Signifcantly altered metabolic genes  in response to hypoxanthine deprivation
Tewari SG, Rajaram K, Schyman P, Swift R, Reifman J, Prigge ST, Wallqvist A. Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability. Malar J. 2019 18(1):86.PMID: 30890151.
Functional category PfID Annotation EC# Transcript Altered within 24 hrs Altered after 24 hrs
40135 Translation PF3D7_1218600
arginine-tRNA ligase; arginyl-tRNA synthetase 6.1.1.19
+
40087 PF3D7_0925300
proline--tRNA ligase, putative 6.1.1.15
+
40132 PF3D7_1213800
prolyl-tRNA synthetase proline--tRNA ligase 6.1.1.15
+
40135 PF3D7_1218600
arginine-tRNA ligase; arginyl-tRNA synthetase 6.1.1.19
+
40023 PF3D7_0102900
aspartate--tRNA ligase 6.1.1.12
+
40034 PF3D7_0211800 asparagine--tRNA ligase 6.1.1.22
+
40045 PF3D7_0509600
asparagine--tRNA ligase 6.1.1.22
+
40048 PF3D7_0514300 aspartate--tRNA ligase, putative 6.1.1.12
+
40167 PF3D7_1357200
glutamate--tRNA ligase 6.1.1.17
+
40154 PF3D7_1331700
glutamine--tRNA ligase, putative 6.1.1.18
+
40163 PF3D7_1349200 glutamate--tRNA ligase, putative 6.1.1.17
+
40183 PF3D7_1420400
glycine--tRNA ligase 6.1.1.14
+
40079 PF3D7_0828200 leucine--tRNA ligase, putative 6.1.1.4
+
40155 PF3D7_1332900
isoleucine--tRNA ligase, putative 6.1.1.5
+
40204 PF3D7_1461900
valine--tRNA ligase, putative 6.1.1.9
+
40037 PF3D7_0311200 valine--tRNA ligase, putative 6.1.1.9
+
40060 PF3D7_0622800
leucine--tRNA ligase, putative 6.1.1.4
+
40165 PF3D7_1350100
lysine--tRNA ligase 6.1.1.6
+
40181 PF3D7_1416800
lysine--tRNA ligase, putative 6.1.1.6
+
40093 PF3D7_1005000
methionine--tRNA ligase, putative 6.1.1.10
+
40106 PF3D7_1034900
methionine--tRNA ligase 6.1.1.10
+
40071 PF3D7_0807900
tyrosine--tRNA ligase 6.1.1.1
+
40109 PF3D7_1104000
phenylalanine--tRNA ligase beta subunit 6.1.1.20
+
40115 PF3D7_1117500
tyrosine--tRNA ligase 6.1.1.1
+
40156 PF3D7_1336900
tryptophanyl-tRNA synthetase tryptophan--tRNA ligase 6.1.1.2
+
40027 PF3D7_0109800
phenylalanyl-tRNA synthetase alpha subunit 6.1.1.20
+
40052 PF3D7_0603700
phenylalanine--tRNA ligase 6.1.1.20
+
40138 PF3D7_1232000
phenylalanine--tRNA ligase 6.1.1.20
+
40068 PF3D7_0717700
serine--tRNA ligase, putative 6.1.1.11
+
40134 PF3D7_1216000 serine--tRNA ligase, putative 6.1.1.11
+
40097 PF3D7_1015200
cysteine--tRNA ligase, putative 6.1.1.16
+
40118 PF3D7_1126000
threonine--tRNA ligase 6.1.1.3
+
40174 PF3D7_1367700
alanine--tRNA ligase 6.1.1.7
+
40198 PF3D7_1445100 histidine--tRNA ligase, putative 6.1.1.21
+
40082 Invasion PF3D7_0918000
glideosome-associated protein 50 secreted acid phosphatase 3.1.3.2
+
40080 Post-translation PF3D7_0831800
histidine-rich protein II + +
40112 PF3D7_1115300
falcipain 2' cysteine proteinase falcipain 2b 3.4.22.-
+
40113 PF3D7_1115400
cysteine proteinase falcipain 3 3.4.22.-
+
40114 PF3D7_1115700
cysteine proteinase falcipain 2a falcipain 2 3.4.22.-
+
40177 PF3D7_1407900
plasmepsin I 3.4.23.38
+
40178 PF3D7_1408000
plasmepsin II 3.4.23.39
+
40168 Amino acid metabolism PF3D7_1357900 pyrroline-5-carboxylate reductase, putative 1.5.1.2
+ +
40056 PF3D7_0608800
ornithine aminotransferase 2.6.1.13
+ +
40081 PF3D7_0906500
arginase 3.5.3.1
+ +
40070 PF3D7_0802000
glutamate dehydrogenase, putative 1.4.1.2
+
40180 PF3D7_1416500
NADP-specific glutamate dehydrogenase 1.4.1.4
+
40074 PF3D7_0815900
dihydrolipoyl dehydrogenase, apicoplast 1.1.1.35
+ +
40172 PF3D7_1365500
glycine cleavage system T protein, putative aminomethyltransferase, mitochondrial, putative 2.1.2.10
+
40104 PF3D7_1033100
S-adenosylmethionine decarboxylase/ornithine decarboxylase 4.1.1.17
+
40050 PF3D7_0520900
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase 3.3.1.1
+ +
40084 PF3D7_0922200
