idc:'Winged helix' DNA-binding domain 'Winged helix' DNA-binding domain replication termination factor idc:replication termination factor idc:Ribonuclease HI/HII idc:Topoisomerase II Topoisomerase I DNA polymerase (Pole) DNA polymerase (Pola) DNA polymerase (Pol d) DNA ligase Topoisomerase III Single-stranded Binding proteins Sliding clamp Sliding clamp DNA primase Helicase Replication factor-C Proliferating cell nuclear antigen Ribonuclease HI/HII Topoisomerase IV idc:DNA polymerase (Pole) idc:Helicase idc:DNA primase idc:Replication factor-C idc:DNA polymerase (Pola) idc:Proliferating cell nuclear antigen idc:Topoisomerase IV idc:Topoisomerase I idc:Topoisomerase III idc:Single-stranded Binding proteins idc:Sliding clamp idc:Sliding clamp idc:DNA ligase Topoisomerase II idc:DNA polymerase (Pol d) mcl1 domain-containing protein idc:mcl1 domain-containing protein




Online articles related to DNA Replication retrieved from PubMed

RX Drugs affecting pathway with unknown specific target

Drug Name PubMed Articles (year of publication)
(3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone + 17-(Allylamino)-17-demethoxygeldanamycin
1-(2-dimethylaminoethylamino)-9(10H)-thioacridone
1-(chloromethyl)-5-hydroxy-1,2 -dihydro-3- [(panisylbenzimidazole-2-carbonyl]-3H-furano[2,3e]indoline,
1,1' -(4,4' -(1,3-phenylenebis(oxy))bis(4,1-phenylene))bis(N' -methylguanidine)
1,1' -(4,4' -(1,3-phenylenebis(oxy))bis(4,1-phenylene))bis(N’- isopropylguanidine)
1,1' -(4,4' -(1,3-phenylenebis(oxy))bis(4,1-phenylene))diguanidine
1,4-Bis-[5' -(N' -methylguanidino)-pyridin-2' -yl]-phenylene
1,4-Bis-[5' -guanidinopyridin-2' -yl]phenylene
16-hydroxy-17-(7-hydroxy-6-methyl-3-oxoheptan-2-yl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
2-(40 -Amidino-2-hydroxybiphenyl-3-yl)-1H-benzimidazole-5-amidine acetate salt
2-(5' -Amidino-2,2'-bifuran-5-yl)-1H-indole-6-amidine hydrochloride salt
2,5-Bis-(4′-amidinophenyl)-pyrimidine
2,5-bis(4-amidinophenyl)-1hindole
2,5-Bis[2-amidino-5-pyridyl]furan Acetate Salt
2,5-bis[amidinoaryl]thiazoles
2,6-diphenylpyrazines
2,7-Bis(N′-ethyl)guanidino-9H-fluorene
2,7-Bis(N′-isopropyl)guanidino-9H-fluorene
