Transcriptomic response of dihydroartemisinin (DHA) treated K1 strain trophozoites
Shaw PJ, Chaotheing S, Kaewprommal P, Piriyapongsa J, Wongsombat C, Suwannakitti N, Koonyosying P, Uthaipibull C, Yuthavong Y, Kamchonwongpaisan S. Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study. BMC Genomics. 2015 Oct 21;16(1):830.  PMID: 26490244
Only outliers are shown
PfID Annotation Fold change EC Transcript
15002 PF3D7_1201100 RESA-like protein with PHIST and DnaJ domains; MEC domain-containing protein 44.40
15004 PF3D7_1226100 haloacid dehalogenase-like hydrolase, putative 33.17 3.1.3.1
14984 PF3D7_0927200 zinc finger protein, putative 30.74
15012 PF3D7_1401500
esterase, putative 29.13 3.1.1.5
15018 PF3D7_1473700
nucleoporin NUP116/NSP116, putative 28.17
14945 PF3D7_0202200
EMP1-trafficking protein 27.93
14941 PF3D7_0102600
serine/threonine protein kinase, FIKK family 27.27 2.7.11.1
14943 PF3D7_0114000 exported protein family 1; MEC domain-containing protein 25.48
14955 PF3D7_0401800
Plasmodium exported protein (PHISTb), unknown function 22.26
14978 PF3D7_0830500 tryptophan/threonine-rich antigen sporozoite and liver stage tryptophan-rich protein, putative 22.12
14949 PF3D7_0220300 Plasmodium exported protein, unknown function 21.14
15003 PF3D7_1221400 inner membrane complex protein 1h, putative 20.06
14948 PF3D7_0215300
acyl-CoA synthetase 19.99 6.2.1.3
14956 PF3D7_0424300 erythrocyte binding antigen-165, pseudogene 18.98
15007 PF3D7_1350900
AP2 domain transcription factor AP2-O4, putative 18.76
14957 PF3D7_0424500
serine/threonine protein kinase, FIKK family 18.69 2.7.11.1
14959 PF3D7_0502400
ring-stage membrane protein 1 merozoite surface protein 8 17.10
14950 PF3D7_0220500 Plasmodium exported protein (hyp2), unknown function 16.63
14975 PF3D7_0731200 Plasmodium exported protein, unknown function 16.32
14958 PF3D7_0424700
serine/threonine protein kinase, FIKK family 15.13 2.7.11.1
14982 PF3D7_0919200 PPPDE peptidase, putative 15.10
14979 PF3D7_0902300 serine/threonine protein kinase, FIKK family 14.99 2.7.11.1
14988 PF3D7_1016700 Plasmodium exported protein (PHISTc), unknown function 14.95
14970 PF3D7_0702200
lysophospholipase lpl20 14.84 3.1.1.5
14969 PF3D7_0702100 Plasmodium exported protein (PHISTb), unknown function, pseudogene 14.61
15000 PF3D7_1149300
serine/threonine protein kinase, FIKK family 14.52 2.7.11.1
15016 PF3D7_1455300 conserved Plasmodium protein, unknown function 14.24
14951 PF3D7_0301800 Plasmodium exported protein, unknown function 14.05
14974 PF3D7_0730900
EMP1-trafficking protein 13.95
14973 PF3D7_0726200
serine/threonine protein kinase, FIKK family 13.69 2.7.11.1
15001 PF3D7_1200700 acyl-CoA synthetase 13.03 6.2.1.3
14963 PF3D7_0532600 Plasmodium exported protein, unknown function 13.00
14944 PF3D7_0114400 erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene 12.96
15019 PF3D7_1474000 probable protein, unknown function 12.57
14976 PF3D7_0805100 conserved Plasmodium protein, unknown function 12.31
14980 PF3D7_0902600 serine/threonine protein kinase, FIKK family 12.09 2.7.11.1
20785 PF3D7_1401300
