Co-inhibition of S-adenosylmethionine decarboxylase/ornithine decarboxylase effect on gene expression
van Brummelen AC, Olszewski KL, Wilinski D, Llinás M, Louw AI, Birkholtz LM. Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory  mechanisms by transcriptome, proteome, and metabolome analyses. J Biol Chem. 2009 284(7):4635-46 PMID: 19073607
over expressed; all others are down regulated
Functional category PfID Annotation 19 hrs 27 hrs 34 hrs EC# Transcript
Replication and DNA metabolism PF3D7_1335500 DNA replication complex gins protein, putative 1.78
PF3D7_1107400
DNA repair protein RAD51 0.49 0.59 0.61
PF3D7_1111100 replication factor C subunit 5, putative 0.51 0.48 0.56
PF3D7_1112600 ATPase, putative 1.71
PF3D7_1317100 DNA replication licensing factor MCM4 0.46 0.61 0.74
PF3D7_1355100
DNA replication licensing factor MCM6 0.55 0.69 0.85
PF3D7_1408400 FANCJ-like helicase, putative 0.59 0.69 0.76 3.6.4.12
PF3D7_1411400
plastid replication-repair enzyme 0.49 0.50 0.57 2.7.7.7
PF3D7_1427500
DNA mismatch repair protein MSH2, putative 0.57 0.61 0.73
PF3D7_1433500
DNA topoisomerase 2 1.34 0.76 0.58 5.99.1.3
PF3D7_1463200
replication factor C subunit 3, putative 0.50 0.61 0.62
PF3D7_0105900 3'-5' exonuclease, putative 0.66 0.56 0.68 3.1.11.1
PF3D7_0203900
5'-3' exonuclease, putative 0.54 3.1.16.1
PF3D7_0219600
replication factor c subunit 1 0.50 0.74 0.83
?PF3D7_1477000 replication protein A1, large subunit 0.53 0.41 0.42
PF3D7_0513600
deoxyribodipyrimidine photo-lyase, putative 0.56 0.61 0.65 4.1.99.3
PF3D7_0630300 DNA polymerase epsilon catalytic subunit A, putative 0.59 0.67 2.7.7.7
PF3D7_0904800 replication protein A1, small fragment 0.55 0.77
PF3D7_0910900 DNA primase large subunit, putative 0.56 0.64 0.82 2.7.7.6
PF3D7_1234300 DNA polymerase epsilon subunit B, putative 0.46 2.7.7.7
PF3D7_1031300 SAE2 domain-containing protein, putative 1.73 1.97 2.13
PF3D7_0613800
AP2 domain transcription factor, putative 1.87 1.40 1.44
PF3D7_0914800 GINS complex subunit Psf3, putative 0.56 0.77
PF3D7_1222400
AP2 domain transcription factor 0.59
PF3D7_1361900
proliferating cell nuclear antigen 1 0.31 0.42 0.54
Transcription and RNA metabolism PF3D7_1439500 oocyst rupture protein 2, putative 2.06
PF3D7_0408900
tRNA N6-adenosine threonylcarbamoyltransferase 0.41 0.50 0.55 2.6.99.4
PF3D7_1239200
transcription factor with AP2 domain(s) 0.70
PF3D7_1126000
threonine--tRNA ligase 1.69 1.29 6.1.1.3
0.71 0.27 0.27
0.41 0.47 0.59
PF3D7_1360900 RNA-binding protein, putative 0.53 0.62 0.77
PF3D7_0810600 ATP-dependent RNA helicase dbp1, putative 0.57 0.65 3.6.4.13
PF3D7_1004400 RNA-binding protein, putative 0.57
PF3D7_1006100 CCR4-NOT transcription complex subunit 5, putative 0.60 0.57
