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Rab proteins |
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Guided by: Kinchen JM, Ravichandran KS. Phagosome maturation: going through the acid test. Nat Rev Mol Cell Biol. 2008 9:781-95. PMID:18813294 |
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Generic name |
PfID |
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Annotation |
Transcript |
Role |
Associated Phosphoinositide |
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| 8282 |
Rab1 |
PF3D7_0513800 |
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ras-related protein Rab-1A |
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ER to Golgi transport |
PtdIns(3)P (ER) PtdIns(4)P (Golgi) |
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| 8281 |
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PF3D7_0512600 |
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ras-related protein Rab-1B |
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ER to Golgi transport |
PtdIns(3)P (ER) PtdIns(4)P (Golgi) |
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| 8286 |
Rab2 |
PF3D7_1231100 |
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ras-related protein Rab-2 |
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ER to Golgi transport |
PtdIns(3)P |
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| 8279 |
Rab5 |
PF3D7_0211200 |
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ras-related protein Rab-5A |
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Intermediate between plasma membrane and early endosome and/or rrecycling endosomes, etc |
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| 8287 |
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PF3D7_1310600 |
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ras-related protein Rab-5B secretory complex protein 61 alpha |
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secretory complex protein 61 alpha |
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| 8278 |
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PF3D7_0106800 |
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ras-related protein Rab-5C |
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Endosome-endosome and/or fusion of vacuoles |
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| 8285 |
Rab6 |
PF3D7_1144900 |
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ras-related protein Rab-6 |
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Intra-Golgi trafic; Retrograde transport, Golgi to ER |
PtdIns(4)P |
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| 8284 |
Rab7 |
PF3D7_0903200 |
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ras-related protein RAB7 |
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Trafficking from early to late endosome/lysosome |
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| 8288 |
Rab11 |
PF3D7_1320600 |
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ras-related protein Rab-11A |
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Transport from Golgi to polarized membrane (apical face), V-ATPase dependent transport |
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| 8289 |
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PF3D7_1340700 |
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ras-related protein Rab-11B |
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Not expressed in erythrcoytic satge; Recycling endosomes; Cytokinesis |
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| 8290 |
Rab14 |
PF3D7_1348100 |
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GTPase, putative |
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Phagosome and early endosome fusion, trafficking between early endosomes and Golgi |
PtdIns(3)P (Ea End) PtdIns(4)P (TGN) |
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| 8283 |
Rab18 |
PF3D7_0807300 |
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ras-related protein Rab-18 |
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ER to Golgi transport, stabilization of ER |
PtdIns(3)P |
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| 8280 |
Rab5ip |
PF3D7_0414300 |
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Rab5-interacting protein, putative |
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Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5 |
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Rab homologs not found in the genome but their sequences Blast well with existing Rab genes |
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Blasts with |
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Rab8 |
Rab1b, GTPase |
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Trafficking between Golgi, endosomes, and plasma membrane |
activates PIP5KI |
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Rab9 |
PfRab7, or Rab1a |
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Lysosomal enzyme trafficking, late endosome to trans-Golgi transport |
PtdIns(3,5)P2 (La End) |
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Rab10 |
Rab1b, Rab 1a |
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Transport form Golgi to polarized membrane (basolateral face). May cooperate with Rab8 |
PtdIns(3)P |
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Rab20 |
Rab11b |
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apical transport, Golgi, v-ATPase trafficking |
? |
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Rab22 |
Rab5c, Rab6 |
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Trans-Golgi-endosome transport |
PtdIns(3)P |
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Rab23 |
Rab1a |
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Endosomes and plasma membrane; Protein recycling/transport to plasma membrane |
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Rab32 |
Rab1a, Rab7 |
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Mitochondria? |
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Rab33 |
Rab1a,Rab1b |
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Retrograde transport from Golgi to ER |
PtdIns(3)P |
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Rab35 |
Rab1a |
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Cytokinesis |
PtdIns(3)P |
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No orthologs in Pf genome |
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Rab3 |
NO |
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Exocytosis |
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