Hemozoin and b-hematin formation

Online articles related to Hemozoin and b-hematin formation retrieved from PubMed

Drugs affecting pathway with unknown specific target

Drug Name	PubMed Articles (year of publication)
(±)-(3-chlorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]methanol	Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore
(±)-N-[2-(Pyrrolidin-1-yl)ethyl]-2-(2-chlorophenyl)-2-(1H-imidazol-1yl)ethylamine	Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore
(±)-N-[3-(N,N-Diethylamino)propyl]-2-(2-chlorophenyl)-2-(1H-imidazol- 1yl)ethylamine	Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore
(1-benzyl-4-piperidyl)[6,7-dimethoxy-2-(4-methyl-1,4-diazepin-1-yl)-4-quinazolinyl]amine	In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol derivatives
(1S,3aR,4S,5aS,7R,8R,8aS,10aS,10cS)-4,7,8-trimethyl-2,3,3a,4,5,5a,6,7,8a,9,10,10a,10b,10c-tetradecahydro-1H-pyrene-1,8-dicarbonitrile	Antiplasmodial activity: the first proof of inhibition of heme crystallization by marine isonitriles
(2S,3R,4S,6R)-4,5-dihydroxy-2-(((4R,4aS,7S,10aS)-7-hydroxy-7-isopropyl-1,1,4a-trimethyl-5,9-dioxo-1,2,3,4,4a,5,6,7,8,9,10,10a-dodecahydrophenanthren-4-yl)methyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl acetate	New abietane diterpenoid glucosides from underground parts of Isodon taliensis
(2S,4R,5R,8S,11S,12R,13R,14R)-11-(((2S,3S,4S,6R)-3-(3-((7-chloroquinolin-4-yl)amino)propoxy)-4-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,5R,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one	Novel class of fast acting antimalarial agents: substituted 15-membered azalides
(3-aminopropyl)piperazine	Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives
(3s,4s)-4-((s)-2-((s)-6-amino-2-(phenylmethylsulfonamido)hexanamido)-3-methylbutanamido)-3-hydroxy-6-methyl-n-phenethylheptanamide	Kojic acid derived hydroxypyridinone-chloroquine hybrids: synthesis, crystal structure, antiplasmodial activity and ß-haematin inhibition
(E)-((4-((7-chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)((4-((3-methoxy-1-(3-methylpyridin-2-yl)prop-1-en-1-yl)amino)pentyl)amino)gold	A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent
(E)-(2-(3,5-dichloro-2-hydroxybenzylidene)-1l2-diazaneyl)(o-tolyl)methanone	2D-quantitative structure-activity relationships model using PLS method for anti-malarial activities of anti-haemozoin compounds
(E)-1-(4-Bromophenyl)-3-(2-chloro-6-methylquinoline-3yl) prop-2-en-1-one	Antiprotozoal activity of chloroquinoline based chalcones
(E)-2-(1-ferrocenylethylidene)-N-(3-(trimethylsilyl)propyl)hydrazine-1-carbothioamide	Cyclopalladated organosilane-tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity
(E)-2-isopropyl-5-methyl-4-((2-(pyridin-4-yl) hydrazono) methyl) phenol	Hydrazonophenol, a Food Vacuole-Targeted and Ferriprotoporphyrin IX-Interacting Chemotype Prevents Drug-Resistant Malaria
(E)‐3‐(2‐(2‐(1‐(2‐Amino‐4‐methylthiazol‐5‐yl)ethylidene)hydrazinyl)‐thiazol‐4‐yl)‐6‐bromo‐2H‐chromen‐2‐one	Synthesis of thiazolyl hydrazonothiazolamines and 1,3,4-thiadiazinyl hydrazonothiazolamines as a class of antimalarial agents
(E)-4-(((2-((7-chloroquinolin-4-yl)amino)ethyl)imino)methyl)benzoic acid	In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization
(R)-((1S,2S,4S,5S)-5-((E)-5-bromo-2-fluorostyryl)quinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol	Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum
(R)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-(2-((2-((7-nitrobenzo[c][1,2,5]oxadiazol-4- yl)amino)ethyl)thio)ethyl)quinuclidin-2-yl)methanol,	Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum
(R)-7-hydroxy-3-(2-hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)-8-(3-methylbut-2-en-1-yl)chroman-4-one	A new prenylated coumestan from the roots of Campylotropis hirtella
(S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-(2-((2-((7-nitrobenzo[c][1,2,5]oxadiazol-4- yl)amino)ethyl)thio)ethyl)quinuclidin-2-yl)methanol,	Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum
(Z)-2-(2-((4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)methylene)hydrazineyl)-N-(4-((7-chloroquinolin-4-yl)amino)phenyl)-2-oxoacetamide	Design and synthesis of a new class of 4-aminoquinolinyl- and 9-anilinoacridinyl Schiff base hydrazones as potent antimalarial agents
(Z)-3-(3-(7-Chloroquinolin-4-ylamino) propyl)-5-(4- fluorobenzylidene)-2-thioxothiazolidin-4-one	Synthesis and biological evaluation of a new class of 4-aminoquinoline-rhodanine hybrid as potent anti-infective agents
(Z)-3-(3-(7-Chloroquinolin-4-ylamino) propyl)-5-(4- nitrobenzylidene)-2 thioxothiazolidin-4-one	Synthesis and biological evaluation of a new class of 4-aminoquinoline-rhodanine hybrid as potent anti-infective agents
(Z)-3-(4-(7-Chloroquinolin-4-ylamino) propyl)-2-thioxo-5- (3,4,5-trimethoxybenzylidene) thiazolidin-4-one	Synthesis and biological evaluation of a new class of 4-aminoquinoline-rhodanine hybrid as potent anti-infective agents
(η5-Pentamethylcyclopentadienyl){(N-(2-((2-hydroxyphenyl)methylimino)ethyl)-7-chloroquinolin-4-amine)}chlororhodium(III)	Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization and antimalarial properties
(η5-Pentamethylcyclopentadienyl){(N-(2-((5-fluro-2-hydroxyphenyl)methylimino)ethyl)-7-chloroquinolin-4-amine)}chlororhodium(III)	Potential Interaction of Plasmodium falciparum Hsp60 and Calpain
(η6‑p‑Cymene)(N‑(2‑((5‑fluoro‑2‑hydroxyphenyl)methylimino)propyl)‑7‑chloroquinolin‑4‑amine)benzPTA ruthenium(II) chloride	Evaluation of PTA-derived ruthenium(II) and iridium(III) quinoline complexes against chloroquine-sensitive and resistant strains of the Plasmodium falciparum malaria parasite
(κ3-C,N,S-(Z)-1-(((E)-1-(3,4-dichlorophenyl)ethylidene)hydrazono)-1-(λ1-sulfanyl)-N-((trimethylsilyl)methyl)methanamine)(1,3,5-triaza-7-phosphaadamantane)palladium(II)	Cyclopalladated organosilane-tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity
(κ3-C,N,S-N-((Z)-(((E)-1-(3,4-dichlorophenyl)ethylidene)hydrazono)(λ1-sulfanyl)methyl)-2,2-dimethylpropan-1-amine)(1,3,5-triaza-7-phosphaadamantane)palladium(II)	Cyclopalladated organosilane-tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity
(κ3-C,N,S-N-((Z)-(((E)-1-(3,4-dichlorophenyl)ethylidene)hydrazono)(λ1-sulfanyl)methyl)-3-(trimethylsilyl)propan-1-amine)(1,3,5-triaza-7-phosphaadamantane)palladium(II)	Cyclopalladated organosilane-tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity
[(1R,2R,3aS,5S,5aR,8aS,10aS,10bS,10cR)-8-cyano-1,2,5-trimethyl-3,3a,4,5,5a,6,7,8,8a,9,10,10a,10b,10c-tetradecahydro-2H-pyren-1-yl] cyanate	Antiplasmodial activity: the first proof of inhibition of heme crystallization by marine isonitriles
[(aryl)arylsulfanylmethyl]pyridine	Antiplasmodial activity of [(aryl)arylsulfanylmethyl]Pyridine
[{1,12-bis(2-hydroxy-3-ethyl-benzyl)-1,5,8,12-tetraazadodecane}Fe3+)]+	Metalloantimalarials: targeting of P. falciparum strains with novel iron(III) and gallium(III) complexes of an amine phenol ligand
[{1,12-bis(2-hydroxy-3-ethyl-benzyl)-1,5,8,12-tetraazadodecane}Ga3+]+	Metalloantimalarials: targeting of P. falciparum strains with novel iron(III) and gallium(III) complexes of an amine phenol ligand
[2(20 -chloroquinolin-30 -yl)-1- chloro]ethenylphenyl sulfone	Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities
[2(30 ,40 -methylendioxyphenyl)-1- chloro]ethenylphenyl sulfone	Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities
[2-(7-chloro-quinolin-4-ylamino)-ethyl]-amide hydrochloride	Design, synthesis of 4-aminoquinoline-derived thiazolidines and their antimalarial activity and heme polymerization inhibition studies
[2-(N,N-Diethylaminomethylferrocenyl)]- {4-[(2,8-bistrifluoromethyl)quinolyl]}methanol	Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents
[2-(N,N-Dimethylaminomethylferrocenyl)]- {4-[(2,8-bistrifluoromethyl)quinolyl]}methanol	Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents
[2-(N,N-Dimethylaminomethylferrocenyl)]-(6-methoxyquinolyl)methanol	Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents
[2-(N-Methylpiperazinomethylferrocenyl)]- {4-[(2,8-bistrifluoromethyl)quinolyl]}methanol	Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents
[2-(Piperidinomethylferrocenyl)]- {4-[(2,8-bistrifluoromethyl)quinolyl]}methanol	Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents
[2-(Piperidinomethylferrocenyl)]-(6-methoxyquinolyl)methanol	Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents
[3-(4-Hydroxy-phenyl)-5-(4-isopropoxy-phenyl)-4,5-dihydropyrazol-1-yl]-pyridin-3-yl-methanone	Synthesis of 1,3,5-trisubstituted pyrazolines as potential antimalarial and antimicrobial agents
[5-(3,4-Dimethoxy-phenyl)-3-(4-hydroxy-phenyl)-4,5-dihydropyrazol-1-yl]-pyridin-3-yl-methanone	Synthesis of 1,3,5-trisubstituted pyrazolines as potential antimalarial and antimicrobial agents
[5-(4-Bromo-phenyl)-3-(4-hydroxy-phenyl)-4,5-dihydropyrazol-1-yl]-pyridin-3-yl-methanone	Synthesis of 1,3,5-trisubstituted pyrazolines as potential antimalarial and antimicrobial agents
[Au(CQ)(PPh3)]PF6	The mechanism of antimalarial action of [Au(CQ)(PPh(3))]PF(6): structural effects and increased drug lipophilicity enhance heme aggregation inhibition at lipid/water interfaces
[AuAQPQ]PF6	A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis
