Genes coding for components of the proteasome degradation machinery & their timed transcription
Component Gene ID Annotated function (Yeast ortholog; curator's comment) E.C Transcript
2343 19 S regulatory particle Lid subuint PF3D7_1338100 26S proteasome regulatory subunit RPN3, putative
2313 PF3D7_1017900 26S proteasome regulatory subunit p55, putative 3.4.25.1
2353 PF3D7_1402300
26S proteasome regulatory subunit RPN6
2321 PF3D7_1129200 26S proteasome regulatory subunit RPN7, putative
2304 PF3D7_0912900 26S proteasome regulatory subunit RPN8, putative
2315 PF3D7_1030500 26S proteasome regulatory subunit RPN9, putative 3.4.25.1
2352 PF3D7_1368100 26S proteasome regulatory subunit RPN11, putative
2266 PF3D7_0312300 26S proteasome regulatory subunit RPN12, putative 3.4.25.1
2262 Base subunits PF3D7_0205900 26S proteasome regulatory subunit RPN1, putative
2360 PF3D7_1466300 26S proteasome regulatory subunit RPN2, putative 3.4.25.1
2294 PF3D7_0807800 26S proteasome regulatory subunit RPN10, putative
2356 PF3D7_1414000 26S proteasome regulatory subunit RPN13, putative
23962 PF3D7_1311500
26S protease regulatory subunit 7, putative; 26S proteasome AAA-ATPase subunit RPT1, putative 3.6.4.8
2309 PF3D7_1008400
26S protease regulatory subunit 4, putative 3.6.4.8
23511 PF3D7_0413600
26S protease regulatory subunit 6B, putative; 26S proteasome AAA-ATPase subunit RPT3 3.6.4.8
23880 PF3D7_1306400
26S protease regulatory subunit 10B, putative; 26S proteasome AAA-ATPase subunit RPT4, putative 3.6.4.8
2322 PF3D7_1130400
26S protease regulatory subunit 6A, putative 3.6.4.8
23971 PF3D7_1248900
26S protease regulatory subunit 8, putative 3.6.4.8
2293 20 S core protease PF3D7_0807500 proteasome subunit alpha type-6, putative 3.4.25.1
2282 PF3D7_0608500 proteasome subunit alpha type-2, putative 3.4.25.1
30676 PF3D7_1353800 proteasome subunit alpha type-4, putative 3.4.25.1
30683 PF3D7_1353900 proteasome subunit alpha type-7, putative 3.4.25.1
30669 PF3D7_0727400
proteasome subunit alpha type-5, putative 3.4.25.1
2362 PF3D7_1474800 proteasome subunit alpha type-1, putative 3.4.25.1
2268 PF3D7_0317000 proteasome subunit alpha type-3, putative 3.4.25.1
2308 PF3D7_0931800
proteasome subunit beta type-6, putative 3.4.25.1
30652 PF3D7_1328100 proteasome subunit beta type-7, putative 3.4.25.1
30660 PF3D7_0108000
proteasome subunit beta type-3, putative 3.4.25.1
2361 PF3D7_1470900
proteasome subunit beta type-2, putative 3.4.25.1
30647 PF3D7_1011400
proteasome subunit beta type-5 3.4.25.1
30648 PF3D7_0518300
proteasome subunit beta type-1, putative 3.4.25.1
30651 PF3D7_0803800
proteasome subunit beta type-4 3.4.25.1
20338 Ubiquitin activating enzyme E1 PF3D7_1237000
SUMO-activating enzyme subunit 2 6.2.1.45
2329 PF3D7_1225800
ubiquitin-activating enzyme E1 6.2.1.45
2342 PF3D7_1333200
ubiquitin-activating enzyme 6.2.1.45
2299 PF3D7_0817000 NEDD8-activating enzyme E1 catalytic subunit, putative 6.2.1.45
2345 PF3D7_1350400 ubiquitin-activating enzyme E1, putative
2326 PF3D7_1144500 SUMO-activating enzyme subunit 1
2320 PF3D7_1126100
autophagy-related protein 7, putative
2349 PF3D7_1365400 adenylyltransferase and sulfurtransferase uba4, putative 2.7.7.-
2327 Ubiquitin-conjugating enzyme E2 PF3D7_1203900
ubiquitin-conjugating enzyme E2 2.3.2.23
23675 PF3D7_0921000 ubiquitin-conjugating enzyme E2, putative 2.3.2.2
2264 PF3D7_0305700 ubiquitin-conjugating enzyme mms2, putative 6.3.2.19
23834 PF3D7_0319300 ubiquitin-conjugating enzyme E2, putative 2.3.2.23
2279 PF3D7_0527100
ubiquitin-conjugating enzyme E2 13 6.3.2.19
27573 PF3D7_0606200 ubiquitin-conjugating enzyme E2 PEX4, putative 6.3.2.19
23726 PF3D7_0812600 ubiquitin-conjugating enzyme E2, putative 2.3.2.23
2344 PF3D7_1345500
ubiquitin-conjugating enzyme E2 6.3.2.19
23902 PF3D7_1033900 ubiquitin-conjugating enzyme e2, putative 2.3.2.23
23835 PF3D7_1356300 ubiquitin-conjugating enzyme E2, putative 2.3.2.23
23977 PF3D7_1412900 ubiquitin-conjugating enzyme E2, putative 6.3.2.19
2336 PF3D7_1243700
ubiquitin-conjugating enzyme E2, putative 6.3.2.19
