Genes coding for Fe-S containing proteins
Swift RP, Rajaram K, Elahi R, Liu HB, Prigge ST. Roles of Ferredoxin-Dependent Proteins in the Apicoplast of Plasmodium falciparum Parasites. mBio. 2022 Feb 15:e0302321. PMID: 35164549.
PfID Annotation Signal peptide Transit peptide P. falciparum1 P. falciparum (This study) E.C Transcript
PF3D7_1344600
lipoyl synthase ++ ++ Essential Dispensable 2.8.1.8
PF3D7_0921400
NifU-like scaffold protein ++ ++ Essential Dispensable
PF3D7_1103400
sulfur cluster assembly protein SufD ++ ++ Essential
PF3D7_716600 ++ ++ Slow/ Dispensable
PF3D7_522700 ++ ++ Essential Dispensable
PF3D7_1318100 ferredoxin, putative ++ ++ Slow/ Dispensable Essential
PF3D7_910800 ++ ++ Slow
PF3D7_622200 + ++ Dispensable Dispensable
PF3D7_1022800
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), putative + ++ Essential Essential 1.17.7.1
PF3D7_910900 - ++ Essential
PF3D7_1342100
aconitate hydratase - ++ Slow/ Dispensable 4.2.1.3
PF3D7_1214600 adrenodoxin-type ferredoxin, putative - ++ Slow/ Essential
PF3D7_1454500 iron-sulfur cluster assembly protein ISCU - ++ Essential
PF3D7_207200 - ++ Essential
PF3D7_727200 - ++ Slow/ Essential
PF3D7_720400 - ++ Dispensable
PF3D7_614800 - ++ Dispensable
PF3D7_1220500 ribosome biogenesis protein TSR3, putative - ++ Essential
PF3D7_1361600 Fe-S assembly protein iscx, putative - ++ Essential
PF3D7_1439400
cytochrome b-c1 complex subunit Rieske, putative - ++ Dispensable 1.10.2.2
PF3D7_927300 - ++ Essential
PF3D7_1212800
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial - ++ Dispensable 1.3.99.1
PF3D7_709200 - ++ Dispensable
PF3D7_416700 - ++ Dispensable
PF3D7_930900 - ++ Dispensable
PF3D7_1306300 SAM dependent methyltransferase, putative - ++ Dispensable 2.1.1.35
PF3D7_API04700 iron-sulfur cluster assembly protein SUFb - ++ ND
PF3D7_1472700 DNA-directed RNA polymerase, alpha subunit, putative + + Essential 2.7.7.6
PF3D7_1406900 radical SAM protein, putative - + Essential
PF3D7_322500 - + Dispensable
PF3D7_104400 - - Dispensable Essential
PF3D7_1017000
DNA polymerase delta catalytic subunit - - Essential 2.7.7.7
PF3D7_934100 - - Essential
PF3D7_1128500 Fe-S cluster assembly factor hcf101, putative - - Essential
PF3D7_1227800 elongator complex protein 3, putative - - Slow/ Dispensable 2.3.1.48
PF3D7_1022900 COX13 CDGSH iron-sulfur domain-containing protein, putative - - Dispensable
PF3D7_0524900 S-adenosyl-l-methionine-dependent trna 4-demethylwyosine synthase, putative - - Dispensable 4.1.3.44
PF3D7_1458700
exonuclease V, mitochondrial, putative - - Essential 3.1.11.5
PF3D7_1238800
acyl-CoA synthetase - - Essential 6.2.1.3
PF3D7_1435300
glutamate synthase [NADH], putative - - Dispensable 1.4.1.14
PF3D7_606900 - - Essential
PF3D7_1408400 FANCJ-like helicase, putative - - Essential 3.6.4.12
PF3D7_1143300 DNA-directed RNA polymerases I and III subunit RPAC1, putative - - Essential 2.7.7.6
PF3D7_515800 - - Essential
PF3D7_1415200 DNA-directed RNA polymerases I and III subunit RPAC2, putative - - Essential 2.7.7.6
PF3D7_1413800 diphthamide biosynthesis protein 1, putative - - Slow/ Dispensable 6.3.2.22
PF3D7_923000 - - Essential
PF3D7_614200 - - Essential
PF3D7_1324500 DEAD box helicase, putative - - Essential
PF3D7_302700 - - Essential
PF3D7_1129500 A/G-specific adenine glycosylase, putative - - Dispensable 3.2.2.20
PF3D7_306300 - - Essential
PF3D7_824600 - - Essential
PF3D7_1368200
ABC transporter E family member 1, putative - 0 Essential
1. Zhang M, Wang C, Otto TD, Oberstaller J, Liao X, Adapa SR, Udenze K, Bronner IF, Casandra D, Mayho M, Brown J, Li S, Swanson J, Rayner JC ,Jiang RHY, Adams JH. 2018. Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis. Science 360:eaap7847.
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