Transcriptomic changes in HbAS RBC infected cells
Saelens JW, Petersen JEV, Freedman E, Moseley RC, Konaté D, Diakité SAS, Traoré K, Vance N, Fairhurst RM, Diakité M, Haase SB, Taylor SM. Impact of Sickle Cell Trait Hemoglobin on the Intraerythrocytic Transcriptional Program of Plasmodium falciparum. mSphere. 2021 Oct 20:e0075521.PMID: 34668757.
Functional group PfID Annotation Fold change EC# Transcript
Amino acid metabolism PF3D7_0906500
arginase 1.55
PF3D7_1025100 glutamine--fructose-6-phosphate aminotransferase [isomerizing], putative 0.60
methionine aminopeptidase 2 1.62
PF3D7_1020400 rRNA(cytosine-c(5))-methyltransferase, putative 1.51
Carbohydrate metabolism PF3D7_0306400 FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.49
PF3D7_1420900 mannose-1-phosphate guanyltransferase, putative 0.63
PF3D7_0413500 phosphoglucomutase-2 0.52
PF3D7_1352500 thioredoxin-related protein, putative 0.50
Lipid metabolism PF3D7_1444300 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.49
PF3D7_1135900 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.49
PF3D7_1001100 acyl-CoA binding protein, isoform 1, ACBP1 1.78
PF3D7_1253400 acyl-CoA synthetase 0.44
PF3D7_1372400 acyl-CoA synthetase 0.60
PF3D7_0401900 acyl-CoA synthetase 1.65
acyl-CoA synthetase 1.60
beta-hydroxyacyl-ACP dehydratase 2.19
beta-hydroxyacyl-ACP dehydratase 2.79
beta-hydroxyacyl-ACP dehydratase 2.16
CDP-diacylglycerol--inositol 3-phosphatidyltransferase phosphatidylinositol synthase 0.46
PF3D7_0826400 cis-prenyltransferase, putative 0.49
PF3D7_0211600 udp-n-acetylglucosamine transferase subunit alg14, putative 0.42
dolichol-phosphate mannosyltransferase 0.66
GPI ethanolamine phosphate transferase 3, putative 0.55
PF3D7_1128700 GPI-anchor transamidase 0.60
GPI-anchored wall transfer protein 1, putative 0.63
lipase, putative 1.55
lipase, putative 1.59
lipase, putative 2.41
lipoyl synthase 0.64
lipoyl synthase 0.60
lysophospholipase, putative 1.54
PF3D7_1401500 esterase, putative 1.88
lysophospholipase, putative 1.92
PF3D7_1401500 esterase, putative 3.00
PF3D7_1401500 esterase, putative 2.32
PF3D7_1476800 lysophospholipase, putative 0.64
PF3D7_1358000 patatin-like phospholipase, putative 0.64
PF3D7_0618900 phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI1 0.60
PF3D7_0618900 phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI1 0.54
cgmp-specific 3',5'-cyclic phosphodiesterase delta, putative 0.62
PF3D7_0814400 phospholipase DDHD1, putative 0.66
sphingomyelin phosphodiesterase 0.60
stearoyl-CoA desaturase 0.61
stearoyl-CoA desaturase 0.48
PF3D7_1126600 steryl ester hydrolase, putative 1.62
PF3D7_1002200 tryptophan-rich antigen 3 1.89
PF3D7_0109850 phosphatidate cytidylyltransferase, putative 0.49
Nucleoside metabolism PF3D7_0105300 cyclase-associated protein 0.56
PF3D7_1008200 flap endonuclease, putative 0.55
PF3D7_1349100 nucleoside diphosphate hydrolase, putative 0.52
PF3D7_0908000 plasma membrane protein 1, putative 0.63
PF3D7_0305800 P-loop containing nucleoside triphosphate hydrolase, putative 3.18
PF3D7_1443500 poly(A)-specific ribonuclease PARN, putative 1.69
PF3D7_1453500 NAD(P) transhydrogenase, putative, nth 2.30
PF3D7_1453500 NAD(P) transhydrogenase, putative, nth 2.77
p-loop containing nucleoside triphosphate hydrolase, putative 0.64
PF3D7_0517500 UTP--glucose-1-phosphate uridylyltransferase, putative 2.82
Cofactor metabolism PF3D7_1467300
1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.64
pentafunctional AROM polypeptide, putative, pseudogene 1.60
pyridoxine biosynthesis protein PDX1 1.96
DNA metabolism PF3D7_0514100
ATP-dependent DNA helicase UvrD 0.66
DNA ligase I 0.59
DNA mismatch repair protein MSH2, putative 0.50
DNA mismatch repair protein MSH2, putative 2.22
DNA polymerase 1, putative 0.63
PF3D7_0411900 DNA polymerase alpha 0.63
PF3D7_0910900 DNA primase large subunit, putative 0.61
PF3D7_1438700 DNA primase small subunit 0.66
PF3D7_1368800 DNA repair endonuclease XPF, putative 0.59
PF3D7_0527000 DNA replication licensing factor MCM3, putative 0.64
