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Protein kinase coding genes |
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The list was prepared following Ward P, Equinet L, Packer J, Doerig C. 2004. Protein kinases of the human malaria parasite |
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Plasmodium falciparum: the kinome of a divergent eukaryote. BMC Genomics.5:79. |
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PlasmoDB ID |
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Annotation |
Literature Name |
Location |
Transcript |
EC# |
Essential |
Role |
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Cell-cycle-regulated protein kinases, Ser/Thr kinase |
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| 38021 |
PF3D7_1201600 |
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NIMA related kinase 3 |
NEK3 |
Apicoplast |
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2.7.11.1 |
not likely |
Dispensable for blood-stage asexual proliferation |
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| 37974 |
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Displays both Ser/Thr and Tyr kinase activities |
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| 37983 |
PF3D7_0605300 |
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erine/threonine protein kinase ark1 |
NEK5 |
Spindle poles |
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2.7.11.1 |
yes |
Nuclear division - Associates with spindle pole bodies during erythrocytic schizogony |
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| 37973 |
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Epistatic interaction with Pfnek-1 |
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| 38024 |
PF3D7_0719200 |
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NIMA related kinase 4 |
NEK4 |
Spindle poles |
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2.7.11.1 |
no |
Proposed role in commitment to gametocytogenesis; associates with nuclei of committed schizonts |
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PF3D7_0525900 |
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NIMA related kinase 2 |
NEK2 |
microtubules |
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2.7.11.1 |
not likely |
DNA replication during meiosis and ookinete development in P. berghei |
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| 38027 |
PF3D7_1228300 |
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NIMA related kinase 1 |
NEK1 |
cytoplasmic/ nuclear |
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2.7.11.1 |
yes |
Essential for asexual proliferation - Male-specific in gametocytes |
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| 38002 |
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Epistatic interaction with PfARK1 |
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| 38046 |
Cyclic-nucleotide- and calcium/phospholipid dependent kinases (AGC/Akt group) |
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| 38038 |
PF3D7_1246900 |
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RAC-beta serine/threonine protein kinase |
PKB |
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2.7.11.1 |
yes |
Invasion of erythrocytes - Phosphorylates Glideosome-associated protein GAP45 |
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| 37958 |
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Regulated by calcium/calmodulin |
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| 38017 |
PF3D7_0934800 |
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cAMP-dependent protein kinase catalytic subunit |
PKAr |
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2.7.11.11 |
likely |
Invasion of erythrocytes |
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| 38013 |
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Phosphorylation of the moving junction protein AMA1 during invasion |
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Interacts with Rab proteins |
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| 38042 |
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Activated by melatonin treatment |
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| 37975 |
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Regulatory subunit regulated anion channel conductance |
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| 38034 |
PF3D7_1436600 |
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cGMP-dependent protein kinase |
PKG |
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2.7.11.12 |
yes |
Invasion of, and egress from, erythrocytes; Phosphorylates PfCDPK1 |
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| 37959 |
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Phosphorylation-deficient PfPKG is functionally incompetent in merozoite egress |
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| 37981 |
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Release of the SUB1 protease from secretory organelles to mediate egress |
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| 37955 |
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Epistatic interaction with PfCDPK1 and PfCDKP4 |
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| 37963 |
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Gametogenesis |
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| 37954 |
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Nucleotide-binding domain used as a cGMP sensor in mammalian cells |
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| 37960 |
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Control of calcium mobilisation, probably through phosphorylation of a calcium channel |
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| 38015 |
PF3D7_1356800 |
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serine/threonine protein kinase ark3, putative |
ARK3 |
perinuclear |
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2.7.11.1 |
yes |
Merozoite ontogeny during late schizogony |
