Malaria Parasite Metabolic Pathways
Drugs affecting pathway with unknown specific target
| Drug Name | PubMed Articles (year of publication) |
|---|---|
| 4-Hydroxytamoxifen | |
| chlorpromazine | |
| cPF4PD | |
| Desipramine | |
| dynasore | |
| Ferroquine | |
| MMV085071 | |
| N1-(3-chloropropyl)-N2-(7-chloroquinolin-4-yl)-N1-ethylethane-1,2-diamine | |
| Promethazine |
Transporters of the ER/Golgi and digestive vacuole membranes map details
| PFID | PFID Old | Annotation | Formal Annotation | EC | Transcript |
|---|---|---|---|---|---|
PF3D7_1037300
|
PF10_0366 | AAC2 | ADP, ATP carrier protein 1, aac1 |
|
|
|
PF3D7_0629500
|
PFF1430c | AAT1 | amino acid transporter aat1 |
|
|
| PF3D7_1036800 | PF10_0360 | ACT | acetyl-CoA transporter, putative, ACT |
|
|
|
PF3D7_0516100
|
PFE0805w | ATP1 | cation-transporting ATPase 1 | 3.6.3.12 |
|
|
PF3D7_0106300
|
PFA0310c | ATP6 | calcium-transporting ATPase, ATP6 | 3.6.3.8 |
|
| PF3D7_1348800 | MAL13P1.246 | ATP9 | E1-E2 ATPase, putative | 3.6.3.8 |
|
|
PF3D7_0603500
|
PFF0170w | CAX | cation/H+ antiporter CAX |
|
|
|
PF3D7_0709000
|
MAL7P1.27 | CRT | chloroquine resistance transporter |
|
|
| PF3D7_1250200 | PFL2410w | CSC1 | csc1-like protein, putative |
|
|
|
PF3D7_0824400
|
MAL8P1.32 | ENT2 | nucleoside transporter 2, NT2 |
|
|
|
PF3D7_0316600
|
PFC0725c | FNT | formate-nitrite transporter, FNT |
|
|
| PF3D7_0212000 | PFB0535w | GFT | GDP-fructose:GMP antiporter, putative |
|
|
| PF3D7_0106100 | PFA0300c | H+-pump (ATP) V-type | V-type proton ATPase subunit C, putative | 3.6.3.14 |
|
|
PF3D7_0406100
|
PFD0305c | H+-pump (ATP) V-type | V-type proton ATPase subunit B | 3.6.3.14 |
|
|
PF3D7_0519200
|
PFE0965c | H+-pump (ATP) V-type | V-type proton ATPase 16 kDa proteolipid subunit | 3.6.3.14 |
|
|
PF3D7_0806800
|
PF08_0113 | H+-pump (ATP) V-type | v-type proton atpase subunit a, putative | 3.6.3.14 |
|
| PF3D7_0934500 | PFI1670c | H+-pump (ATP) V-type | V-type proton ATPase subunit E, putative | 3.6.3.14 |
|
| PF3D7_1140100 | PF11_0412 | H+-pump (ATP) V-type | V-type proton ATPase subunit F, putative | 3.6.3.14 |
|
| PF3D7_1306600 | PF13_0034 | H+-pump (ATP) V-type | V-type proton ATPase subunit H, putative | 3.6.3.14 |
|
|
PF3D7_1311900
|
PF13_0065 | H+-pump (ATP) V-type | V-type proton ATPase catalytic subunit A | 3.6.3.14 |
|
| PF3D7_1323200 | PF13_0130 | H+-pump (ATP) V-type | V-type proton ATPase subunit G, putative | 3.6.3.14 |
|
|
PF3D7_1341900
|
PF13_0227 | H+-pump (ATP) V-type | V-type proton ATPase subunit D, putative | 3.6.3.14 |
|
| PF3D7_1354400 | MAL13P1.271 | H+-pump (ATP) V-type | V-type proton ATPase 21 kDa proteolipid subunit, putative | 3.6.3.14 |
|
| PF3D7_1464700 | PF14_0615 | H+-pump (ATP) V-type | ATP synthase (C/AC39) subunit, putative | 3.6.3.14 |
|
|
PF3D7_1456800
|
PF14_0541 | H+-pump (PPi) V-type | V-type H(+)-translocating pyrophosphatase, putative, VP1 | 3.6.1.1 |
|
|
PF3D7_0523000
|
PFE1150w | MDR1 | multidrug resistance protein 1. MDR1, IP3 receptor | 3.6.3.44 |
|
|
PF3D7_1447900
|
PF14_0455 | MDR2 | multidrug resistance protein 2, MDR2 | 3.6.3.44 |
|
|
PF3D7_0914700
|
PFI0720w | MFR4 | apicomplexan amino acid transporter apiat2, putative |
|
|
| PF3D7_0306700 | PFC0282w | MMgT | ER membrane protein complex subunit 5, putative |
|
|
| PF3D7_0505300 | PFE0260w | NGT | UDP-n-acetylglucosamine transporter, putative |
|
|
|
PF3D7_0523800
|
PFE1185w | NRAMP | divalent metal transporter, putative |
|
|
|
PF3D7_0210000
|
PFB0450w | Sec61 | secretory complex protein 61 gamma subunit |
|
|
| PF3D7_0216600 | PFB0760w | SWEET | Sugar transporter |
|
|
