cGMP-dependent protein kinaseidc:cGMP-dependent protein kinase idcUbiquitin conjugating factor E4 B Ubiquitin conjugating factor E4 B idc:Ariadne Ariadne Deubiquinating enzyme I ubiquitin carboxyl-terminal hydrolase ubiquitin carboxyl-terminal hydrolase Ubiquitin-protein ligase E3 ubiquitin specific protease ubiquitin carboxyl-terminal hydrolase Proteasome ATPase Ubiquitin polyubiquitin Ubiquitin activating enzyme E1 Ubiquitin-conjugating enzyme E2 a subunits 1-7 b subunits 1-7 Lid subunits Base subunits Proteasome activator p28 idc:ubiquitin carboxyl-terminal hydrolase idc:Deubiquinating enzyme I idc:ubiquitin carboxyl-terminal hydrolase idc:ubiquitin carboxyl-terminal hydrolase idc:ubiquitin specific protease idc:Ubiquitin activating enzyme E1 idc:Ubiquitin-conjugating enzyme E2 idc:Ubiquitin-protein ligase E3 idc:Proteasome ATPase idc:a subunits 1-7 idc:b subunits 1-7 idc:Lid subunits idc:Base subunits idc:Ubiquitin idc:Proteasome activator p28 Rpn13 idc:Rpn13 proteasome assembly chaperone 4 idc:UMP1 UMP1 PI31 PITH domain-containing protein, putative idc:PITH domain-containing protein, putative idc:PI31


Online articles related to Proteasome-mediated proteolysis of ubiquinated proteins retrieved from PubMed

RX Drugs affecting pathway with unknown specific target

Drug Name PubMed Articles (year of publication)
6-Cyano-uridine 5′-OMonophosphate
adamantane-acetyl-(6-aminohexanoyl)(3)-(leucinyl)(3)-vinyl-(methyl)-sulfone
Argyrin f
b-AP15
Bortezomib
Carfilzomib
Dihydroartemisinin
Epomixine
Epoxomicin
Fellutamide
Gliotoxin
Lactacystin
Luzindole
Melatonin
MG132
Mg-132
Mln-273
N-((4S,7R,10R,E)-7-(2-methoxyethyl)-12-(methylsulfonyl)-5,8-dioxo-1-phenyl-10-(2-(thiophen-2-yl)ethyl)dodec-11-en-4-yl)-5-methylisoxazole-3-carboxamide
N-(4-Morpholinylacetyl)-L-tryptophyl-N-[(1E,3S)-5-methyl-1-(methylsulfonyl)-1-hexen-3-yl]-L-leucinamide
N-[(2S)-3-Methyl-1-{[(2S)-1-({(2S)-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-1-oxo-2-pentanyl}amino)-4-(methylsulfonyl)-1-oxo-2-butanyl]amino}-1-oxo-2-butanyl]hexanamide
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Ormulide
Qsar) modeling, pharmacophore mapping
Salinosporamide a
WLW-vs
YU101
Z-Leu-Leu-LeuB(OH)2

Proteasome-mediated proteolysis of ubiquinated proteins map details

PFID PFID Old Annotation Formal Annotation EC Transcript
PF3D7_1306400 drugs PF13_0033 26S protease regulatory subunit 10B, putative; 26S proteasome AAA-ATPase subunit RPT4, putative 26S protease regulatory subunit 10B, putative; 26S proteasome AAA-ATPase subunit RPT4, putative 3.6.4.8 pie diagram
PF3D7_0413600 drugs PFD0665c 26S protease regulatory subunit 6B, putative; 26S proteasome AAA-ATPase subunit RPT3 26S protease regulatory subunit 6B, putative; 26S proteasome AAA-ATPase subunit RPT3 3.6.4.8 pie diagram
PF3D7_0108000 drugs PFA0400c a subunits 1-7 proteasome subunit beta type-3, putative 3.4.25.1 pie diagram
PF3D7_0317000 PFC0745c a subunits 1-7 proteasome subunit alpha type-3, putative 3.4.25.1 pie diagram
PF3D7_0518300 drugs PFE0915c a subunits 1-7 proteasome subunit beta type-1, putative 3.4.25.1 pie diagram
PF3D7_0608500 PFF0420c a subunits 1-7 proteasome subunit alpha type-2, putative 3.4.25.1 pie diagram
PF3D7_0727400 loop PF07_0112 a subunits 1-7 proteasome subunit alpha type-5, putative 3.4.25.1 pie diagram