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| 38007 |
PF3D7_0309200 |
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serine/threonine protein kinase ark2, putative |
ARK2 |
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2.7.11.1 |
yes |
Likely essential for asexual proliferation - No functional data |
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| 38014 |
PF3D7_1145200 |
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serine/threonine protein kinase, putative |
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Apicoplast |
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2.7.11.1 |
likely |
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| 37979 |
PF3D7_1121900 |
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3-phosphoinositide-dependent protein kinase 1 |
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2.7.11.1 |
likely |
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| 38016 |
Calmodulin-dependent kinases (CamK) |
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PF3D7_1423600 |
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calcium-dependent protein kinase, putative |
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2.7.11.17 |
not likely |
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| 38003 |
PF3D7_0610600 |
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calcium-dependent protein kinase 2 |
CDPK2 |
Mitochondrion |
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2.7.11.1 |
likely |
Male gametogenesis (exflagellation) |
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| 38039 |
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Epistatic interaction with other CDPKs during invasion and motility |
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| 37976 |
PF3D7_1337800 |
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calcium-dependent protein kinase 5, CDPK5 |
CDPK5 |
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2.7.1.1 |
yes |
Egress of merozoite from iRBCs |
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| 37965 |
PF3D7_0310100 |
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calcium-dependent protein kinase 3, CDPK3 |
CDPK3 |
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2.7.11.17 |
likely |
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| 37962 |
PF3D7_0717500 |
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calcium-dependent protein kinase 4, CDPK4 |
CDPK4 |
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2.7.11.1 |
no |
Male gametogenesis (exflagellation) |
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| 37964 |
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Epistatic interaction with PfPKG and other PfCDPKs |
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| 38033 |
PF3D7_0217500 |
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Calcium-dependent protein kinases; CDPK1 |
CDPK1 |
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2.7.11.1 |
yes |
Invasion of erythrocytes - Phosphorylates Glideosome-associated protein GAP45 |
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| 40779 |
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Invasion of erythrocytes - Interacts with 14-3-3 |
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| 37970 |
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Egress from erythrocytes - Phosphorylates the SERA5 protease |
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| 38008 |
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Epistatic interaction with PfPKG |
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| 38050 |
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Early schizont development |
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| 37957 |
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Gametogenesis |
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| 38048 |
PF3D7_0321400 |
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pseudo protein kinase 1, putative |
STK |
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2.7.11.17 |
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| 38035 |
PF3D7_0214600 |
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serine/threonine protein kinase stk2, putative |
- |
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2.7.11.1 |
no |
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| 38011 |
PF3D7_0311400 |
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kinase-related protein pkrp |
- |
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not likely |
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| 37990 |
PF3D7_1123100 |
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calcium-dependent protein kinase 7 |
CDPK7 |
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2.7.11.17 |
no |
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| 38031 |
PF3D7_1104900 |
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calcium/calmodulin-dependent protein kinase, putative |
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2.7.11.17 |
no |
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| 38009 |
PF3D7_1122800 |
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calcium-dependent protein kinase 6 |
CDPK6 |
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2.7.11.13 |
no |
Transition from a migratory to an invasive phenotype in P. berghei sporozoites |
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| 37961 |
PF3D7_0704500 |
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serine/threonine protein kinase, putative |
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Mitochondrion |
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2.7.11.1 |
no |
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| 38010 |
PF3D7_1136500 |
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casein kinase 1 |
CK1 |
micronemes |
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2.7.11.1 |
yes |
Associates with host erythrocyte membrane and is secreted to the extracellular medium |