| PF3D7_1113300 | PF11_0141 | UGT | UDP-galactose transporter, putative, UGT |
|
|
| PF3D7_1230200 | PFL1455w | vacuolar transporter chaperone | vacuolar transporter chaperone, putative, pseudogene | 2.7.1.151 | |
|
PF3D7_1223700
|
PFL1140w | VIT | vacuolar iron transporter. VIT |
|
|
|
PF3D7_1235200
|
PFL1700c | VP2 | V-type K+-independent H+-translocating inorganic pyrophosphatase, VP2 | 3.6.1.1 |
|
Total number of related proteins: 12
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFA0300c | V-type proton ATPase subunit C, putative |
| 2 |
PFD0305c
|
V-type proton ATPase subunit B |
| 3 |
PFE0965c
|
V-type proton ATPase 16 kDa proteolipid subunit |
| 4 |
PF08_0113
|
v-type proton atpase subunit a, putative |
| 5 | PFI1670c | V-type proton ATPase subunit E, putative |
| 6 | PF11_0412 | V-type proton ATPase subunit F, putative |
| 7 | PF13_0034 | V-type proton ATPase subunit H, putative |
| 8 |
PF13_0065
|
V-type proton ATPase catalytic subunit A |
| 9 | PF13_0130 | V-type proton ATPase subunit G, putative |
| 10 |
PF13_0227
|
V-type proton ATPase subunit D, putative |
...
Please click for the full list of related proteins
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFA0310c
|
calcium-transporting ATPase, ATP6 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFB0450w
|
secretory complex protein 61 gamma subunit |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFB0535w | GDP-fructose:GMP antiporter, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFB0760w | Sugar transporter |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFC0282w | ER membrane protein complex subunit 5, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFC0725c
|
formate-nitrite transporter, FNT |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFE0260w | UDP-n-acetylglucosamine transporter, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFE0805w
|
cation-transporting ATPase 1 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFE1150w
|
multidrug resistance protein 1. MDR1, IP3 receptor |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFE1185w
|
divalent metal transporter, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFF0170w
|
cation/H+ antiporter CAX |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFF1430c
|
amino acid transporter aat1 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
MAL7P1.27
|
chloroquine resistance transporter |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
MAL8P1.32
|
nucleoside transporter 2, NT2 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFI0720w
|
apicomplexan amino acid transporter apiat2, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF10_0360 | acetyl-CoA transporter, putative, ACT |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF10_0366
|
ADP, ATP carrier protein 1, aac1 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF11_0141 | UDP-galactose transporter, putative, UGT |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFL1140w
|
vacuolar iron transporter. VIT |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFL1455w | vacuolar transporter chaperone, putative, pseudogene |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFL1700c
|
V-type K+-independent H+-translocating inorganic pyrophosphatase, VP2 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFL2410w | csc1-like protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | MAL13P1.246 | E1-E2 ATPase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF14_0455
|
multidrug resistance protein 2, MDR2 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF14_0541
|
V-type H(+)-translocating pyrophosphatase, putative, VP1 |