Mitochondrial electron flow

Online articles related to Mitochondrial electron flow retrieved from PubMed

Drugs affecting pathway with unknown specific target

Drug Name	PubMed Articles (year of publication)
(-)-R,S-dehydroemetine	Lead Optimization of Dehydroemetine for Repositioned Use in Malaria
(1S,5S,12aS)-3a-((E)-but-2-en-1-yl)-2,2-dimethyl-11-(3-(triphenyl-l5-phosphaneylidene)propoxy)-1,2-dihydro-1,5-methanofuro[2,3-d]xanthene-4,7(3aH,5H)-dione	Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity
(1S,5S,12aS)-3a-((E)-but-2-en-1-yl)-2,2-dimethyl-9-(3-(triphenyl-l5-phosphaneylidene)propoxy)-1,2-dihydro-1,5-methanofuro[2,3-d]xanthene-4,7(3aH,5H)-dione	Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity
(3S,4S)-8-hydroxy-3-((S)-2-hydroxypentyl)-4,6,7-trimethoxy-3,4-dihydronaphthalen-1(2H)-one	Semisynthesis, Antiplasmodial Activity, and Mechanism of Action Studies of Isocoumarin Derivatives
(L-cyclohexyl alanine-D-arginine)3	A Mitochondria-Penetrating Peptide Exerts Potent Anti-Plasmodium Activity and Localizes at Parasites' Mitochondria
(rs)-1-(1-benzothiophen-2-ylethyl)-1-hydroxyurea	Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues
(Z)-(12-(4-(2-(dimethylamino)ethoxy)phenyl)-11,12-diphenyldodec-11-en-1-yl)triphenylphosphonium	Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens
1,4-naphthoquinone	Biological evaluation of hydroxynaphthoquinones as anti-malarials
1-[(3S,9S,10R)-12-[(1S)-2-(dimethylamino)-1-methyl-ethyl]-3,10-dimethyl-9-(2-methyl-3-methylene-3-phenyl-but-3-enyl)-13-oxo-8-oxa-12-azabicyclo[12.4.0]octadeca-1(14),15,17-trien-16-yl]-3-phenyl-urea	A Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-Regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors
3-(4-(4-chlorobenzylthio) phenyl)-2,6-dimethylpyridin-4(1H)-one	In-Silico Design, Chemical Synthesis and Biological Screening of Novel 4-(1H)-Pyridone-based Antimalarial Agents
4-aminoquinoline	Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity
-4-hydroxy-1,2-naphthoquinone	Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone
6-(3-Thienyl)-6H-benzo[b]indeno[1,2-e][1,4]thiazepin-5-ol	A Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-Regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors
Antimycin a	A Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-Regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors
Artemisinin	Yeast model uncovers dual roles of mitochondria in action of artemisinin Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation
Atovaquone	Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum A Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-Regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors
Aurachins	Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues
Bilirubin	Bilirubin inhibits Plasmodium falciparum growth through the generation of reactive oxygen species
biphenyl;7-(4-phenylphosphanylbutoxy)-[1,3]dioxolo[4,5-c]xanthen-6-one	Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity
buparvaquone	Transition metal complexes of buparvaquone as potent new antimalarial agents. 1. Synthesis, X-ray crystal-structures, electrochemistry and antimalarial activity against Plasmodium falciparum
Decoquinate	A Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-Regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors
Desferrioxamine	Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation
DSM265	Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
Ferrocene	Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum
Hydroxynaphthoquinone	Transition metal complexes of buparvaquone as potent new antimalarial agents. 1. Synthesis, X-ray crystal-structures, electrochemistry and antimalarial activity against Plasmodium falciparum
MMV000563	Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
MMV006188	Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
MMV006820	Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
MMV007875	Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
MMV011099	Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
MMV019670	Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
MMV665940	Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
Myxothiazol	Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites
N-[2-[(4-benzylpiperazin-1-yl)methyl]-1-ethylbenzimidazol-5-yl]thiophene-2-carboxamide	Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
oligomycin A	A Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-Regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors
Oz209	Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation
Proguanil	An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum Revisiting the mode of action of the antimalarial proguanil using the yeast model
TCMDC-123667	Discovery of Dual-Stage Malaria Inhibitors with New Targets
Tcmdc-135426	Thousands of chemical starting points for antimalarial lead identification
TCMDC-135461	Discovery of Dual-Stage Malaria Inhibitors with New Targets
TCMDC-137395	Discovery of Dual-Stage Malaria Inhibitors with New Targets
TCMDC-137973	Discovery of Dual-Stage Malaria Inhibitors with New Targets

