RNA Degradation Factors
Compiled according to Houseley J, Tollervey D. The many pathways of RNA degradation. Cell. 2009 Feb 20;136(4):763-76. Review. PubMed PMID: 19239894, guided by S. cerevisiae orthologs
Sc ortholog PfID Annotation Transcript EC# Role
5'-End Processing Enzymes
Dcp1 PF3D7_1032100
mRNA-decapping enzyme subunit 1, putative
Member of decapping complex with Dcp2
Dcp2 PF3D7_1308900
mRNA-decapping enzyme 2, putative
Catalytic pyrophosphatase subunit of decapping complex
Rat1 PF3D7_1106300 5'-3' exoribonuclease 1, putative
3.1.4.1 Nuclear 5' Exonuclease
Xrn1 PF3D7_1106300 5'-3' exoribonuclease 1, putative
3.1.4.1 Cytoplasmic 5' Exonuclease
Xrn1 PF3D7_0909400 exoribonuclease, putative
3.1.13.1 Cytoplasmic 5' Exonuclease
Core Exosome Highly conserved RNA decay complex
Rrp44 PF3D7_1359300
exosome complex exonuclease RRP44
3.1.16.1 3' hydrolytic Exonuclease and endonuclease activity
Csl4 PF3D7_0720000 exosome complex component CSL4, putative
3.1.13.1 Member of core Exosome complex
Rrp4 PF3D7_0410400
exosome complex component RRP4, putative
Member of core Exosome complex
Rrp40 PF3D7_1307000 exosome complex component RRP40, putative
Member of core Exosome complex
Rrp41 PF3D7_1427800
exosome complex exonuclease RRP41, putative
3.1.13.1 Member of core Exosome complex
Rrp42 PF3D7_1340100
exosome complex component RRP42, putative
2.7.7.56 Member of core Exosome complex
Rrp43/45 PF3D7_1364500
exosome complex component RRP45, putative
2.7.7.56 Member of core Exosome complex
Rrp46/Mtr3 PF3D7_1427800
exosome complex exonuclease RRP41, putative
3.1.13.1 Member of core Exosome complex
Exosome-Associated Factors
Rrp6 PF3D7_1449700
exosome complex exonuclease RRP6
3.1.13.- 3' hydrolytic Exonuclease
Rrp47 Not in Pf Nuclear Exosome cofactor
Mpp6 PF3D7_0928900
guanylate kinase
2.7.4.8 Nuclear Exosome cofactor
Ski7 PF3D7_1357100 elongation factor 1-alpha
Cytoplasmic Exosome cofactor, connects Exosome to Ski complex
TRAMP complexes Nuclear RNA degradation factors involved in RNA quality control and cryptic RNA degradation
Trf4 PF3D7_1332400
nucleotidyltransferase, putative
2.7.7.7 Nuclear poly(A) polymerase,
Trf5 PF3D7_1332400
nucleotidyltransferase, putative
2.7.7.7 Nuclear poly(A) polymerase,
Air1 Not in Pf TRAMP complex components
Mtr4 PF3D7_0602100 ATP-dependent RNA helicase, mtr4
3.6.4.13 Helicase,
Ski complex Cytoplasmic mRNA degradation complex
Ski3 Not in Pf Member of Exosome cofactor Ski complex
Ski8 PF3D7_0631000 tetratricopeptide repeat protein, putative
Member of Exosome cofactor Ski complex
Sen1-Nrd1-Nab3
Sen1 PF3D7_1005500
regulator of nonsense transcripts 1, putative
Helicase
Nrd1 Not in Pf RNA-binding protein
Nab3 Not in Pf RNA-binding protein
Lsm 7 member ring-shaped RNA chaperone complexes
Lsm1 PF3D7_1124400
U6 snRNA-associated Sm-like protein LSm1, putative
Member of both Lsm complexes
Lsm2 PF3D7_0520300 U6 snRNA-associated Sm-like protein LSm2, putative Member of both Lsm complexes
Lsm3 PF3D7_0819900 U6 snRNA-associated Sm-like protein LSm3, putative Member of both Lsm complexes
Lsm4 PF3D7_1107000 U6 snRNA-associated Sm-like protein LSm4, putative
Member of both Lsm complexes
Lsm5 PF3D7_1443300 U6 snRNA-associated Sm-like protein LSm5, putative Member of both Lsm complexes
Lsm6 PF3D7_1325000 U6 snRNA-associated Sm-like protein LSm6, putative
Member of both Lsm complexes
Lsm7 PF3D7_1209200
U6 snRNA-associated Sm-like protein LSm7, putative
Member of both Lsm complexes
Lsm8 PF3D7_0829300 U6 snRNA-associated Sm-like protein LSm8, putative
Member of both Lsm complexes
Ccr4-NOT complex Cytoplasmic deadenylation complex
Ccr4 PF3D7_0519500 ccr4 domain-containing protein 1, putative
Member of Ccr4-NOT complex
Ccr4 PF3D7_0319200
ccr4 domain-containing protein 4, putative
Member of Ccr4-NOT complex
Pop2 PF3D7_1014600 transcriptional coactivator ADA2
Member of Ccr4-NOT complex
Not1 PF3D7_1103800 CCR4-NOT transcription complex subunit not1-g, putative
Member of Ccr4-NOT complex
Not1 PF3D7_1417200 CCR4-NOT transcription complex subunit not1, putative
Member of Ccr4-NOT complex
Caf40 PF3D7_0507600 protein caf40, putative
Member of Ccr4-NOT complex
Mot2 PF3D7_1235300 CCR4-NOT transcription complex subunit 4, putative Member of Ccr4-NOT complex
Caf130 Not in Pf Member of Ccr4-NOT complex
Not3/ Not5 PF3D7_1128600 CCR4-NOT transcription complex subunit 2, putative
Member of Ccr4-NOT complex
Cdc36 PF3D7_1006100 CCR4-NOT transcription complex subunit 5, putative
Member of Ccr4-NOT complex
Caf120 Not in Pf Member of Ccr4-NOT complex
Caf16 PF3D7_1447900
multidrug resistance protein 2, MDR2
3.6.3.44 Member of Ccr4-NOT complex
Miscellaneous
Dbr1 PF3D7_1340600 RNA lariat debranching enzyme, putative
3.1.4.- Debranches intron lariat structures
PF3D7_1220400 debranching enzyme-associated ribonuclease, putative Debranches intron lariat structures
Rnt1 Not in Pf Endonuclease involved in Pol I termination and Pol II termination on some small RNAs
Swt1 PF3D7_1238300 pre-mRNA-splicing factor CWC22, putative
Endonuclease involved in perinuclear mRNP surveillance
Snap50 PF3D7_1460800 snRNA-activating protein complex subunit 3, putative
Online articles related to RNA Degradation Factors retrieved from PubMed