PF3D7_0803800 drugs MAL8P1.142 a subunits 1-7 proteasome subunit beta type-4 3.4.25.1 pie diagram
PF3D7_0807500 MAL8P1.128 a subunits 1-7 proteasome subunit alpha type-6, putative 3.4.25.1 pie diagram
PF3D7_0931800 drugs PFI1545c a subunits 1-7 proteasome subunit beta type-6, putative 3.4.25.1 pie diagram
PF3D7_1011400 loop drugs PF10_0111 a subunits 1-7 proteasome subunit beta type-5 3.4.25.1 pie diagram
PF3D7_1327900 PF13_0156a a subunits 1-7 conserved Plasmodium protein, unknown function 3.4.25.1
PF3D7_1353800 PF13_0282 a subunits 1-7 proteasome subunit alpha type-4, putative 3.4.25.1 pie diagram
PF3D7_1353900 MAL13P1.270 a subunits 1-7 proteasome subunit alpha type-7, putative 3.4.25.1 pie diagram
PF3D7_1470900 drugs PF14_0676 a subunits 1-7 proteasome subunit beta type-2, putative 3.4.25.1 pie diagram
PF3D7_1474800 PF14_0716 a subunits 1-7 proteasome subunit alpha type-1, putative 3.4.25.1 pie diagram
PF3D7_0303800 PFC0175w Ariadne IBR domain protein, putative pie diagram
PF3D7_0108000 drugs PFA0400c b subunits 1-7 proteasome subunit beta type-3, putative 3.4.25.1 pie diagram
PF3D7_0518300 drugs PFE0915c b subunits 1-7 proteasome subunit beta type-1, putative 3.4.25.1 pie diagram
PF3D7_0803800 drugs MAL8P1.142 b subunits 1-7 proteasome subunit beta type-4 3.4.25.1 pie diagram
PF3D7_0931800 drugs PFI1545c b subunits 1-7 proteasome subunit beta type-6, putative 3.4.25.1 pie diagram
PF3D7_1011400 loop drugs PF10_0111 b subunits 1-7 proteasome subunit beta type-5 3.4.25.1 pie diagram
PF3D7_1327900 PF13_0156a b subunits 1-7 conserved Plasmodium protein, unknown function 3.4.25.1
PF3D7_1470900 drugs PF14_0676 b subunits 1-7 proteasome subunit beta type-2, putative 3.4.25.1 pie diagram
PF3D7_0205900 PFB0260w Base subunits 26S proteasome regulatory subunit RPN1, putative pie diagram
PF3D7_0413600 drugs PFD0665c Base subunits 26S protease regulatory subunit 6B, putative; 26S proteasome AAA-ATPase subunit RPT3 3.6.4.8 pie diagram
PF3D7_0807800 PF08_0109 Base subunits 26S proteasome regulatory subunit RPN10, putative pie diagram
PF3D7_1008400 drugs PF10_0081 Base subunits 26S protease regulatory subunit 4, putative 3.6.4.8 pie diagram
PF3D7_1130400 drugs PF11_0314 Base subunits 26S protease regulatory subunit 6A, putative 3.6.4.8 pie diagram
PF3D7_1248900 drugs PFL2345c Base subunits 26S protease regulatory subunit 8, putative 3.6.4.8 pie diagram
PF3D7_1306400 drugs PF13_0033 Base subunits 26S protease regulatory subunit 10B, putative; 26S proteasome AAA-ATPase subunit RPT4, putative 3.6.4.8 pie diagram
PF3D7_1311500 drugs PF13_0063 Base subunits 26S protease regulatory subunit 7, putative; 26S proteasome AAA-ATPase subunit RPT1, putative 3.6.4.8 pie diagram
PF3D7_1466300 PF14_0632 Base subunits 26S proteasome regulatory subunit RPN2, putative 3.4.25.1 pie diagram
PF3D7_1436600 loop drugs PF14_0346 cGMP-dependent protein kinase cGMP-dependent protein kinase 2.7.11.12 pie diagram
PF3D7_1203900 loop drugs PFL0190w E2 ubiquitin-conjugating enzyme E2 2.3.2.23 pie diagram
PF3D7_1356300 PF13_0301 E2 ubiquitin-conjugating enzyme E2, putative 2.3.2.23 pie diagram
PF3D7_0826100 MAL8P1.23 E3 ubiquitin ligase HECT-like E3 ubiquitin ligase, putative 2.3.2.31 pie diagram
PF3D7_0205400 PFB0240w Lid subunits PCI domain-containing protein, putative pie diagram
PF3D7_0312300 PFC0520w Lid subunits 26S proteasome regulatory subunit RPN12, putative 3.4.25.1 pie diagram