S-adenosylmethionine synthetase 2.5.1.6
+
40088 PF3D7_0926700
glutamine-dependent NAD(+) synthetase, putative 6.3.5.1
+
40121 PF3D7_1129000
spermidine synthase 2.5.1.16
+
40038 Carbohydrate metabolism PF3D7_0318800
triosephosphate isomerase, putative 5.3.1.1
+
40201 PF3D7_1453800
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 1.1.1.49
+ +
40202 PF3D7_1454700
6-phosphogluconate dehydrogenase, decarboxylating, putative 1.1.1.44
+ +
40057 PF3D7_0610800
transketolase 2.2.1.1
+
40136 PF3D7_1219900
ribulose-phosphate 3-epimerase, putative 5.1.3.1
+
40095 PF3D7_1012500 phosphoglucomutase, putative 5.4.2.2
+
40107 PF3D7_1037100
pyruvate kinase 2, pyrkii 2.7.1.40
+
40159 PF3D7_1342800
phosphoenolpyruvate carboxykinase 4.1.1.49
+ +
40185 PF3D7_1426700
phosphoenolpyruvate carboxylase 4.1.1.31
+
40103 Nucleotide metabolism PF3D7_1029600
adenosine deaminase 3.5.4.4
+ +
40047 PF3D7_0513300
purine nucleoside phosphorylase 2.4.2.1
+ +
40031 PF3D7_0206700
adenylosuccinate lyase 4.3.2.2
+
40166 PF3D7_1354500
adenylosuccinate synthetase 6.3.4.4
+
40170 PF3D7_1360500 guanylyl cyclase beta 4.6.1.2
+
40123 PF3D7_1138400
guanylyl cyclase alfa Gca 4.6.1.2
+
40119 PF3D7_1127100
deoxyuridine 5'-triphosphate nucleotidohydrolase dUTP pyrophosphatase 3.6.1.23
+
40164 PF3D7_1349400 cytidine and deoxycytidylate deaminase, putative 3.5.4.5
+
40144 PF3D7_1251300
thymidylate kinase 2.7.4.9 +
40173 PF3D7_1366500
nucleoside diphosphate kinase 2.7.4.6
+
40053 PF3D7_0605600
nucleoside diphosphate kinase, putative 2.7.4.6
+
40098 PF3D7_1015800
ribonucleoside-diphosphate reductase small chain, putative 1.17.4.1
+
40176 PF3D7_1405600
ribonucleoside-diphosphate reductase small chain, putative 1.17.4.1
+
40190 PF3D7_1437200
ribonucleoside-diphosphate reductase large subunit, putative 1.17.4.1
+
40151 PF3D7_1321500
3',5'-cyclic nucleotide phosphodiesterase beta 3.1.4.17
+
40152 PF3D7_1321600
cGMP-specific 3',5'-cyclic phosphodiesterase gamma, putative 3.1.4.17
+
40094 PF3D7_1012400
hypoxanthine-guanine phosphoribosyltransferase 2.4.2.8
+
40207 PF3D7_1470500
cgmp-specific 3',5'-cyclic phosphodiesterase delta, putative 3.1.4.17
+
40126 PF3D7_1206100
imp-specific 5'-nucleotidase 1 3.1.3.5
+
40128 PF3D7_1209500
cGMP-specific 3',5'-cyclic phosphodiesterase alpha 3.1.4.35
+
40160 Lipid metabolism PF3D7_1343000
phosphoethanolamine N-methyltransferase 2.1.1.103
+ +
MAL6P1.97 +
40149 PF3D7_1318200
glycerol-3-phosphate 1-O-acyltransferase, putative 2.3.1.15
+
40197 PF3D7_1444300 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 2.3.1.51
+
40208 PF3D7_1471400 diacylglycerol kinase, putative 2.7.1.107
+
40092 PF3D7_0930500 diacylglycerol kinase, putative 2.7.1.107
+
40157 PF3D7_1337200
1-deoxy-D-xylulose 5-phosphate synthase 2.2.1.7
+
40101 PF3D7_1022800
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), putative 1.17.7.1
+
40205 PF3D7_1467300
1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267
+
40025 PF3D7_0104400
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1.17.1.2
+
40026 PF3D7_0106900
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative 2.7.7.60
+
40032 PF3D7_0209300
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12
+
40043 PF3D7_0503100
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative 2.7.1.148
+
40175 PF3D7_1401800
choline kinase 2.7.1.32
+
40075 PF3D7_0820200 phosphatidylglycerophosphate synthase 2.7.8.5
+
40117 PF3D7_1124600
ethanolamine kinase 2.7.1.82
+ +
40179 PF3D7_1409900
cytidine diphosphate-diacylglycerol synthase 2.7.7.41
+
40208 PF3D7_1471400 diacylglycerol kinase, putative 2.7.1.107
+
40092 PF3D7_0930500 diacylglycerol kinase, putative 2.7.1.107
+
40120 PF3D7_1128400