Rab proteins
Guided by: Kinchen JM, Ravichandran KS. Phagosome maturation: going through the acid test. Nat Rev Mol Cell Biol. 2008 9:781-95. PMID:18813294
Generic name PfID Annotation Transcript Role Associated Phosphoinositide
8282 Rab1 PF3D7_0513800
ras-related protein Rab-1A
ER to Golgi transport PtdIns(3)P (ER)   PtdIns(4)P (Golgi)
8281 PF3D7_0512600
ras-related protein Rab-1B
ER to Golgi transport PtdIns(3)P (ER)   PtdIns(4)P (Golgi)
8286 Rab2 PF3D7_1231100
ras-related protein Rab-2
ER to Golgi transport PtdIns(3)P
8279 Rab5 PF3D7_0211200
ras-related protein Rab-5A
Intermediate between plasma membrane and early endosome and/or rrecycling endosomes, etc
8287 PF3D7_1310600
ras-related protein Rab-5B secretory complex protein 61 alpha
secretory complex protein 61 alpha     
8278 PF3D7_0106800
ras-related protein Rab-5C Endosome-endosome and/or fusion of vacuoles
8285 Rab6 PF3D7_1144900
ras-related protein Rab-6
Intra-Golgi trafic; Retrograde transport, Golgi to ER PtdIns(4)P
8284 Rab7 PF3D7_0903200
ras-related protein RAB7
Trafficking from early to late endosome/lysosome
8288 Rab11 PF3D7_1320600
ras-related protein Rab-11A
Transport from Golgi to polarized membrane (apical face), V-ATPase dependent transport
8289 PF3D7_1340700
ras-related protein Rab-11B
Not expressed in erythrcoytic satge; Recycling endosomes; Cytokinesis
8290 Rab14 PF3D7_1348100 GTPase, putative
Phagosome and early endosome fusion, trafficking between early endosomes and Golgi PtdIns(3)P (Ea End) PtdIns(4)P (TGN)
8283 Rab18 PF3D7_0807300
ras-related protein Rab-18
ER to Golgi transport, stabilization of ER PtdIns(3)P
8280 Rab5ip PF3D7_0414300 Rab5-interacting protein, putative Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5
Rab homologs not found in the genome but their sequences Blast well with existing Rab genes
Blasts with
Rab8 Rab1b, GTPase Trafficking between Golgi, endosomes, and plasma membrane activates PIP5KI
Rab9 PfRab7, or Rab1a Lysosomal enzyme trafficking, late endosome to trans-Golgi transport PtdIns(3,5)P2 (La End)
Rab10 Rab1b,  Rab 1a Transport form Golgi to polarized membrane (basolateral face). May cooperate with Rab8 PtdIns(3)P
Rab20 Rab11b apical transport, Golgi, v-ATPase trafficking ?
Rab22 Rab5c, Rab6 Trans-Golgi-endosome transport PtdIns(3)P
Rab23 Rab1a Endosomes and plasma membrane; Protein recycling/transport to plasma membrane
Rab32 Rab1a, Rab7 Mitochondria?
Rab33 Rab1a,Rab1b Retrograde transport from Golgi to ER PtdIns(3)P
Rab35 Rab1a Cytokinesis PtdIns(3)P
No orthologs in Pf genome
Rab3 NO Exocytosis
Online articles related to Rab proteins retrieved from PubMed