PF3D7_1107100 nucleic acid binding protein, putative 1.69
PF3D7_1310700
PhIL1-interacting protein PhIP 1.94 0.63 0.52
PF3D7_1355800 splicing factor 3B subunit 5, putative 0.68 0.57
PF3D7_1409800 CUGBP Elav-like family member 2 0.74 1.32 1.72
PF3D7_1418800 ncRNA 1.64 1.80 1.92
PF3D7_0205700 RNA-binding protein, putative 1.71
PF3D7_0518700 mRNA-binding protein PUF1 1.91
PF3D7_0525000 zinc finger protein, putative 1.29 1.70
PF3D7_0909800
small nuclear ribonucleoprotein Sm D3, putative 2.24 1.73
PF3D7_1244000 glucose inhibited division protein a homologue, putative 0.48 0.56 0.74
snRNA-1 1.77
PF3D7_1307900 tripartite motif protein, putative 2.05
PF3D7_1015500 nucleotidyltransferase, putative 0.52
PF3D7_1032900
RNA polymerase II-associated protein 1, putative 0.59
PF3D7_1117600
peptidyl-tRNA hydrolase ICT1, putative 0.52 3.1.1.29
PF3D7_1350900
AP2 domain transcription factor AP2-O4, putative 1.80
PF3D7_1469800 mediator of RNA polymerase II transcription subunit 21 0.48 0.60 0.61
PF3D7_0105200
RAP01 0.52 1.28
PF3D7_0205700 RNA-binding protein, putative 2.00 1.56
PF3D7_0308100 zinc finger protein, putative 2.26
PF3D7_0604800 RAP protein, putative 0.47
PF3D7_1212300 WD repeat-containing protein, putative 0.56 0.80
PF3D7_1234100
bromodomain protein 5 1.81 1.60 1.62
Translation PF3D7_0611600
basal complex transmembrane protein 1 0.57 0.62
PF3D7_1365100
ribosomal protein s17, mitochondrial, mtrps17 1.68
PF3D7_0715600 GTP-binding translation elongation factor tu family protein, putative 0.54 0.76 0.81
PF3D7_0719700 40S ribosomal protein S10, putative 1.89 1.60
PF3D7_1003500 40S ribosomal protein S20e, putative 2.25 2.30
PF3D7_1034900
methionine--tRNA ligase 0.58 0.59 0.66 6.1.1.10
PF3D7_1117500
tyrosine--tRNA ligase 0.56 0.72 6.1.1.1
PF3D7_1144000 40S ribosomal protein S21 1.77 2.04 1.67
PF3D7_1302800 40S ribosomal protein S7, putative 1.53 1.84 1.84
PF3D7_1331800 60S ribosomal protein L23, putative 1.97 1.79
PF3D7_1342000 40S ribosomal protein S6 1.51 1.79 1.69
PF3D7_1421200 40S ribosomal protein S25 1.82 2.38 1.79
PF3D7_1424400 60S ribosomal protein L7-3, putative 1.83 1.72
PF3D7_1460700 60S ribosomal protein L27 2.10 1.73
PF3D7_0210100.1 1.72 1.55 1.43
PF3D7_0312800 60S ribosomal protein L26, putative 2.00 1.76
PF3D7_0322900 40S ribosomal protein S3A, putative 1.75
PF3D7_0503800 60S ribosomal protein L31 1.82
PF3D7_0925300
proline--tRNA ligase, putative 0.56 6.1.1.15
PF3D7_1125800 kelch domain-containing protein, putative 0.58 0.69
PF3D7_0202400
translation-enhancing factor 1.68 2.54 3.32
PF3D7_0524400 ribosome-interacting GTPase 1, putative 2.30 1.71
Post translational modifications PF3D7_1455200 methyltransferase aamt 0.35 0.44 0.47 2.1.1.201
PF3D7_1015600
heat shock protein 60 0.55 0.80
PF3D7_1120900