[Cu(CQ)(PPh3 )2 ]NO3	Copper (I)-Chloroquine Complexes: Interactions with DNA and Ferriprotoporphyrin, Inhibition of ß-Hematin Formation and Relation to Antimalarial Activity
[metal(fctpy)2][pf6]2	Synthesis of 4'-(2-ferrocenyl)-2,2':6'2''-terpyridine: characterization and antiprotozoal activity of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes
-{5-[({2-[(7-Chloroquinolin-4-yl)amino]ethyl}- amino)methyl]thiophen-2-yl}phenyl)acetamide	Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice
1-(2-methoxyquinolin-3-yl)-N-(pyridin-2-ylmethyl)methanamine	Design, synthesis and biological evaluation of mono- and bisquinoline methanamine derivatives as potential antiplasmodial agents
1-(3,6-dichlorocarbazol-9-yl)-3-(hexylamino)propan-2-ol	Novel carbazole aminoalcohols as inhibitors of ß-hematin formation: Antiplasmodial and antischistosomal activities
1-(3-Amidinophenyl)-4-(4-amidinophenyl)-[1,2,3]triazole dihydrochloride	Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues
1-(3-N-Methoxyamidinophenyl)-4-(4-N-methoxyamidinophenyl)- [1,2,3]triazole dihydrochloride (	Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues
1-(3-pyridinyl)-3-ferrocenylprop-2-en-1-one	Antiplasmodial activity of ferrocenyl chalcones: investigations into the role of ferrocene
1-(4-Fluoronaphthalen-1-yl)-3-((1-(4-nitro-2-(tri- fluoromethyl)phenyl)piperidin-4-yl) amino) propan-1-ol	Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration
1-(6-methoxyquinolin-4-yl)propan-1-ol	The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex
1-(butylamino)-3-(3,6-dichlorocarbazol-9-yl)propan-2-ol	Novel carbazole aminoalcohols as inhibitors of ß-hematin formation: Antiplasmodial and antischistosomal activities
1,10-phenanthroline	In vitro antimalarial activity of a series of cationic 2,2'-bipyridyl- and 1,10-phenanthrolineplatinum(II) benzoylthiourea complexes
1,2-dimethyl imidazole)	Synthesis, characterization and biological activity of new mixed ligand complexes of Zn(II) naproxen with nitrogen based ligands
1,2-o,o-diacetyl-4-nerolidylcatechol	Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice
1,4-bis(2-((E)-6-(l6-oxidaneylidyne)hexa-2,4-diyn-1-ylidene)hydrazineyl)phthalazine	Antimalarial Activity of Highly Coordinative Fused Heterocycles Targeting ß - Hematin Crystallization
1,4-Bis-(4-benzamidine)-1H-[1,2,3]triazole dihydrochloride	Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues
1,4-Bis-(4-N-methoxyamidinophenyl)-[1,2,3]triazole dihydrochloride	Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues
1,4-dimethoxynaphthalene	Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum
1,4-naphthoquinone	Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents
1,6,8-Trihydroxyxanthone	In Vitro Antiplasmodial, Heme Polymerization, and Cytotoxicity of Hydroxyxanthone Derivatives
1-[(4-chlorophenyl)-phenyl-[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]imidazole	Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies
1-[3-(7-chloro-quinolin-4-ylamino)-propyl]-3-cyclopropylthiourea	4-Aminoquinoline derived antimalarials: synthesis, antiplasmodial activity and heme polymerization inhibition studies
1-[4,7-bis(7-chloro-4-quinolyl)-1,4,7-triazonan-1-yl]-3-(3-piperidyl)propan-1-one	Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers
1-{(4-Chlorophenyl)bis[4-(pyrrolidin-1-ylmethyl)phenyl]methyl}-1H-imidazole	Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies
10-((2,5-dihydrothiazol-2-yl)thio)decan-1-ol	Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability
10-(1,2-propadienyl)-9(10h)-acridinone	Antimalarial activity of new acridinone derivatives
10-(3-methyl-2-butenyl)-)-9(10h)-acridinone	Antimalarial activity of new acridinone derivatives
10-alyl--9(10h)-acridinone	Antimalarial activity of new acridinone derivatives
1-ferrocenyl-3-(4-nitrophenyl)prop-2-en-1-one	Antiplasmodial activity of ferrocenyl chalcones: investigations into the role of ferrocene
1-methoxyethyl-6-(p-n-octylanilino)uracil	Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria
2-((3-((6-chloronaphthalen-1-yl)amino)propyl)amino)-N-(3'-chlorospiro[cyclopentane-1,9'-fluoren]-2'-yl)acetamide	Fluorene-Chloroquine Hybrids: Synthesis, in vitro Antiplasmodial Activity, and Inhibition of Heme Detoxification Machinery of Plasmodium falciparum
2-((6-methoxyquinolin-4-yl)methyl)-8- vinylquinuclidine	The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex
2-(1H-Benzo[d]imidazol-2-yl)-3-(3-methoxyphenyl)acrylonitrile	Synthesis of novel benzimidazole acrylonitriles for inhibition of Plasmodium falciparum growth by dual target inhibition
2-(2,6-dichloro-phenyl)-thiazolidine-4-carboxylic acid	Design, synthesis of 4-aminoquinoline-derived thiazolidines and their antimalarial activity and heme polymerization inhibition studies
2-(3-((7-chloroquinolin-4-yl)amino)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione	Functionalized Naphthalimide-4-aminoquinoline Conjugates as Promising Antiplasmodials, with Mechanistic Insights
2-(3-(4-Morpholino)propylamino)-4-methyl-5-hydroxynaphtho [1,2-d]thiazolium chloride hydrochloride	In vitro and in vivo antimalarial activity of amphiphilic naphthothiazolium salts with amine-bearing side chains
2-(3-(trifluoromethyl)phenyl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-imidazo[4,5-c]pyridin-6-amine	The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance
2-(3,4-dimethoxyphenyl)-3,5,7-trimethoxychroman-4-one	Correlation study on methoxylation pattern of flavonoids and their heme-targeted antiplasmodial activity
2-(3,5-Difluorophenyl)-4-(4-((4-methylpiperazin-1-yl)methyl)- piperidin-1-yl)-1H-imidazo[4,5-c]pyridine	Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model
2-(4-chlorophenyl)-3-(2-((7-chloroquinolin-4-yl)amino)ethyl)-2,3-dihydro-4H-benzo[e][1,3]thiazin-4-one	Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives
2-(4-chloro-phenyl)-thiazolidine-4-carboxylic acid	Design, synthesis of 4-aminoquinoline-derived thiazolidines and their antimalarial activity and heme polymerization inhibition studies
2-(6-benzoyl-β-D-glucopyranosyloxy)-7-(1α, 2α, 6α-trihydroxy-3-oxocyclohex-4-enoyl)-5-hydroxybenzyl alcohol	A phenolic glycoside from Flacourtia indica induces heme mediated oxidative stress in Plasmodium falciparum and attenuates malaria pathogenesis in mice
2-(cyclohexylimino)-1,2-dihydro-4-methyl-1-[3-(dimethylamino)propyl]naphtho-[1,2-d]thiazol-5-ol dihydrochloride	In vitro and in vivo antimalarial activity of amphiphilic naphthothiazolium salts with amine-bearing side chains
2-(diethylamino)-1-(6-methoxyquinolin-4-yl)ethanol	The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex
2,2'-bipyridyl	In vitro antimalarial activity of a series of cationic 2,2'-bipyridyl- and 1,10-phenanthrolineplatinum(II) benzoylthiourea complexes
2,3,4,5,6,7-hexahydroxyxanthone	Xanthones as antimalarial agents: stage specificity
2,3,4,5,6-pentahydroxyxanthone	Xanthones as antimalarial agents: stage specificity
2,3,4,5-tetrahydroxyxanthone	Xanthones as antimalarial agents: stage specificity
2,9-dimethyl-1,10-phenanthroline	Synthesis, characterization and biological activity of new mixed ligand complexes of Zn(II) naproxen with nitrogen based ligands
2-[(tert-butylamino)methyl]-5-[(7-chloroquinolin-4-yl)amino]phenol;dihydrochloride	Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century
2-[[3-[1-[2- (aminoiminomethyl) hydrazono]ethyl]phenyl]-amino]-4-methylnaphthol[1,2-d]thiazol-5-ol dihydrochloride	In vitro and in vivo antimalarial activity of amphiphilic naphthothiazolium salts with amine-bearing side chains
2-[2-(7-Chloroquinolin-4-ylthio)-4-methylthyazol-5-yl]-N'-(4-phenoxybenzoyl)acetohydrazide	Synthesis and antimalarial and anticancer evaluation of 7-chlorquinoline-4-thiazoleacetic derivatives containing aryl hydrazide moieties
2-aminopyrimidine	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies
2-Chloro-6,7-dimethoxy-3-[(4′-methyl-1′-indanoyl)-2′-methyliden]-quinoline (	Synthesis and antimalarial activity of E-2-quinolinylbenzocycloalcanones
2-Chloro-6,7-dimethoxy-3-[(5′-methoxy-1′-tetralonyl)-2′-methyliden]-quinoline	Synthesis and antimalarial activity of E-2-quinolinylbenzocycloalcanones
2-Chloro-8-methyl-3-[(4′-methoxy-1′-indanoyl)-2′- methyliden]-quinoline	Synthesis and antimalarial activity of E-2-quinolinylbenzocycloalcanones
2-Chloro-8-methyl-3-[(4′-methyl-1′-indanoyl)-2′- methyliden]-quinoline	Synthesis and antimalarial activity of E-2-quinolinylbenzocycloalcanones
2-cyclopentylamino-N6 -cyclopentyladenine	2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities
2-hydroxybenzaldehyde	Metalloantimalarials: targeting of P. falciparum strains with novel iron(III) and gallium(III) complexes of an amine phenol ligand
2-imidazoline	Antiplasmodial, beta-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines
2-styrylquinolin-8-ol	Use of the NP-40 detergent-mediated assay in discovery of inhibitors of beta-hematin crystallization
2-tert-butylprimaquine	2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization
3- (3- (benzyloxy) -2-methyl-4- oxopyridin1(4H)-yl) propyl 3-chlorobenzoate	Synthesis, characterization, molecular docking, antimalarial, and antiproliferative activities of benzyloxy-4-oxopyridin benzoate derivatives
3-((2-((1-(4-methoxyphenethyl)piperidin-4-yl)amino)-1H-benzo[d]imidazol-1- yl)methyl)benzonitrile	Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action