PF3D7_1211700 DNA replication licensing factor MCM5, putative 0.58
PF3D7_0705400 DNA replication licensing factor MCM7 0.63
PF3D7_1247000 F-box only protein 9 homolog, putative 0.48
PF3D7_1010200 DNA2/NAM7 helicase, putative 1.59
PF3D7_0926900 replication termination factor, putative 0.63
RuvB-like helicase 1 0.65
PF3D7_0530600 XAP-5 DNA binding protein, putative 1.69
RNA metabolism PF3D7_0827000 ATP-dependent RNA helicase DBP10, putative 1.69
PF3D7_0630900 ATP-dependent RNA helicase HAS1 1.67
ATP-dependent RNA helicase ddx55 1.81
PF3D7_0113800 DBL containing protein, unknown function 1.73
PF3D7_0411400 DEAD box ATP-dependent RNA helicase, putative 1.51
PF3D7_1251500 ATP-dependent RNA helicase drs1, putative 1.82
PF3D7_1302700 ATP-dependent RNA helicase  dhr1, putative 1.73
PF3D7_1418900 ATP-dependent RNA helicase DBP4, putative 1.93
PF3D7_1143300 DNA-directed RNA polymerases I and III subunit RPAC1, putative 1.51
PF3D7_0817100 tRNA modification GTPase, putative 1.54
PF3D7_1354300 large subunit rRNA methyltransferase, putative 1.97 2.1.1.-
PF3D7_0212900 arginyl-trna--protein transferase 0.63
mRNA-binding protein puf3 1.74
PF3D7_0518700 mRNA-binding protein PUF1 2.29
PF3D7_1109200 conserved Plasmodium protein, unknown function 1.72
RNA polymerase II-associated protein 1, putative 1.62
PF3D7_1445600 RNA-binding protein, putative 1.61
PF3D7_1004400 RNA-binding protein, putative 1.66
PF3D7_1126800 alternative splicing factor sr-mg, putative 2.69
PF3D7_1405900 RNA-binding protein, putative 2.10
rRNA 2'-O-methyltransferase fibrillarin, putative 1.56
PF3D7_1207100 pre-rRNA-processing protein esf1, putative 1.86
PF3D7_1225500 small subunit rRNA processing factor, putative 1.61
PF3D7_1358100 sas10 domain-containing protein, putative 2.13
PF3D7_1217200 multiple rna-binding domain-containing protein 1 1.54
AP2 domain transcription factor AP-G 1.88
AP2 domain transcription factor AP2-G2 1.60
PF3D7_0730300 AP2 domain transcription factor AP2-L, putative 1.80
PF3D7_0516800 AP2 domain transcription factor AP2-O2, putative 0.65
AP2 domain transcription factorAP2-HC 0.66
PF3D7_1139300 AP2 domain transcription factor, putative 1.53
PF3D7_1317200 AP2 domain transcription factor AP2-FG 2.10
PF3D7_1342900 AP2 domain transcription factor, putative 1.76
AP2 domain transcription factor AP2Tel 1.56
PF3D7_0407300 transcription factor, putative 1.63
PF3D7_0717300 transcription initiation factor IIE subunit alpha, putative 1.51
transcriptional regulatory protein sir2a 2.24
PF3D7_0516300 tRNA pseudouridine synthase, putative 1.60
PF3D7_0516300 tRNA pseudouridine synthase, putative 1.73
PF3D7_0516300 tRNA pseudouridine synthase, putative 1.66
PF3D7_0524900 S-adenosyl-l-methionine-dependent trna 4-demethylwyosine synthase, putative 1.59
PF3D7_1035000 U2 snRNA/tRNA pseudouridine synthase, putative 1.53
PF3D7_1027100 U3 small nucleolar ribonucleoprotein protein MPP10, putative 2.70
PF3D7_1448000 U3 small nucleolar RNA-associated protein 12, putative 1.56
PF3D7_1333600 U3 small nucleolar RNA-associated protein 4, putative 1.91
PF3D7_0522900 zinc finger protein, putative 2.93
PF3D7_1210200 zinc finger protein, putative 2.69
PF3D7_0522900 zinc finger protein, putative 1.80
PF3D7_0525000 zinc finger protein, putative 1.94
PF3D7_1420300 DNL-type zinc finger protein; hsp70-escort protein 1 1.82
ring finger protein rnf1 1.94
PF3D7_1134600 zinc finger protein, putative 2.15
PF3D7_1358500 zinc finger protein, putative 2.00
Chromatin structure and cell cycle control PF3D7_0624500 anaphase-promoting complex subunit 11, putative 0.51
bacterial histone-like protein 0.46
PF3D7_1220300 cell cycle associated protein, putative 0.67
PF3D7_1238300 pre-mRNA-splicing factor CWC22, putative 2.03
cell division cycle protein 48 homologue, putative 0.58
centrin-2 0.67
structural maintenance of chromosomes protein 4 0.56
PF3D7_1304000 condensin complex subunit 2, putative, caph 0.63
PF3D7_1304000 condensin complex subunit 2, putative, caph 0.65