CoA biosynthesis

Online articles related to CoA biosynthesis retrieved from PubMed

Drugs affecting pathway with unknown specific target

Drug Name	PubMed Articles (year of publication)
2-(2-furyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazole	Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages
4-[4-(5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazol-2-yl)phenyl]sulfonylmorpholine	Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages
4'-Phospho-N-phenethyl pantothenamide	Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target
5‐(Furan‐2‐yl)‐3‐(thieno[2,3‐d]pyrimidine‐4‐ylthio)‐1,2,4‐triazole	Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages
cinnamon	The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using (1)HNMR Spectroscopy
Cj-15,801	CJ-15,801, a fungal natural product, inhibits the intraerythrocytic stage of Plasmodium falciparum in vitro via an effect on pantothenic acid utilisation
Mmv000304	A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway
Mmv000570	A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway
Mmv011438	A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway
Mmv665820	A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway
Mmv665980	A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway
N-Phenethyl pantothenamide 4'-O,O-dibenzylphosphate	Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target
N-phenethyl-a-methyl-pantothenamide	Toward a Stable and Potent Coenzyme A-Targeting Antiplasmodial Agent: Structure-Activity Relationship Studies of N-Phenethyl-a-methyl-pantothenamide

CoA biosynthesis map details

PFID	PFID Old	Annotation	Formal Annotation	EC	Transcript
PF3D7_0208500	PFB0385w	Apo-[acyl-carrier protein]	acyl carrier protein
PF3D7_1443700	PF14_0415	Dephospho-CoA kinase	dephospho-CoA kinase	2.7.1.24
PF3D7_0420200	PFD0980w	Holo-[acyl-carrier-protein] synthase	holo-[acyl-carrier-protein] synthase, putative	2.7.8.7
PF3D7_0704700	PF07_0018	Pantetheine-phosphate adenylyltransferase	phosphopantetheine adenylyltransferase, putative	2.7.7.3
PF3D7_1420600	PF14_0200	pantothenate kinase 1, putative	pantothenate kinase 1	2.7.1.33
PF3D7_1437400	PF14_0354	pantothenate kinase 2, putative	pantothenate kinase 2	2.7.1.33
PF3D7_0412300	PFD0610w	Phosphopantothenate-cysteine ligase	phosphopantothenoylcysteine synthetase, putative	6.3.2.5
PF3D7_1102400	PF11_0036	Phosphopantothenate-cysteine ligase	phosphopantothenate-cysteine ligase, putative	6.3.2.5
PF3D7_0816100	MAL8P1.81	Phosphopantothenoylcysteine decarboxylase	phosphopantothenoylcysteine decarboxylase, putative	4.1.1.36

Total number of related proteins: 1

#	PFID	Formal Name
1	PFB0385w	acyl carrier protein

Total number of related proteins: 2

#	PFID	Formal Name
1	PFD0610w	phosphopantothenoylcysteine synthetase, putative
2	PF11_0036	phosphopantothenate-cysteine ligase, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PFD0980w	holo-[acyl-carrier-protein] synthase, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PF07_0018	phosphopantetheine adenylyltransferase, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	MAL8P1.81	phosphopantothenoylcysteine decarboxylase, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0200	pantothenate kinase 1

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0354	pantothenate kinase 2

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0415	dephospho-CoA kinase