2,7-Bis-guanidinofluoren-9-one Dihydrochloride
2,8-bis(trifluoromethyl) quinoline-4-(N4-ethyl-5-nitroimidazolo) methylene
2-aminoimidazoline
2-aminopyrimidine
3-Chloro-5-methyl-11-[3-(diethylamino)propylamino]-10Hindolo[3,2-b]quinolin-5-ium Chloride
4,4'-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2,6-diyl)dibenzimidamide
4,4''-Bis(N' -methyl)-guanidino- [1,1' ;4' ,1'']terphenyl
4,4''-Bis-guanidino-[1,1' ;4' ,1'']terphenyl
4-[2-(4-carbamimidoylphenyl)pyrimidin-5-yl]benzamidine
4-[4-(4-carbamimidoylphenyl)phenyl]benzamidine
4acc3ptencl2
5' -(4-Amidinophenyl)-2,2' -bifuran-5-carboxamidine hydrochloride
5-(4-amidinophenyl)-2-(5- amidinothien-2-yl)-1h-indole
5-[2-(6-carbamimidoyl-3-pyridyl)pyrimidin-5-yl]pyridine-2-carboxamidine
5-[4-(4-carbamimidoylphenyl)phenyl]pyridine-2-carboxamidine
5-[4-(4-carbamimidoylphenyl)phenyl]pyrimidine-2-carboxamidine
5-[4-(6-carbamimidoyl-3-pyridyl)phenyl]pyridine-2-carboxamidine
5-[5-(6-carbamimidoyl-3-pyridyl)pyrazin-2-yl]pyridine-2-carboxamidine
6-[5-(4-Carbamimidoyl-phenyl)-furan-2-yl]-nicotinamidine Acetate Salt
8,8-dialkyldihydroberberines
9-aminoacc3ptencl2
Acridone
Adozelesin
Aminoalkyl
amphotericin B
Aurothioglucose
Aurothiomalate
Azaterphenyl diamidines
azathioprine
Benzimidazole diamidine
Berberine
Biphenyl benzimidazole diamidines
Bis-2-aminopyridinium
Bis-amidine
Bis-guanidine
Bis-n-substituted guanidine
Bis-quaternary Ammonium
Bizelesin
Carboplatin
Cc-1065
Centanamycin
Chloroquine
Chr-2863
Cisplatin
Daphnetin
Dapi
Db921
duocarmycin
etoposide
Furamidine
Guanidino
Hybrids of 4-aminoquinoline and pyrimidine moieties
methyl methanesulphonate
N′-(6-chloro-2-methoxyacridin-9-yl)-2-cyano-3-phenylacrylohydrazide
N1-(4,5-dihydro-1H-imidazol-2-yl)-N4-(4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)benzene-1,4-diamine
N-2-((N,N-Dimethylamino)methyl)ferrocenemethyl 4-bromo-α-amino-o-cresol
N-hydroxy bisguanidines
NSC371488
NSC639017
N-substituted guanidines
Pentamidine
Ptencl2
Quinomycin a
quinoxaline-2,3-(1,4H)-dione
Sduocarmycin
Thiosemicarbazone
Transplatinum
Triaryl bis-guanidines
Triaryl guanidines
Trichostatin a
Trifluoromethyl-quinoline
UK-63,596

