Total palmitome of Plasmodium falciparum

Total palmitome of Plasmodium falciparum

Jones ML, Collins MO, Goulding D, Choudhary JS, Rayner JC.Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis. Cell Host Microbe. 2012 Aug 16;12(2):246-58.

Function

Protein ID

Protein Description

EC#

Trancript

Amino acid metabolism

S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase

glutaminyl-peptide cyclotransferase, putative

NADP-specific glutamate dehydrogenase

ornithine aminotransferase

S-adenosylmethionine synthetase

aspartate carbamoyltransferase

spermidine synthase

serine hydroxymethyltransferase

selenoprotein

Carbohydrate metabolism

lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex

enolase

FAD-dependent glycerol-3-phosphate dehydrogenase, putative

fructose-bisphosphate aldolase

glucose-6-phosphate isomerase

glyceraldehyde-3-phosphate dehydrogenase

phosphoglycerate kinase

phosphoglucomutase-2

triosephosphate isomerase

pyruvate kinase

pyruvate kinase 2, pyrkii

L-lactate dehydrogenase

glyoxalase I-like protein gilp

phosphoribosylpyrophosphate synthetase

Lipid metabolism

acyl-CoA synthetase

acyl-CoA synthetase

acyl-CoA synthetase

acyl-CoA synthetase

1-acyl-sn-glycerol-3-phosphate acyltransferase, putative

diacylglycerol kinase, putative

ethanolamine kinase

choline/ethanolaminephosphotransferase, putative

glycerol-3-phosphate 1-O-acyltransferase

phosphatidylserine decarboxylase

phosphoethanolamine N-methyltransferase

stearoyl-CoA desaturase

Nucleotide metabolism

adenosine deaminase

adenylate kinase

GMP synthase [glutamine-hydrolyzing]

hypoxanthine-guanine phosphoribosyltransferase

inosine-5'-monophosphate dehydrogenase

purine nucleoside phosphorylase

ribonucleoside-diphosphate reductase large subunit, putative

thymidylate kinase

TCA cycle

2-oxoglutarate dehydrogenase E1 component

aconitate hydratase

citrate synthase-like protein, putative

dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex

isocitrate dehydrogenase [NADP], mitochondrial

succinate--CoA ligase [ADP-forming] subunit alpha, putative

dihydrolipoyl dehydrogenase, mitochondrial

Redox metabolism

1-cys peroxiredoxin

1-cys peroxiredoxin

glutathione peroxidase-like thioredoxin peroxidase

thioredoxin 2

thioredoxin peroxidase 1

thioredoxin reductase

thioredoxin-related protein, putative

oxidoreductase, short-chain dehydrogenase family, putative

ribonucleoside-diphosphate reductase small chain, putative

endoplasmic reticulum oxidoreductin, putative

Hemoglobin digestion

falcilysin

cysteine proteinase falcipain 3

plasmepsin III histo-aspartic protease

M17 leucyl aminopeptidase

M1-family alanyl aminopeptidase

plasmepsin I

plasmepsin II

plasmepsin IV

Cofactor synthesis

1-deoxy-D-xylulose 5-phosphate synthase

2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative

protein DJ-1

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial, putative

aminomethyltransferase, putative

hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase

hydroxyethylthiazole kinase

pyridoxine biosynthesis protein PDX1

Organellar functions

ATP synthase subunit beta, mitochondrial

cysteine desulfurase ISCS

ferrodoxin reductase-like protein

protein yop1, putative

LETM1-like protein, putative

mitochondrial import receptor subunit TOM40, putative

mitochondrial import inner membrane translocase subunit TIM23, putative

mitochondrial phosphate carrier protein, MPC

cytochrome b-c1 complex subunit 2, putative

type II NADH:ubiquinone oxidoreductase

cytosolic Fe-S cluster assembly factor NBP35, putative

cytochrome b-c1 complex subunit Rieske, putative

stomatin-like protein

phospholipid or glycerol acyltransferase, putative

Replication and DNA repair

AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative

DNA-(apurinic or apyrimidinic site) lyase 1

deoxyribodipyrimidine photo-lyase, putative

DNA ligase I

DNA primase large subunit, putative

DNA replication licensing factor MCM5, putative

DNA replication licensing factor MCM7

proliferating cell nuclear antigen 1

RAP21

replication protein A1, small fragment

RuvB-like helicase 2

Mitosis and chromosome separation

nucleosome assembly protein

T-complex protein 1 subunit gamma

SPE2-interacting protein transcription factor with AP2 domain(s)