heat shock factor-binding protein 1 0.57 0.64 0.67
PF3D7_1143200 DnaJ protein, putative 1.76 1.84 2.20
PF3D7_1149200
ring-infected erythrocyte surface antigen 0.39 0.33
PF3D7_1401100 DnaJ protein, putative 0.44 0.37
PF3D7_0102200
ring-infected erythrocyte surface antigen 1.68 0.34 0.26
PF3D7_0201700 DnaJ protein, putative 1.94 0.62 0.37
PF3D7_0523400 DnaJ protein, putative 1.67 1.69
PF3D7_1232100
60 kDa chaperonin 0.51 0.80
PF3D7_0809600 peptidase family C50, putative separase, putative 0.64 0.58 0.61 3.4.22.49
PF3D7_1113400 ubiquitin domain-containing protein DSK2, putative 1.89 2.10
PF3D7_1353800 proteasome subunit alpha type-4, putative 0.55 0.78 3.4.25.1
PF3D7_1401300
proline aminopeptidase 1.92 1.67 1.31 3.4.11.5
PF3D7_1436800 ATP-dependent Clp protease proteolytic subunit 0.56 0.60 0.63 3.4.21.92
PF3D7_1446200
M17 leucyl aminopeptidase 0.76 0.66 0.57 3.4.11.1
PF3D7_1470900
proteasome subunit beta type-2, putative 1.70 1.80 3.4.25.1
PF3D7_0404700
dipeptidyl aminopeptidase 3 0.59 0.60 3.4.14.4
PF3D7_0521300 zinc finger protein, putative 2.15 1.86
PF3D7_0628100
hect domain-containing protein 1, putative 2.01 6.3.2.19
PF3D7_0902800
serine repeat antigen 9 0.52 0.47 0.58 3.4.22.2
PF3D7_1211800 polyubiquitin 0.80 1.50 2.10
PF3D7_0314700
ring finger protein rnf1 1.81 1.63 1.87
PF3D7_1331300
signal peptidase complex catalytic subunit SEC11 0.59 0.66 0.73 3.4.21.89
PF3D7_0704500 serine/threonine protein kinase, putative 2.05 1.56 2.7.11.1
PF3D7_1039000
serine/threonine protein kinase, FIKK family 0.65 0.55 2.7.11.1
PF3D7_1114700
cyclin-dependent-like kinase clk3 0.57 2.7.11.1
PF3D7_1121300
tyrosine kinase-like protein 2.30 1.71 1.61 2.7.10.2
PF3D7_1441300 serine/threonine protein kinase, putative 1.34 0.27 0.24 2.7.11.1
PF3D7_1444200
EF-hand calcium-binding domain-containing protein, putative 1.85
PF3D7_1466100 protein phosphatase containing kelch-like domains 0.71 0.57 0.64
PF3D7_0102600
serine/threonine protein kinase, FIKK family 2.47 1.81 2.7.11.1
PF3D7_0213400
protein kinase 7 0.75 0.58 0.72 2.7.11.1
PF3D7_0424500
serine/threonine protein kinase, FIKK family 0.76 0.49 2.7.11.1
PF3D7_0424700
serine/threonine protein kinase, FIKK family 1.69 1.23 2.7.11.1
PF3D7_0501400 interspersed repeat antigen 0.58 0.34
PF3D7_0513800
ras-related protein Rab-1A 0.31 3.6.5.2
PF3D7_0623800
tyrosine kinase-like protein, putative 0.69 0.58 2.7.10.2
PF3D7_0902000
serine/threonine protein kinase, FIKK family 0.57 0.54 0.48 2.7.11.1
PF3D7_0902500
serine/threonine protein kinase, FIKK family 0.70 0.49 2.7.11.1
PF3D7_1238900
protein kinase 2 1.69 2.26 2.7.11.1
PF3D7_1147500
protein farnesyltransferase subunit beta 1.63 1.69 2.5.1.58
PF3D7_1412800
peptide N-myristoyltransferase glycylpeptide N-tetradecanoyltransferase 0.66 0.59 2.3.1.97
