Differential proteome analysis under drug treatment
Prieto JH, Fischer E, Koncarevic S, Yates J, Becker K. Large-scale differential proteome analysis in Plasmodium falciparum under drug treatment. Methods Mol Biol. 2015;1201:269-79. PMID: 25388121.
Artemisinin
PfID Annotation Fold change EC Transcript
PF3D7_0306000
cytochrome b-c1 complex subunit 8, putative 31.43
PF3D7_1335700 conserved oligomeric golgi complex subunit 3, putative 9.62
PF3D7_1422500
ERAD-associated E3 ubiquitin-protein ligase HRD1 8.46 6.3.2.19
PF3D7_1251300
thymidylate kinase 4.88 2.7.4.9
PF3D7_0217900 thioesterase/thiol ester dehydrase-isomerase, putative 3.40 3.1.2.20
PF3D7_0525100
acyl-CoA synthetase 3.11 6.2.1.3
PF3D7_0619000 fpl domain-containing protein, putative 3.07
PF3D7_1011400
proteasome subunit beta type-5 2.95 3.4.25.1
PF3D7_1113400 ubiquitin domain-containing protein DSK2, putative 2.94
PF3D7_0919900
regulator of chromosome condensation, putative 2.75
PF3D7_0609000 nucleoporin nup637, putative 2.52
PF3D7_1105000
histone H4 2.34
PF3D7_1426200
protein arginine N-methyltransferase 1 2.09 2.1.1.125
PF3D7_1004000 60S ribosomal protein L13, putative 2.02
PF3D7_0610400
histone H3 1.96
PF3D7_0422000 steroid dehydrogenase, putative 1.94 1.1.1.35
PF3D7_1231100
ras-related protein Rab-2 1.92 3.6.5.2
PF3D7_0804800
peptidyl-prolyl cis-trans isomerase 1.90 5.2.1.8
PF3D7_1206000
shewanella-like protein phosphatase 2 1.89 3.1.3.16
PF3D7_0312800 60S ribosomal protein L26, putative 1.86
PF3D7_1249800 THO complex subunit 2, putative 1.86
PF3D7_1341200 60S ribosomal protein L18, putative 1.84
PF3D7_0618300 60S ribosomal protein L27a, putative 1.82
PF3D7_0709700
monoglyceride lipase 1.80 3.1.-.-
PF3D7_0523000
multidrug resistance protein 1. MDR1, IP3 receptor 1.75 3.6.3.44
PF3D7_0320800
ATP-dependent RNA helicase DDX6 1.69 3.6.4.13
PF3D7_0518300
proteasome subunit beta type-1, putative 1.69 3.4.25.1
PF3D7_1368100 26S proteasome regulatory subunit RPN11, putative 1.63
PF3D7_0407800
coordinator of nascent cell detachment CINCH 1.61
PF3D7_1137300 Clptm1 domain-containing protein, putative 1.60
PF3D7_1459400
conserved Plasmodium protein, unknown function 1.60
PF3D7_0321400
pseudo protein kinase 1, putative 1.58 2.7.11.17
PF3D7_0422700 eukaryotic initiation factor 4A-III, putative 1.57
PF3D7_1104200
chromatin remodeling protein 1.53
PF3D7_0807600 conserved Plasmodium protein, unknown function 1.52
PF3D7_0316500 kinetochore protein NUF2, putative 1.50
PF3D7_0711500 regulator of chromosome condensation, putative 1.49
PF3D7_1347200
nucleoside transporter 1, NT1 1.47
PF3D7_1214900 conserved Plasmodium membrane protein, unknown function 1.45
PF3D7_1141300 apical polar ring protein apr1, putative 1.45
PF3D7_1232200
dihydrolipoyl dehydrogenase, mitochondrial 1.40 1.8.1.4
PF3D7_0506900
rhomboid protease ROM4 1.35 3.4.21.105
PF3D7_1318800 translocation protein SEC63 1.34
PF3D7_0320300 T-complex protein 1 subunit epsilon 1.31
PF3D7_1424400 60S ribosomal protein L7-3, putative 1.31
PF3D7_1233600 asparagine and aspartate rich protein 1 1.28
PF3D7_1211700 DNA replication licensing factor MCM5, putative 1.26
PF3D7_1335400
reticulocyte binding protein 2 homologue a 1.24
PF3D7_1229400
macrophage migration inhibitory factor 1.22 5.3.2.1
PF3D7_0923900 polyadenylate-binding protein 2, putative 1.21
PF3D7_0904800 replication protein A1, small fragment 1.14
PF3D7_1361600 Fe-S assembly protein iscx, putative 1.11
PF3D7_0815800 vacuolar protein sorting-associated protein 9, putative 1.09
PF3D7_1133800
RNA (uracil-5-)methyltransferase, putative 1.06 2.1.1.35
PF3D7_0905900 coatomer subunit beta, putative 1.02
PF3D7_0308600 pre-mRNA-processing factor 19, putative 1.02