Histone and modifications

histone H2A

histone H3 variant

FACT complex subunit SSRP1, putative

Transcription

ATP-dependent RNA helicase DDX6

pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative

transcription factor btf3, putative

DNA-directed RNA polymerase II subunit RPB3

ribosome biogenesis protein rpf2, putative

polyadenylate-binding protein 1, putative

pre-mRNA-processing factor 19, putative

H/ACA ribonucleoprotein complex subunit 4, putative

regulator of nonsense transcripts 1, putative

G-strand-binding protein 2

PhIL1-interacting protein PhIP

alternative splicing factor ASF-1, putative

small nuclear ribonucleoprotein Sm D2, putative

splicing factor 3A subunit 3, putative

eukaryotic initiation factor 4A helicase 45

Translation

40S ribosomal protein S11, putative

40S ribosomal protein S19

40S ribosomal protein S23, putative

40S ribosomal protein S27

40S ribosomal protein S4, putative

40S ribosomal protein S5, putative

40S ribosomal protein S7, putative

40S ribosomal protein S8e, putative

60S acidic ribosomal protein P2

60S ribosomal protein L11a, putative

60S ribosomal protein L12, putative

60S ribosomal protein L23, putative

60S ribosomal protein L27

60S ribosomal protein L3

60S ribosomal protein L30e, putative

60S ribosomal protein L35ae, putative

60S ribosomal protein L5, putative

60S ribosomal protein L6, putative

60s ribosomal protein l6, putative

60S ribosomal protein P0

ribosome biogenesis protein MRT4, putative

translocation protein SEC63

elongation factor 1-gamma, putative

elongation factor 2

elongation factor 1-alpha

eukaryotic translation initiation factor 5A

eukaryotic translation initiation factor 2 subunit gamma, putative

eukaryotic translation initiation factor 3 subunit I, putative

eukaryotic translation initiation factor 3 subunit d, putative

rRNA 2'-O-methyltransferase fibrillarin, putative

asparagine--tRNA ligase

glutamate--tRNA ligase, putative

tyrosine--tRNA ligase

threonine--tRNA ligase

tRNA import protein tRIP

peptidyl-tRNA hydrolase 2, putative

protein transport protein SEC61 subunit alpha

secretory complex protein 62

signal peptidase complex catalytic subunit SEC11

signal peptidase complex subunit SPC2, putative

signal peptide peptidase

signal recognition particle receptor subunit beta, putative

translation initiation factor eIF-2B subunit alpha, putative

Chaperones

T-complex protein 1 subunit zeta

60 kDa chaperonin

20 kDa chaperonin

DnaJ protein, putative

chaperone protein dnaj; heat shock protein 40

DnaJ protein, putative

DnaJ protein, putative

DnaJ protein, putative

DnaJ protein, putative

ring-infected erythrocyte surface antigen

DnaJ protein, putative

DnaJ protein, putative

endoplasmin, putative

protein SIS1

heat shock protein 60

PfHsp70-1

PfHsp70-2

PfHsp70-y

heat shock protein 90

heat shock protein 90, putative

heat shock protein 40, type ii

heat shock protein DNAJ homologue Pfj4

PfHsp70-3

PfHsp70-z

HSP40, subfamily A

peptidyl-prolyl cis-trans isomerase

peptidyl-prolyl cis-trans isomerase

RESA-like protein with PHIST and DnaJ domains; MEC domain-containing protein

ring-infected erythrocyte surface antigen

single-stranded DNA-binding protein

T-complex protein 1 subunit alpha

T-complex protein 1 subunit eta

Post-translational modifications

14-3-3 protein

palmitoyltransferase

E3 ubiquitin-protein ligase, putative

Calcium-dependent protein kinases; CDPK1

calpain

casein kinase II beta chain

AAA family ATPase, CDC48 subfamily

cell division cycle protein 48 homologue, putative

ATP-dependent zinc metalloprotease FTSH 1

cysteine proteinase falcipain 1

leucine-rich repeat protein

peptide N-myristoyltransferase glycylpeptide N-tetradecanoyltransferase

aminopeptidase P

PEXEL protease plasmepsin V

26S proteasome regulatory subunit RPN1, putative

proteasome subunit alpha type-3, putative

proteasome subunit beta type-7, putative

proteasome subunit alpha type-7, putative

proteasome subunit alpha type-4, putative

protein disulfide isomerase

protein disulfide isomerase, putative

protein phosphatase PPM6, putative

protein phosphatase PPM5, putative

protein phosphatase, putative

protein tyrosine phosphatase

serine/threonine protein kinase, FIKK family

serine/threonine protein kinase, FIKK family

NEDD8-conjugating enzyme UBC12, putative

ubiquitin-activating enzyme E1

autophagy-related protein 8

palmitoyltransferase, putative

palmitoyltransferase, putative

Protein trafic

ADP-ribosylation factor 1

transmembrane emp24 domain-containing protein, putative

early transcribed membrane protein 10.2

early transcribed membrane protein 5

exported protein 2

G-protein associated signal transduction protein, putative

GTP-binding nuclear protein RAN/TC4

knob-associated histidine-rich protein

macrophage migration inhibitory factor

erythrocyte membrane protein 2 mature parasite-infected erythrocyte surface antigen

