Folate biosynthesis

Components in the map that are indicated with a red star

have relevant reagents

in the MR4 site of ATCC.

Online articles related to Folate biosynthesis retrieved from PubMed

Drugs affecting pathway with unknown specific target

Drug Name	PubMed Articles (year of publication)
4-[5-bromo-1-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridin-3-yl]pyridin-2-amine	Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Aminopterin	Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer
Chlorcycloguanil	Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer
Chlorproguanil	Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer
Dapsone	Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer
Methotrexate	Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer
MMV007978	Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
MMV665906	Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
MMV688345	Metabolic dependency of chorismate in Plasmodium falciparum suggests an alternative source for the ubiquinone biosynthesis precursor
Proguanil	Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer
pyrimidine primaquine hybrids	Primaquine-pyrimidine hybrids: synthesis and dual-stage antiplasmodial activity
Pyronaridine	Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer
Suggested target	Genetic and metabolic analysis of folate salvage in the human malaria parasite Plasmodium falciparum
TCMDC-124964	Discovery of Dual-Stage Malaria Inhibitors with New Targets
TCMDC-137381	Discovery of Dual-Stage Malaria Inhibitors with New Targets
TCMDC-137930	Discovery of Dual-Stage Malaria Inhibitors with New Targets
Trimetrexate	Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer
Wr99210	Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer

Folate biosynthesis map details

PFID	PFID Old	Annotation	Formal Annotation	EC	Transcript
PF3D7_0628000	PFF1360w	6-pyruvoyltetrahydro-pterin synthase	6-pyruvoyltetrahydropterin synthase	4.2.3.12
PF3D7_1226100	PFL1260w	Alkaline phosphatase	haloacid dehalogenase-like hydrolase, putative	3.1.3.1
PF3D7_1458400	PF14_0557	Aminodeoxychorismate lyase	aminodeoxychorismate lyase	4.1.3.38
PF3D7_0922400	PFI1100w	Aminodeoxychorismate synthase	para-aminobenzoic acid synthetase	2.6.1.85
PF3D7_0417200	PFD0830w	Dihydrofolate reductase	bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3
PF3D7_1324800	PF13_0140	Dihydrofolate synthase	dihydrofolate synthase/folylpolyglutamate synthase	6.3.2.12
PF3D7_0810800	PF08_0095	Dihydropteroate synthase	hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase	2.5.1.15
PF3D7_1224000	PFL1155w	GTP cyclohydrolase	GTP cyclohydrolase I	3.5.4.16
PF3D7_0810800	PF08_0095	Hydroxymethyldihydropteridine pyrophosphokinase	hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase	2.7.6.3
PF3D7_0630700	PFF1490w	Methenyltetrahydrofolate cyclohydrolase	bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, putative	3.5.4.9
PF3D7_1313200	MAL13P1.67	Methionyl-tRNA formyltransferase	methionyl-tRNA formyltransferase, putative	2.1.2.9
PF3D7_0630700	PFF1490w	Methylenetetrahydrofolate dehydrogenase	bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, putative	1.5.1.5
PF3D7_1235600	PFL1720w	Serine hydroxymethyltransferase	serine hydroxymethyltransferase	2.1.2.1
PF3D7_1456100	PF14_0534	serine hydroxymethyltransferase	serine hydroxymethyltransferase	2.1.2.1
PF3D7_1324800	PF13_0140	Tetrahydrofolylpolyglutamate synthase	dihydrofolate synthase/folylpolyglutamate synthase	6.3.2.17
PF3D7_0417200	PFD0830w	Thymidylate synthase	bifunctional dihydrofolate reductase-thymidylate synthase	2.1.1.45

Total number of related proteins: 1

#	PFID	Formal Name
1	PFD0830w	bifunctional dihydrofolate reductase-thymidylate synthase

Total number of related proteins: 1

#	PFID	Formal Name
1	PFD0830w	bifunctional dihydrofolate reductase-thymidylate synthase

Total number of related proteins: 1

#	PFID	Formal Name
1	PFF1360w	6-pyruvoyltetrahydropterin synthase

Total number of related proteins: 1

#	PFID	Formal Name
1	PFF1490w	bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PFF1490w	bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PF08_0095	hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase

Total number of related proteins: 1

#	PFID	Formal Name
1	PF08_0095	hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase

Total number of related proteins: 1

#	PFID	Formal Name
1	PFI1100w	para-aminobenzoic acid synthetase

Total number of related proteins: 1

#	PFID	Formal Name
1	PFL1155w	GTP cyclohydrolase I

Total number of related proteins: 1

#	PFID	Formal Name
1	PFL1260w	haloacid dehalogenase-like hydrolase, putative

Total number of related proteins: 2

#	PFID	Formal Name
1	PFL1720w	serine hydroxymethyltransferase
2	PF14_0534	serine hydroxymethyltransferase

Total number of related proteins: 1

#	PFID	Formal Name
1	MAL13P1.67	methionyl-tRNA formyltransferase, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PF13_0140	dihydrofolate synthase/folylpolyglutamate synthase

Total number of related proteins: 1

#	PFID	Formal Name
1	PF13_0140	dihydrofolate synthase/folylpolyglutamate synthase

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0557	aminodeoxychorismate lyase