PF3D7_1238700 BTB/POZ domain-containing protein, putative 0.57 1.44
PF3D7_1331600 3-hydroxyacyl-coa dehydratase deh 0.40 0.43 3.1.3.48
PF3D7_1372200 histidine-rich protein III 0.59
PF3D7_0808300 ubiquitin regulatory protein, putative 2.10
PF3D7_0823400 alpha/beta hydrolase, putative 0.57 0.49
PF3D7_0812220
GTP-binding protein YihA3 0.45
PF3D7_0702300 sporozoite threonine and asparagine-rich protein 0.52
PF3D7_1133700 FHA domain-containing protein, putative 0.60 0.35
PF3D7_1353200
membrane associated histidine-rich protein 2 0.53 0.31
PF3D7_1406400
pentatricopeptide repeat domain-containing protein 1 0.57 0.63
PF3D7_1427900 leucine-rich repeat protein 0.41 0.51 0.57
PF3D7_0209700 RING zinc finger protein, putative 1.75 1.38
PF3D7_0220000 liver stage antigen 3 0.59 0.48
PF3D7_0314300 DER1-like protein 0.70 0.57 0.68
PF3D7_0924200 heptatricopeptide repeat-containing protein, putative 1.83 1.32
PF3D7_1205600 tetratricopeptide repeat protein, putative 0.52 0.62 0.71
PF3D7_1243900
double C2-like domain-containing protein 1.94 1.28
Amino acid metabolism PF3D7_1033100
S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.61 0.53 0.62 4.1.1.17
PF3D7_1432700 protein-L-isoaspartate(D-aspartate) O-methyltransferase, putative 0.54 2.1.1.77
PF3D7_0405700
lysine decarboxylase, putative 1.83 2.49 2.78 4.1.1.18
PF3D7_0520900
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase 0.54 0.65 0.68 3.3.1.1
PF3D7_0608800
ornithine aminotransferase 1.46 1.88 1.79 2.6.1.13
PF3D7_0922200
S-adenosylmethionine synthetase 0.42 0.55 0.67 2.5.1.6
PF3D7_0829400 prolyl 4-hydroxylase subunit alpha, putative 1.71 1.63 1.14.11.2
PF3D7_0815000
selenoprotein 0.59 0.80
PF3D7_0413700 lysine decarboxylase-like protein, putative 0.39 0.56 0.62 4.1.1.18
Carbohydrate metabolism PF3D7_1015900
enolase 0.55 0.55 0.51 4.2.1.11
PF3D7_1324900
L-lactate dehydrogenase 0.57 0.65 0.66 1.1.1.27
PF3D7_1351600
glycerol kinase 1.49 0.55 0.54 2.7.1.30
PF3D7_1439900
triosephosphate isomerase 0.53 0.78 0.87 5.3.1.1
PF3D7_1462800
glyceraldehyde-3-phosphate dehydrogenase 0.47 0.51 0.52 1.2.1.12
PF3D7_0626800
pyruvate kinase 0.51 0.58 0.66 2.7.1.40
Lipid metabolism PF3D7_1343000
phosphoethanolamine N-methyltransferase 0.37 0.36 0.37 2.1.1.103
PF3D7_1341600
GPI mannosyltransferase 3 0.57 0.75 2.4.1.-
PF3D7_0702200
lysophospholipase lpl20 0.73 0.49 3.1.1.5
PF3D7_0731600
acyl-CoA synthetase 0.48 0.56 0.63 6.2.1.3
PF3D7_1001100 acyl-CoA binding protein, isoform 1, ACBP1 0.35 0.27
PF3D7_1001200 acyl-CoA binding protein, isoform 2, ACBP2 0.37 0.57 0.65
PF3D7_1124600
ethanolamine kinase 0.39 0.57 0.73 2.7.1.82
PF3D7_1126600 steryl ester hydrolase, putative 1.68 1.57 3.1.1.13
PF3D7_1312000
malonyl CoA-acyl carrier protein transacylase precursor 0.37 0.21 2.3.1.39