DNA Replication map details

PFID PFID Old Annotation Formal Annotation EC Transcript
PF3D7_1112600 PF11_0131 ATPase, putative ATPase, putative pie diagram
PF3D7_1304100 drugs MAL13P1.22 DNA ligase DNA ligase I 6.5.1.1 pie diagram
PF3D7_1322300 PF13_0126 DNA ligase 3 brct domain-containing protein, putative pie diagram
PF3D7_1017000 drugs PF10_0165 DNA polymerase (Pol d) DNA polymerase delta catalytic subunit 2.7.7.7 pie diagram
PF3D7_0411900 PFD0590c DNA polymerase (Pola) DNA polymerase alpha 2.7.7.7 pie diagram
PF3D7_1463300 PF14_0602 DNA polymerase (Pola) DNA polymerase alpha subunit B, putative 2.7.7.7 pie diagram
PF3D7_0630300 PFF1470c DNA polymerase (Pole) DNA polymerase epsilon catalytic subunit A, putative 2.7.7.7 pie diagram
PF3D7_0308000 PFC0340w DNA polymerase delta small subunit, putative DNA polymerase delta small subunit, putative 2.7.7.7 pie diagram
PF3D7_1234300 PFL1655c DNA polymerase epsilon subunit B, putative DNA polymerase epsilon subunit B, putative 2.7.7.7 pie diagram
PF3D7_0910900 PFI0530c DNA primase DNA primase large subunit, putative 2.7.7.6 pie diagram
PF3D7_1438700 PF14_0366 DNA primase DNA primase small subunit 2.7.7.6 pie diagram
PF3D7_1106700 PF11_0078 DNA replication ATP-dependent helicase/nuclease dna2, putative DNA replication ATP-dependent helicase/nuclease dna2, putative 3.6.4.12 pie diagram
PF3D7_0317400 PFC0765c GINS DNA replication complex gins protein, putative pie diagram
PF3D7_1303900 MAL13P1.20 GINS GINS complex, subunit Psf3 pie diagram
PF3D7_0216000 PFB0730w Helicase DEAD/DEAH box helicase, putative 3.6.4.13 pie diagram
PF3D7_0310500 PFC0440c Helicase DEAD box helicase, putative 3.6.4.13 pie diagram
PF3D7_0514100 loop drugs PFE0705c Helicase ATP-dependent DNA helicase UvrD 3.6.4.12 pie diagram
PF3D7_0604600 PFF0225w Helicase DNA helicase, putative 3.6.4.12 pie diagram
PF3D7_0918600 loop drugs PFI0910w Helicase ATP-dependent DNA helicase Q1; bloom protein homolog 3.6.4.12 pie diagram
PF3D7_1211300 PFL0560c Helicase DNA helicase MCM8, putative 3.6.4.12 pie diagram
PF3D7_1324500 MAL13P1.134 Helicase DEAD box helicase, putative 3.6.4.12 pie diagram
PF3D7_1357500 PF13_0308 Helicase DNA helicase, putative 3.6.4.12 pie diagram
PF3D7_1362200 loop drugs PF13_0330 helicase RuvB-like helicase 3 3.6.4.12 pie diagram
PF3D7_1429900 loop drugs PF14_0278 Helicase ADP-dependent DNA helicase RecQ 3.6.4.12 pie diagram
PF3D7_1305000 PF13_0024 mcl1 domain-containing protein MCL1 domain-containing protein, putative pie diagram
PF3D7_1226600 loop PFL1285c Proliferating cell nuclear antigen proliferating cell nuclear antigen 2 pie diagram
PF3D7_1361900 loop drugs PF13_0328 Proliferating cell nuclear antigen 1 proliferating cell nuclear antigen 1 pie diagram
PF3D7_0218000 drugs PFB0840w Replication factor-C replication factor C subunit 2, putative pie diagram
PF3D7_0219600 loop drugs PFB0895c Replication factor-C replication factor c subunit 1 pie diagram
PF3D7_1111100 PF11_0117 Replication factor-C replication factor C subunit 5, putative pie diagram
PF3D7_1241700 drugs PFL2005w Replication factor-C replication factor C subunit 4, putative pie diagram
PF3D7_0926900 PFI1320c replication termination factor replication termination factor, putative pie diagram
PF3D7_0623900 PFF1150w Ribonuclease HI/HII ribonuclease H2 subunit A, putative 3.1.26.4 pie diagram
PF3D7_0915200 PFI0745w Ribonuclease HI/HII ribonuclease H2 subunit C, putative 3.1.26.4 pie diagram
PF3D7_1435100 PF14_0332 Ribonuclease HI/HII ribonuclease H2 subunit B, putative pie diagram
PF3D7_0508800 loop drugs PFE0435c Single-stranded Binding proteins single-stranded DNA-binding protein pie diagram
PF3D7_0520400 PFE1025c single-stranded DNA-binding protein, putative single-stranded DNA-binding protein, putative pie diagram
PF3D7_1361900 loop drugs PF13_0328 Sliding clamp proliferating cell nuclear antigen 1 pie diagram
PF3D7_0510500 drugs PFE0520c Topoisomerase I topoisomerase I 5.99.1.2 pie diagram
PF3D7_1433500 drugs PF14_0316 Topoisomerase II DNA topoisomerase 2 5.6.2.2 pie diagram
PF3D7_1347100 loop drugs PF13_0251 Topoisomerase III DNA topoisomerase 3 5.6.2.1 pie diagram
PF3D7_1365600 loop drugs MAL13P1.328 Topoisomerase IV DNA topoisomerase 6 subunit b, putative pie diagram
PF3D7_1120600 PF11_0213 'Winged helix' DNA-binding domain ddrgk domain-containing protein, putative pie diagram