3-(2-((7-chloroquinolin-4-yl)amino)ethyl)-2-(2,6-dichlorophenyl)thiazolidin-4-one	Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives
3-(3-(7-chloroquinolin-4-ylamino) propyl)-2- thioxothiazolidin-4-one	Synthesis and biological evaluation of a new class of 4-aminoquinoline-rhodanine hybrid as potent anti-infective agents
3-(4-bromophenyl)-N-[(E)-(4-hydroxy-3-methoxy-phenyl)methyleneamino]-1,2,4-oxadiazole-5-carboxamide	Conjugation of N-acylhydrazone and 1,2,4-oxadiazole leads to the identification of active antimalarial agents
3,4,5,6-tetrahydroxyxanthone	Xanthones as antimalarial agents: stage specificity
3,4-dihydropyrimidin-2(1 h )-one	Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: synthesis and evaluation for antimalarial, beta-haematin inhibition, and cytotoxic activity
3,4-Di-O-heptyl-a-D-ribo-2-deoxypentopyranosyl hydroperoxide	Glycosyl hydroperoxides: a new class of potential antimalarial agents
3,5-dinitro-N-(pyridin-3-yl)benzamide	A Diverse Range of Hemozoin Inhibiting Scaffolds Act on Plasmodium falciparum as Heme Complexes
3,6-bis-(x-n,n-diethylaminoamyloxy)-4,5-difluoroxanthone	Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(omega-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone
3,6-bis-omega-diethylaminoamyloxyxanthone	The kinetics of uptake and accumulation of 3,6-bis-omega-diethylamino-amyloxyxanthone by the human malaria parasite Plasmodium falciparum
3,6-bis-v-diethylamino-alkoxyxanthone	The kinetics of uptake and accumulation of 3,6-bis-omega-diethylamino-amyloxyxanthone by the human malaria parasite Plasmodium falciparum
3,6-bis-ω-n,n-diethylaminoalkoxyxanthone	Optimization of xanthones for antimalarial activity: the 3,6-bis-omega-diethylaminoalkoxyxanthone series
3-[(7-chloro-1-oxidoquinolin-4- ylamino)alkyl]-1,3-thiazolidin-4-ones	Design and synthesis of 3-[(7-chloro-1-oxidoquinolin-4-ylamino)alkyl]-1,3-thiazolidin-4-ones as antimalarial agents
3-[(7-chloroquinolin-4-yl)amino]acetophenone	[(7-chloroquinolin-4-yl)amino]acetophenones and their copper(II) derivatives: Synthesis, characterization, computational studies and antimalarial activity
3-{3-[4-(7-Chloro-quinolin-4-yl)-piperazin-1-ylmethyl]-4-hydroxy-5- methoxyphenyl}-1-(2,4-dimethoxy-phenyl)-propenone	Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies
3-chloro-N-[(E)-(3,5-dimethoxyphenyl)methyleneamino]-4-fluoro-aniline	Antimalarial Activity of Small-Molecule Benzothiazole Hydrazones
3-ferrocenyl-3-[(diphenylphosphaneyl)-1-(furan-2-yl)propan-1-one] gold(I) chloride.	Evaluation of ferrocenyl phosphines as potent antimalarials targeting the digestive vacuole function of Plasmodium falciparum
3-heptyl-3-hydroxyquinoline-2,4(1H,3H)-dione	Potent antiplasmodial alkaloids from the rhizobacterium Pantoea agglomerans as hemozoin modulators
3-hydroxy-11-keto-β-boswellic acid	Inhibition of heme detoxification pathway in malaria parasite by 3-hydroxy-11-keto-ß-boswellic acid isolated from Boswellia serrata
3-iodo-CQ	3-Iodo-4-aminoquinoline derivative sensitises resistant strains of Plasmodium falciparum to chloroquine
3-phenyl-4,5-dihydropyrazole	Use of the NP-40 detergent-mediated assay in discovery of inhibitors of beta-hematin crystallization
3-phenylquinozaline-2-carbonitrile 1,4dioxide	Synthesis and antimalarial activity of new 3-arylquinoxaline-2-carbonitrile derivatives
4-((1-(6-(Pyridin-3-yl)-2-(pyridin-4-yl)pyrimidin-4-yl)-piperidin-4-yl)methyl)morpholine Fumarate	Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials
4-((2-(but-3-yn-1-yl(prop-2-yn-1-yl)amino)ethyl)amino)-7-chloroquinolin-1-ium	A simple quinoline salt derivative is active in vitro against plasmodium Faciparum asexual blood stages and inhibits the development of cerebral malaria in murine model
4-(1-(6-(Pyridin-3-yl)-2-(pyridin-4-yl)pyrimidin-4-yl)-piperidin-4-yl)morpholine	Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials
4'-(2-ferrocenyl)-2,2' :6' 2''-terpyridine	Synthesis of 4'-(2-ferrocenyl)-2,2':6'2''-terpyridine: characterization and antiprotozoal activity of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes
4-(3-(4-((4,5-dihydrooxazol-2-yl)methoxy)phenyl)-5-(4- methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide	4, 5-Dihydrooxazole-pyrazoline hybrids: Synthesis and their evaluation as potential antimalarial agents
4-(4,5-diphenyl-1H-imidazol-2-yl)-2,6-dimethoxy-phenol	Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum
4-(4,5-diphenyl-1H-imidazol-2-yl)phenol	Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum
4-(5-(4-methoxyphenyl)-1'-phenyl-3'-(p-tolyl)-3,4-dihydro-1'H,2H-[3,4'-bipyrazol]-2- yl)benzenesulfonamide	Pyrazole-pyrazoline as promising novel antimalarial agents: A mechanistic study
4-(n-aminobutyl)amino-7-chloroquinoline	N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials
4,5-diphenyl-2-(3,4,5-trimethoxyphenyl)-1H-imidazole	Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum
4-[(4-(7-chloroquinolin-4-yl)piperazin-1-yl)methyl)]-N-(4-methylpentan-2-yl)benzamidine	Synthesis of novel amodiaquine analogs and evaluation of their in vitro and in vivo antimalarial activities
4-[(7-chloro-4-quinolyl)amino]-2-(methylaminomethyl)phenol	Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity
4-[(E)-(1,3-benzothiazol-2-ylhydrazono)methyl]phenol	Antimalarial Activity of Small-Molecule Benzothiazole Hydrazones
4-[(E)-2-(Methoxycarbonyl)-2-(7-chloroquinolin-4-ylthio)vinyl]phenyl 2-methoxybenzoate	Optimization of antimalarial, and anticancer activities of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate
4-[[(2R,4R)-5-vinylquinuclidin-2-yl]methyl]quinoline	Bayesian models trained with HTS data for predicting ß-haematin inhibition and in vitro antimalarial activity
4-[4-[[4-(diethylamino)-1-methyl-butyl]amino]-2-quinolyl]butyl-[6-[4-(1-methylpentylamino)-7-quinolyl]hexyl]vanadium	Synthesis, antimalarial activity and inhibition of haem detoxification of novel bisquinolines
4-{5-[({3-[(7-Chloroquinolin-4-yl)amino]propyl} amino)methyl]thiophen-2-yl}benzonitrile	Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice
4′-Fluoro-N-tert-butylamodiaquine	Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine
4-amino-7-chloroquinoline	Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT) Synthesis, characterization, antiparasitic and cytotoxic evaluation of thioureas conjugated to polyamine scaffolds
4-aminochloroquinoline	Synthesis and evaluation of 7-chloro-4-(piperazin-1-yl)quinoline-sulfonamide as hybrid antiprotozoal agents
4-aminopyridine	Carbon isosteres of the 4-aminopyridine substructure of chloroquine: effects on pK(a), hematin binding, inhibition of hemozoin formation, and parasite growth
4-aminoquinoline	Design and synthesis of new antimalarial agents from 4-aminoquinoline Antiplasmodial, beta-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines Effects of highly active novel artemisinin-chloroquinoline hybrid compounds on ß-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum Structure-activity relationships for ferriprotoporphyrin IX association and ß-hematin inhibition by 4-aminoquinolines using experimental and ab initio methods Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies Antimalarial drug resistance: new treatments options for Plasmodium Synthesis, Antiplasmodial Activity, and ß-Hematin Inhibition of Hydroxypyridone-Chloroquine Hybrids Antiplasmodial activity of new 4-aminoquinoline derivatives against chloroquine resistant strain
4-bromo-N-[(E)-(3,4-dimethoxyphenyl)methyleneamino]aniline	Antimalarial Activity of Small-Molecule Benzothiazole Hydrazones
4-methoxyacetophenone thiosemicarbazone	Theoretical analysis of the binding of iron(III) protoporphyrin IX to 4-methoxyacetophenone thiosemicarbazone via DFT-D3, MEP, QTAIM, NCI, ELF, and LOL studies
4-oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,8a,9-tetramethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid	Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the Plasmodium Life Cycle
4-quinolinylydrazones	Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents
5-[(3-Aminoisoquinolin-6-yl)methyl]-4’-(trifluoromethyl)-[1,1’-biphenyl]-3-sulfonamide	Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents
5’-Hydroxyombuoside	Four new phenolic glycosides from Dobinea delavayi
5-Cyano-N,N-diphenylisophthalamide	Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum
5-Methyl-11-(diethylamino)-10H-indolo[3,2-b]quinolin-5-ium chloride	Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies
5-Nitro-N,N-di(pyridin-3-yl)isophthalamide	Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum
5-Nitro-N,N-di(pyridin-4-yl)isophthalamide	Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum
5-tert-butyl-N1,N3-bis(2-pyridyl)benzene-1,3-dicarboxamide	The Effects of Quinoline and Non-Quinoline Inhibitors on the Kinetics of Lipid-Mediated ß-Hematin Crystallization
5-tert-butyl-N1,N3-bis(4-pyridyl)benzene-1,3-dicarboxamide	The Effects of Quinoline and Non-Quinoline Inhibitors on the Kinetics of Lipid-Mediated ß-Hematin Crystallization
60% fraction of MeOH extract of Scrophularia Oxysepala	Chemical Composition and Biological Activities of Methanolic Extract of Scrophularia Oxysepala Boiss
6-Chloro-N2-(4-(7-chloroquinolin-4-ylamino)phenyl)-N4,N4-diisopropyl-1,3,5-triazine-2,4-diamine	Docking, synthesis and antimalarial activity of novel 4-anilinoquinoline derivatives