PF3D7_1323000
beta-hydroxyacyl-ACP dehydratase 0.46 0.47 4.2.1.59
PF3D7_0511200
stearoyl-CoA desaturase 0.57 0.68 1.14.19.1
PF3D7_0511800
inositol-3-phosphate synthase 0.53 0.72 5.5.1.4
PF3D7_0605900 elongation of fatty acids protein, putative 0.49 0.39 6.2.1.3
PF3D7_0628300
choline/ethanolaminephosphotransferase, putative 0.43 0.49 2.7.8.1
PF3D7_0918100 cytochrome b5-like heme/steroid binding protein, putative 0.63 0.53
PF3D7_1406300
glycerophosphodiester phosphodiesterase 0.67 0.56 0.65 3.1.4.46
PF3D7_1001100 acyl-CoA binding protein, isoform 1, ACBP1 0.38 0.32
PF3D7_1001600
exported lipase 2 0.47 0.33 0.40 3.1.1.23
PF3D7_1010400 morn repeat protein, putative, VIRMA 0.41 0.42 2.7.1.68
PF3D7_1141400 phosphatidylinositol N-acetylglucosaminyltransferase subunit H, putative 0.65 0.59 0.65 2.4.1.198
PF3D7_1214100
GPI ethanolamine phosphate transferase 3, putative 0.58 0.66
Nucleotide metabolism PF3D7_1015800
ribonucleoside-diphosphate reductase small chain, putative 0.56 0.69 1.17.4.1
PF3D7_1127100
deoxyuridine 5'-triphosphate nucleotidohydrolase dUTP pyrophosphatase 0.45 0.31 0.35 3.6.1.23
PF3D7_1366500
nucleoside diphosphate kinase 0.41 0.46 0.52 2.7.4.6
PF3D7_1405600
ribonucleoside-diphosphate reductase small chain, putative 0.37 0.63 0.74 1.17.4.1
PF3D7_1431800
apyrase 0.61 0.57 0.66 3.6.1.5
PF3D7_1029600
adenosine deaminase 0.38 0.41 0.42 3.5.4.4
PF3D7_0513300
purine nucleoside phosphorylase 0.31 0.34 0.37 2.4.2.1
PF3D7_1321500
3',5'-cyclic nucleotide phosphodiesterase beta 1.68 1.62 3.1.4.17
Redox metabolism PF3D7_1027300
peroxiredoxin merozoite capping protein 1 2.02 0.76 1.11.1.15
PF3D7_0802200
1-cys peroxiredoxin 0.31 0.33 0.35 1.11.1.15
PF3D7_1419300
glutathione S-transferase 0.56 0.61 0.66 2.5.1.18
PF3D7_1419800
glutathione reductase 0.59 0.77 1.8.1.7
PF3D7_1419200 thioredoxin-like protein, putative 0.52 0.78 0.83
Cofactor biosynthesis PF3D7_0417200
bifunctional dihydrofolate reductase-thymidylate synthase 0.47 0.64 0.64 1.5.1.3
PF3D7_1022800
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), putative 0.54 1.17.7.1
PF3D7_1028100
protoporphyrinogen oxidase 0.53 1.3.3.4
PF3D7_1020800
dihydrolipoamide acyltransferase component E2 0.55 0.49 2.3.1.12
PF3D7_1443700
dephospho-CoA kinase 1.85 0.61 0.70 2.7.1.24
PF3D7_1450900 acetyl-CoA acetyltransferase, putative 0.54 0.57 0.75 2.3.1.9
PF3D7_1477900 acyl-CoA synthetase, pseudogene 1.78 6.2.1.3
PF3D7_0215300
acyl-CoA synthetase 1.71 0.60 6.2.1.3
PF3D7_0320500
nicotinamidase, putative 1.80 2.06 3.5.1.19
PF3D7_1200700 acyl-CoA synthetase 1.00 0.46 0.25 6.2.1.3
PF3D7_1437400
pantothenate kinase 2 0.59 0.67 0.68 2.7.1.33
PF3D7_1459700 pyridoxal 5'-phosphate synthase, putative 0.46 0.59 1.4.3.5
Mitosis and chromosome separation PF3D7_1105500
