Differential proteome analysis under drug treatment
Prieto JH, Fischer E, Koncarevic S, Yates J, Becker K. Large-scale differential proteome analysis in Plasmodium falciparum under drug treatment. Methods Mol Biol. 2015;1201:269-79. PMID: 25388121.
Artemisinin
PfID Annotation Fold change EC Transcript
23062 PF3D7_0306000 cytochrome b-c1 complex subunit 8, putative 31.43
33981 PF3D7_1335700 conserved oligomeric golgi complex subunit 3, putative 9.62
14853 PF3D7_1422500
ERAD-associated E3 ubiquitin-protein ligase HRD1 8.46 6.3.2.19
14842 PF3D7_1251300
thymidylate kinase 4.88 2.7.4.9
14774 PF3D7_0217900 thioesterase/thiol ester dehydrase-isomerase, putative 3.40 3.1.2.20
14794 PF3D7_0525100 acyl-CoA synthetase 3.11 6.2.1.3
23716 PF3D7_0619000 fpl domain-containing protein, putative 3.07
14819 PF3D7_1011400
proteasome subunit beta type-5 2.95 3.4.25.1
14823 PF3D7_1113400 ubiquitin domain-containing protein DSK2, putative 2.94
14815 PF3D7_0919900
regulator of chromosome condensation, putative 2.75
14797 PF3D7_0609000 nucleoporin nup637, putative 2.52
14822 PF3D7_1105000
histone H4 2.34
14856 PF3D7_1426200
protein arginine N-methyltransferase 1 2.09 2.1.1.125
14818 PF3D7_1004000 60S ribosomal protein L13, putative 2.02
14798 PF3D7_0610400
histone H3 1.96
14788 PF3D7_0422000 steroid dehydrogenase, putative 1.94 1.1.1.35
14836 PF3D7_1231100
ras-related protein Rab-2 1.92 3.6.5.2
14810 PF3D7_0804800
peptidyl-prolyl cis-trans isomerase 1.90 5.2.1.8
14830 PF3D7_1206000
shewanella-like protein phosphatase 2 1.89 3.1.3.16
14779 PF3D7_0312800 60S ribosomal protein L26, putative 1.86
14841 PF3D7_1249800 THO complex subunit 2, putative 1.86
14849 PF3D7_1341200 60S ribosomal protein L18, putative 1.84
14802 PF3D7_0618300 60S ribosomal protein L27a, putative 1.82
23850 PF3D7_0709700
monoglyceride lipase 1.80 3.1.-.-
14793 PF3D7_0523000
multidrug resistance protein 1. MDR1 1.75 3.6.3.44
14783 PF3D7_0320800
ATP-dependent RNA helicase DDX6 1.69 3.6.4.13
14792 PF3D7_0518300
proteasome subunit beta type-1, putative 1.69 3.4.25.1
14852 PF3D7_1368100 26S proteasome regulatory subunit RPN11, putative 1.63
14786 PF3D7_0407800
coordinator of nascent cell detachment CINCH 1.61
20775 PF3D7_1137300 Clptm1 domain-containing protein, putative 1.60
14858 PF3D7_1459400
conserved Plasmodium protein, unknown function 1.60
14784 PF3D7_0321400
pseudo protein kinase 1, putative 1.58 2.7.11.17
14789 PF3D7_0422700 eukaryotic initiation factor 4A-III, putative 1.57
14821 PF3D7_1104200 chromatin remodeling protein 1.53
14811 PF3D7_0807600 conserved Plasmodium protein, unknown function 1.52
14780 PF3D7_0316500 kinetochore protein NUF2, putative 1.50
14805 PF3D7_0711500 regulator of chromosome condensation, putative 1.49
14850 PF3D7_1347200
nucleoside transporter 1, NT1 1.47
14832 PF3D7_1214900 conserved Plasmodium membrane protein, unknown function 1.45
14828 PF3D7_1141300 apical polar ring protein apr1, putative 1.45
14837 PF3D7_1232200
dihydrolipoyl dehydrogenase, mitochondrial 1.40 1.8.1.4
