Replication in prokaryotes – a model for apicoplast and mitochondion DNA replication

Online articles related to Replication in prokaryotes – a model for apicoplast and mitochondion DNA replication retrieved from PubMed

Drugs affecting pathway with unknown specific target

Drug Name	PubMed Articles (year of publication)
ciprofloxacin	The effects of anti-bacterials on the malaria parasite Plasmodium falciparum
Minocycline	Inhibition of mitochondrial and plastid activity of Plasmodium falciparum by minocycline
Polyketomycin	In vitro antimalarial activities of the microbial metabolites
Suggested target	The plastidic DNA replication enzyme complex of Plasmodium falciparum

Replication in prokaryotes – a model for apicoplast and mitochondion DNA replication map details

PFID	PFID Old	Annotation	Formal Annotation	EC	Transcript
PF3D7_0504200	PFE0205w	ATP-dependent RNA helicase ddx27, putative	ATP-dependent RNA helicase ddx27, putative	3.6.4.13
PF3D7_0625300	PFF1225c	DNA POL I	mitochondrial DNA polymerase	2.7.7.7
PF3D7_1206600	PFL0330c	DNA POL III	DNA-directed RNA polymerase III subunit RPC2, putative	2.7.7.6
PF3D7_1329000	PF13_0150	DNA POL III	DNA-directed RNA polymerase III subunit RPC1, putative	2.7.7.6
PF3D7_1421400	PF14_0207	DNA POL III	DNA-directed RNA polymerase III subunit RPC6, putative	2.7.7.6
PF3D7_1463400	PF14_0603	DNA POL III	DNA-directed RNA polymerase III subunit RPC4, putative	2.7.7.6
PF3D7_0910900	PFI0530c	DNA primase	DNA primase large subunit, putative	2.7.7.6
PF3D7_1438700	PF14_0366	DNA primase	DNA primase small subunit	2.7.7.6
PF3D7_1223300	PFL1120c	Gyrase	DNA gyrase subunit A	5.99.1.3
PF3D7_1239500	PFL1915w	Gyrase	DNA gyrase subunit B	5.99.1.3
PF3D7_0504400	PFE0215w	Helicase	ATP-dependent helicase, putative	3.6.4.13
PF3D7_1304100	MAL13P1.22	Ligase	DNA ligase I	6.5.1.1
PF3D7_1411400	PF14_0112	PREX	plastid replication-repair enzyme	2.7.7.7
PF3D7_0508800	PFE0435c	Single-stranded binding protein	single-stranded DNA-binding protein

Total number of related proteins: 1

#	PFID	Formal Name
1	PFE0205w	ATP-dependent RNA helicase ddx27, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PFE0215w	ATP-dependent helicase, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PFE0435c	single-stranded DNA-binding protein

Total number of related proteins: 1

#	PFID	Formal Name
1	PFF1225c	mitochondrial DNA polymerase

Total number of related proteins: 2

#	PFID	Formal Name
1	PFI0530c	DNA primase large subunit, putative
2	PF14_0366	DNA primase small subunit

Total number of related proteins: 4

#	PFID	Formal Name
1	PFL0330c	DNA-directed RNA polymerase III subunit RPC2, putative
2	PF13_0150	DNA-directed RNA polymerase III subunit RPC1, putative
3	PF14_0207	DNA-directed RNA polymerase III subunit RPC6, putative
4	PF14_0603	DNA-directed RNA polymerase III subunit RPC4, putative

Total number of related proteins: 2

#	PFID	Formal Name
1	PFL1120c	DNA gyrase subunit A
2	PFL1915w	DNA gyrase subunit B

Total number of related proteins: 1

#	PFID	Formal Name
1	MAL13P1.22	DNA ligase I

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0112	plastid replication-repair enzyme