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| 38044 |
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Associates with human CK1 and components of the erythrocyte trafficking machinery |
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Interacts with Rab proteins |
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| 38037 |
Cyclin-dependent-(CDK), mitogen-activated- (MAPK), glycogen-synthase-(GSK) |
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| 38026 |
PF3D7_1014400 |
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MO15-related protein kinase |
MRK |
Nucleus |
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2.7.11.22 |
Yes |
Cell cycle control - Homologue of human CDK-activating kinase CDK7; associates with cyclin 1 |
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| 37978 |
PF3D7_1356900 |
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protein kinase 5 |
PK5 |
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2.7.11.22 |
yes |
Cell cycle control - activation of Origin of Replication Control (ORC) components |
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| 38000 |
PF3D7_0615500 |
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cdc2-related protein kinase 5 |
CRK5 |
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2.7.11.22 |
not likely |
Regulation of the number of daughter merozoites; DNA replication during gametogenesis |
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| 37998 |
PF3D7_0417800 |
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cdc2-related protein kinase 1 |
CRK1 |
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2.7.11.22 |
yes |
Homologue of mammalian p58 kinases that negatively regulate proliferation - no functional data |
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| 37980 |
PF3D7_0317200 |
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cdc2-related protein kinase 4 |
CRK4 |
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2.7.11.22 |
yes |
DNA replication during schizogony |
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| 38028 |
PF3D7_0415300 |
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cdc2-related protein kinase 3 |
CRK3 |
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2.7.11.22 |
yes |
Epigenetic control of gene expression - Associates with histone deacetylase activity in asexual parasites |
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| 38052 |
PF3D7_1337100 |
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protein kinase 6 |
PK6 |
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2.7.11.22 |
yes |
Possesses features of both MAPKs and CDKs – no functional data available |
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| 37953 |
PF3D7_0105800 |
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cyclin-dependent kinases regulatory subunit, putative |
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likely |
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| 38054 |
PF3D7_0503500 |
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protein kinase, putative |
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2.7.11.- |
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| 38047 |
PF3D7_1106800 |
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pseudo-tyrosine kinase-like protein |
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2.7.10.2 |
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| 38049 |
PF3D7_1445400 |
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protein serine/threonine kinase-1 |
CLK1 |
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2.7.11.1 |
yes |
Splicing - Phosphorylation of splicing factors in vitro |
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| 38032 |
PF3D7_0302100 |
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serine/threonine protein kinase |
SRPK1 |
|
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2.7.11.1 |
yes |
likely essential for asexual proliferation |
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| 37950 |
PF3D7_1443000 |
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serine/threonine protein kinase |
SRPK2 |
|
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2.7.11.1 |
yes |
Splicing - Phosphorylation of splicing factors in vitro |
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| 38030 |
PF3D7_1338900 |
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serine/threonine protein kinase, putative |
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Apicoplast |
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2.7.11.1 |
no |
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| 38001 |
PF3D7_1114700 |
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cyclin-dependent-like kinase clk3 |
CLK3 |
|
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2.7.11.1 |
likely |
Essential for liver and blood schizogony and gametocyte development |
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| 37982 |
PF3D7_0821100 |
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protein kinase 1 |
PK1 |
|
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2.7.11.1 |
no |
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| 37952 |
PF3D7_1316000 |
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protein kinase, putative |
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Mitochondrion |
 |
2.7.11.1 |
likely |
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| 37977 |
PF3D7_1108400 |
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casein kinase 2, alpha subunit |
CK2 |
|
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2.7.11.1 |
yes |
Invasion of erythrocytes - Phosphorylates reticulocyte homologue protein 2b (PfRhbp2) |
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| 37999 |
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Chromatin assembly - Phosphorylates nucleosome assembly proteins, histones and Alba protein in vitro |
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| 38000 |