14791 PF3D7_0506900
rhomboid protease ROM4 1.35 3.4.21.105
14846 PF3D7_1318800 translocation protein SEC63 1.34
14782 PF3D7_0320300 T-complex protein 1 subunit epsilon 1.31
14854 PF3D7_1424400 60S ribosomal protein L7-3, putative 1.31
14838 PF3D7_1233600 asparagine and aspartate rich protein 1 1.28
14831 PF3D7_1211700 DNA replication licensing factor MCM5, putative 1.26
14847 PF3D7_1335400
reticulocyte binding protein 2 homologue a 1.24
14835 PF3D7_1229400
macrophage migration inhibitory factor 1.22 5.3.2.1
29888 PF3D7_0923900 polyadenylate-binding protein 2, putative 1.21
14813 PF3D7_0904800 replication protein A1, small fragment 1.14
14851 PF3D7_1361600 Fe-S assembly protein iscx, putative 1.11
14812 PF3D7_0815800 vacuolar protein sorting-associated protein 9, putative 1.09
14825 PF3D7_1133800
RNA (uracil-5-)methyltransferase, putative 1.06 2.1.1.35
14814 PF3D7_0905900 coatomer subunit beta, putative 1.02
14777 PF3D7_0308600 pre-mRNA-processing factor 19, putative 1.02
27654 PF3D7_0606800 VFT protein 0.99
14807 PF3D7_0717700
serine--tRNA ligase, putative 0.97 6.1.1.11
27508 PF3D7_1426100 transcription factor btf3, putative 0.93
14817 PF3D7_1002700 conserved Plasmodium protein, unknown function 0.91
14839 PF3D7_1235300 CCR4-NOT transcription complex subunit 4, putative 0.86
14778 PF3D7_0309300 N2227-like protein, putative 0.84
14799 PF3D7_0612700
6-cysteine protein p12 0.74
14827 PF3D7_1138500
protein phosphatase 2C protein phosphatase PPM2 0.73 3.1.3.16
14800 PF3D7_0617800
histone H2A 0.73
14857 PF3D7_1436000 glucose-6-phosphate isomerase 0.73 5.3.1.9
14795 PF3D7_0527100
ubiquitin-conjugating enzyme E2 13 0.72 6.3.2.19
14790 PF3D7_0423800
RH5-Ripr membrane anchoring protein cysteine-rich protective antigen 0.72
14845 PF3D7_1317800 40S ribosomal protein S19 0.72
14840 PF3D7_1238100 calcyclin binding protein, putative 0.71
14785 PF3D7_0323000 translation machinery-associated protein 7, putative 0.71
14801 PF3D7_0618200 conserved Plasmodium protein, unknown function 0.70
14787 PF3D7_0416500 repressor of RNA polymerase III transcription MAF1, putative 0.70
14771 PF3D7_0214100
protein transport protein SEC31 0.69
14820 PF3D7_1017500
myosin essential light chain ELC 0.67
14833 PF3D7_1224000
GTP cyclohydrolase I 0.66 3.5.4.16
14859 PF3D7_1473700
nucleoporin NUP116/NSP116, putative 0.65
14781 PF3D7_0316700 protein yop1, putative 0.65
14829 PF3D7_1142100 conserved Plasmodium protein, unknown function 0.63
14770 PF3D7_0202500
early transcribed membrane protein 2 0.58
14772 PF3D7_0214900
rhoptry neck protein 6 0.56
14834 PF3D7_1227700
kelch13 interaction candidate kic2 0.52
14843 PF3D7_1302100
gamete antigen 27/25 0.46
14808 PF3D7_0723800 conserved Plasmodium protein, unknown function 0.45
14824 PF3D7_1124700
GrpE protein homolog, mitochondrial, putative 0.39
14775 PF3D7_0302900 exportin-1, putative 0.28
14809 PF3D7_0802000
glutamate dehydrogenase, putative 0.23 1.4.1.2