PF3D7_0317800 PFC0785c Lid subunits 26s proteasome non-atpase regulatory subunit 9, putative pie diagram
PF3D7_0912900 PFI0630w Lid subunits 26S proteasome regulatory subunit RPN8, putative pie diagram
PF3D7_1017900 PF10_0174 Lid subunits 26S proteasome regulatory subunit p55, putative 3.4.25.1 pie diagram
PF3D7_1030500 PF10_0298 Lid subunits 26S proteasome regulatory subunit RPN9, putative 3.4.25.1 pie diagram
PF3D7_1129200 PF11_0303 Lid subunits 26S proteasome regulatory subunit RPN7, putative pie diagram
PF3D7_1338100 MAL13P1.190 Lid subunits 26S proteasome regulatory subunit RPN3, putative pie diagram
PF3D7_1368100 MAL13P1.343 Lid subunits 26S proteasome regulatory subunit RPN11, putative pie diagram
PF3D7_1402300 loop drugs PF14_0025 Lid subunits 26S proteasome regulatory subunit RPN6 pie diagram
PF3D7_1010100 PF10_0098 PI31 pi31 domain-containing protein, putative pie diagram
PF3D7_1330000 drugs MAL13P1.159 PITH domain-containing protein, putative pith domain-containing protein, putative pie diagram
PF3D7_1211800 PFL0585w polyubiquitin polyubiquitin pie diagram
PF3D7_0907700 PFI0370c Proteasome activator p28 proteasome activator 28 pie diagram
PF3D7_0723600 PF07_0099 proteasome assembly chaperone 4 proteasome assembly chaperone 4, putative pie diagram
PF3D7_1008400 drugs PF10_0081 Proteasome ATPase 26S protease regulatory subunit 4, putative 3.6.4.8 pie diagram
PF3D7_1130400 drugs PF11_0314 Proteasome ATPase 26S protease regulatory subunit 6A, putative 3.6.4.8 pie diagram
PF3D7_1248900 drugs PFL2345c Proteasome ATPase 26S protease regulatory subunit 8, putative 3.6.4.8 pie diagram
PF3D7_1311500 drugs PF13_0063 Proteasome ATPase 26S protease regulatory subunit 7, putative; 26S proteasome AAA-ATPase subunit RPT1, putative 3.6.4.8 pie diagram
PF3D7_0707400 loop drugs MAL7P1.209 Proteasome regulatory component AAA family ATPase, putative pie diagram
PF3D7_0815700 loop PF08_0067 Ubiquitin apicoplast ubiquitin-like protein aubl pie diagram
PF3D7_0818500 PF08_0056 Ubiquitin zinc finger protein, putative pie diagram
PF3D7_0922100 loop PFI1085w ubiquitin ubiquitin-like protein, putative pie diagram
PF3D7_1132000 PF11_0329 ubiquitin ubiquitin-like protein, putative pie diagram
PF3D7_1314800 loop PF13_0084 Ubiquitin ubiquitin-like protein, putative pie diagram
PF3D7_1365900 loop PF13_0346 Ubiquitin ubiquitin-60S ribosomal protein L40 pie diagram
PF3D7_0817000 MAL8P1.75 Ubiquitin activating enzyme E1 NEDD8-activating enzyme E1 catalytic subunit, putative 6.2.1.45 pie diagram
PF3D7_1225800 loop drugs PFL1245w Ubiquitin activating enzyme E1 ubiquitin-activating enzyme E1 6.2.1.45 pie diagram
PF3D7_1237000 drugs PFL1790w Ubiquitin activating enzyme E1 SUMO-activating enzyme subunit 2 6.2.1.45 pie diagram
PF3D7_1333200 loop PF13_0182 Ubiquitin activating enzyme E1 ubiquitin-activating enzyme 6.2.1.45 pie diagram
PF3D7_1414700 PF14_0145 ubiquitin carboxyl-terminal hydrolase ubiquitin carboxyl-terminal hydrolase, putative 3.4.19.12 pie diagram
PF3D7_1460400 drugs PF14_0576 ubiquitin carboxyl-terminal hydrolase ubiquitin carboxyl-terminal hydrolase isozyme L3 3.4.19.12 pie diagram
PF3D7_0104300 loop drugs PFA0220w ubiquitin carboxyl-terminal hydrolase 1, putative ubiquitin carboxyl-terminal hydrolase 1, putative 3.4.19.12 pie diagram
