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Proteome of the parasitophorous vacuole |
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based on proteins interacting with PfEMP1 in the parasitophorous vacuole and in the host cytosol |
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Batinovic S, McHugh E, Chisholm SA, Matthews K, Liu B, Dumont L, Charnaud SC, Schneider MP, Gilson PR, de Koning-Ward TF, Dixon MWA, Tilley L. An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes. Nat Commun. 2017 0;8:16044. PMID: 28691708 |
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Color legend |
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EPIC (Exported Protein-Interacting Complex) |
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PTEX |
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Parasite surface (PPM) |
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Secreted (PV lumen/PVM) |
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Exported protein (Transit through PV) |
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Unknown |
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Parasite proteins that are unique to, or ≥ 5-fold enriched in, PfEMP1B co-IP ((PV)-located ) compared to control PfEMP1F. |
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PfID |
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Avg fold change |
E.C |
Transcript |
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| 8275 |
- |
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>196 |
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| 28400 |
PF3D7_1024800 |
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exported protein 3 |
>26.25 |
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| 28405 |
PF3D7_1116800 |
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heat shock protein 101 chaperone protein ClpB2 |
>18 |
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| 28428 |
PF3D7_1436300 |
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translocon component PTEX150 |
>11.75 |
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| 28407 |
PF3D7_1129100 |
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parasitophorous vacuolar protein 1 |
10 |
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| 28375 |
PF3D7_0629200 |
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DnaJ protein, putative |
>8.25 |
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| 28377 |
PF3D7_0721100 |
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conserved Plasmodium protein, unknown function |
>7.5 |
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| 28403 |
PF3D7_1105600 |
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translocon component PTEX88 |
>5.25 |
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| 28395 |
PF3D7_0936300 |
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ring-exported protein 3 |
>4 |
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| 28399 |
PF3D7_1016400 |
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serine/threonine protein kinase, FIKK family |
>3.5 |
2.7.11.1 |
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| 28371 |
PF3D7_0501200 |
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parasite-infected erythrocyte surface protein |
>2 |
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| 28410 |
PF3D7_1226900 |
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parasitophorous vacuolar protein 2 |
>2 |
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| 28408 |
PF3D7_1135400 |
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hotdog domain-containing protein, putative |
>2 |
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| 28415 |
PF3D7_1311800 |
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M1-family alanyl aminopeptidase |
>2 |
3.4.11.2 |
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| 28372 |
PF3D7_0501300 |
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skeleton-binding protein 1 |
>2 |
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| 28376 |
PF3D7_0716300 |
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conserved Plasmodium protein, unknown function |
>2 |
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| 28364 |
PF3D7_0112800 |
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Plasmodium exported protein (hyp11), unknown function |
>1.75 |
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| 28393 |
PF3D7_0935900 |
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ring-exported protein 1 |
>1.75 |
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| 28432 |
PF3D7_1471100 |
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exported protein 2 |
>1.25 |
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| 28389 |
PF3D7_0925900 |
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lipocalin, lcn |
>1.25 |
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| 28390 |
PF3D7_0928600 |
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conserved Plasmodium protein, unknown function |
>1.25 |
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| 28420 |
PF3D7_1345100 |
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thioredoxin 2 |
>1.25 |
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| 28423 |
PF3D7_1370300 |
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membrane associated histidine-rich protein |
>1.25 |