Mitochondrial electron flow map details

PFID	PFID Old	Annotation	Formal Annotation	EC
PF3D7_1025800	PF10_0253b	bc1 complex	respiratory chain complex 4 associated protein 2
PF3D7_0722700	PF07_0093	b-c1 complex subunit 11	respiratory chain complex 3 associated protein 1
PF3D7_0807400	MAL8P1.300	COQ10	coenzyme q-binding protein coq10 homolog, mitochondrial
PF3D7_1439600	PF14_0375	COX26	cytochrome c oxidase subunit ndufa4, putative, ndufa4
PF3D7_0915700	PFI0770c	COX30	COX30
PF3D7_1201800	PFL0090c	Cytochrom C oxidase	COX19 cytochrome c oxidase assembly protein, putative
mal_mito_3	mal_mito_3	Cytochrome b	apocytochrome b (cyb)
PF3D7_0523100	PFE1155c	cytochrome b-c1 complex subunit 2	cytochrome b-c1 complex subunit 2, putative	3.4.24.64
PF3D7_0622600	PFF1085a	cytochrome b-c1 complex subunit 9, putative	cytochrome b-c1 complex subunit 9, putative	1.10.2.2
PF3D7_1439400	PF14_0373	cytochrome b-c1 complex subunit Rieske, putative	cytochrome b-c1 complex subunit Rieske, putative	1.10.2.2
PF3D7_1311700	MAL13P1.55	Cytochrome c	cytochrome c, putative
PF3D7_1404100	PF14_0038	Cytochrome c	cytochrome c, putative
PF3D7_1462700	PF14_0597	Cytochrome c	cytochrome c1, heme protein, mitochondrial, putative, CYTC1
PF3D7_0825600	PF08_0025	cytochrome c oxidase	cytochrome c oxidase assembly factor 5, putative
PF3D7_0927800	PFI1365w	Cytochrome c oxidase	COX5B cytochrome c oxidase subunit 5B, putative	1.9.3.1
PF3D7_0928000	PFI1375w	cytochrome c oxidase	COX6b cytochrome c oxidase subunit 6B, putative	1.9.3.1
PF3D7_1003000	PF10_0034	cytochrome c oxidase	guanylate cyclase organizer ugo, putative
PF3D7_1025600	PF10_0252	cytochrome c oxidase	COX17 cytochrome c oxidase copper chaperone, putative
PF3D7_1361700	PF13_0327	Cytochrome c oxidase	cytochrome c oxidase subunit 2a, putative	1.9.3.1
PF3D7_1422000	PF14_0787	cytochrome c oxidase	COX14 cytochrome c oxidase assembly protein cox14, putative
PF3D7_1430900	PF14_0288	Cytochrome c oxidase	cytochrome c oxidase subunit 2b, putative	1.9.3.1
PF3D7_1435000	PF14_0331	cytochrome c oxidase	cytochrome c oxidase assembly protein cox15
PF3D7_1465000	PF14_0617	Cytochrome c oxidase	cytochrome c oxidase subunit 6a, putative, cox6a	1.9.3.1
PF3D7_1475300	PF14_0721	Cytochrome c oxidase	COX11 cytochrome c oxidase assembly protein putative	1.9.3.1
mal_mito_1	mal_mito_1	Cytochrome c oxidase	COX3 cytochrome c oxidase subunit 3	1.9.3.1
mal_mito_2	mal_mito_2	Cytochrome c oxidase	COX 1 cytochrome c oxidase subunit I	1.9.3.1
PF3D7_0603300	PFF0160c	Dihydroorotate dehydrogenase	dihydroorotate dehydrogenase	1.3.5.2
PF3D7_0722700	PF07_0093	espiratory chain complex 3 associated protein	respiratory chain complex 3 associated protein 1
PF3D7_1034400	PF10_0334	Flavoprotein subunit of succinate dehydrogenase SDHA	flavoprotein subunit of succinate dehydrogenase	1.3.5.1
PF3D7_1416500	PF14_0164	Glutamate dehydrogenase	NADP-specific glutamate dehydrogenase	1.4.1.4
