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Characteristics of Plasmodium falciparum export proteins that remodel infected erythrocyte |
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Prajapati SK, Singh OP. Remodeling of human red cells infected with Plasmodium falciparum and the impact of PHIST proteins. Blood Cells Mol Dis. 2013 Oct;51(3):195-202. PMID: 23880461. |
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PfID |
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Annotation |
Transcript |
Sub-cellular location |
Putative function |
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RBC cytoplasm RBCMS modifying proteins |
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| 8682 |
PF3D7_0202000 |
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knob-associated histidine-rich protein |
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RBCMS |
Essential for knob formation; binds to RBC spectrin, actin and cytoplasmic tail of PfEMP-1 |
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| 8695 |
PF3D7_0500800 |
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erythrocyte membrane protein 2 mature parasite-infected erythrocyte surface antigen |
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RBCMS |
Binds to RBC protein 4.1 |
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| 8679 |
PF3D7_0102200 |
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ring-infected erythrocyte surface antigen |
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RBCMS |
Binds to RBC spectrin and has a role in changing RBC rigidity and influence the dynamic microcirculatory behavior in ring stage |
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| 8681 |
PF3D7_0201900 |
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erythrocyte membrane protein 3 |
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RBCMS |
MC Appears to be involved in trafficking of PfEMP-1 and also it destabilizes erythrocyte membrane skeleton |
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| 26262 |
PF3D7_1149000 |
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antigen 332, DBL-like protein |
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RBC cytoplasm |
Binds with actin protein and provides deformability to erythrocyte |
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Remodeling proteins that establish trafficking machinery |
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| 8717 |
PF3D7_1436300 |
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translocon component PTEX150 |
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PVM |
Core translocation complex |
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| 8709 |
PF3D7_1116800 |
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heat shock protein 101 chaperone protein ClpB2 |
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PVM |
Molecular chaperon assist denature and renature of exported proteins in PVM |
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| 8692 |
PF3D7_0416800 |
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small GTP-binding protein sar1 |
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MC |
Small GTPase |
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| 8684 |
PF3D7_0214100 |
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protein transport protein SEC31 |
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MC |
COPII coat protein |
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| 8701 |
PF3D7_0822600 |
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protein transport protein SEC23 |
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MC |
COPII coat protein |
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| 8687 |
PF3D7_0303000 |
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N-ethylmaleimide-sensitive fusion protein |
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MC, RBC cytoplasm |
Vesicle fusion component |
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Membrane proteins |
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| 8718 |
PF3D7_1471100 |
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exported protein 2 |
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PVM and TVN |
Member of the core complex of translocons and forms pore like structure that enables translocation of exported proteins beyond PVM |
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| 8710 |
PF3D7_1121600 |
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parasitophorous vacuole membrane antigen QF 116 exported protein 1 circumsporozoite-related antigen |
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PVM and TVN |
NK |
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| 8720 |
PfEMP1 |
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PfEMP1 |
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RBC surface |
Major virulence factor and cytoadhering ligand; involved in antigenic variation |
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| 8715 |
PF3D7_1353200 |
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membrane associated histidine-rich protein 2 |
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MC |
Maintenance of MC morphology and trafficking of PfEMP-1 from PV to MC |
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| 8696 |
PF3D7_0501300 |
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skeleton-binding protein 1 |
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MC |
MC resident protein and plays important role in trafficking of PfEMP-1 from MC to surface of erythrocyte |
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| 8721 |
RIFIN |
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RIFIN |
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MC, RBC surface |
Member of RBCMS complex and plays a role in resetting |
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STEVOR |
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STEVOR |
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MC, RBC surface |
Possibly antigenic variation |
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SURFIN |
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SURFIN |
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MC, RBC surface |
Possibly antigenic variation |
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| 8698 |
PF3D7_0631400 |
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Pfmc-2TM Maurer's cleft two transmembrane protein |
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MC |
Possibly involved in antigenic variation |
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| 8683 |
PF3D7_0202500 |
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early transcribed membrane protein 2 |
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PVM TVN and MC |
NK |
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| 8693 |
PF3D7_0423700 |
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early transcribed membrane protein 4 |
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PVM |
NK |
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| 8702 |
PF3D7_0935900 |
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ring-exported protein 1 |
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MC |
Maintenance of MC architecture and essential for assembly of virulence complex at the surface of erythrocyte |
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| 8703 |
PF3D7_0936000 |
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ring-exported protein 2 |
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MC |
NK |