27535 Ubiquitin-protein ligase E3 PF3D7_0826100 HECT-like E3 ubiquitin ligase, putative 6.3.2.19
2270 PF3D7_0319100 E3 ubiquitin-protein ligase RBX1, putative 6.3.2.19
2283 PF3D7_0627300 E3 ubiquitin-protein ligase RNF5, putative 6.3.2.19
27315 PF3D7_1012000 ring zinc finger protein, putative
2287 PF3D7_0707700 E3 ubiquitin-protein ligase, putative 6.3.2.19
2286 PF3D7_0704600
HECT-type E3 ubiquitin ligase UT 6.3.2.19
2301 PF3D7_0826500 ubiquitin conjugation factor E4 B, putative 6.3.2.19
2319 PF3D7_1119400 ubiquitin-protein ligase, putative 6.3.2.19
2284 PF3D7_0628100
hect domain-containing protein 1, putative 6.3.2.19
23627 PF3D7_1028200 ring zinc finger protein, putative
2263 PF3D7_0215100 RING zinc finger protein, putative
2331 PF3D7_1233600 asparagine and aspartate rich protein 1
2265 PF3D7_0312100
E3 ubiquitin-protein ligase, putative 6.3.2.19
2267 PF3D7_0316900
E3 ubiquitin-protein ligase, putative 6.3.2.19
2328 Ubiquitin PolyUbiquitin PF3D7_1211800 polyubiquitin
2340 Ubiquitin PF3D7_1314800
ubiquitin-like protein, putative
2307 PF3D7_0922100
ubiquitin-like protein, putative
2350 PF3D7_1365900
ubiquitin-60S ribosomal protein L40
2298 PF3D7_0815700
apicoplast ubiquitin-like protein aubl
2318 PF3D7_1117100 ubiquitin carboxyl-terminal hydrolase uch54 3.4.19.12
25924 Ubiquitin thioesterase PF3D7_0726500 ubiquitin carboxyl-terminal hydrolase, putative 3.4.19.12
PF3D7_1319100 ubiquitin carboxyl-terminal hydrolase mindy, putative 3.4.19.12
25920 PF3D7_0403500 ubiquitin specific protease, putative 3.1.2.15
2357 PF3D7_1414700 ubiquitin carboxyl-terminal hydrolase, putative 3.4.19.12
2302 PF3D7_0904600 ubiquitin specific protease, putative 3.4.19.12
25921 Ubiquitinyl hydrolase PF3D7_0413900 ubiquitin carboxyl-terminal hydrolase 13, putative 3.4.19.12
25922 PF3D7_0516700 ubiquitin carboxyl-terminal hydrolase 2, putative 3.4.19.12
25923 PF3D7_0527200
ubiquitin carboxyl-terminal hydrolase 14 3.4.19.12
25924 PF3D7_0726500 ubiquitin carboxyl-terminal hydrolase, putative 3.4.19.12
2318 PF3D7_1117100 ubiquitin carboxyl-terminal hydrolase uch54 3.4.19.12
25919 PF3D7_0104300
ubiquitin carboxyl-terminal hydrolase 1, putative 3.4.19.12
25925 PF3D7_1460400
ubiquitin carboxyl-terminal hydrolase isozyme L3 3.4.19.12
25921 PF3D7_0413900 ubiquitin carboxyl-terminal hydrolase 13, putative 3.4.19.12
2288 PF3D7_0722300 ubiquitin carboxyl-terminal hydrolase, putative 3.4.19.12
2311 Regulators PF3D7_1011700 DNA repair protein RAD23, putative
2317 Dsk2 PF3D7_1113400 ubiquitin domain-containing protein DSK2, putative
2323 PF3D7_1132000 ubiquitin-like protein, putative
2354 PF3D7_1409300
DNA damage-inducible protein 1 3.4.23.-
2358 PF3D7_1435700 ataxin-2 like protein, putative
2330 PF3D7_1226800 ataxin-3, putative 3.4.19.12
23984 PF3D7_0907700 proteasome activator 28
2269 PF3D7_0317800 26s proteasome non-atpase regulatory subunit 9, putative
2335 PF3D7_1238100 calcyclin binding protein, putative
2285 PF3D7_0629800 cullin-2, putative
2296 PF3D7_0811000 cullin-1, putative
2351 PF3D7_1367000 suppressor of kinetochore protein 1, putative
2275 PF3D7_0418200 eukaryotic translation initiation factor 3 subunit m, putative
2295 PF3D7_0808300 ubiquitin regulatory protein, putative
2276 PF3D7_0505800
small ubiquitin-related modifier
2324 PF3D7_1138100 ubiquitin-related modifier 1, putative
2325 PF3D7_1141700 OTU domain-containing protein, putative
2332 PF3D7_1233900 sentrin-specific protease 1 3.4.22.68
2291 PF3D7_0801700 sentrin-specific protease 2, putative 5.3.1.8
2334 PF3D7_1237800
ubiquitin-like modifier HUB1, putative
PF3D7_1304400 PUB domain-containing protein, putative
PF3D7_1328900 pub domain-containing protein, putative 3.5.1.52
PF3D7_0813500 PUB domain-containing protein, 3.5.1.52
Online articles related to Genes coding for components of the proteasome degradation machinery & their timed transcription retrieved from PubMed

RX Drugs affecting pathway with unknown specific target

Drug Name PubMed Articles (year of publication)
Bortezomib
Pr3

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