proline aminopeptidase 12.08 3.4.11.5
14993 PF3D7_1038800 RESA-like protein with PHIST and DnaJ domains? MEC domain-containing protein 11.74
14947 PF3D7_0214300 conserved Plasmodium protein, unknown function 11.51
14968 PF3D7_0629300 phospholipase, putative phosphatidylcholine-sterol acyltransferase, putative 10.88 2.3.1.43
15009 PF3D7_1370300
membrane associated histidine-rich protein 10.73
15008 PF3D7_1353100
Plasmodium exported protein, unknown function 10.66
14981 PF3D7_0918700 conserved Plasmodium protein, unknown function 10.36
15020 PF3D7_0730800 Plasmodium exported protein, unknown function 10.04
14999 PF3D7_1148900 Plasmodium exported protein, unknown function 9.96
14960 PF3D7_0513300
purine nucleoside phosphorylase 0.34 2.4.2.1
15010 PF3D7_1372600 PIR protein rifin 0.33
15006 PF3D7_1313200
methionyl-tRNA formyltransferase, putative 0.33 2.1.2.9
14995 PF3D7_1113300 UDP-galactose transporter, putative, UGT 0.33
14961 PF3D7_0514500 conserved Plasmodium membrane protein, unknown function 0.33
14942 PF3D7_0104600 conserved Plasmodium protein, unknown function 0.33
14987 PF3D7_1010000 ribosomal protein L43, mitochondrial, putative 0.33
14989 PF3D7_1027600
meiotic recombination protein spo11-2, putative 0.32
14954 PF3D7_0322700 conserved Plasmodium protein, unknown function 0.32
15005 PF3D7_1229700 mitochondrial respiratory chain complex ii subunit, putative 0.32
14992 PF3D7_1032600 conserved protein, unknown function 0.32
14985 PF3D7_0931900
adenylate kinase-like protein 2 0.32 2.7.4.3
14964 PF3D7_0604600 DNA helicase, putative 0.32 3.6.4.12
14953 PF3D7_0321500 peptidase, putative 0.32 3.4.21.26
14991 PF3D7_1032200 conserved Plasmodium protein, unknown function 0.31
14967 PF3D7_0627500
protein DJ-1 0.31
14965 PF3D7_0605100 KH domain-containing protein, putative 0.31
14972 PF3D7_0718700 conserved Plasmodium membrane protein, unknown function 0.31
14971 PF3D7_0714400
calmodulin, putative 0.30
15015 PF3D7_1446200
M17 leucyl aminopeptidase 0.30 3.4.11.1
14962 PF3D7_0521100 conserved Plasmodium protein, unknown function 0.30
14986 PF3D7_1001300
Plasmodium exported protein (PHISTa), unknown function 0.30
14990 PF3D7_1030300 conserved Plasmodium protein, unknown function 0.30
15013 PF3D7_1415500 conserved Plasmodium membrane protein, unknown function 0.29
14977 PF3D7_0806600 kinesin-like protein, putative 0.28
14952 PF3D7_0303600
plasmoredoxin 0.27
14996 PF3D7_1117000 mfs domain-containing protein p115, putative 0.26
14998 PF3D7_1135600 condensin-2 complex subunit d3, putative 0.26
14946 PF3D7_0203800 conserved Plasmodium protein, unknown function 0.26
15014 PF3D7_1439100 DEAD/DEAH box helicase, putative 0.25 3.6.4.13
14983 PF3D7_0924900
alpha-tubulin N-acetyltransferase, putative 0.24 2.3.1.108
14997 PF3D7_1121200 conserved Plasmodium protein, unknown function 0.24
14994 PF3D7_1039200 Plasmodium exported protein, unknown function, pseudogene 0.24
15017 PF3D7_1465800
dynein beta chain, putative 0.20
14966 PF3D7_0622000 conserved Plasmodium protein, unknown function 0.17
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