PF3D7_1430700	PF14_0286	Glutamate dehydrogenase	NADP-specific glutamate dehydrogenase	1.4.1.4
PF3D7_0306400	PFC0275w	Glycerol-3-phosphate dehydrogenase (FAD+)	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	1.1.5.3
PF3D7_1114800	PF11_0157	Glycerol-3-phosphate dehydrogenase (NAD+)	glycerol-3-phosphate dehydrogenase, putative	1.1.1.8
PF3D7_1216200	PFL0780w	Glycerol-3-phosphate dehydrogenase (NAD+)	glycerol-3-phosphate dehydrogenase [NAD+], putative	1.1.1.8
PF3D7_1212800	PFL0630w	Iron-sulfur centres of succinate dehydrogenase SDHB	succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	1.3.99.1
PF3D7_0616800	PFF0815w	Malate:quinone oxidoreductase	malate:quinone oxidoreductase, putative	1.1.5.4
PF3D7_0508500	PFE0420c	NADH dehydrogenase	nd6 protein, putative
PF3D7_0915000	PFI0735c	NADH dehydrogenase	type II NADH:ubiquinone oxidoreductase	1.6.5.3
PF3D7_0808450	PF3D7_0808450	respiratory chain complex 2	respiratory chain complex 2 associated protein 1
PF3D7_0817800	PF08_0057	respiratory chain complex 3 associated protein	respiratory chain complex 3 associated protein 3
PF3D7_0608400	PFF0415c	respiratory chain complex 4 associated protein	respiratory chain complex 4 associated protein 4
PF3D7_1003100	PF10_0034a	respiratory chain complex 4 associated protein	respiratory chain complex 4 associated protein 3, c4ap4
PF3D7_1025800	PF10_0253b	respiratory chain complex 4 associated protein	respiratory chain complex 4 associated protein 2
PF3D7_1125600	PF11_0266a	respiratory chain complex 4 associated protein	respiratory chain complex 4 associated protein 1
PF3D7_0809250	A0A5K1K8Z8	respiratory chain complex 4 associated protein	respiratory chain complex 4 associated protein 5
PF3D7_0109850	PFA0485w	respiratory chain complex ii subunit	phosphatidate cytidylyltransferase, putative
PF3D7_0213200	PFB0600c	respiratory chain complex ii subunit	mitochondrial respiratory chain complex ii subunit, putative
PF3D7_1229700	PFL1432w	respiratory chain complex ii subunit	mitochondrial respiratory chain complex ii subunit, putative
PF3D7_1322800	MAL13P1.128	respiratory chain complex ii subunit	respiratory chain complex 2 associated protein 2, c2ap2
PF3D7_1346600	PF13_0246	respiratory chain complex ii subunit	respiratory chain complex 2 associated protein 4
PF3D7_1448900	PF14_0815	respiratory chain complex ii subunit	mitochondrial respiratory chain complex ii subunit, putative
PF3D7_0611100	PFF0545c	SDH3/4	succinate dehydrogenase subunit 3, putative	1.3.5.1
PF3D7_1010300	PF10_0100	SDH3/4	succinate dehydrogenase subunit 4, putative	1.3.5.1
PF3D7_1012300	PF10_0120	Ubiquinol cytochrome c oxidoreductase bc1 complex	cytochrome b-c1 complex subunit 7, putative	1.10.2.2
PF3D7_1426900	PF14_0248	Ubiquinol cytochrome c oxidoreductase bc1 complex	cytochrome b-c1 complex subunit 6, putative	1.10.2.2
PF3D7_0211300	PFB0501c	UbQ-cyt-c reductase complex assembly factor 1	ubiquinol-cytochrome-c reductase complex assembly factor 1, putative