14806 PF3D7_0716800 eukaryotic translation initiation factor 3 subunit I, putative 0.22
14844 PF3D7_1312800
protein aap2, putative 0.15
14773 PF3D7_0217800 40S ribosomal protein S26 0.10
Chloroquine Chloroquine
23062 PF3D7_0306000 cytochrome b-c1 complex subunit 8, putative 26.16
14831 PF3D7_1211700 DNA replication licensing factor MCM5, putative 5.76
14775 PF3D7_0302900 exportin-1, putative 5.11
14851 PF3D7_1361600 Fe-S assembly protein iscx, putative 3.40
14815 PF3D7_0919900
regulator of chromosome condensation, putative 3.18
23716 PF3D7_0619000 fpl domain-containing protein, putative 3.00
14822 PF3D7_1105000
histone H4 2.56
14788 PF3D7_0422000 steroid dehydrogenase, putative 2.56 1.1.1.35
14805 PF3D7_0711500 regulator of chromosome condensation, putative 2.28
14786 PF3D7_0407800
coordinator of nascent cell detachment CINCH 2.15
14836 PF3D7_1231100
ras-related protein Rab-2 1.96 3.6.5.2
14825 PF3D7_1133800
RNA (uracil-5-)methyltransferase, putative 1.86 2.1.1.35
14798 PF3D7_0610400
histone H3 1.79
14845 PF3D7_1317800 40S ribosomal protein S19 1.78
14835 PF3D7_1229400
macrophage migration inhibitory factor 1.74 5.3.2.1
14830 PF3D7_1206000
shewanella-like protein phosphatase 2 1.69 3.1.3.16
14858 PF3D7_1459400
conserved Plasmodium protein, unknown function 1.68
14799 PF3D7_0612700
6-cysteine protein p12 1.66
14793 PF3D7_0523000
multidrug resistance protein 1. MDR1 1.66 3.6.3.44
14838 PF3D7_1233600 asparagine and aspartate rich protein 1 1.65
14847 PF3D7_1335400
reticulocyte binding protein 2 homologue a 1.65
14781 PF3D7_0316700 protein yop1, putative 1.61
27654 PF3D7_0606800 VFT protein 1.61
14853 PF3D7_1422500
ERAD-associated E3 ubiquitin-protein ligase HRD1 1.59 6.3.2.19
14828 PF3D7_1141300 apical polar ring protein apr1, putative 1.56
14777 PF3D7_0308600 pre-mRNA-processing factor 19, putative 1.55
14782 PF3D7_0320300 T-complex protein 1 subunit epsilon 1.55
29888 PF3D7_0923900 polyadenylate-binding protein 2, putative 1.52
14807 PF3D7_0717700
serine--tRNA ligase, putative 1.51 6.1.1.11
14814 PF3D7_0905900 coatomer subunit beta, putative 1.51
14813 PF3D7_0904800 replication protein A1, small fragment 1.50
14850 PF3D7_1347200
nucleoside transporter 1, NT1 1.49
14854 PF3D7_1424400 60S ribosomal protein L7-3, putative 1.48
14849 PF3D7_1341200 60S ribosomal protein L18, putative 1.45
14784 PF3D7_0321400
pseudo protein kinase 1, putative 1.45 2.7.11.17
14846 PF3D7_1318800 translocation protein SEC63 1.43
14837 PF3D7_1232200
dihydrolipoyl dehydrogenase, mitochondrial 1.43 1.8.1.4
14832 PF3D7_1214900 conserved Plasmodium membrane protein, unknown function 1.38
14789 PF3D7_0422700 eukaryotic initiation factor 4A-III, putative 1.37
14823 PF3D7_1113400 ubiquitin domain-containing protein DSK2, putative 1.37
14779 PF3D7_0312800 60S ribosomal protein L26, putative 1.33
14791 PF3D7_0506900
rhomboid protease ROM4 1.33 3.4.21.105
14809 PF3D7_0802000
glutamate dehydrogenase, putative 1.32 1.4.1.2
20775 PF3D7_1137300 Clptm1 domain-containing protein, putative 1.29
23850 PF3D7_0709700