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| 28397 |
PF3D7_1002100 |
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EMP1-trafficking protein |
>1 |
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| 28382 |
PF3D7_0831400 |
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Plasmodium exported protein, unknown function |
>1 |
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| 28421 |
PF3D7_1353200 |
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membrane associated histidine-rich protein 2 |
>1 |
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| 28412 |
PF3D7_1239700 |
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ATP-dependent zinc metalloprotease FTSH 1 |
>0.75 |
3.4.24.- |
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| 28401 |
PF3D7_1033200 |
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early transcribed membrane protein 10.2 |
>0.5 |
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Mass spectrometry analysis of PV1-HA interacting proteins Proteins that are unique to, or ≥ 5-fold enriched in, PV1-HA co-IP compared to control wildtype (WT) |
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| 28407 |
PF3D7_1129100 |
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parasitophorous vacuolar protein 1 |
>104 |
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| 28400 |
PF3D7_1024800 |
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exported protein 3 |
>85.5 |
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| 28428 |
PF3D7_1436300 |
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translocon component PTEX150 |
>29 |
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| 28383 |
PF3D7_0831700 |
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PfHsp70-x |
>22.75 |
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| 28405 |
PF3D7_1116800 |
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heat shock protein 101 chaperone protein ClpB2 |
>22.5 |
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| 28427 |
PF3D7_1420700 |
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surface protein P113 |
>17.25 |
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| 28410 |
PF3D7_1226900 |
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parasitophorous vacuolar protein 2 |
>12.5 |
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| 28431 |
PF3D7_1464600 |
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serine/threonine protein phosphatase uis2, putative |
>12 |
3.1.3.16 |
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| 28411 |
PF3D7_1228600 |
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merozoite surface protein 9 |
>10 |
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| 28429 |
PF3D7_1454400 |
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aminopeptidase P |
9 |
3.4.11.9 |
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| 28392 |
PF3D7_0930300 |
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merozoite surface protein 1 |
>7.25 |
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| 28403 |
PF3D7_1105600 |
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translocon component PTEX88 |
>6.25 |
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| 28384 |
PF3D7_0902800 |
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serine repeat antigen 9 |
>5.25 |
3.4.22.2 |
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| 28401 |
PF3D7_1033200 |
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early transcribed membrane protein 10.2 |
>5 |
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| 28377 |
PF3D7_0721100 |
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conserved Plasmodium protein, unknown function |
>5 |
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| 28391 |
PF3D7_0929400 |
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high molecular weight rhoptry protein 2 |
>5 |
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| 28398 |
PF3D7_1016300 |
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glycophorin binding protein |
>4.75 |
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| 28365 |
PF3D7_0207600 |
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serine repeat antigen 5 |
>4.75 |
3.4.22.- |
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| 28415 |
PF3D7_1311800 |
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M1-family alanyl aminopeptidase |
>4.75 |
3.4.11.2 |
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| 28360 |
PF3D7_0104200 |
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StAR-related lipid transfer protein |
>4.5 |
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| 28432 |
PF3D7_1471100 |
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exported protein 2 |
>4.5 |
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| 28404 |
PF3D7_1116700 |
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dipeptidyl aminopeptidase 1 cathepsin C, homolog |
>4.5 |
3.4.14.1 |
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| 28378 |
PF3D7_0730900 |
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EMP1-trafficking protein |
>3.75 |
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| 28369 |
PF3D7_0406200 |
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parasitophorous vacuole membrane protein s16; sexual stage-specific protein s16 |
>3 |
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| 28376 |