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Epigenetic control of gene expression - Phosphorylates heterochromatin protein 1 in vitro |
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| 37951 |
PF3D7_0312400 |
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glycogen synthase kinase 3 |
GSK3 |
|
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2.7.11.26 |
yes |
Erythrocyte invasion - Phosphorylation of the moving junction protein AMA1; Exported to the erythrocyte |
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|
|
| 38018 |
PF3D7_1113900 |
|
|
mitogen-activated protein kinase 2 |
MAPK2 |
|
 |
2.7.11.24 |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38012 |
PF3D7_1431500 |
|
|
mitogen-activated protein kinase 1 |
MAPK1 |
|
 |
2.7.11.24 |
not likely |
Pfmap-1 lines do not display apparent phenotypes, but causes overexpression of Pfmap-2; Double Pfmap-1/Pfmap-2 KO do not display phenotypes in asexual proliferation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38045 |
Tyrosine kinase like |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38043 |
PF3D7_1349300 |
|
|
tyrosine kinase-like protein |
TKL3 |
|
 |
2.7.10.2 |
yes |
Co-localises with cytoskeleton microtubules |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38051 |
|
|
|
|
|
|
|
|
|
Mediates resistance to a compound targeting PfPKG |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38000 |
PF3D7_1238900 |
|
|
protein kinase 2 |
PK2 |
|
 |
2.7.11.1 |
likely |
Important for invasion |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0628200 |
|
|
eukaryotic translation initiation factor 2-alpha kinase |
PK4 |
|
 |
2.7.11.1 |
yes |
Arrest of global translation in mature schizonts and gametocytes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37968 |
PF3D7_0926300 |
|
|
protein kinase, putative |
|
|
 |
2.7.11.17 |
? |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38005 |
PF3D7_0926000 |
|
|
protein kinase, putative |
|
|
|
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38004 |
PF3D7_0715300 |
|
|
calcium/calmodulin-dependent protein kinase, putative |
|
|
 |
2.7.11.17 |
not likely |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37956 |
PF3D7_1247500 |
|
|
serine/threonine protein kinase, putative |
|
|
 |
2.7.11.1 |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38019 |
PF3D7_1454300 |
|
|
snf1-related serine/threonine protein kinase kin |
KIN |
|
 |
|
yes |
Nutrient sensing in P. berghei |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37949 |
PF3D7_0213400 |
|
|
protein kinase 7 |
PK7 |
|
 |
2.7.11.1 |
not likely |
Regulation of the number of daughter merozoites and oocyst maturation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38055 |
|
|
|
|
|
|
|
|
|
Response to melatonin |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37996 |
PF3D7_1474700 |
|
|
protein kinase, putative |
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37967 |
PF3D7_1441300 |
|
|
serine/threonine protein kinase, putative |
|
|
 |
2.7.11.1 |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38020 |
PF3D7_1444500 |
|
|
eukaryotic initiation factor 2alpha kinase 1 |
eIK1 |
|
 |
|
not likely |
Regulation of stress-response to amino-acid starvation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37994 |
PF3D7_1331000 |
|
|
protein kinase, putative |
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37997 |
PF3D7_0107600 |
|
|
eukaryotic translation initiation factor 2-alpha kinase 2 |
|
|
 |
2.7.11.1 |
not likely |
Regulation of sporozoites latency in the mosquito salivary glands (P. berghei) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37993 |
|
|
|
|
|
|
|
|
|
Upregulated in P. cynomolgi hypnozoites |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37985 |
PF3D7_1315100 |
|
|
serine/threonine protein kinase PK9 |
PK9 |
|
 |
2.7.11.1 |
yes |
Phosphorylation of the E2 ubiquitin-conjugating enzyme 13 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37986 |
|
|
|
|
|
|
|
|
|
Liver stage maturation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37991 |
PF3D7_0928800 |
|
|
serine/threonine protein kinase, putative |
|
|
 |
2.7.11.1 |
? |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37969 |
PF3D7_0718100 |
|
|
exported serine/threonine protein kinase |
EST |
|
 |
2.7.11.1 |
likely |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38014 |
PF3D7_0211700 |
|
|
tyrosine kinase-like protein, putative |
TKL1 |
Mitochondrion |
 |
2.7.11.1 |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37995 |
PF3D7_0623800 |
|
|
tyrosine kinase-like protein, putative |
TKL4 |
|
 |
2.7.10.2 |
not likely |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37992 |
PF3D7_0926100 |
|
|
protein kinase, putative |
|
|
 |
2.7.11.1 |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38040 |
PF3D7_0926300 |
|
|
protein kinase, putative |
|
|
|
2.7.11.17 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0203100 |
|
|
protein kinase, putative |
PfPK8 |
|
 |
2.7.11.1 |
no |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37988 |
PF3D7_1148000 |
|
|
serine/threonine protein kinase, putative |
|
|
 |
2.7.11.1 |
yes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38041 |
PF3D7_1121300 |
|
|
tyrosine kinase-like protein |
TKL2 |
|
 |
2.7.10.2 |
no |
Closely related to human IRAK kinases; secreted to the extracellular medium; proposed role in immunomodulation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38025 |
PF3D7_1433900 |
|
|
protein kinase, putative |
|
Apicoplast |
 |
2.7.11.1 |
? |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37966 |
PF3D7_1428500 |
|
|
protein kinase, putative |
|
|
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37984 |
PF3D7_1450000 |
|
|
serine/threonine protein kinase, putative |
|
|
 |
2.7.11.17 |
not likely |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0926300 |
|
|
protein kinase, putative |
|
|
|
2.7.11.17 |
not likely |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38006 |
FIKK family - apicomplexan protein kinases |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38036 |