PF3D7_0606800 VFT protein 0.99
PF3D7_0717700
serine--tRNA ligase, putative 0.97 6.1.1.11
PF3D7_1426100 transcription factor btf3, putative 0.93
PF3D7_1002700 conserved Plasmodium protein, unknown function 0.91
PF3D7_1235300 CCR4-NOT transcription complex subunit 4, putative 0.86
PF3D7_0309300 N2227-like protein, putative 0.84
PF3D7_0612700
6-cysteine protein p12 0.74
PF3D7_1138500
protein phosphatase 2C protein phosphatase PPM2 0.73 3.1.3.16
PF3D7_0617800
histone H2A 0.73
PF3D7_1436000 glucose-6-phosphate isomerase 0.73 5.3.1.9
PF3D7_0527100
ubiquitin-conjugating enzyme E2 13 0.72 6.3.2.19
PF3D7_0423800
RH5-Ripr membrane anchoring protein cysteine-rich protective antigen 0.72
PF3D7_1317800 40S ribosomal protein S19 0.72
PF3D7_1238100 calcyclin binding protein, putative 0.71
PF3D7_0323000 translation machinery-associated protein 7, putative 0.71
PF3D7_0618200 conserved Plasmodium protein, unknown function 0.70
PF3D7_0416500 repressor of RNA polymerase III transcription MAF1, putative 0.70
PF3D7_0214100
protein transport protein SEC31 0.69
PF3D7_1017500
myosin essential light chain ELC 0.67
PF3D7_1224000
GTP cyclohydrolase I 0.66 3.5.4.16
PF3D7_1473700
nucleoporin NUP116/NSP116, putative 0.65
PF3D7_0316700 protein yop1, putative 0.65
PF3D7_1142100
conserved Plasmodium protein, unknown function 0.63
PF3D7_0202500
early transcribed membrane protein 2 0.58
PF3D7_0214900
rhoptry neck protein 6 0.56
PF3D7_1227700
kelch13 interaction candidate kic2 0.52
PF3D7_1302100
gamete antigen 27/25 0.46
PF3D7_0723800 conserved Plasmodium protein, unknown function 0.45
PF3D7_1124700
GrpE protein homolog, mitochondrial, putative 0.39
PF3D7_0302900 exportin-1, putative 0.28
PF3D7_0802000
glutamate dehydrogenase, putative 0.23 1.4.1.2
PF3D7_0716800
eukaryotic translation initiation factor 3 subunit I, putative 0.22
PF3D7_1312800
protein aap2, putative 0.15
PF3D7_0217800 40S ribosomal protein S26 0.10
Chloroquine Chloroquine
PF3D7_0306000
cytochrome b-c1 complex subunit 8, putative 26.16
PF3D7_1211700 DNA replication licensing factor MCM5, putative 5.76
PF3D7_0302900 exportin-1, putative 5.11
PF3D7_1361600 Fe-S assembly protein iscx, putative 3.40
PF3D7_0919900
regulator of chromosome condensation, putative 3.18
PF3D7_0619000 fpl domain-containing protein, putative 3.00
PF3D7_1105000
histone H4 2.56
PF3D7_0422000 steroid dehydrogenase, putative 2.56 1.1.1.35
PF3D7_0711500 regulator of chromosome condensation, putative 2.28
PF3D7_0407800
coordinator of nascent cell detachment CINCH 2.15
PF3D7_1231100
ras-related protein Rab-2 1.96 3.6.5.2
PF3D7_1133800
RNA (uracil-5-)methyltransferase, putative 1.86 2.1.1.35
PF3D7_0610400
histone H3 1.79
PF3D7_1317800 40S ribosomal protein S19 1.78
PF3D7_1229400
macrophage migration inhibitory factor 1.74 5.3.2.1
PF3D7_1206000
shewanella-like protein phosphatase 2 1.69 3.1.3.16
PF3D7_1459400
conserved Plasmodium protein, unknown function 1.68
PF3D7_0612700
6-cysteine protein p12 1.66
PF3D7_0523000
multidrug resistance protein 1. MDR1, IP3 receptor 1.66 3.6.3.44
PF3D7_1233600 asparagine and aspartate rich protein 1 1.65
PF3D7_1335400
reticulocyte binding protein 2 homologue a 1.65
PF3D7_0316700 protein yop1, putative 1.61
PF3D7_0606800 VFT protein 1.61
PF3D7_1422500
ERAD-associated E3 ubiquitin-protein ligase HRD1 1.59 6.3.2.19
PF3D7_1141300 apical polar ring protein apr1, putative 1.56
PF3D7_0308600 pre-mRNA-processing factor 19, putative 1.55
PF3D7_0320300 T-complex protein 1 subunit epsilon 1.55
PF3D7_0923900 polyadenylate-binding protein 2, putative 1.52
PF3D7_0717700
serine--tRNA ligase, putative 1.51 6.1.1.11
PF3D7_0905900 coatomer subunit beta, putative 1.51