membrane associated histidine-rich protein

membrane associated histidine-rich protein 2

Pfmc-2TM Maurer's cleft two transmembrane protein

Pfmc-2TM Maurer's cleft two transmembrane protein

Pfmc-2TM Maurer's cleft two transmembrane protein

ras-related protein Rab-5B secretory complex protein 61 alpha

ras-related protein Rab-5C

ras-related protein Rab-11A

ras-related protein Rab-18

DNA repair protein RAD51

SNARE protein, putative

syntaxin-6, putative

syntaxin, Qa-SNARE family

transmembrane emp24 domain-containing protein, putative

LEM3/CDC50 family protein, putative

UVB-resistance protein UVR8 homologue

vacuolar protein sorting-associated protein 2, putative

vesicle-associated membrane protein, putative

sortilin

parasite-infected erythrocyte surface protein

Plasmodium exported protein (hyp15), unknown function

EMP1-trafficking protein

Plasmodium exported protein (hyp6), unknown function

Plasmodium exported protein (hyp8)

Plasmodium exported protein (PHISTa), unknown function

Plasmodium exported protein (PHISTb), unknown function

Plasmodium exported protein (PHISTc), unknown function gametocyte exported protein 12

Plasmodium exported protein (PHISTc), unknown function

Plasmodium exported protein, unknown function

gametocyte exported protein 14 Plasmodium exported protein, unknown function

Plasmodium exported protein, unknown function

Plasmodium exported protein (PHIST), unknown function

Plasmodium exported protein, unknown function

EMP1-trafficking protein

Plasmodium exported protein, unknown function

Plasmodium exported protein, unknown function

Plasmodium exported protein, unknown function

Cell-cell interactions

cytoadherence linked asexual protein 8

cytoadherence linked asexual protein 2

cytoadherence linked asexual protein 3.1

cytoadherence linked asexual protein 9

erythrocyte membrane protein 1, PfEMP1

rifin

PIR protein rifin

PIR protein rifin

stevor

rifin

rifin PIR protein

PIR protein stevor

Invasion and motility

6-cysteine protein

6-cysteine protein p12

actin-depolymerizing factor 1

apical merozoite protein

apical sushi protein

6-cysteine protein p92

dynein-related AAA-type ATPase, putative

glideosome-associated protein 45

glideosome-associated protein 45

glycophorin binding protein

high molecular weight rhoptry protein 2

inner membrane complex protein 1c, putative

inner membrane complex protein 1e, putative

inner membrane complex protein 1g, putative

merozoite surface protein 1

merozoite surface protein 7

merozoite surface protein 10

rhoptry neck protein 4

myosin a-tail interacting protein

myosin E, putative

rhomboid protease ROM4

high molecular weight rhoptry protein 3

rhoptry neck protein 2

rhoptry neck protein 3

rhoptry-associated protein 1

rhoptry-associated protein 2

rhoptry-associated protein 3

rhoptry-associated membrane antigen

serine repeat antigen 5

serine repeat antigen 6

surface protein P113

Transport

tubulin beta chain

ABC transporter I family member 1, putative, ABCI3

ADP, ATP carrier protein 1, aac1

phospholipid-transporting ATPase 2

aquaglyceroporin

trafficking protein particle complex subunit 3, putative

chloroquine resistance transporter

copper transporter, CTR1

copper transporter, putative, CTR2

copper-transporting ATPase

folate transporter 2 FT2

formate-nitrite transporter, FNT

Sugar transporter

inorganic anion exchanger, inorganic anion antiporter, SulP

Niemann-Pick type c1-related protein

glideosome-associated protein 40, putative

multidrug resistance protein 1. MDR1, IP3 receptor

multidrug resistance protein 2, MDR2

non-SERCA-type Ca2+ -transporting P-ATPase, ATP4

nucleoside transporter 1, NT1

nucleoside transporter 2, NT2

nucleoside transporter 4, NT4

major facilitator superfamily-related transporter, MFR1

dicarboxylate/tricarboxylate carrier, DTC

phospholipid scramblase, plscr

phospholipid-transporting ATPase, putative

apicomplexan amino acid transporter apiat4

apicomplexan amino acid transporter apiat8, putative

apicomplexan amino acid transporter apiat2, putative

triose phosphate transporter, TPT

V-type proton ATPase subunit B

V-type proton ATPase subunit E, putative

v-type proton atpase subunit a, putative

V-type proton ATPase 21 kDa proteolipid subunit, putative

V-type H(+)-translocating pyrophosphatase, putative, VP1

V-type K+-independent H+-translocating inorganic pyrophosphatase, VP2

zinc transporter zip1, putative

Other proteins not associated with known processes

3-oxo-5-alpha-steroid 4-dehydrogenase, putative

allantoicase, putative

protein transport protein YIF1, putative

Clptm1 domain-containing protein, putative

palmitoyltransferase, putative

hemolysin III

rhoptry protein ROP14

kelch protein K13

6-cysteine protein p12p

+129 conserved proteins of unknown function

Online articles related to Total palmitome of Plasmodium falciparum retrieved from PubMed

Related Maps

N-myristoylation, S-palmitoylation and prenylation of proteins