PF3D7_0716300 |
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conserved Plasmodium protein, unknown function |
>2.75 |
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| 28371 |
PF3D7_0501200 |
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parasite-infected erythrocyte surface protein |
>2.5 |
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| 28399 |
PF3D7_1016400 |
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serine/threonine protein kinase, FIKK family |
>2.5 |
2.7.11.1 |
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| 28363 |
PF3D7_0112200 |
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multidrug resistance-associated protein 1 MRP1 |
>2.5 |
3.6.3.44 |
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| 33887 |
PF3D7_1104400 |
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thioredoxin-like mero protein |
>2.5 |
|
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| 28367 |
PF3D7_0215000 |
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acyl-CoA synthetase |
>2.25 |
6.2.1.3 |
 |
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| 28373 |
PF3D7_0532100 |
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early transcribed membrane protein 5 |
>2.25 |
|
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| 28374 |
PF3D7_0532400 |
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lysine-rich membrane-associated PHISTb protein |
>2.25 |
|
 |
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| 28430 |
PF3D7_1462300 |
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GTP-binding protein, putative |
>2.25 |
|
 |
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| 28408 |
PF3D7_1135400 |
|
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hotdog domain-containing protein, putative |
>2 |
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| 28418 |
PF3D7_1334500 |
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MSP7-like protein |
>1.75 |
|
 |
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| 28366 |
PF3D7_0207800 |
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|
serine repeat antigen 3 |
>1.75 |
3.4.22.- |
 |
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| 28385 |
PF3D7_0905400 |
|
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high molecular weight rhoptry protein 3 |
>1.75 |
|
 |
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| 28396 |
PF3D7_1001500 |
|
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early transcribed membrane protein 10., ETRAMP10.1 |
>1.75 |
|
 |
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| 28413 |
PF3D7_1252700 |
|
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Plasmodium exported protein (PHISTb), unknown function |
>1.75 |
|
 |
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| 28425 |
PF3D7_1408000 |
|
|
plasmepsin II |
>1.5 |
3.4.23.39 |
 |
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| 28380 |
PF3D7_0829200 |
|
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prohibitin, putative |
>1.5 |
|
 |
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| 28389 |
PF3D7_0925900 |
|
|
lipocalin, lcn |
>1.25 |
|
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|
|
|
|
|
|
|
| 28426 |
PF3D7_1419200 |
|
|
thioredoxin-like protein, putative |
>1.25 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28394 |
PF3D7_0936000 |
|
|
ring-exported protein 2 |
>1.25 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28381 |
PF3D7_0830400 |
|
|
cra domain-containing protein, putative |
>1.25 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28406 |
PF3D7_1121600 |
|
|
parasitophorous vacuole membrane antigen QF 116 exported protein 1 circumsporozoite-related antigen |
>1.25 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28379 |
PF3D7_0811600 |
|
|
conserved Plasmodium protein, unknown function |
>1 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28387 |
PF3D7_0912400 |
|
|
alkaline phosphatase, putative |
>1 |
3.1.3.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28370 |
PF3D7_0500800 |
|
|
erythrocyte membrane protein 2 mature parasite-infected erythrocyte surface antigen |
>1 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28419 |
PF3D7_1335100 |
|
|
merozoite surface protein 7 |
>0.75 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28362 |
PF3D7_0104500 |
|
|
conserved protein, unknown function |
>0.75 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28361 |
PF3D7_0104400 |
|
|
4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
>0.75 |
1.17.1.2 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28422 |
PF3D7_1364100 |
|
|
6-cysteine protein p92 |
>0.75 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28388 |
PF3D7_0913700 |
|
|
conserved protein, unknown function |
>0.75 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Proteins that are unique to, or ≥ 5-fold enriched in, PV2-HA co-IP compared to control wildtype (WT). |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28410 |
PF3D7_1226900 |
|
|
parasitophorous vacuolar protein 2 |
>41.75 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28407 |
PF3D7_1129100 |
|
|
parasitophorous vacuolar protein 1 |
19.5 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28400 |
PF3D7_1024800 |
|
|
exported protein 3 |
>12.00 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28405 |
PF3D7_1116800 |
|
|
