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Cholesterol binding proteins |
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Maier AG, van Ooij C. The role of cholesterol in invasion and growth of malaria parasites. Front Cell Infect Microbiol. 2022 12:984049. PMID: 36189362 |
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Gene ID |
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Protein |
Expression |
Conserved |
Essential |
Phenotype of mutant |
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PF3D7_1463500 |
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fam-a protein |
unknown |
All Plasmodium |
no |
ND |
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PF3D7_0107500 |
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Niemann-Pick type c1-related protein |
liver stage, asexual (trophozoite, schizont), very low gametocytes, ookinetes, sporozoites |
All Plasmodium |
yes (asexual) |
Lethal |
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PF3D7_1426500 |
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ABC transporter G family member 2 |
female gametocytes (low expression male) |
All Plasmodium |
no (asexual) |
Decreased cholesteryl esters, diacylglycerols and triacylglycerols in gametocytes |
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PF3D7_1131800 |
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oxysterol-binding protein, putative |
liver stage, asexual stage (trophozoite, schizont), gametocytes (male, female), ookinete |
All Plasmodium |
no (asexual) |
ND |
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PF3D7_0629300 |
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phospholipase, putative phosphatidylcholine-sterol acyltransferase, putative |
liver stage, asexual stage (trophzoite, schizont), oocyst, sprozoite (injected) |
All Plasmodium |
no (asexual) |
Delayed egress from PV in liver stage |
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PF3D7_0113700 |
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heat shock protein 40, type II |
asexual stage |
Lavernia |
no (asexual) |
Malformation of knobs |
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