|
Characteristic features of Hsp70s |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Barth J, Schach T, Przyborski JM. HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets. Front Mol Biosci. 2022 9:968248. PMID: 35992276; |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PfID |
|
|
Annotation |
Size (kDa) |
Localization |
Cellular functions |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0818900 |
 |
 |
PfHsp70-1 |
74 |
Nucleus and cytosol |
folding/translocation/aggregation suppression |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0708800 |
|
|
PfHsp70-z |
100 |
Cytosol |
Predicted NEF of PfHsp70-1; |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0917900 |
|
|
PfHsp70-2 |
73 |
E.R |
Protein import and folding in the ER, retrograde translocation of proteins for degradation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1344200 |
|
|
PfHsp70-y |
108 |
E.R |
Thought to be NEF for PfHsp70-2 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1134000 |
|
|
PfHsp70-3 |
73 |
Mitochondrion |
Protein translocation into the mitochondrion |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0831700 |
|
|
PfHsp70-x |
76 |
P.V and exported to parasite infected RBC infected RBC |
Protein export and subsequent protein folding of exported proteins in the infected RBC |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|