PF3D7_0904800 replication protein A1, small fragment 1.50
PF3D7_1347200
nucleoside transporter 1, NT1 1.49
PF3D7_1424400 60S ribosomal protein L7-3, putative 1.48
PF3D7_1341200 60S ribosomal protein L18, putative 1.45
PF3D7_0321400
pseudo protein kinase 1, putative 1.45 2.7.11.17
PF3D7_1318800 translocation protein SEC63 1.43
PF3D7_1232200
dihydrolipoyl dehydrogenase, mitochondrial 1.43 1.8.1.4
PF3D7_1214900 conserved Plasmodium membrane protein, unknown function 1.38
PF3D7_0422700 eukaryotic initiation factor 4A-III, putative 1.37
PF3D7_1113400 ubiquitin domain-containing protein DSK2, putative 1.37
PF3D7_0312800 60S ribosomal protein L26, putative 1.33
PF3D7_0506900
rhomboid protease ROM4 1.33 3.4.21.105
PF3D7_0802000
glutamate dehydrogenase, putative 1.32 1.4.1.2
PF3D7_1137300 Clptm1 domain-containing protein, putative 1.29
PF3D7_0709700
monoglyceride lipase 1.28 3.1.-.-
PF3D7_1249800 THO complex subunit 2, putative 1.17
PF3D7_1104200
chromatin remodeling protein 1.12
PF3D7_0518300
proteasome subunit beta type-1, putative 1.12 3.4.25.1
PF3D7_0804800
peptidyl-prolyl cis-trans isomerase 1.11 5.2.1.8
PF3D7_0316500 kinetochore protein NUF2, putative 1.11
PF3D7_1124700
GrpE protein homolog, mitochondrial, putative 1.11
PF3D7_1251300
thymidylate kinase 1.05 2.7.4.9
PF3D7_0618300 60S ribosomal protein L27a, putative 1.05
PF3D7_1011400
proteasome subunit beta type-5 1.02 3.4.25.1
PF3D7_0320800
ATP-dependent RNA helicase DDX6 0.98 3.6.4.13
PF3D7_0807600 conserved Plasmodium protein, unknown function 0.96
PF3D7_0716800
eukaryotic translation initiation factor 3 subunit I, putative 0.94
PF3D7_1368100 26S proteasome regulatory subunit RPN11, putative 0.94
PF3D7_0609000 nucleoporin nup637, putative 0.89
PF3D7_1426200
protein arginine N-methyltransferase 1 0.89 2.1.1.125
PF3D7_0217900 thioesterase/thiol ester dehydrase-isomerase, putative 0.84 3.1.2.20
PF3D7_0525100
acyl-CoA synthetase 0.84 6.2.1.3
PF3D7_1004000 60S ribosomal protein L13, putative 0.83
PF3D7_1312800
protein aap2, putative 0.82
PF3D7_1335700 conserved oligomeric golgi complex subunit 3, putative 0.81
PF3D7_1227700
kelch13 interaction candidate kic2 0.75
PF3D7_0617800
histone H2A 0.74
PF3D7_0214900
rhoptry neck protein 6 0.70
PF3D7_1436000 glucose-6-phosphate isomerase 0.69 5.3.1.9
PF3D7_0423800
RH5-Ripr membrane anchoring protein cysteine-rich protective antigen 0.68
PF3D7_1473700
nucleoporin NUP116/NSP116, putative 0.67
PF3D7_0618200 conserved Plasmodium protein, unknown function 0.67
PF3D7_0416500 repressor of RNA polymerase III transcription MAF1, putative 0.66
PF3D7_0527100
ubiquitin-conjugating enzyme E2 13 0.66 6.3.2.19
PF3D7_0323000 translation machinery-associated protein 7, putative 0.65
PF3D7_0214100
protein transport protein SEC31 0.65
PF3D7_0723800 conserved Plasmodium protein, unknown function 0.62
PF3D7_1142100
conserved Plasmodium protein, unknown function 0.59
PF3D7_1138500
protein phosphatase 2C protein phosphatase PPM2 0.59 3.1.3.16
PF3D7_0202500
early transcribed membrane protein 2 0.56
PF3D7_1017500
myosin essential light chain ELC 0.53
PF3D7_1238100 calcyclin binding protein, putative 0.45
PF3D7_0309300 N2227-like protein, putative 0.41
PF3D7_1224000
GTP cyclohydrolase I 0.38 3.5.4.16
PF3D7_1235300 CCR4-NOT transcription complex subunit 4, putative 0.36
PF3D7_0815800 vacuolar protein sorting-associated protein 9, putative 0.35
PF3D7_1302100
gamete antigen 27/25 0.24
PF3D7_1002700 conserved Plasmodium protein, unknown function 0.18
PF3D7_0217800 40S ribosomal protein S26 0.06
PF3D7_1426100 transcription factor btf3, putative 0.01
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