PF3D7_0413900 PFD0680c ubiquitin carboxyl-terminal hydrolase 13, putative ubiquitin carboxyl-terminal hydrolase 13, putative 3.4.19.12 pie diagram
PF3D7_0527200 drugs PFE1355c ubiquitin carboxyl-terminal hydrolase 14 ubiquitin carboxyl-terminal hydrolase 14 3.4.19.12 pie diagram
PF3D7_0516700 PFE0835w ubiquitin carboxyl-terminal hydrolase 2, putative ubiquitin carboxyl-terminal hydrolase 2, putative 3.4.19.12 pie diagram
PF3D7_1117100 PF11_0177 ubiquitin carboxyl-terminal hydrolase uch54 ubiquitin carboxyl-terminal hydrolase uch54 3.4.19.12 pie diagram
PF3D7_0722300 MAL7P1.120 ubiquitin carboxyl-terminal hydrolase, putative ubiquitin carboxyl-terminal hydrolase, putative 3.4.19.12 pie diagram
PF3D7_0726500 MAL7P1.147 ubiquitin carboxyl-terminal hydrolase, putative ubiquitin carboxyl-terminal hydrolase, putative 3.4.19.12 pie diagram
PF3D7_0826500 PF08_0020 Ubiquitin conjugating factor E4 B ubiquitin conjugation factor E4 B, putative 6.3.2.19 pie diagram
PF3D7_0403500 PFD0165w ubiquitin specific protease ubiquitin specific protease, putative 3.4.19.12 pie diagram
PF3D7_0904600 PFI0225w ubiquitin specific protease ubiquitin specific protease, putative 3.4.19.12 pie diagram
PF3D7_0319300 PFC0855w Ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E2, putative 2.3.2.23 pie diagram
PF3D7_0527100 drugs PFE1350c Ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E2 13 2.3.2.23 pie diagram
PF3D7_0606200 PFF0305c Ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E2 PEX4, putative 2.3.2.23 pie diagram
PF3D7_0915100 drugs PFI0740c Ubiquitin-conjugating enzyme E2 SUMO-conjugating enzyme UBC9 2.3.2.23 pie diagram
PF3D7_1033900 PF10_0330 Ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme e2, putative 2.3.2.23 pie diagram
PF3D7_1243700 loop PFL2100w Ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E2, putative 2.3.2.23
PF3D7_1345500 loop MAL13P1.227 Ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E2 2.3.2.23 pie diagram
PF3D7_0305700 PFC0255c ubiquitin-conjugating enzyme E2, putative ubiquitin-conjugating enzyme mms2, putative 2.3.2.23 pie diagram
PF3D7_0812600 PF08_0085 ubiquitin-conjugating enzyme E2, putative ubiquitin-conjugating enzyme E2, putative 2.3.2.23 pie diagram
PF3D7_1412900 PF14_0128 ubiquitin-conjugating enzyme E2, putative ubiquitin-conjugating enzyme E2, putative 2.3.2.23 pie diagram
PF3D7_0312100 loop drugs PFC0510w Ubiquitin-protein ligase E3 E3 ubiquitin-protein ligase, putative 6.3.2.19 pie diagram
PF3D7_0316900 loop PFC0740c Ubiquitin-protein ligase E3 E3 ubiquitin-protein ligase, putative 2.3.2.31 pie diagram
PF3D7_0319100 PFC0845c Ubiquitin-protein ligase E3 E3 ubiquitin-protein ligase RBX1, putative 2.3.2.31 pie diagram
PF3D7_0627300 PFF1325c Ubiquitin-protein ligase E3 E3 ubiquitin-protein ligase RNF5, putative 2.3.2.31 pie diagram
PF3D7_0628100 loop PFF1365c Ubiquitin-protein ligase E3 hect domain-containing protein 1, putative 2.3.2.31 pie diagram
PF3D7_0704600 loop MAL7P1.19 Ubiquitin-protein ligase E3 HECT-type E3 ubiquitin ligase UT 2.3.2.26 pie diagram
PF3D7_0707700 PF07_0026 Ubiquitin-protein ligase E3 E3 ubiquitin-protein ligase, putative 2.3.2.31 pie diagram
PF3D7_1119400 PF11_0201 Ubiquitin-protein ligase E3 ubiquitin-protein ligase, putative 2.3.2.31 pie diagram
PF3D7_0528000 PFE1395c UMP1 proteasome maturation factor UMP1, putative pie diagram