6-methyl-5h-indolo[2,3-b]quinoline	Synthesis and in vitro testing of antimalarial activity of non-natural-type neocryptolepines: structure–activity relationship study of 2,11- and 9,11-disubstituted 6-methylindolo[2,3-b]quinolines
7,9-dichloro-1-((2-(ethylamino)ethyl)amino)-3-(trifluoromethyl)benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile	Antimalarial Pyrido[1,2- a]benzimidazoles Exert Strong Parasiticidal Effects by Achieving High Cellular Uptake and Suppressing Heme Detoxification
78703-86-3	Synthesis, antimalarial activity and inhibition of haem detoxification of novel bisquinolines
7-chloro-2-quinoxalinecarbonitrile-1,4-di-n-oxide	Anti-malarial activity of some 7-chloro-2-quinoxalinecarbonitrile-1,4-di-N-oxide derivatives
7-Chloro-4-(ethylamino)quinoline	Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth
7-Chloro-4-[2-(N′-substituted aminomethyl)-N-ferrocenylmethyl- (amino-4,4′-dimethylpentyl)]quinoline	Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties
7-chloro-4-[4-[3-[4-(7-chloro-4,4a-dihydroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]-4,4a-dihydroquinoline	Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance
7-chloro-4-aminoquinoline	Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline
7-chloro-4-methylquinoline	Synthesis and antimalarial evaluation of new 1,4-bis(3-aminopropyl)piperazine derivatives
7-Chloro-N-((4’-((diethylamino)methyl)-[1,1’-biphenyl]-4-yl)methyl)quinolin-4-amine	Synthesis of New 4-Aminoquinolines and Evaluation of Their In Vitro Activity against Chloroquine-Sensitive and Chloroquine-Resistant Plasmodium falciparum
7-chloro-N-(1-methylheptyl)quinolin-4-amine	Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth
7-chloro-N-(2-(4-(4-ethynyl-2-fluorophenyl)-1H-1,2,3-triazol-1-yl)ethyl)quinolin-4-amine	Antiplasmodial Activity and In Vivo Bio-Distribution of Chloroquine Molecules Released with a 4-(4-Ethynylphenyl)-Triazole Moiety from Organometallo-Cobalamins
7‑Chloro‑N‑(2,3‑dihydro‑5,6‑dimethoxy‑1H‑inden‑2‑yl) quinolin‑4‑amine	Synthesis and in silico ADME/Tox profiling studies of heterocyclic hybrids based on chloroquine scaffolds with potential antimalarial activity
7-chloro-N-(3-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)quinolin-4-amine	Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs
7-chloro-N-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)quinolin-4-amine	Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs
7-chloro-N-(3-(4-(4-methoxyphenyl)piperazin-1-yl)propyl)quinolin-4-amine	Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs
7-chloro-N-(3-(4-phenylpiperazin-1-yl)propyl)quinolin-4-amine	Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs
7-Chloro-N-(4' -chloro-6-(piperidin-1-ylmethyl)-[1,1' - biphenyl]-3-yl)quinolin-4-amine dihydrochloride	Synthesis, ß-hematin inhibition studies and antimalarial evaluation of dehydroxy isotebuquine derivatives against Plasmodium berghei
7-Chloro-N-(4' -chloro-6-(pyrrolidin-1-ylmethyl)-[1,1' - biphenyl]-3-yl)quinolin-4-amine dihydrochloride	Synthesis, ß-hematin inhibition studies and antimalarial evaluation of dehydroxy isotebuquine derivatives against Plasmodium berghei
7-Chloro-N-(6-((diethylamino)methyl)-[1,1' -biphenyl]- 3-yl)quinolin-4-amine monohydrochloride	Synthesis, ß-hematin inhibition studies and antimalarial evaluation of dehydroxy isotebuquine derivatives against Plasmodium berghei
7-Chloro-N-(6-(morpholinomethyl)-[1,1' -biphenyl]-3- yl)quinolin-4-amine dihydrochloride	Synthesis, ß-hematin inhibition studies and antimalarial evaluation of dehydroxy isotebuquine derivatives against Plasmodium berghei
7-Chloro-N-(6-(piperidin-1-ylmethyl)-[1,10 -biphenyl]-3-yl)quinolin-4-amine dihydrochloride	Synthesis, ß-hematin inhibition studies and antimalarial evaluation of dehydroxy isotebuquine derivatives against Plasmodium berghei
7-Chloro-N-(6-(pyrrolidin-1-ylmethyl)-[1,1' -biphenyl]- 3-yl)quinolin-4-amine dihydrochloride	Synthesis, ß-hematin inhibition studies and antimalarial evaluation of dehydroxy isotebuquine derivatives against Plasmodium berghei
7-chloro-N-[(1R)-1-methyl-4-(4-methyl-1-piperazinyl)butyl]-4-quinolinamine	Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application
7-chloro-N-[[2-(ethylaminomethyl)ferrocen-1-yl]methyl]quinolin-4-amine	Plasmodium falciparum Plasmodium helical interspersed subtelomeric proteins contribute to cytoadherence and anchor P. falciparum erythrocyte membrane protein 1 to the host cell cytoskeleton
7-chloro-N-[2-(4-chloro-4-cyclopenta-1,3-dien-1-yl-5-oxa-3$l^5-azabicyclo[4.4.0]deca-1(6),2,7,9-tetraen-3-yl)ethyl]quinolin-4-amine	Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization and antimalarial properties
7-chloro-N-[2-[1-[2-[(7-chloro-4-quinolyl)amino]propyl]-4-piperidyl]-1-methyl-ethyl]quinolin-4-amine	Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance
7-chloro-N-[3-(diethylaminomethyl)phenyl]quinolin-4-amine	Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity
7-chloro-N-[3-(pyrrolidin-1-ylmethyl)phenyl]quinolin-4-amine	Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity
7-chloro-N-[4-methyl-3-(pyrrolidin-1-ylmethyl)phenyl]quinolin-4-amine	Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity
7-chloroquinoline	Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity
8-[1-[2-(aminoiminomethyl) hydrazono]ethyl]- 2-(butylimino)-1,2-dihydro-1,4- dimethylnaphtho[1,2-d]thiazol-5-ol monohydrochloride	In vitro and in vivo antimalarial activity of amphiphilic naphthothiazolium salts with amine-bearing side chains
8-aminoquinoline	Amino acid, dipeptide and pseudodipeptide conjugates of ring-substituted 8-aminoquinolines: synthesis and evaluation of anti-infective, ß-haematin inhibition and cytotoxic activities
8-hydroxyquinoline	Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds
9-(n-aminobutyl)amino-6-chloro-2-methoxyacridine	N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials
96% ethanol extract of root of Helianthus annuus	Targeting Plasmodium Plasmepsin V: Hitting Two Birds with One Stone
9-acrydinylhydrazones	Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents
9-anilinoacridine	Antimalarial 9-anilinoacridine compounds directed at hematin
Acridine	Antimalarial acridines: synthesis, in vitro activity against P. falciparum and interaction with hematin
Adenosylcobalamin	Naturally occurring cobalamins have antimalarial activity
Aminochloroquinoline	Kojic acid derived hydroxypyridinone-chloroquine hybrids: synthesis, crystal structure, antiplasmodial activity and ß-haematin inhibition
Aminopyridine	Synthesis, characterization and biological activity of new mixed ligand complexes of Zn(II) naproxen with nitrogen based ligands
Amodiaquine	A microtitre-based method for measuring the haem polymerization inhibitory activity (HPIA) of antimalarial drugs Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds Synthesis and antimalarial activity of new amino analogues of amodiaquine Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity Colorimetric high-throughput screen for detection of heme crystallization inhibitors Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth Bayesian models trained with HTS data for predicting ß-haematin inhibition and in vitro antimalarial activity Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds Plasmodium falciparum Plasmodium helical interspersed subtelomeric proteins contribute to cytoadherence and anchor P. falciparum erythrocyte membrane protein 1 to the host cell cytoskeleton Design, Synthesis and Evaluation of New Fluoroamodiaquine Analogues Antimalarial Quinoline Drugs Inhibit ß-Hematin and Increase Free Hemin Catalyzing Peroxidative Reactions and Inhibition of Cysteine Proteases
Amopyroquine	Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity
Andrographolide	In Vitro Antiplasmodium and Chloroquine Resistance Reversal Effects of Andrographolide
Apigenin	Molecular docking analysis of apigenin and quercetin from ethylacetate fraction of Adansonia digitata with malaria-associated calcium transport protein: An in silico approach
Aquocobalamin	Naturally occurring cobalamins have antimalarial activity
Artemether	A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds In vitro redox activity of haemozoin and ß-haemozoin interacting with the following antimalarials: artemether, lumefantrine and quinine
Artemisinin	A microtitre-based method for measuring the haem polymerization inhibitory activity (HPIA) of antimalarial drugs Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol A simple and inexpensive haemozoin-based colorimetric method to evaluate anti-malarial drug activity Glycosyl hydroperoxides: a new class of potential antimalarial agents Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds A second mechanism employed by artemisinins to suppress Plasmodium falciparum hinges on inhibition of hematin crystallization
Artesunate	Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds Artemisinin - Based Drugs Target the Plasmodium falciparum heme-detoxification pathway
Artesunate-heme	A Second Mechanism Employed by Artemisinins to Suppress Plasmodium Falciparum Hinges on Inhibition of Hematin Crystallization
Arylpyrrolylaminoquinolines	Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines
Atovaquone	Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials
BCQ	Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents
Benzimidazole	Investigation of antimalarial activity, cytotoxicity and action mechanism of piperazine derivatives of betulinic acid
Benzophenone	Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores
Benzopyrazolooxazine	Use of the NP-40 detergent-mediated assay in discovery of inhibitors of beta-hematin crystallization
Benzoxanthones	A physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs
Benzoxazine	Use of the NP-40 detergent-mediated assay in discovery of inhibitors of beta-hematin crystallization
Benzyl-1,4-naphthoquinones	A physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs
Benzylethene	Identification of ß-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity
berenil	Diamidine compounds: selective uptake and targeting in Plasmodium falciparum
bergenin	Antimalarial activity and safety assessment of Flueggea virosa leaves and its major constituent with special emphasis on their mode of action
Bilirubin	Bilirubin inhibits Plasmodium falciparum growth through the generation of reactive oxygen species
Biochem characterization, suggested target	Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasites
Bioesteric tetrazole	Double-drug development against antioxidant enzymes from Plasmodium falciparum
Bis-2-aminopyridinium	Potent antimalarial activity of 2-aminopyridinium salts, amidines, and guanidines
Bis-alkylamine quindolone	Bis-alkylamine quindolone derivatives as new antimalarial leads
Bis-amidine	Potent antimalarial activity of 2-aminopyridinium salts, amidines, and guanidines
Bisbenzamidines	Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities
Bis-guanidine	Potent antimalarial activity of 2-aminopyridinium salts, amidines, and guanidines
Bisphosphonate	Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials
Bisquinoline	Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers
bromoquine	Mode of action of quinoline antimalarial drugs in red blood cells infected by Plasmodium falciparum revealed in vivo
Carbodiimides	Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives
Chloro-N-(4-(3-(3,4-dimethoxybenzyl)pyrrolidin-1-yl)butyl)-2-methoxyacridin-9-amine	Pyrrolidine-Acridine hybrid in Artemisinin-based combination: a pharmacodynamic study
Chloroquine	A microtitre-based method for measuring the haem polymerization inhibitory activity (HPIA) of antimalarial drugs Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena A non-radiolabelled ferriprotoporphyrin IX biomineralisation inhibition test for the high throughput screening of antimalarial compounds Solution structures of antimalarial drug-heme complexes Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 1. Quantification of hemozoin development for drug sensitive versus resistant malaria Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in Plasmodium falciparum Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases Resonance Raman spectroscopy can detect structural changes in haemozoin (malaria pigment) following incubation with chloroquine in infected erythrocytes Colorimetric high-throughput screen for detection of heme crystallization inhibitors Aggregated enhanced Raman scattering in Fe(III)PPIX solutions: the effects of concentration and chloroquine on excitonic interactions Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA Solution behavior of hematin under acidic conditions and implications for its interactions with chloroquine Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds A physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs A novel way to grow hemozoin-like crystals in vitro and its use to screen for hemozoin inhibiting antimalarial compounds Synthesis and in vitro evaluation of new chloroquine-chalcone hybrids against chloroquine-resistant strain of Plasmodium falciparum Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum Antimalarial drug resistance: new treatments options for Plasmodium Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents Bayesian models trained with HTS data for predicting ß-haematin inhibition and in vitro antimalarial activity Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds 3-Iodo-4-aminoquinoline derivative sensitises resistant strains of Plasmodium falciparum to chloroquine Antimalarials inhibit hematin crystallization by unique drug-surface site interactions Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites Antimalarial Quinoline Drugs Inhibit ß-Hematin and Increase Free Hemin Catalyzing Peroxidative Reactions and Inhibition of Cysteine Proteases
Chromium protoporphyrin ix	In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum
Chromone	Synthesis, characterization and biological activity of new mixed ligand complexes of Zn(II) naproxen with nitrogen based ligands
Clotrimazole	Clotrimazole binds to heme and enhances heme-dependent hemolysis: proposed antimalarial mechanism of clotrimazole Effect of antifungal azoles on the heme detoxification system of malarial parasite Enhancement of heme-induced membrane damage by the anti-malarial clotrimazole: the role of colloid-osmotic forces Clotrimazole inhibits hemoperoxidase of Plasmodium falciparum and induces oxidative stress. Proposed antimalarial mechanism of clotrimazole Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies
clotrimazole	Applying malaria parasite's heme detoxification system for screening potential antimalarial drugs Disturbance in hemoglobin metabolism and in vivo antimalarial activity of azole antimycotics
Cobalt protoporphyrin ix	In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum
Cryptolepine	Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action
Crystal structure, suggested target	Alkoxide coordination of iron(III) protoporphyrin IX by antimalarial quinoline methanols: a key interaction observed in the solid-state and solution Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds
Cytochalasin d	Actin is required for endocytic trafficking in the malaria parasite Plasmodium falciparum A new model for hemoglobin ingestion and transport by the human malaria parasite Plasmodium falciparum
DCM extract of Scrophularia umbrosa	Phytochemical Analysis and In-vitro Bioactivity of Scrophularia umbrosa Rhizome ( Scrophulariaceae)
DCM extract of Scrophularia frigida	Screening of Anti-Malarial Activity of Different Extracts Obtained from Three Species of Scrophularia Growing in Iran
diamidine	Diamidine compounds: selective uptake and targeting in Plasmodium falciparum
dibemequine	4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice
dichloromethane extract of Trema orientalis	In vitro antiplasmodial activity and prophylactic potentials of extract and fractions of Trema orientalis (Linn.) stem bark
Dichlorophenyl)sulfonyl-amidephenyl]	Synthesis and antimalarial activity of sulfonamide chalcone derivatives
Diethyl(1-((1-([2,20:60,200-terpyridin]-40-yl)ethoxy)(1-hydroxy-2-methylpropan-2-yl)amino)-2,2-dimethylpropyl)phosphonate	Alkoxyamines Designed as Potential Drugs against Plasmodium and Schistosoma Parasites
Dihydroartemisinin	A microtitre-based method for measuring the haem polymerization inhibitory activity (HPIA) of antimalarial drugs
dihydroferrocenyl	Antiplasmodial activity of ferrocenyl chalcones: investigations into the role of ferrocene
Dihydroxynaphthoic acid	Oriented nucleation of hemozoin at the digestive vacuole membrane in Plasmodium falciparum
Diisopropyl 3-(5-isopropyl-4-methoxy-2-methylphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-pyrazole-1,2(3H)-dicarboxylate	Synthesis of thymol-based pyrazolines: An effort to perceive novel potent-antimalarials
Diospyros mespiliformis	ln vitro inhibition of beta-hematin formation and in vivo effects of Diospyros mespiliformis and Mondia whitei methanol extracts on chloroquine-susceptible Plasmodium berghei-induced malaria in mice
Dispiro-1,2,4,5-tetraoxanes	Influence of stereoisomer of dispiro-1,2,4,5-tetraoxanes on their binding mode with heme and on antimalarial activity: molecular docking studies
Docosahexaenoic acid	Docosahexaenoic acid is potent against the growth of mature stages of Plasmodium falciparum; inhibition of hematin polymerization a possible target
Ellagic acid	In vitro studies on the mechanism of action of two compounds with antiplasmodial activity: ellagic acid and 3,4,5-trimethoxyphenyl(6'-O-aalloyl)-beta-D-glucopyranoside
epoxy endoperoxide	Novel endoperoxide antimalarials: synthesis, heme binding, and antimalarial activity
Ethyl (±)-2-(2-chlorophenyl)-2-(1h-imidazol-1-yl)acetate	Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore
extracts of Eremostachys macrophylla	In vitro antimalarial activity of different extracts of Eremostachys macrophylla Montbr. & Auch
F. virosa leaves crude extract	Antimalarial activity and safety assessment of Flueggea virosa leaves and its major constituent with special emphasis on their mode of action
FCQ	Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents
Fe3O4-Q-He	Anti-plasmodial effects of quinine-loaded magnetic nanocomposite coated with heparin
ferrocene	Structural characteristics of chloroquine-bridged ferrocenophane analogues of ferroquine may obviate malaria drug-resistance mechanisms
