Signaling machinery in malaria parasites
Pharmacological evidence does not necessarily relate to the gene identified in PlasmodB. N/A: not applicable.
Budu A, Garcia CR. Generation of second messengers in Plasmodium. Microbes Infect. 2012 14(10):787-95. PMID: 22584103.
PfID Signalling component Experimental data or in silico identification Transcript EC
8346 PF3D7_1246900
RAC-beta serine/threonine protein kinase Cloning and expression of P.falciparum protein: Ca-CAM as activator; PLC as upstream activator
8339 PF3D7_0826700
receptor for activated c kinase Cloning and expression profile in P.falciparum; reduces [Ca2]cyt rise from internal stores in heterologous systems.
8341 PF3D7_1013500
phosphoinositide-specific phospholipase C U73122 as inhibitor of [Ca2]cyt rise ; IP3 formation,
8348 PF3D7_1404600
Adenylyl cyclase Aca Forskolin as activator of cAMP production; knockout in P.berghei for Aca
14587 PF3D7_0802600
Adenylyl cyclase, Acb
8340 PF3D7_0934800
cAMP-dependent protein kinase catalytic subunit PKI as inhibitor of cAMP-induced [Ca2]cyt rise, 6-Bz-cAMP as activator of [Ca2]cyt rise  inhibition of P. falciparum development by H89
8345 PF3D7_1223100
cAMP-dependent protein kinase regulatory subunit
PF3D7_1103900 riia domain-containing protein, putative
8352 N/A
N/A Detected in Plasmodium
8349 PF3D7_1435700 ataxin-2 like protein, putative none
not found Blocking of calcium release by dantrolene and ruthenium red
not found IP3 releases calcium from internal stores
8338 PF3D7_0607400 G-protein associated signal transduction protein, putative ADP-ribosylation by cholera and pertussis toxins of P. falciparum proteins
8337 PF3D7_0525400
G-protein coupled receptor, putative
8347 PF3D7_1362400
calpain Cleavage of FRET-peptides in murine parasites and P. falciparum. Calpain is an essential gene
8350 PF3D7_1436600
cGMP-dependent protein kinase Compound 1 prevents round up of gametocytes of P. falciparum
8351 PF3D7_1470500
cgmp-specific 3',5'-cyclic phosphodiesterase delta, putative Knockout of PDEd in P. berghei ookinetes promotes round up of cGMP-dependent phosphodiesterase activity; cGMP phosphodiesterase inhibitor zaprinast induces gametocytogenesis in P. falciparum
8343 PF3D7_1138400
guanylyl cyclase alfa Gca
14588 PF3D7_1360500 guanylyl cyclase beta GCb is essential for gliding motility of the P. berghei ookinete, Double knockout in P. berghei with Phosphodiesterase d promotes recovery of wild phenotype
8335 PF3D7_0217500
Calcium-dependent protein kinases; CDPK1
PF3D7_1003000 guanylate cyclase organizer ugo, putative
14589 PF3D7_0310100
calcium-dependent protein kinase 3, CDPK3 CDPK3 necessary for P. berghei ookinete migration to epithelial cells
14590 PF3D7_0717500
calcium-dependent protein kinase 4, CDPK4 CDPK4 necessary for exflagellation of P.berghei gametocytes
14591 PF3D7_1337800
calcium-dependent protein kinase 5, CDPK5
8342 PF3D7_1131100
serpentine receptor 1, putative, PfSr1
14592 PF3D7_1215900
serpentine receptor 10, PfSr10
14593 PF3D7_0422800
serpentine receptor 12, putative
27531 PF3D7_0713400
GPCR-like receptor sr25; serpentine receptor SR25
8344 PF3D7_1211900
non-SERCA-type Ca2+ -transporting P-ATPase, ATP4 Functional characterization of P. falciparum proteins PFATP4 and PfATP6
14595 PF3D7_0106300
calcium-transporting ATPase, ATP6
8336 PF3D7_0515300
phosphatidylinositol 3-kinase Exported to the RBC, involved in haemoglobin endocytosis and trafficking in P. falciparum
PF3D7_1403200 egf domain-containing protein, putative
PF3D7_0211500 GAF domain-related protein, putative
Online articles related to Signaling machinery in malaria parasites retrieved from PubMed