PF3D7_0424700 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK4.2 |
|
 |
2.7.11.1 |
|
Regulation of knob structures on infected erythrocytes that mediate cytoadhesion |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38053 |
PF3D7_1039000 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK10.2 |
Mitochondrion |
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38029 |
PF3D7_1016400 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK10.1 |
|
 |
2.7.11.1 |
|
Associates with Maurer’s cleft and J-dots (trafficking structures in infected erythrocytes) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37972 |
PF3D7_0301200 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK3 |
|
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38022 |
PF3D7_1149300 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK11 |
|
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 38023 |
PF3D7_0102600 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK1 |
|
 |
2.7.11.1 |
|
Direct or indirect phosphorylation of FIKK10.2 and host erythrocyte Adducin |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37987 |
PF3D7_1476400 |
|
|
serine/threonine protein kinase, FIKK family, pseudogene |
FIKK14 |
Apicoplast |
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37989 |
PF3D7_0902500 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK9.6 |
|
 |
2.7.11.1 |
|
Associates with Maurer’s clefts (trafficking structures in infected erythrocytes) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 37971 |
PF3D7_0424500 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK4.1 |
Maurer's clefts |
 |
2.7.11.1 |
|
Regulates rigidification of the erythrocyte cytoskeleton and trafficking of the PfEMP1 adhesin to the host cell surface; localises mainly to the cytoskeleton. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Phosphorylates human dematin (a cytoskeleton protein) in vitro |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Associates with Maurer’s clefts (trafficking structures in infected erythrocytes) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1200800 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK12 |
Maurer's clefts |
 |
2.7.11.1 |
|
Regulation of the rigidity of infected erythrocytes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0902300 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK9.4 |
|
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0902600 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK9.7 |
Apicoplast |
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0902200 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK9.3 |
Apicoplast |
 |
2.7.11.1 |
|
Associates with Maurer’s clefts (trafficking structures in infected erythrocytes) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0726200 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK7.1 |
|
 |
2.7.11.1 |
|
Regulation of the rigidity of infected erythrocytes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0731400 |
|
|
serine/threonine protein kinase, FIKK family, pseudogene |
FIKK7.2 |
|
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0805700 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK8 |
|
 |
2.7.11.1 |
|
Involved in asexual proliferation, as conditional KO results in impaired growth |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0902000 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK9.1 |
Apicoplast |
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0500900 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK5 |
|
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1122800 |
|
|
calcium-dependent protein kinase 6 |
CDPK6 |
|
|
2.7.11.13 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0902400 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK9.5 |
Apicoplast |
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0902100 |
|
|
serine/threonine protein kinase, FIKK family |
FIKK9.2 |
Maurer's clefts |
|
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1371700 |
|
|
serine/threonine protein kinase, FIKK family fikk13 |
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Atypical protein kinases |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0810200 |
|
|
ABC1 family, putative, ABCK1 |
ABCK1 |
Mitochondrion |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1414500 |
|
|
atypical protein kinase, ABC-1 family, putative |
ABCk2 |
|
 |
1.14.13.- |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1230900 |
|
|
serine/threonine protein kinase RIO1, putative |
RIO1 |
|
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0420100 |
|
|
serine/threonine protein kinase RIO2 |
RIO2 |
|
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0724600 |
|
|
protein kinase, putative |
|
|
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Protein kinase regulators |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1103700 |
|
|
casein kinase II beta chain |
CK2beta1 |
|
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1342400 |
|
|
casein kinase II beta chain |
CK2beta2 |
|
 |
2.7.11.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1463700 |
|
|
cyclin 1 |
CYC1 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1304700 |
|
|
cyclin |
CYC4 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0518400 |
|
|
cyclin |
CYC3 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1223100 |
|
|
cAMP-dependent protein kinase regulatory subunit |
PKAr |
|
 |
2.7.11.11 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_1227500 |
|
|
protein soc2, putative |
SOC2 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0803300 |
|
|
mitogen-activated protein kinase organizer 1, putative |
MORG1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0817500 |
|
|
histidine triad nucleotide-binding protein 1 |
HINT1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PF3D7_0511700 |
|
|
EKC/KEOPS complex subunit CGI121 |
CGI121 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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Drugs affecting pathway with unknown specific target