Ferrocene covalently linked into a chloroquine	Ferrocene-chloroquine analogues as antimalarial agents: in vitro activity of ferrochloroquine against 103 Gabonese isolates of Plasmodium falciparum Probing the role of the covalent linkage of ferrocene into a chloroquine template
Ferrocenic mefloquine	Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents
ferrocenyl	Antiplasmodial activity of ferrocenyl chalcones: investigations into the role of ferrocene
Ferrocenyl carbohydrate conjugates	Synthesis, structure, and biological activity of ferrocenyl carbohydrate conjugates
ferrocenyl pyrrolo[1,2-a]quinoxaline	New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity--Part II
Ferroquine	Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA Antimalarial drug discovery - approaches and progress towards new medicines
ferroquine-derived polyamine	Ferroquine-derived polyamines that target resistant Plasmodium falciparum
FFCQ	Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents
Floxacrine	Short report: floxacrine analog WR 243251 inhibits hematin polymerization
fluconazole	Disturbance in hemoglobin metabolism and in vivo antimalarial activity of azole antimycotics
Gallium deuteroporphyrin ix	In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum
Gallium hematoporphyrin ix	In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum
Gallium protoporphyrin ix	In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum
glycosyl hydroperoxide	Glycosyl hydroperoxides: a new class of potential antimalarial agents
Halofantrine	Bayesian models trained with HTS data for predicting ß-haematin inhibition and in vitro antimalarial activity Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds
Halofantrine hydrochloride	The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex
heme binding oligonucleotide aptamers	Inhibiting Plasmodium falciparum growth and heme detoxification pathway using heme-binding DNA aptamers
Hexanoic acid	Double-drug development against antioxidant enzymes from Plasmodium falciparum
Hybrids of 4-aminoquinoline and pyrimidine moieties	Quinoline-pyrimidine hybrids: synthesis, antiplasmodial activity, SAR, and mode of action studies
Hydrazide,	Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores
Hydroquinine	The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex
Hydroxychloroquine	Double-drug development against antioxidant enzymes from Plasmodium falciparum
hydroxypiperaquine	Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases
Icl670	In vitro antimalarial activity of ICL670: a further proof of the correlation between inhibition of ß-hematin formation and of peroxidative degradation of hemin
Imidazo[2,1-a]isoindole	The imidazo[2,1-a]isoindole system. A new skeletal basis for antiplasmodial compounds
Imidazole	Use of the NP-40 detergent-mediated assay in discovery of inhibitors of beta-hematin crystallization Synthesis, characterization and biological activity of new mixed ligand complexes of Zn(II) naproxen with nitrogen based ligands
Imide	Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores
Indolo[3,2-c]quinoline	Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities Synthesis, ß-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11
Iron protoporphyrin ix	A novel endogenous antimalarial: Fe(II)-protoporphyrin IX alpha (heme) inhibits hematin polymerization to beta-hematin (malaria pigment) and kills malaria parasites
Isonitrile	In vivo active antimalarial isonitriles
Isopropyl 2-[(1-(3-(7-chloroquinolin-4-ylamino)propyl)-1H-1,2,3-triazol-4- yl)methoxy]-4-methyl-6-(4-nitrophenyl)pyrimidine-5-carboxylate	Pyrimidine-chloroquinoline hybrids: Synthesis and antiplasmodial activity
Isoxazoles	Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores
Jasplankinolide	Actin is required for endocytic trafficking in the malaria parasite Plasmodium falciparum A new model for hemoglobin ingestion and transport by the human malaria parasite Plasmodium falciparum
JPC-3210	Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum
Kalafungin	Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol
Ketoconazole	Effect of antifungal azoles on the heme detoxification system of malarial parasite
ketoconazole	Disturbance in hemoglobin metabolism and in vivo antimalarial activity of azole antimycotics
L. siceraria and ZnO NPs	Enhancing malaria control using Lagenaria siceraria and its mediated zinc oxide nanoparticles against the vector Anopheles stephensi and its parasite Plasmodium falciparum
Latrunculin a	Actin is required for endocytic trafficking in the malaria parasite Plasmodium falciparum
Manganese protoporphyrin ix	In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum
MCQ	Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents
Mefloquine	Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds Colorimetric high-throughput screen for detection of heme crystallization inhibitors Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and investigation of the presumed underlying mechanism of action Bayesian models trained with HTS data for predicting ß-haematin inhibition and in vitro antimalarial activity
Metaquine	Mapping antimalarial pharmacophores as a useful tool for the rapid discovery of drugs effective in vivo: design, construction, characterization, and pharmacology of metaquine
methyl 3-[5-[3-(1-benzylpyridin-1-ium-3-yl)propoxy]pentyl-tert-butoxycarbonyl-amino]propanoate	Revealing the Binding Process of New 3-Alkylpyridine Marine Alkaloid Analogue Antimalarials and the Heme Group: An Experimental and Theoretical Investigation
Methylcobalamin	Naturally occurring cobalamins have antimalarial activity
Methylene blue	A non-radiolabelled ferriprotoporphyrin IX biomineralisation inhibition test for the high throughput screening of antimalarial compounds A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds Interactions of the antimalarial drug methylene blue with methemoglobin and heme targets in Plasmodium falciparum: a physico-biochemical study A physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs
Miconazole	Effect of antifungal azoles on the heme detoxification system of malarial parasite
MMV000753	Identification of ß-hematin inhibitors in the MMV Malaria Box
MMV006767	Identification of ß-hematin inhibitors in the MMV Malaria Box
MMV007273	Identification of ß-hematin inhibitors in the MMV Malaria Box
Mmv007384	Identification of ß-hematin inhibitors in the MMV Malaria Box
Mmv008138	N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity
MMV011895	Identification of ß-hematin inhibitors in the MMV Malaria Box
MMV020750	Identification of ß-hematin inhibitors in the MMV Malaria Box
MMV665799	Identification of ß-hematin inhibitors in the MMV Malaria Box
MMV665888	Identification of ß-hematin inhibitors in the MMV Malaria Box
MMV666607	Identification of ß-hematin inhibitors in the MMV Malaria Box
MMV666689	Identification of ß-hematin inhibitors in the MMV Malaria Box
Monoquinoline	Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasites
Mono-salicylaldamine ferrocenyl quinoline	Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics
Morphology, suggested target	Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum
N-(1-(4-ethylpiperazin-1-yl)-3-methylbutan-2-yl)-7-(trifluoromethyl)quinolin-4-amine	Synthesis, Biological Evaluation, and Molecular Modeling Studies of Chiral Chloroquine Analogues as Antimalarial Agents
N-(2-((2-((1S,3R,4S,6R)-6-((S)-hydroxy(6-methoxyquinolin-4-yl)methyl)quinuclidin-3- yl)ethyl)thio)ethyl)-12-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)dodecanamide	Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum
N-(2-((2-((1S,3R,4S,6R)-6-((S)-hydroxy(6-methoxyquinolin-4-yl)methyl)quinuclidin-3- yl)ethyl)thio)ethyl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide,	Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum
N-(2-(4-([2,2′-bipyridin]-4-yl)-1H-1,2,3-triazol-1-yl)ethyl)-7-chloroquinolin-4-amin	Rhenium(I) derivatives of aminoquinoline and imidazolopiperidine-based ligands: Synthesis, in vitro and in silico biological evaluation against Plasmodium falciparum
N-(2-(6-chloro-3-(4-methoxy-3-(morpholinothio)phenyl)-2-methyl-2,3-dihydroimidazo[1,2-b]pyridazin-8-yl)ethyl)acetamide	Correlation study on methoxylation pattern of flavonoids and their heme-targeted antiplasmodial activity
N-(3-((4-(1H-benzo[d]imidazol-2-yl)piperazin-1-yl)- methyl)-4-fluorophenyl)-7-chloroquinolin-4-amine	Design, Synthesis and Evaluation of New Fluoroamodiaquine Analogues
N-(3-Fluoro-5-(trifluoromethyl)benzyl)-N-(pyrimidin-5-yl(1-(otolyl)-1H-tetrazol-5-yl)methyl)cyclopropanamine	Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum
N-(4-((4-methyl-6-(phenylamino)pyrimidin-2-yl)amino)phenyl)-2-oxochromane-3-carboxamide	Identifying inhibitors of ß-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches
N-(4-((tert-butylamino)methyl)phenyl)-7-chloroquinolin-4- amine hydrochloride	Synthesis, ß-hematin inhibition studies and antimalarial evaluation of new dehydroxy isoquine derivatives against Plasmodium berghei: A promising antimalarial agent
N-(4-(1H-benzo[d]imidazol-2-yl)cyclohexyl)-3,5-dinitrobenzamide	Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites
N-(4-(5-(1H-benzo[d]imidazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)-N-(1-isopentylpiperidin-4-yl)-4-pentylbenzamide	Downstream effects of haemoglobinase inhibition in Plasmodium falciparum-infected erythrocytes