Total number of related proteins: 6

#	PFID	Formal Name
1	PFA0485w	phosphatidate cytidylyltransferase, putative
2	PFB0600c	mitochondrial respiratory chain complex ii subunit, putative
3	PFL1432w	mitochondrial respiratory chain complex ii subunit, putative
4	MAL13P1.128	respiratory chain complex 2 associated protein 2, c2ap2
5	PF13_0246	respiratory chain complex 2 associated protein 4
6	PF14_0815	mitochondrial respiratory chain complex ii subunit, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PFB0501c	ubiquinol-cytochrome-c reductase complex assembly factor 1, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PFC0275w	FAD-dependent glycerol-3-phosphate dehydrogenase, putative

Total number of related proteins: 2

#	PFID	Formal Name
1	PFE0420c	nd6 protein, putative
2	PFI0735c	type II NADH:ubiquinone oxidoreductase

Total number of related proteins: 1

#	PFID	Formal Name
1	PFE1155c	cytochrome b-c1 complex subunit 2, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PFF0160c	dihydroorotate dehydrogenase

Total number of related proteins: 5

#	PFID	Formal Name
1	PFF0415c	respiratory chain complex 4 associated protein 4
2	PF10_0034a	respiratory chain complex 4 associated protein 3, c4ap4
3	PF10_0253b	respiratory chain complex 4 associated protein 2
4	PF11_0266a	respiratory chain complex 4 associated protein 1
5	A0A5K1K8Z8	respiratory chain complex 4 associated protein 5

Total number of related proteins: 2

#	PFID	Formal Name
1	PFF0545c	succinate dehydrogenase subunit 3, putative
2	PF10_0100	succinate dehydrogenase subunit 4, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PFF0815w	malate:quinone oxidoreductase, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PFF1085a	cytochrome b-c1 complex subunit 9, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PF07_0093	respiratory chain complex 3 associated protein 1

Total number of related proteins: 1

#	PFID	Formal Name
1	PF07_0093	respiratory chain complex 3 associated protein 1

Total number of related proteins: 1

#	PFID	Formal Name
1	MAL8P1.300	coenzyme q-binding protein coq10 homolog, mitochondrial

Total number of related proteins: 1

#	PFID	Formal Name
1	PF08_0057	respiratory chain complex 3 associated protein 3

Total number of related proteins: 13

#	PFID	Formal Name
1	PF08_0025	cytochrome c oxidase assembly factor 5, putative
2	PFI1365w	COX5B cytochrome c oxidase subunit 5B, putative
3	PFI1375w	COX6b cytochrome c oxidase subunit 6B, putative
4	PF10_0034	guanylate cyclase organizer ugo, putative
5	PF10_0252	COX17 cytochrome c oxidase copper chaperone, putative
6	PF13_0327	cytochrome c oxidase subunit 2a, putative
7	PF14_0787	COX14 cytochrome c oxidase assembly protein cox14, putative
8	PF14_0288	cytochrome c oxidase subunit 2b, putative
9	PF14_0331	cytochrome c oxidase assembly protein cox15
10	PF14_0617	cytochrome c oxidase subunit 6a, putative, cox6a

...

Please click for the full list of related proteins

Total number of related proteins: 1

#	PFID	Formal Name
1	PFI0770c	COX30

Total number of related proteins: 2

#	PFID	Formal Name
1	PF10_0120	cytochrome b-c1 complex subunit 7, putative
2	PF14_0248	cytochrome b-c1 complex subunit 6, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PF10_0253b	respiratory chain complex 4 associated protein 2

Total number of related proteins: 1

#	PFID	Formal Name
1	PF10_0334	flavoprotein subunit of succinate dehydrogenase

Total number of related proteins: 2

#	PFID	Formal Name
1	PF11_0157	glycerol-3-phosphate dehydrogenase, putative
2	PFL0780w	glycerol-3-phosphate dehydrogenase [NAD+], putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PFL0090c	COX19 cytochrome c oxidase assembly protein, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PFL0630w	succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Total number of related proteins: 3

#	PFID	Formal Name
1	MAL13P1.55	cytochrome c, putative
2	PF14_0038	cytochrome c, putative
3	PF14_0597	cytochrome c1, heme protein, mitochondrial, putative, CYTC1

Total number of related proteins: 2

#	PFID	Formal Name
1	PF14_0164	NADP-specific glutamate dehydrogenase
2	PF14_0286	NADP-specific glutamate dehydrogenase

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0373	cytochrome b-c1 complex subunit Rieske, putative

Total number of related proteins: 1

#	PFID	Formal Name
1	PF14_0375	cytochrome c oxidase subunit ndufa4, putative, ndufa4

Total number of related proteins: 1

#	PFID	Formal Name
1	mal_mito_3	apocytochrome b (cyb)

Total number of related proteins: 1

#	PFID	Formal Name
1	PF3D7_0808450	respiratory chain complex 2 associated protein 1

Malaria Parasite Metabolic Pathways

Drugs affecting pathway with unknown specific target

Mitochondrial electron flow map details

Total number of related proteins: 6

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Total number of related proteins: 5

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Total number of related proteins: 13

Please click for the full list of related proteins

Total number of related proteins: 1

Total number of related proteins: 2

Total number of related proteins: 1

Total number of related proteins: 1

Total number of related proteins: 2

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Total number of related proteins: 1

Total number of related proteins: 3

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