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Signaling machinery in malaria parasites |
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Pharmacological evidence does not necessarily relate to the gene identified in PlasmodB. N/A: not applicable.
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Budu A, Garcia CR. Generation of second messengers in Plasmodium. Microbes Infect. 2012 14(10):787-95. PMID: 22584103.
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PfID |
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Signalling component |
Experimental data or in silico identification |
Transcript |
EC |
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| 8346 |
PF3D7_1246900 |
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RAC-beta serine/threonine protein kinase |
Cloning and expression of P.falciparum protein: Ca-CAM as activator; PLC as upstream activator |
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2.7.11.1 |
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| 8339 |
PF3D7_0826700 |
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receptor for activated c kinase |
Cloning and expression profile in P.falciparum; reduces [Ca2]cyt rise from internal stores in heterologous systems. |
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| 8341 |
PF3D7_1013500 |
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phosphoinositide-specific phospholipase C |
U73122 as inhibitor of [Ca2]cyt rise ; IP3 formation, |
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3.1.4.11 |
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| 8348 |
PF3D7_1404600 |
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Adenylyl cyclase Aca |
Forskolin as activator of cAMP production; knockout in P.berghei for Aca |
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4.6.1.1 |
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| 14587 |
PF3D7_0802600 |
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Adenylyl cyclase, Acb |
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4.6.1.1 |
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| 8340 |
PF3D7_0934800 |
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cAMP-dependent protein kinase catalytic subunit |
PKI as inhibitor of cAMP-induced [Ca2]cyt rise, 6-Bz-cAMP as activator of [Ca2]cyt rise inhibition of P. falciparum development by H89 |
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2.7.11.11 |
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| 8345 |
PF3D7_1223100 |
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cAMP-dependent protein kinase regulatory subunit |
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2.7.11.11 |
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PF3D7_1103900 |
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riia domain-containing protein, putative |
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| 8352 |
N/A |
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N/A |
Detected in Plasmodium |
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| 8349 |
PF3D7_1435700 |
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ataxin-2 like protein, putative |
none |
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not found |
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Blocking of calcium release by dantrolene and ruthenium red |
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not found |
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IP3 releases calcium from internal stores |
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| 8338 |
PF3D7_0607400 |
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G-protein associated signal transduction protein, putative |
ADP-ribosylation by cholera and pertussis toxins of P. falciparum proteins |
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| 8337 |
PF3D7_0525400 |
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G-protein coupled receptor, putative |
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| 8347 |
PF3D7_1362400 |
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calpain |
Cleavage of FRET-peptides in murine parasites and P. falciparum. Calpain is an essential gene |
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3.4.22.- |
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| 8350 |
PF3D7_1436600 |
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cGMP-dependent protein kinase |
Compound 1 prevents round up of gametocytes of P. falciparum |
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2.7.11.12 |
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| 8351 |
PF3D7_1470500 |
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cgmp-specific 3',5'-cyclic phosphodiesterase delta, putative |
Knockout of PDEd in P. berghei ookinetes promotes round up of cGMP-dependent phosphodiesterase activity; cGMP phosphodiesterase inhibitor zaprinast induces gametocytogenesis in P. falciparum |
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3.1.4.17 |
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| 8343 |
PF3D7_1138400 |
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guanylyl cyclase alfa Gca |
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4.6.1.2 |
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| 14588 |
PF3D7_1360500 |
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guanylyl cyclase beta |
GCb is essential for gliding motility of the P. berghei ookinete, Double knockout in P. berghei with Phosphodiesterase d promotes recovery of wild phenotype |
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4.6.1.2 |
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| 8335 |
PF3D7_0217500 |
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Calcium-dependent protein kinases; CDPK1 |
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2.7.11.1 |
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PF3D7_1003000 |
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guanylate cyclase organizer ugo, putative |
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| 14589 |
PF3D7_0310100 |
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calcium-dependent protein kinase 3, CDPK3 |
CDPK3 necessary for P. berghei ookinete migration to epithelial cells |
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2.7.11.17 |
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| 14590 |
PF3D7_0717500 |
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calcium-dependent protein kinase 4, CDPK4 |
CDPK4 necessary for exflagellation of P.berghei gametocytes |
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2.7.11.1 |
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| 14591 |
PF3D7_1337800 |
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calcium-dependent protein kinase 5, CDPK5 |
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2.7.1.1 |
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| 8342 |
PF3D7_1131100 |
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serpentine receptor 1, putative, PfSr1 |
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| 14592 |
PF3D7_1215900 |
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serpentine receptor 10, PfSr10 |
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| 14593 |
PF3D7_0422800 |
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serpentine receptor 12, putative |
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| 27531 |
PF3D7_0713400 |
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GPCR-like receptor sr25; serpentine receptor SR25 |
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| 8344 |
PF3D7_1211900 |
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non-SERCA-type Ca2+ -transporting P-ATPase, ATP4 |
Functional characterization of P. falciparum proteins PFATP4 and PfATP6 |
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3.6.3.2 |
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| 14595 |
PF3D7_0106300 |
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calcium-transporting ATPase, ATP6 |
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3.6.3.8 |
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| 8336 |
PF3D7_0515300 |
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phosphatidylinositol 3-kinase |
Exported to the RBC, involved in haemoglobin endocytosis and trafficking in P. falciparum |
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2.7.1.137 |
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PF3D7_1403200 |
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egf domain-containing protein, putative |
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PF3D7_0211500 |
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GAF domain-related protein, putative |
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Drugs affecting pathway with unknown specific target