N-(7-chloro-4-quinolyl)-1,4-diaminobutane	Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum
N-(7-chloro-4-quinolyl)-1,ndiaminoalkanes	4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria
N-(7-chloro-4-quinolyl)-N',N'-diethyl-ethane-1,2-diamine;hydrochloride	The Effects of Quinoline and Non-Quinoline Inhibitors on the Kinetics of Lipid-Mediated ß-Hematin Crystallization
N'-(7-chloro-4-quinolyl)-N-[2-[(7-chloro-4-quinolyl)amino]ethyl]ethane-1,2-diamine	Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers
N-(7-chloro-4-quinolyl)-n’,n’- diethyl-1,(n)-diaminoalkane	4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria
N-(7-chloro-4-quinolyl)-n′-(n″-t-boc-aminoethyl)-1,4-diaminobutane	Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth
N-(7-chloro-4-quinolyl)-n′-(n″-t-boc-aminoethyl)-n′-(3-hydroxypropyl)-1,4-diaminobutane	Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth
N-(7-chloro-4-quinolyl)-N'-isopropyl-ethane-1,2-diamine	Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA
N-(7-Chloroquinolin-4-yl)-N' -[(5-phenylfuran-2-yl)- methyl]propane-1,3-diamine	Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice
N-(7-Chloroquinolin-4-yl)-N' -[(5-phenylthiophen-2-yl) methyl]ethane-1,2-diamine	Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice
N-(7-Chloroquinolin-4-yl)-N' -{[5-(4-methylphenyl)thiophen-2-yl]methyl}ethane-1,2-diamine	Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice
N-(7-Chloroquinolin-4-yl)-N'-{[5-(4-fluorophenyl)thiophen-2-yl]methyl}ethane-1,2-diamine	Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice
N-(7-Chloroquinolin-4-yl)-N'-{[5-(4-methoxyphenyl)- thiophen-2-yl]methyl}propane-1,3-diamine	Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice
N,c-capped peptides	Comparison of hematin-targeting properties of pynacrine, an acridine analog of the benzonaphthyridine antimalarial pyronaridine
N,N-bis[2,8-bis(trifluoromethyl)quinolin-4-yl]diaminoethane	N,N-Bis(trifluoromethylquinolin-4-yl)diamino alkanes: synthesis and antimalarial activity
N',N'-dimethyl-N-[2-(2-naphthyl)-4-quinolyl]ethane-1,2-diamine	Bayesian models trained with HTS data for predicting ß-haematin inhibition and in vitro antimalarial activity
N-[(E)-(4-hydroxy-3-methoxy-phenyl)methyleneamino]-3-(p-tolyl)-1,2,4-oxadiazole-5-carboxamide	Conjugation of N-acylhydrazone and 1,2,4-oxadiazole leads to the identification of active antimalarial agents
N-[(E)-1,3-benzodioxol-5-ylmethyleneamino]-3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carboxamide	Conjugation of N-acylhydrazone and 1,2,4-oxadiazole leads to the identification of active antimalarial agents
N-[4-(7-Chloro-quinolin-4-ylamino)-phenyl]-N' -(3- morpholin-4-yl-propyl)-N''-phenyl-[1,3,5]triazine-2,4,6-triamine	4-anilinoquinoline triazines: a novel class of hybrid antimalarial agents
N-[4-[(7-chloro-4-quinolyl)amino]butyl]-3-hydroxy-propanamide	N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials
N-[4-[(7-chloro-4-quinolyl)amino]butyl]-4-hydroxy-pentanamide	N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials
N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-Ohexanoylbetulinamide	Investigation of antimalarial activity, cytotoxicity and action mechanism of piperazine derivatives of betulinic acid
N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-Oisovalerylbetulinamide	Investigation of antimalarial activity, cytotoxicity and action mechanism of piperazine derivatives of betulinic acid
N1 -(7-chloroquinolin-4-yl)-N2 -(6-methyl-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)- N 2 -(pyridin-2-ylmethyl)ethane-1,2-diam	N-Substituted aminoquinoline-pyrimidine hybrids: Synthesis, in vitro antimalarial activity evaluation and docking studies
N1 -(7-Chloroquinolin-4-yl)-N5 -{2-[(dimethylamino)methyl]benzyl}- pentan-1,5-diamine	Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents
N1 ,N1 - Diethyl-N4 -(5-methyl-5H-indolo[2,3-b]quinolin-8-yl)pentane-1,4-diamine	Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine
N1 -[2-(7-Chloroquinolin-4-ylamino)ethyl]-N2 -{2-[(dimethylamino)- methyl]ferrocenylmethyl}oxalamide	Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents
N1 -[5-(7-Chloroquinolin-4-ylamino)pentyl]-N5 -{2-[(dimethylamino)methyl]ferrocenylmethyl}oxalamide	Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents
N1 -[6-(7-Chloroquinolin-4-ylamino)hexyl]-N6 -{2-[(dimethylamino)- methyl]ferrocenylmethyl}oxalamide	Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents
N1-(4-Chloro-6-(piperidin-1-yl)-1,3,5-triazin-2-yl)-N4-(7-chloroquinolin-4-yl)benzene-1,4-diamine	Docking, synthesis and antimalarial activity of novel 4-anilinoquinoline derivatives
N1-(7-Chloro-4-quinolyl)-N2-ferrocenyl 1,2-ethanediamine	Probing the role of the covalent linkage of ferrocene into a chloroquine template
N1-(7-Chloro-4-quinolyl)-N3-ethyl-N3-ferrocenyl-1,3-propanediamine	Probing the role of the covalent linkage of ferrocene into a chloroquine template
N1-(7-Chloro-4-quinolyl)-N3-ferrocenyl-2,2-dimethyl-1,3-propanediamine	Probing the role of the covalent linkage of ferrocene into a chloroquine template
N1-(7-chloroquinolin-4-yl)-N4,N4-diethylbut-2-ene-1,4-diamine	Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity
N1-(7-chloroquinoline4-yl)-N2-(2-(4-ethylpiperazin-1-yl)-6-methylpyrimidin-4-yl)-N2-(furan-2-ylmethyl)ethane-1,2-diamine	Synthesis, antimalarial activity, heme binding and docking studies of N-substituted 4-aminoquinoline-pyrimidine molecular hybrids
N1-(Benzo[d][1,3]dioxol-5-ylmethyl)-N2-(7-chloroquinolin- 4-yl)-N1-(2-(4-ethylpiperazin-1-yl)-6-methylpyrimidin-4-yl) ethane-1,2-diamine	N-Piperonyl substitution on aminoquinoline-pyrimidine hybrids: Effect on the antiplasmodial potency
N1,N1-diethyl-N4-(10H-phenoxazin-2-yl)pentane-1,4-diamine	Adsorption to the surface of hemozoin crystals: Structure-based design and synthesis of new amino-phenoxazine ß-hematin inhibitors
N1,N1-diethyl-N4-(2-methyl-4-quinolyl)pentane-1,4-diamine	Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth
N1,N2-bis(7-chloro-4-quinolyl)cyclohexane-1,2-diamine	Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines
N1,N2-bis[7-(trifluoromethyl)-4-quinolyl]cyclohexane-1,2-diamine	Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines
N-2-((N,N-Dimethylamino)methyl)ferrocenemethyl 4-bromo-α-amino-o-cresol	The in Vitro Antiplasmodial and Antiproliferative Activity of New Ferrocene-Based a-Aminocresols Targeting Hemozoin Inhibition and DNA Interaction
N4-(7-chloro-4-quinolyl)-N1-ethyl-pentane-1,4-diamine	Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth
N4-[4-(diethylamino)-1-methyl-butyl]-2-methyl-quinoline-4,7-diamine	Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth
N5 -(7-Chloroquinolin-4-yl)-N2 -(2-(piperidin-1-yl)ethyl)- benzoxazole-2,5-diamine	Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies
N5 -(7-Chloroquinolin-4-yl)-N2 -(2-(pyrrolidin-1-yl)- ethyl)-benzoxazole-2,5-diamine	Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies
N5 -(7-Chloroquinolin-4-yl)-N2 -(2-morpholinoethyl)- benzoxazole-2,5-diamine	Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies
N5 -(7-Chloroquinolin-4-yl)-N2 -(3-(diethylamino)propyl)- benzoxazole-2,5-diamine	Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies
N5 -(7-Chloroquinolin-4-yl)-N2 -(3-(dimethylamino)- propyl)benzoxazole-2,5-diamine	Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies
N5 -(7-Chloroquinolin-4-yl)-N2 -(3-(piperidin-1-yl)- propyl)benzoxazole-2,5-diamine	Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies
N5 -(7-Chloroquinolin-4-yl)-N2 -(3-morpholinopropyl)- benzoxazole-2,5-diamine	Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies
nanaomycin A	Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol
nanaomycin D	Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol
Nanomimics of host cell membranes	Evaluation of naphthoquinones identified the acetylated isolapachol as a potent and selective antiplasmodium agent
Naphthylisoquinoline	Synthesis and pharmacological evaluation of fluorescent and photoactivatable analogues of antiplasmodial naphthylisoquinolines
Narasin	A physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs
N‑cinnamic	N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads
Neocryptolepine	Synthesis and antimalarial testing of neocryptolepine analogues: addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines
Nerolidylcatechol	Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice
Nicotinic acid	Pharmacophore based discovery of potential antimalarial agent targeting haem detoxification pathway
N-tert-Butyl-N′-(7-chloro-quinolin-4-yl)- ethane-1,2-diamine	Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum
N-tert-Butyl-N′-(7-trifluoromethyl-quinolin-4-yl)ethane- 1,2-diamine	Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum
O-(7-chloro-4-quinolyl)-n,ndiethylaminoalkanols	4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria
octahydro-1-methyl-1H-pyrido[1,2-a] pyrimidine	Synthesis of 1,3,5-trisubstituted pyrazolines as potential antimalarial and antimicrobial agents
-othiazole	Use of the NP-40 detergent-mediated assay in discovery of inhibitors of beta-hematin crystallization
Oxo-b-carbolines	In vitro and in vivo antimalarial activity of amphiphilic naphthothiazolium salts with amine-bearing side chains
