Non-redundant malarial structures in the Protein Data Bank (PDB)
Guy AJ, Irani V, Beeson JG, Webb B, Sali A, Richards JS, Ramsland PA.Proteome-wide mapping of immune features onto Plasmodium protein three-dimensional structures. Sci Rep. 2018 8(1):4355. PMID: 29531293
PfID Annotation PDB Ids Ligands EC# Transcript
PF3D7_0729200
1-cys peroxiredoxin 1XIY 1.11.1.15
PF3D7_0628000 6-pyruvoyltetrahydropterin synthase 1Y13 Biopterin 4.2.3.12
PF3D7_1477800
acyl-CoA binding protein 1HBK
PF3D7_1354500
adenylosuccinate synthetase 1P98 6.3.4.4
PF3D7_1133400
apical membrane antigen 1 1HN6 1Z40
PF3D7_1323000
beta-hydroxyacyl-ACP dehydratase 1Z6B 1ZHG Cacodylate 4.2.1.59
PF3D7_0615500 cdc2-related protein kinase 5 1V0P 1V0O 1OB3 Purvalanol B, Indirubin-5-Sulphonate 2.7.11.22
PF3D7_0307400
ATP-dependent Clp protease proteolytic subunit 2F6I 3.4.21.92
PF3D7_0322000
peptidyl-prolyl cis-trans isomerase 1QNH 1QNG 2FU0 Cyclosporin A 5.2.1.8
PF3D7_0417200
bifunctional dihydrofolate reductase-thymidylate synthase 1J3J 1J3I 1J3K 3DG8 3QGT 3DGA 3JSU Pyrimethamine, NADPH , dUMP, WR99210, NADPH dihydro-nicotneamide-adenine-dinucleotide phosphate, 5-(4-chlorophenyl)-6-ethyl-pyrimidine-2,4-diamine, 2-(N-morpholino)ethanesulfonic acid, N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide CP7 1.5.1.3
PF3D7_0603300
dihydroorotate dehydrogenase 1TV5 orotic acid, FMN, (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide; 3,6,9,12,15-pentaoxatricosan-1-ol 1.3.5.2
PF3D7_1415800
ribosomal RNA small subunit methyltransferase a1 2H1R 2.1.1.183
PF3D7_1127100
deoxyuridine 5'-triphosphate nucleotidohydrolase dUTP pyrophosphatase 1VYQ 2 ,3-deoxy-3-fluoro-5-o-trityluridine 3.6.1.23
PF3D7_1213600
dynein light chain 1, putative 5WOF
PF3D7_0615100
enoyl-acyl carrier reductase 1NHG 1NHW 1VRW 1ZSN 1NNU 1ZW1 1ZXL Triclosan, NAD+, 5-chloro-2-(2-chloro-4-nitro-phenoxy)phenol, 2-(4-amino-2-chloro-phenoxy)-5-chloro-phenol,2-[(2,4-dichlorophenyl)amino]phenol, 5-chloro-2-(2,4-dichlorophenoxy)pheno 1.3.1.9
PF3D7_1115700
cysteine proteinase falcipain 2a falcipain 2 1YVB 2GHU 3BPF E64 3.4.22.-
PF3D7_1115400
cysteine proteinase falcipain 3 3BWK 3BPM N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide, SO4 3.4.22.-
PF3D7_1318100 ferredoxin, putative 1IUE
PF3D7_0814900
superoxide dismutase [Fe] 2AWP 1.15.1.1
PF3D7_1444800
fructose-bisphosphate aldolase 1A5C 2EPH 2PC4 4.1.2.13
PF3D7_1416500
NADP-specific glutamate dehydrogenase 2BMA 1.4.1.4
PF3D7_1419800
glutathione reductase 1ONF FAD 1.8.1.7
PF3D7_1419300
glutathione S-transferase 1PA3 1Q4J 1OKT 2AAW S-Hexyl-Gsh, hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol, (2S,3S)-butane-1,2,3,4-tetrol 2.5.1.18
PF3D7_1462800
glyceraldehyde-3-phosphate dehydrogenase 1YWG 2B4R 2B4T NAD+, glycerol, 4-(2-azanylethyl)benzenesulfonyl fluoride 1.2.1.12
PF3D7_1216200 glycerol-3-phosphate dehydrogenase [NAD+], putative 1YJ8 1.1.1.8
PF3D7_0928900
guanylate kinase 1Z6G 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid, SO4 2.7.4.8
PF3D7_1351100 conserved protein, unknown function 1ZSO
PF3D7_1012400
hypoxanthine-guanine phosphoribosyltransferase 1CJB 1U5A [(2R,3R,4S,5S)-3,4-dihydroxy-5-(4-oxo-3,5-dihydropyrrolo[4,5-d]pyrimidin-7-yl)pyrrolidin-2-yl]methyl dihydrogen phosphate, Pyrophosphate 2-, [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl dihydrogen phosphate 2.4.2.8
PF3D7_1324900
