Protein factors in pre-mRNA 3’-end processing
Mammalian factor (yeast factor) Mammalian protein (yeast homolog) PfID Annotation Transcript Mammalian protein partners (yeast protein partners) Protein function and characteristics
1125 CPSF (CPF) CPSF-160 PF3D7_0317700
CPSF (cleavage and polyadenylation specific factor), subunit A, putative
CstF-77, Pol II CTD, PAP, hFip1, TFIID Binds RNA (mammalian AAUAAA site, yeast cleavage site), three possible b-propellers
(Cft1p/Yhh1p) (Fip1p, Pol II CTD, Cft2p/Ydh1p and Swd2p)
1127 CPSF (CPF) CPSF-100 PF3D7_0318600 cleavage and polyadenylation specificity factor, putative
CPSF-73 Binds RNA at the U-rich sequence in yeast, may act as a scaffolding protein, contains a non-metal binding metallo-blactamase domain
(Cft2p/Ydh1p) (Pol II CTD, Brr5p/Ysh1p, Cft1p/Yhh1p, Pta1p, Pfs2p, Ssu72p, Pcf11p, YDL094C)
1141 CPSF (CPF) CPSF-73 PF3D7_1438500
cleavage and polyadenylation specificity factor subunit 3, putative
CPSF-100 Endonuclease for the cleavage reaction, contains a metal binding metallo-b-lactamase domain
(Brr5p/Ysh1p) (Pta1p, Cft2p/Ydh1p, Yth1p, Clp1p, Syc1p, Swd2p)
23980 CPSF (CPF) CPSF-30 PF3D7_1008600 zinc finger (ccch type) protein, putative
hFip1 Binds U-richRNAsequences, contains five zinc fingers and a zinc knuckle (mammalian)
(Yth1p) (Fip1p, Brr5p/Ysh1p)
1139 CPSF (CPF) hFip1 PF3D7_1321700 splicing factor 1
PAP, CPSF-160, CPSF-30, CstF-77 Directs PAP to correct polyadenylation site and binds U-rich sequences, contains a conserved region that binds CPSF-30
(Fip1p) (Pap1p, Yth1p, Rna14p)
1129 CstF (CF IA) CstF-77 PF3D7_0526500 conserved Plasmodium protein, unknown function
CPSF-160, CstF64, CstF50, Scaffolding protein, links CstF and CPSF, contains a HAT domain and a Pro-rich segment
(Rna14p) Pol II CTD (Rna15p, Pcf11p)
29794 CstF (CF IA) CstF-64 PF3D7_1224300
polyadenylate-binding protein 1, putative
CstF-77, Symplekin Binds to RNA through an N-terminal RRM (G/U rich sequence in mammals, A-rich sequence in yeast)
1136 PF3D7_1107300 polyadenylate-binding protein-interacting protein 1, putative
25745 (Rna15p) PF3D7_0933000 cstf domain-containing protein, putative
(Pcf11p, Rna14p)
1130 CstF CstF-50 PF3D7_0620500 cleavage stimulation factor subunit 1, putative
CstF-77, Pol II CTD, BARD1  Binds Pol II CTD, contains seven WD-40 repeats
1124 CF Im CF Im-25kD PF3D7_0109200 cleavage and polyadenylation specificity factor subunit 5
PAP, CF Im-68kD CF Im aids AAUAAA site recognition, contains a conserved PAP interaction domain
1128 (None) PF3D7_0403700 pre-mRNA-splicing factor CLF1, putative
1140 CF Im CF Im-68kD PF3D7_1420000 splicing factor 3B subunit 4, putative
CF Im-25kD CF Im aids AAUAAA site recognition, contains an N-terminal RBD
1124 CF Iim (CF IA) hPcf11 PF3D7_0109200 cleavage and polyadenylation specificity factor subunit 5
(Pol II CTD, Rna14p, Rna15p, Clp1p, Swd2p, Cft1p/Yhh1p, Cft2p/Ydh1p, Brr5p/Ysh1p, Pta1p) Interacts with Pol II CTD, acts as a scaffolding protein, contains two zinc finger domains
(Pcf11p) no
CF Iim (CF IA) hClp1 CF Im and CPSF TethersCPSFwithCFIm, contains Walker A and B motifs for ATP binding
23877 (Clp1p) PF3D7_0821600 polyribonucleotide 5'-hydroxyl-kinase clp1, putative (Brr5p/Ysh1p, Cft2p/Ydh1p, Pcf11p)
– (CPF) Symplekin No CstF-64, CPSF Bridges interactions between CPSF and CstF, regulated by phosphorylation
(Pta1p) No (Brr5p/Ysh1p, Syc1p, Cft2p/Ydh1p, Swd2p, Glc7p, Pti1p, Ssu72p)
1138 PAP PF3D7_1232900 nucleotidyltransferase, putative
hFip1, CF Im, CPSF-160 (Fip1p) Adds poly(A) tail to cleaved pre-mRNA
1131 (Pap1p) PF3D7_0625600 poly(A) polymerase PAP, putative
1126 Pol II CTD PF3D7_0318200 DNA-directed RNA polymerase II subunit RPB1
hPcf11, CPSF-160, CstF-50, CstF-77 Transcriptional termination, contains YSPTSPS repeats
(Pol II CTD) (Cft2p/Ydh1p, Cft1p/Yhh1p, Pcf11p)
29881 PABII PF3D7_0923900 polyadenylate-binding protein 2, putative
(Rna15p) Stimulates polyadenylation and stabilizes poly(A) tail, contains two RRM domains
Notice that Pf are generally orthologous to mammalian genes rather than to yeast
Online articles related to Protein factors in pre-mRNA 3’-end processing retrieved from PubMed