Palladium protoporphyrin ix	In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum
Pentahydroxyxanthone	Xanthones as antimalarial agents: stage specificity
Pentamidine	Diamidine compounds: selective uptake and targeting in Plasmodium falciparum
Pepstatin a	Antiplasmodial activity of chloroquine analogs against chloroquine-resistant parasites, docking studies and mechanisms of drug action
Pf-calpain	Identification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug development
PfLPL1	An essential vesicular-trafficking phospholipase mediates neutral lipid synthesis and contributes to hemozoin formation in Plasmodium falciparum
Phenyl benzamide	Identification of ß-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity
Phenylurenyl chalcone	Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives
Piperaquine	Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds Plasmodium falciparum GPCR-like receptor SR25 mediates extracellular K + sensing coupled to Ca 2+ signaling and stress survival
Piperazine	Investigation of antimalarial activity, cytotoxicity and action mechanism of piperazine derivatives of betulinic acid
Primaquine	A microtitre-based method for measuring the haem polymerization inhibitory activity (HPIA) of antimalarial drugs
propamidine	Diamidine compounds: selective uptake and targeting in Plasmodium falciparum
Pynacrine	Comparison of hematin-targeting properties of pynacrine, an acridine analog of the benzonaphthyridine antimalarial pyronaridine
Pyridyl ester	Synthesis and evaluation of new polynuclear organometallic Ru(II), Rh(III) and Ir(III) pyridyl ester complexes as in vitro antiparasitic and antitumor agents
Pyrimethamine	Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials
Pyronaridine	Antimalarials inhibit hematin crystallization by unique drug-surface site interactions
Pyrrolo[1,2-a]quinoxaline	New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity
Quaternary ammonium compounds	Heme binding contributes to antimalarial activity of bis-quaternary ammoniums
Quinacrine	Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds Colorimetric high-throughput screen for detection of heme crystallization inhibitors Bayesian models trained with HTS data for predicting ß-haematin inhibition and in vitro antimalarial activity Antimalarial Quinoline Drugs Inhibit ß-Hematin and Increase Free Hemin Catalyzing Peroxidative Reactions and Inhibition of Cysteine Proteases
Quinidine	A microtitre-based method for measuring the haem polymerization inhibitory activity (HPIA) of antimalarial drugs Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum Bayesian models trained with HTS data for predicting ß-haematin inhibition and in vitro antimalarial activity Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum
Quinidine hydrochloride monohydrate	The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex
Quinine	Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena A non-radiolabelled ferriprotoporphyrin IX biomineralisation inhibition test for the high throughput screening of antimalarial compounds Solution structures of antimalarial drug-heme complexes A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds A physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum A novel flow cytometric hemozoin detection assay for real-time sensitivity testing of Plasmodium falciparum Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum Antimalarials inhibit hematin crystallization by unique drug-surface site interactions
Quinine analogues	Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents
Quinine dihydrochloride	The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex
Quinoline-5,8-dione	Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents
Quinolone	In vitro antimalarial activity, ß-haematin inhibition and structure-activity relationships in a series of quinoline triazoles
Radicicol	Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol
Rhodium complex	Improved antiparasitic activity by incorporation of organosilane entities into half-sandwich ruthenium(II) and rhodium(III) thiosemicarbazone complexes
Ruthenium	The mechanism of antimalarial action of the ruthenium(II)-chloroquine complex [RuCl(2)(CQ)] (2)
s [{Ir (Cp*)}4(μ-η2 -η2 -C2O4)(μ-L)2](CF3SO3)4	Modular synthesis of antimalarial quinoline-based PGM metallarectangles
S-(7-chloro-4-quinolyl)-n- (n,n-diethylamino)alkanethiols	4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria
Silver protoporphyrin ix	In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum
stilbamidine	Diamidine compounds: selective uptake and targeting in Plasmodium falciparum
tert-Butyl (4-{5-[({2-[(7-chloroquinolin-4-yl)amino]- ethyl}amino)methyl]thiophen-2-yl}phenyl)carbamate	Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice
tert-butyl N-[9-[3-(3-pyridyl)propoxy]nonyl]carbamate	Revealing the Binding Process of New 3-Alkylpyridine Marine Alkaloid Analogue Antimalarials and the Heme Group: An Experimental and Theoretical Investigation
tetra-hydrocannabinol	THC shows activity against cultured Plasmodium falciparum
Tetraquinoline	Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers
Theoretical analysis of drug requierment	Classification models for neocryptolepine derivatives as inhibitors of the ß-haematin formation
Thieno[2,3-b]pyridines	Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine
Thionine	A non-radiolabelled ferriprotoporphyrin IX biomineralisation inhibition test for the high throughput screening of antimalarial compounds
Tin protoporphyrin ix	Inhibition of hemozoin formation in Plasmodium falciparum trophozoite extracts by heme analogs: possible implication in the resistance to malaria conferred by the beta-thalassemia trait In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum
trans-N1,N2-bis-(2,8-bis-trifluoromethyl-quinolin-4-yl) cyclohexane-1,2-diamine	Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines
Triaryl imidizole	Identification of ß-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity
Triarylcarbinol	Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores
Trifluoromethyl-substituted N∧gN-coordinated Ir(III)-Cp*complex	Antimicrobial evaluation of neutral and cationic iridium(III) and rhodium(III) aminoquinoline-benzimidazole hybrid complexes
Trisquinolines	Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers
Triterpene	Investigation of antimalarial activity, cytotoxicity and action mechanism of piperazine derivatives of betulinic acid
UTDIF6C12	Prediction Model for Antimalarial Activities of Hemozoin Inhibitors by Using Physicochemical Properties
various knockouts	In silico multiple-targets identification for heme detoxification in the human malaria parasite Plasmodium falciparum
Verapamil	Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 1. Quantification of hemozoin development for drug sensitive versus resistant malaria
WR 238605	8-Aminoquinolines active against blood stage Plasmodium falciparum in vitro inhibit hematin polymerization
WR 242511	8-Aminoquinolines active against blood stage Plasmodium falciparum in vitro inhibit hematin polymerization
WR 249420	8-Aminoquinolines active against blood stage Plasmodium falciparum in vitro inhibit hematin polymerization
WR 268658	8-Aminoquinolines active against blood stage Plasmodium falciparum in vitro inhibit hematin polymerization
Xanthones	A physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs
Zinc protoporphyrin ix	Inhibition of hemozoin formation in Plasmodium falciparum trophozoite extracts by heme analogs: possible implication in the resistance to malaria conferred by the beta-thalassemia trait Zinc protoporphyrin IX binds heme crystals to inhibit the process of crystallization in Plasmodium falciparum
Zinc valporate	New mixed ligand zinc(II) complexes based on the antiepileptic drug sodium valproate and bioactive nitrogen-donor ligands. Synthesis, structure and biological properties
Znbg	Inhibition of hemozoin formation in Plasmodium falciparum trophozoite extracts by heme analogs: possible implication in the resistance to malaria conferred by the beta-thalassemia trait
Α,ω-(7-chloro-4-quinolyl) alkanediols	4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria

Related Maps

Hemozoin and b-hematin formation map details

PFID	PFID Old	Annotation	Formal Annotation	EC
PF3D7_1115300	PF11_0161	falcipain 2b	falcipain 2' cysteine proteinase falcipain 2b	3.4.22.-
PF3D7_1446800	PF14_0446	Heme detoxification protein	heme detoxification protein
PF3D7_1408100	PF14_0078	histo-aspartic protease	plasmepsin III histo-aspartic protease	3.4.23.-
PF3D7_1408000	PF14_0077	plasmepsin II	plasmepsin II	3.4.23.39
PF3D7_1407800	PF14_0075	plasmepsin IV	plasmepsin IV	3.4.23.-

Total number of related proteins: 1

#	PFID	Formal Name
1	PF11_0161	falcipain 2' cysteine proteinase falcipain 2b

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0075	plasmepsin IV

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0077	plasmepsin II

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0078	plasmepsin III histo-aspartic protease

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0446	heme detoxification protein

Malaria Parasite Metabolic Pathways

Drugs affecting pathway with unknown specific target

Related Maps

Hemozoin and b-hematin formation map details

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 1