| Different kinesins with different roles |
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| Kinesin names |
PfID |
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Transcript |
Effect on MT dynamics |
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| Kinesin-1 |
PF3D7_1211000 |
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Vesicle, organelle and mRNA transport. Promotes MT elongation by activating JNK |
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| Kinesin-5 |
PF3D7_0317500 |
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Spindle pole separation and spindle bipolarity. Destabilize MTs by promoting catastrophes |
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| Kinesin-7 |
PF3D7_1211000 |
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Kinetochore–microtubule attachment and chromosome congressionPromotes MT elongation in vitro |
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| Kinesin-8 |
PF3D7_0319400 |
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Chromosome congression. Depolymerizes MTs in a length-dependent manner; Promotes catastrophes/rescue frequencies and inhibits MT growth |
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| kinesin-8 |
PF3D7_0111000 |
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Chromosome congression. Depolymerizes MTs in a length-dependent manner; Promotes catastrophes/rescue frequencies and inhibits MT growth |
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| Kinesin-13 |
PF3D7_1245100 |
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Acts predominantly on MT minus ends at spindle poles to disrupt spindle MT turnover; Induces a conformational change of tubulin into a bent conformation, and hence depolymerize MTs, from both MT ends; Promotes catastrophes and sequesters tubulin; Controls spindle bipolarity |
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| Kinesin-14 |
PF3D7_1146700 |
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Minus end-directed MT motors; Needed in mitosis and in meiosis to organize with kinesin-5 anti-parallel MTs together in spindle; Cross-link MTs to form stable contacts between parallel MTs near the spindle poles and cause sliding between anti-parallel MTs in the spindle midzone. Sequestrated in the nucleus during interphase; Targeted by the non-motor subunit Cik1 (PFC0960c) to the plus ends to depolymerize MTs, each tubulin subunit release event being coupled to one ATP turnover |
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| Kinesin-19 |
PF3D7_0724900 |
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Role unknown |
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| All members of the kinesin superfamily contain a kinesin motor domain (see the figure; light green). In general, the position of the motor domain in the polypeptide sequence indicates the directional motility of the protein. Kinesins with an amino‑terminal motor domain undergo motility to the plus (rapidly growing) end of microtubules, whereas kinesins with a carboxy‑terminal motor (Kinesin‑14 family) undergo minus end‑directed motility. Kinesin motors with a central motor domain (Kinesin‑13 family) do not undergo directed motility but instead destabilize microtubules at their plus and minus ends. Some kinesin motors (Kinesin‑8 and Kinesin‑14 families) can both walk along and destabilize microtubules, and some (Kinesin‑5 and Kinesin‑14 families) can cross‑link and slide adjacent microtubules. Kinesin‑6 motors contain a unique loop in their motor domains. |
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