929 K
PF3D7_1134000
heat shock protein 70 109 122 K
PF3D7_1136500
casein kinase 1 54 K 2.7.11.1
PF3D7_1142500 60S ribosomal protein L28 82 K
PF3D7_1142600 60S ribosomal protein L35ae, putative 72 K
PF3D7_1147300 conserved Plasmodium protein, unknown function 5 K
PF3D7_1149000
antigen 332, DBL-like protein 5875 K
PF3D7_1201000 Plasmodium exported protein (PHISTb), unknown function 88 K
PF3D7_1203700
nucleosome assembly protein 70 K
PF3D7_1212300 WD repeat-containing protein, putative 1025 K
PF3D7_1212600 snd2 domain-containing protein, putative 137 K
PF3D7_1212600 snd2 domain-containing protein, putative 140 K
PF3D7_1228600
merozoite surface protein 9 141 K
PF3D7_1235600
serine hydroxymethyltransferase 334 K 2.1.2.1
PF3D7_1237000
SUMO-activating enzyme subunit 2 108 K 6.2.1.45
PF3D7_1237700 conserved protein, unknown function 156 159 K
PF3D7_1239800
conserved Plasmodium protein, unknown function 3199 K
PF3D7_1240400 erythrocyte membrane protein 1, PfEMP1 1764 1767 K
PF3D7_1248700 conserved protein, unknown function  154 159 166 K
PF3D7_1252100
rhoptry neck protein 3 861 K
PF3D7_1302800 40S ribosomal protein S7, putative 40 K
PF3D7_1311800
M1-family alanyl aminopeptidase 197 347 1016 K 3.4.11.2
PF3D7_1323100 60S ribosomal protein L6, putative 120 K
PF3D7_1323400 60S ribosomal protein L23 12 K
PF3D7_1324900
L-lactate dehydrogenase 38 91 185 301 310 K 1.1.1.27
PF3D7_1331700
glutamine--tRNA ligase, putative 252 K 6.1.1.18
PF3D7_1332900
isoleucine--tRNA ligase, putative 698 K 6.1.1.5
PF3D7_1333000
20 kDa chaperonin 91 K
PF3D7_1335100
merozoite surface protein 7 303 K
PF3D7_1338300 elongation factor 1-gamma, putative 271 K
PF3D7_1341200 60S ribosomal protein L18, putative 29 K
PF3D7_1341300 60S ribosomal protein L18-2, putative 149 K
PF3D7_1342000 40S ribosomal protein S6 229 K
PF3D7_1343000
phosphoethanolamine N-methyltransferase 103 138 225 230 236 K 2.1.1.103
PF3D7_1346300
DNA/RNA-binding protein Alba 2 64 75 104 322 K
PF3D7_1351400 60S ribosomal protein L17, putative 27 131 K
PF3D7_1352500 thioredoxin-related protein, putative 77 107 115 K 5.3.4.1
PF3D7_1353900 proteasome subunit alpha type-7, putative 163 K 3.4.25.1