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RNA Degradation Factors |
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Compiled according to Houseley J, Tollervey D. The many pathways of RNA degradation. Cell. 2009 Feb 20;136(4):763-76. Review. PubMed PMID: 19239894, guided by S. cerevisiae orthologs |
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Sc ortholog |
PfID |
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Annotation |
Transcript |
EC# |
Role |
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5'-End Processing Enzymes |
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15753 |
Dcp1 |
PF3D7_1032100 |
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mRNA-decapping enzyme subunit 1, putative |
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Member of decapping complex with Dcp2 |
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15764 |
Dcp2 |
PF3D7_1308900 |
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mRNA-decapping enzyme 2, putative |
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Catalytic pyrophosphatase subunit of decapping complex |
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15755 |
Rat1 |
PF3D7_1106300 |
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5'-3' exoribonuclease 1, putative |
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3.1.4.1 |
Nuclear 5' Exonuclease |
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15755 |
Xrn1 |
PF3D7_1106300 |
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5'-3' exoribonuclease 1, putative |
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3.1.4.1 |
Cytoplasmic 5' Exonuclease |
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15748 |
Xrn1 |
PF3D7_0909400 |
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exoribonuclease, putative |
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3.1.13.1 |
Cytoplasmic 5' Exonuclease |
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Core Exosome Highly conserved RNA decay complex |
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15770 |
Rrp44 |
PF3D7_1359300 |
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exosome complex exonuclease RRP44 |
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3.1.16.1 |
3' hydrolytic Exonuclease and endonuclease activity |
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15745 |
Csl4 |
PF3D7_0720000 |
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exosome complex component CSL4, putative |
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3.1.13.1 |
Member of core Exosome complex |
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15739 |
Rrp4 |
PF3D7_0410400 |
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exosome complex component RRP4, putative |
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Member of core Exosome complex |
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15763 |
Rrp40 |
PF3D7_1307000 |
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exosome complex component RRP40, putative |
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Member of core Exosome complex |
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15773 |
Rrp41 |
PF3D7_1427800 |
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exosome complex exonuclease RRP41, putative |
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3.1.13.1 |
Member of core Exosome complex |
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15767 |
Rrp42 |
PF3D7_1340100 |
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exosome complex component RRP42, putative |
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2.7.7.56 |
Member of core Exosome complex |
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15771 |
Rrp43/45 |
PF3D7_1364500 |
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exosome complex component RRP45, putative |
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2.7.7.56 |
Member of core Exosome complex |
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15773 |
Rrp46/Mtr3 |
PF3D7_1427800 |
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exosome complex exonuclease RRP41, putative |
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3.1.13.1 |
Member of core Exosome complex |
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Exosome-Associated Factors |
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15776 |
Rrp6 |
PF3D7_1449700 |
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exosome complex exonuclease RRP6 |
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3.1.13.- |
3' hydrolytic Exonuclease |
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Rrp47 |
Not in Pf |
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Nuclear Exosome cofactor |
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15749 |
Mpp6 |
PF3D7_0928900 |
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guanylate kinase |
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2.7.4.8 |
Nuclear Exosome cofactor |
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15769 |
Ski7 |
PF3D7_1357100 |
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elongation factor 1-alpha |
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Cytoplasmic Exosome cofactor, connects Exosome to Ski complex |
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TRAMP complexes Nuclear RNA degradation factors involved in RNA quality control and cryptic RNA degradation |
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15766 |
Trf4 |
PF3D7_1332400 |
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nucleotidyltransferase, putative |
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2.7.7.7 |
Nuclear poly(A) polymerase, |
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15766 |
Trf5 |
PF3D7_1332400 |
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nucleotidyltransferase, putative |
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2.7.7.7 |
Nuclear poly(A) polymerase, |
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Air1 |
Not in Pf |
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TRAMP complex components |
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15743 |
Mtr4 |
PF3D7_0602100 |
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ATP-dependent RNA helicase, mtr4 |
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3.6.4.13 |
Helicase, |
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Ski complex Cytoplasmic mRNA degradation complex |
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Ski3 |
Not in Pf |
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Member of Exosome cofactor Ski complex |
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15744 |
Ski8 |
PF3D7_0631000 |
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tetratricopeptide repeat protein, putative |
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Member of Exosome cofactor Ski complex |
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Sen1-Nrd1-Nab3 |
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15750 |
Sen1 |
PF3D7_1005500 |
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regulator of nonsense transcripts 1, putative |