L-lactate dehydrogenase 1LDG 1CET 1CEQ 2X8L 1T26 IT24 1T2D NADH,Oxamate, Chloroquine, 4-Hydroxy-1,2,5-Thiadiazole-3-Carboxylic Acid, 3-Hydroxyisoxazole-4-Carboxylic Acid, NAD+, 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid, 2,6-dicarboxynaphthalene, naphthalene-2,6-disulfonic acid, 3,7-dihydroxynaphthalene-2-carbo 1.1.1.27
1T2C 1U4O 1U5C 1T2E 1XIV 1T25 2A94
2X8L
PF3D7_0930300
merozoite surface protein 1 `1OB1 2FLG 1CEJ dimethylarsinate
PF3D7_1035400
merozoite surface protein 3 1PSM
PF3D7_1366500
nucleoside diphosphate kinase 1XIQ 2.7.4.6
PF3D7_0922900
3-oxoacyl-[acyl-carrier-protein] reductase 2C07 SO4 1.1.1.35
PF3D7_0922500
phosphoglycerate kinase 1LTK 3OZ7 AMP, Glycerol, SO4 2.7.2.3
PF3D7_1120100
phosphoglycerate mutase, putative 1XQ9 3KKK SCN 5.4.2.11
PF3D7_1408000
plasmepsin II 2IGY 2IGX 5-pentyl-N-[[4-(4-piperidin-1-ylcarbonylphenyl)phenyl]methyl]-N-[1-(pyridin-2-ylmethyl)piperidin-4-yl]pyridine-2-carboxamide, N-[1-(3-methylbutyl)piperidin-4-yl]-N-[[4-(methyl-pyridin-4-yl-amino)phenyl]methyl]-4-pentyl-benzamide 3.4.23.39
PF3D7_1407800
plasmepsin IV 1LS5 5I70 5JOD 2ANL Peptstatin A, Inhibitor Rs370, Statine analog, Inhibitor Rs367, Inhibitor Eh58, JE2 3.4.23.-
PF3D7_1302100
gamete antigen 27/25 1N81
PF3D7_0513300
purine nucleoside phosphorylase 2BSX 1Q1G 1SQ6 1NW4 Inosine, propan-2-ol, 7-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(methylsulfanylmethyl)pyrrolidin-1-ium-2-yl]-3,5-dihydropyrrolo[2,3-e]pyrimidin-4-one, SO4 2.4.2.1
PF3D7_1247400
peptidyl-prolyl cis-trans isomerase fkbp 2FBN 2VN1 5.2.1.8
PF3D7_0907900
peptide deformylase 1JYM 1RQC 1RL4 CO,(2R-2-{[formyl(hydroxy)amino]methyl}hexaoic acd; (2S)-N-[(2S)-6-amino-1-oxo-1-phenylazanyl-hexan-2-yl]-2-[[2-[(2S)-2-[[(2S)-6-amino-1-oxo-1-phenylazanyl-hexan-2-yl]carbamoyl]hexyl]hydrazinyl]methyl]hexanamide 3.5.1.88
PF3D7_1443900
heat shock protein 90, putative 1Y6Z 3IED AMP phosphoramidate
PF3D7_1144900
ras-related protein Rab-6 1D5C GDP, Mg2+ 3.6.5.2
PF3D7_0514600 ribose-5-phosphate isomerase 2F8M Phosphate 5.3.1.6
PF3D7_1219900
ribulose-phosphate 3-epimerase, putative 1TQX SO4, Zinc 5.1.3.1
PF3D7_1457200
thioredoxin 1 1SYR
PF3D7_0318800
triosephosphate isomerase, putative 1LYX 1LZO 1M7O 1M7P 1O5X 1LZO 1VGA 2-Phosphoglycolic acid, Glycerol-3-Phosphate, 2-Phosphoglycolic acid, 3-Phosphoglyceric acid, 2-phosphoglycerate 5.3.1.1
1WOA 1WOB 1YDV 2VFD 2VFE 2VFF 2VFG
2VFH 2VFI
PF3D7_1345500
ubiquitin-conjugating enzyme E2 2H2Y 6.3.2.19
PF3D7_0923800
thioredoxin reductase  4J57 4J56 FAD; GLYCEROL; Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex 1.8.1.9
PF3D7_1457200
thioredoxin 1  4J57 4J56 FAD; GLYCEROL; Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex
PF3D7_1345100
thioredoxin 2 2C0D
PF3D7_0608800
ornithine aminotransferase  3NTJ SO4 2.6.1.13
PF3D7_1454700
6-phosphogluconate dehydrogenase, decarboxylating, putative 6FQZ 6FQY 6FQX 6-Phosphogluconc acid; triethylene glycol; di(hydroxyethyl)ether; glycerol; NADP; 1,2-ethanediol 1.1.1.44
PF3D7_1327600
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 5LM3 2.7.7.18
PF3D7_1430700
NADP-specific glutamate dehydrogenase 3R3J 1.4.1.4
PF3D7_1436300
translocon component PTEX150 6E10 Phosphothiophosphoric acid-adenylate ester
PF3D7_0807500 proteasome subunit alpha type-6, putative 6MUW 6MUV 6MUX 3.4.25.1
80S Ribosom by Wong: 3JBN, but thats cryo.. 3JBN 3JBO
Online articles related to Non-redundant malarial structures in the Protein Data Bank (PDB) retrieved from PubMed