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| 8711 |
PF3D7_1121700 |
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ABC transporter F family member 2 protein GCN20 |
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PVM, RBC cytoplasm |
Membrane protein: transporter component |
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| 8694 |
PF3D7_0424600 |
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plasmodium exported protein (phistb) |
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NK |
Reduction and/or lack of knobs on erythrocyte surface |
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| 8708 |
PF3D7_1039100 |
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DnaJ protein, putative, pseudogene? MEC domain-containing protein |
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NK |
Reduction and/or lack of knobs on erythrocyte surface |
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| 15948 |
PF3D7_0911300 |
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cysteine repeat modular protein 1 |
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MC |
colocalize with PfEMP1 during its export |
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| 15947 |
PF3D7_0718300 |
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cysteine repeat modular protein 2 |
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MC |
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RBC membrane rigidity |
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| 8719 |
PF3D7_1478600 |
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EMP1-trafficking protein |
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RBC cytoplasm |
RBC membrane rigidity |
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| 8706 |
PF3D7_1016300 |
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glycophorin binding protein |
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RBC cytoplasm |
RBC membrane rigidity |
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| 8679 |
PF3D7_0102200 |
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ring-infected erythrocyte surface antigen |
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RBC membrane |
RBC membrane rigidity |
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| 8685 |
PF3D7_0220100 |
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DnaJ protein, putative |
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NK |
RBC membrane rigidity |
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| 8690 |
PF3D7_0404600 |
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conserved Plasmodium membrane protein, unknown function |
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NK |
RBC membrane rigidity |
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| 8699 |
PF3D7_0730900 |
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EMP1-trafficking protein |
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NK |
RBC membrane rigidity |
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| 8705 |
PF3D7_1002100 |
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EMP1-trafficking protein |
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NK |
RBC membrane rigidity |
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| 24565 |
PF3D7_0801900 |
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lysine-specific histone demethylase, putative |
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NK |
RBC membrane rigidity |
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| 8714 |
PF3D7_1301400 |
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Plasmodium exported protein (hyp12), unknown function |
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NK |
RBC membrane rigidity |
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| 8716 |
PF3D7_1401600 |
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Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein |
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NK |
RBC membrane rigidity |
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| 8695 |
PF3D7_0500800 |
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erythrocyte membrane protein 2 mature parasite-infected erythrocyte surface antigen |
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RBCMS |
Binds with RBC cytoskeleton and possibly involved in RBC |
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| 8707 |
PF3D7_1038800 |
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RESA-like protein with PHIST and DnaJ domains? MEC domain-containing protein |
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RBCMS |
Binds with RBC cytoskeleton and possibly involved in RBC |
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| 8680 |
PF3D7_0114000 |
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exported protein family 1; MEC domain-containing protein |
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RBCMS |
Binds with RBC cytoskeleton and possibly involved in RBC |
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| 8686 |
PF3D7_0220400 |
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DnaJ protein, putative, pseudogene; MEC domain-containing protein |
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RBCMS |
Binds with RBC cytoskeleton and possibly involved in RBC |
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| 8689 |
PF3D7_0402100 |
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Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein |
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RBCMS |
Binds with RBC cytoskeleton and possibly involved in RBC |
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| 8697 |
PF3D7_0631100 |
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Plasmodium exported protein (PHISTb), unknown function |
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RBCMS |
Binds with RBC cytoskeleton and possibly involved in RBC |
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| 8704 |
PF3D7_0937000 |
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Plasmodium exported protein (PHISTb), unknown function; MEC domain-containing protein |
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RBCMS |
Binds with RBC cytoskeleton and possibly involved in RBC |
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| 8688 |
PF3D7_0402000 |
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Plasmodium exported protein (PHISTa), unknown function |
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PVM |
Binds with RBC cytoskeleton protein band 4.1R and modulates PVM |
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| 8691 |
PF3D7_0406200 |
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parasitophorous vacuole membrane protein s16; sexual stage-specific protein s16 |
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NK |
Possible role in remodeling of erythrocyte at gametocyte stage |
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| 26261 |
PF3D7_0424700 |
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serine/threonine protein kinase, FIKK family |
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K-dots |
Deletion leads to decreased rigidity and decreased cytoadhesion |
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| 26262 |
PF3D7_1149000 |
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antigen 332, DBL-like protein |
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MC, RBC surface |
Deletion leads to decreased rigidity and decreased cytoadhesion |
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TVN: tubulovesicular membrane, NK: not known |
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