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Helicase |
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Nrd1 |
Not in Pf |
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RNA-binding protein |
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Nab3 |
Not in Pf |
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RNA-binding protein |
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Lsm 7 member ring-shaped RNA chaperone complexes |
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15757 |
Lsm1 |
PF3D7_1124400 |
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U6 snRNA-associated Sm-like protein LSm1, putative |
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Member of both Lsm complexes |
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15742 |
Lsm2 |
PF3D7_0520300 |
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U6 snRNA-associated Sm-like protein LSm2, putative |
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Member of both Lsm complexes |
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15746 |
Lsm3 |
PF3D7_0819900 |
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U6 snRNA-associated Sm-like protein LSm3, putative |
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Member of both Lsm complexes |
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15756 |
Lsm4 |
PF3D7_1107000 |
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U6 snRNA-associated Sm-like protein LSm4, putative |
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Member of both Lsm complexes |
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15774 |
Lsm5 |
PF3D7_1443300 |
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U6 snRNA-associated Sm-like protein LSm5, putative |
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Member of both Lsm complexes |
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15765 |
Lsm6 |
PF3D7_1325000 |
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U6 snRNA-associated Sm-like protein LSm6, putative |
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Member of both Lsm complexes |
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15759 |
Lsm7 |
PF3D7_1209200 |
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U6 snRNA-associated Sm-like protein LSm7, putative |
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Member of both Lsm complexes |
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15747 |
Lsm8 |
PF3D7_0829300 |
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U6 snRNA-associated Sm-like protein LSm8, putative |
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Member of both Lsm complexes |
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Ccr4-NOT complex Cytoplasmic deadenylation complex |
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15741 |
Ccr4 |
PF3D7_0519500 |
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ccr4 domain-containing protein 1, putative |
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Member of Ccr4-NOT complex |
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15738 |
Ccr4 |
PF3D7_0319200 |
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ccr4 domain-containing protein 4, putative |
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Member of Ccr4-NOT complex |
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15752 |
Pop2 |
PF3D7_1014600 |
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transcriptional coactivator ADA2 |
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Member of Ccr4-NOT complex |
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15754 |
Not1 |
PF3D7_1103800 |
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CCR4-NOT transcription complex subunit not1-g, putative |
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Member of Ccr4-NOT complex |
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15772 |
Not1 |
PF3D7_1417200 |
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CCR4-NOT transcription complex subunit not1, putative |
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Member of Ccr4-NOT complex |
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15740 |
Caf40 |
PF3D7_0507600 |
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protein caf40, putative |
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Member of Ccr4-NOT complex |
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15761 |
Mot2 |
PF3D7_1235300 |
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CCR4-NOT transcription complex subunit 4, putative |
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Member of Ccr4-NOT complex |
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Caf130 |
Not in Pf |
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Member of Ccr4-NOT complex |
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15758 |
Not3/ Not5 |
PF3D7_1128600 |
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CCR4-NOT transcription complex subunit 2, putative |
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Member of Ccr4-NOT complex |
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15751 |
Cdc36 |
PF3D7_1006100 |
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CCR4-NOT transcription complex subunit 5, putative |
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Member of Ccr4-NOT complex |
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Caf120 |
Not in Pf |
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Member of Ccr4-NOT complex |
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15775 |
Caf16 |
PF3D7_1447900 |
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multidrug resistance protein 2, MDR2 |
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3.6.3.44 |
Member of Ccr4-NOT complex |
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Miscellaneous |
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15768 |
Dbr1 |
PF3D7_1340600 |
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RNA lariat debranching enzyme, putative |
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3.1.4.- |
Debranches intron lariat structures |
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15760 |
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PF3D7_1220400 |
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debranching enzyme-associated ribonuclease, putative |
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Debranches intron lariat structures |
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Rnt1 |
Not in Pf |
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Endonuclease involved in Pol I termination and Pol II termination on some small RNAs |
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15762 |
Swt1 |
PF3D7_1238300 |
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pre-mRNA-splicing factor CWC22, putative |
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Endonuclease involved in perinuclear mRNP surveillance |
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15777 |
Snap50 |
PF3D7_1460800 |
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snRNA-activating protein complex subunit 3, putative |
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