heat shock protein 101 chaperone protein ClpB2 |
>3.25 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28409 |
PF3D7_1201000 |
|
|
Plasmodium exported protein (PHISTb), unknown function |
>3.00 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28411 |
PF3D7_1228600 |
|
|
merozoite surface protein 9 |
>1.75 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28428 |
PF3D7_1436300 |
|
|
translocon component PTEX150 |
>1.75 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28371 |
PF3D7_0501200 |
|
|
parasite-infected erythrocyte surface protein |
>1.67 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28403 |
PF3D7_1105600 |
|
|
translocon component PTEX88 |
>1.25 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28399 |
PF3D7_1016400 |
|
|
serine/threonine protein kinase, FIKK family |
>1.00 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28432 |
PF3D7_1471100 |
|
|
exported protein 2 |
>0.75 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Proteins that are unique to, or ≥ 5-fold enriched in, PV2-HA co-IP compared to control wildtype (WT). |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28400 |
PF3D7_1024800 |
|
|
exported protein 3 |
>84.25 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28407 |
PF3D7_1129100 |
|
|
parasitophorous vacuolar protein 1 |
>40.75 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28428 |
PF3D7_1436300 |
|
|
translocon component PTEX150 |
>9 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28410 |
PF3D7_1226900 |
|
|
parasitophorous vacuolar protein 2 |
>7 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28404 |
PF3D7_1116700 |
|
|
dipeptidyl aminopeptidase 1 cathepsin C, homolog |
>5.5 |
3.4.14.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28405 |
PF3D7_1116800 |
|
|
heat shock protein 101 chaperone protein ClpB2 |
>5.25 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28429 |
PF3D7_1454400 |
|
|
aminopeptidase P |
>4.5 |
3.4.11.9 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28384 |
PF3D7_0902800 |
|
|
serine repeat antigen 9 |
>3 |
3.4.22.2 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28398 |
PF3D7_1016300 |
|
|
glycophorin binding protein |
>3 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28399 |
PF3D7_1016400 |
|
|
serine/threonine protein kinase, FIKK family |
>2.75 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28403 |
PF3D7_1105600 |
|
|
translocon component PTEX88 |
>2.5 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28409 |
PF3D7_1201000 |
|
|
Plasmodium exported protein (PHISTb), unknown function |
>2.5 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28360 |
PF3D7_0104200 |
|
|
StAR-related lipid transfer protein |
>2.25 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28368 |
PF3D7_0305300 |
|
|
transporter, putative |
>1.75 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28371 |
PF3D7_0501200 |
|
|
parasite-infected erythrocyte surface protein |
>1.5 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28389 |
PF3D7_0925900 |
|
|
lipocalin, lcn |
>1.5 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28414 |
PF3D7_1302300 |
|
|
Plasmodium exported protein, unknown function |
>1.25 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28373 |
PF3D7_0532100 |
|
|
early transcribed membrane protein 5 |
>1.25 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28416 |
PF3D7_1320000 |
|
|
rhoptry protein 2, putative golgi protein 1 |
>1.25 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28417 |
PF3D7_1321900 |
|
|
conserved Plasmodium protein, unknown function |
>1.25 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28432 |
PF3D7_1471100 |
|
|
exported protein 2 |
>1.25 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28411 |
PF3D7_1228600 |
|
|
merozoite surface protein 9 |
>1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28427 |
PF3D7_1420700 |
|
|
surface protein P113 |
>1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28424 |
PF3D7_1404900 |
|
|
conserved Plasmodium protein, unknown function |
>1 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28377 |
PF3D7_0721100 |
|
|
conserved Plasmodium protein, unknown function |
>0.75 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28369 |
PF3D7_0406200 |
|
|
parasitophorous vacuole membrane protein s16; sexual stage-specific protein s16 |
>0.75 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28381 |
PF3D7_0830400 |
|
|
cra domain-containing protein, putative |
>0.75 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28418 |
PF3D7_1334500 |
|
|
MSP7-like protein |
>0.75 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28386 |
PF3D7_0911900 |
|
|
inhibitor of cysteine proteases falstatin |
>0.75 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28408 |
PF3D7_1135400 |
|
|
hotdog domain-containing protein, putative |
>0.75 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28431 |
PF3D7_1464600 |
|
|
serine/threonine protein phosphatase uis2, putative |
>0.75 |
3.1.3.16 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28367 |
PF3D7_0215000 |
|
|
acyl-CoA synthetase |
>0.75 |
6.2.1.3 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28365 |
PF3D7_0207600 |
|
|
serine repeat antigen 5 |
>0.75 |
3.4.22.- |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 28401 |
PF3D7_1033200 |
|
|
early transcribed membrane protein 10.2 |
>0.5 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|