Malaria Parasite Metabolic Pathways
Drugs affecting pathway with unknown specific target
| Drug Name | PubMed Articles (year of publication) |
|---|---|
| 1,3,5-triazine | |
| 2-methylaminobenzoic acid | |
| 4-benzyloxy | |
| Indoleglyoxylamides | |
| Leupeptin | |
| Sodium 1,2-ethanedisulfonate | |
| Suggested target |
Methionine and Polyamine metabolism map details
| PFID | PFID Old | Annotation | Formal Annotation | EC | Transcript |
|---|---|---|---|---|---|
PF3D7_1029600
|
PF10_0289 | Adenosine deaminase | adenosine deaminase | 3.5.4.4 |
|
|
PF3D7_0520900
|
PFE1050w | Adenosylhomocysteinase | S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase | 3.3.1.1 |
|
|
PF3D7_1033100
|
PF10_0322 | Adenosylmethionine decarboxylase | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 4.1.1.50 |
|
PF3D7_0727300
|
MAL7P1.151 | DNA (cytosine-5-)-methyltransferase | DNA (cytosine-5)-methyltransferase | 2.1.1.37 |
|
| PF3D7_1233700 | PFL1625w | Homocysteine S-methyltransferase | homocysteine S-methyltransferase, putative | 2.1.1.10 |
|
|
PF3D7_0922200
|
PFI1090w | Methionine adenosyl transferase | S-adenosylmethionine synthetase | 2.5.1.6 |
|
| PF3D7_1020400 | PF10_0197 | Methionine S-methyltransferase | rRNA(cytosine-c(5))-methyltransferase, putative | 2.1.1.12 |
|
|
PF3D7_1450600
|
PF14_0481 | Methionine S-methyltransferase | S-adenosylmethionine-dependent methyltransferase, putative | 2.1.1.2 |
|
|
PF3D7_1313200
|
MAL13P1.67 | methionyl-tRNA formyltransferase | methionyl-tRNA formyltransferase, putative | 2.1.2.9 |
|
| PF3D7_1303100 | PF13_0016 | methyltransferase, putative | methyltransferase, putative | 2.1.1.37 |
|
|
PF3D7_1005000
|
PF10_0053 | Met-tRNA ligase | methionine--tRNA ligase, putative | 6.1.1.10 |
|
|
PF3D7_1034900
|
PF10_0340 | Met-tRNA ligase | methionine--tRNA ligase | 6.1.1.10 |
|
| PF3D7_0729500 | PF07_0123 | mRNA(2-D-methyladenosine-N6-methyltransferase) | n6-adenosine-methyltransferase mt-a70; METTL3 | 2.1.1.62 |
|
| PF3D7_1350700 | MAL13P1.255 | mRNA(2-D-methyladenosine-N6-methyltransferase) | N6-adenine-specific methylase, putative | 2.1.1.62 |
|
|
PF3D7_0608800
|
PFF0435w | ornithine aminotransferase | ornithine aminotransferase | 2.6.1.13 |
|
|
PF3D7_1344800
|
PF13_0240 | Ornithine carbamoyltransferase | aspartate carbamoyltransferase | 2.1.3.2 |
|
|
PF3D7_1033100
|
PF10_0322 | Ornithine decarboxylase | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 4.1.1.17 |
|
|
PF3D7_1343000
|
MAL13P1.214 | phosphoethanolamine N-methyltransferase | phosphoethanolamine N-methyltransferase | 2.1.1.103 |
|
| PF3D7_1432700 | PF14_0309 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase | protein-L-isoaspartate(D-aspartate) O-methyltransferase, putative | 2.1.1.77 |
|
|
PF3D7_0513300
|
PFE0660c | Purine nucleoside phosphorylase | purine nucleoside phosphorylase | 2.4.2.1 |
|
| PF3D7_1357900 | MAL13P1.284 | pyrroline-5-carboxylate reductase | pyrroline-5-carboxylate reductase, putative | 1.5.1.2 |
|
| PF3D7_1236700 | PFL1775c | S-adenosyl-methyltransferase, putative | S-adenosyl-methyltransferase, putative | 2.1.1.12 |
|
|
PF3D7_1129000
|
PF11_0301 | Spermidine synthase | spermidine synthase | 2.5.1.16 |
|
| PF3D7_1339100 | MAL13_tRNA_Met1:tRNA | tRNAmet | tRNA Methionine | ||
| 1396.pre-tRNA-Met-1:tRNA | 1396.pre-tRNA-Met-1:tRNA | tRNAmet | 1396.pre-tRNA-Met-1:tRNA |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFE0660c
|
purine nucleoside phosphorylase |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFE1050w
|
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFF0435w
|
ornithine aminotransferase |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
MAL7P1.151
|
DNA (cytosine-5)-methyltransferase |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF07_0123 | n6-adenosine-methyltransferase mt-a70; METTL3 |
| 2 | MAL13P1.255 | N6-adenine-specific methylase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFI1090w
|
S-adenosylmethionine synthetase |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF10_0053
|
methionine--tRNA ligase, putative |
| 2 |
PF10_0340
|
methionine--tRNA ligase |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF10_0197 | rRNA(cytosine-c(5))-methyltransferase, putative |
| 2 |
PF14_0481
|
S-adenosylmethionine-dependent methyltransferase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF10_0289
|
adenosine deaminase |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF10_0322
|
S-adenosylmethionine decarboxylase/ornithine decarboxylase |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF10_0322
|
S-adenosylmethionine decarboxylase/ornithine decarboxylase |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF11_0301
|
spermidine synthase |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFL1625w | homocysteine S-methyltransferase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFL1775c | S-adenosyl-methyltransferase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF13_0016 | methyltransferase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
MAL13P1.67
|
methionyl-tRNA formyltransferase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
MAL13P1.214
|
phosphoethanolamine N-methyltransferase |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF13_0240
|
aspartate carbamoyltransferase |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | MAL13P1.284 | pyrroline-5-carboxylate reductase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF14_0309 | protein-L-isoaspartate(D-aspartate) O-methyltransferase, putative |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | MAL13_tRNA_Met1:tRNA | tRNA Methionine |
| 2 | 1396.pre-tRNA-Met-1:tRNA | 1396.pre-tRNA-Met-1:tRNA |