centrin-4 0.65 0.57
PF3D7_1446600
centrin-2 0.56 0.62
PF3D7_0110700
chromatin assembly factor 1 subunit c, putative; caf1c; rbap48 0.48 0.54 0.62
PF3D7_0919900
regulator of chromosome condensation, putative 1.44 1.74
PF3D7_1217600 anaphase-promoting complex subunit 10, putative 0.55 0.45
PF3D7_1123800 structural maintenance of chromosomes protein 5, putative 0.54
PF3D7_1433300
histone-binding protein rbbp7, putative, 1.48 2.08 2.45
PF3D7_0414000
structural maintenance of chromosomes protein 3, putative 0.50 0.77
PF3D7_0419600 ran-specific GTPase-activating protein 1, putative 2.00 1.84
PF3D7_1209300
telomere repeat-binding zinc finger protein, putative 1.55 1.91 2.02
PF3D7_0932100 protein MAM3, putative
PF3D7_0817300 conserved Plasmodium protein, unknown function, asparagine-rich antigen 1.52 1.77 2.44
PF3D7_1135600 condensin-2 complex subunit d3, putative 0.63 0.58 0.70
PF3D7_1468200 telomere length and silencing protein 1, putative 0.74 0.60 0.50
PF3D7_0105800 cyclin-dependent kinases regulatory subunit, putative 0.69 0.58 0.68
PF3D7_0501800
chromatin assembly factor 1 subunit a CAF1A 0.50 1.29
Intracellular trafic PF3D7_1034000 Sec1 family protein, putative, SLY1 1.74 1.83
PF3D7_1034700 ADP-ribosylation factor, putative 0.47
PF3D7_0613500 AP-3 complex subunit beta, putative 1.64 1.89
PF3D7_0815800 vacuolar protein sorting-associated protein 9, putative 1.45 1.77
PF3D7_1007700
AP2 domain transcription transcription factor AP2-I 1.74
PF3D7_1011200 bet1-like protein, putative 1.87 1.51
PF3D7_1130500 conserved oligomeric Golgi complex subunit 2 0.70 0.52 0.58
PF3D7_0316700 protein yop1, putative 0.66 0.57
PF3D7_0320700 signal peptidase complex subunit SPC2, putative 0.47 0.61 0.69 3.4.21.89
PF3D7_0604300 Trs120 1.77 1.56
PF3D7_0616700
ras GTPAse, putative 1.76 1.61 3.6.5.2
Protein export PF3D7_1335300
reticulocyte binding protein 2 homologue b, ALKBH5 2.08
PF3D7_0731500
erythrocyte binding antigen-175 1.51 0.57 0.55
PF3D7_0713300 erythrocyte membrane protein 1 (PfEMP1), pseudogene 1.70 0.57
PF3D7_0712000
erythrocyte membrane protein 1, PfEMP1 1.79
PF3D7_1001500
early transcribed membrane protein 10., ETRAMP10.1 1.41 0.45
PF3D7_1033200
early transcribed membrane protein 10.2 1.42 1.77
PF3D7_1100400 rifin 1.85
PF3D7_1102700 early transcribed membrane protein 11.1 1.74 0.59 0.32
PF3D7_1102800 early transcribed membrane protein 11.2 1.46 0.59 0.36
PF3D7_0200100 erythrocyte membrane protein 1, PfEMP1 2.99 1.44
PF3D7_0201900
erythrocyte membrane protein 3 1.68
PF3D7_0202500
early transcribed membrane protein 2 1.44 0.76 0.49
PF3D7_0302200
cytoadherence linked asexual protein 3.2 1.96
PF3D7_0302300 erythrocyte membrane protein 1 (PfEMP1), pseudogene 1.27 0.80 0.59
PF3D7_0632500
erythrocyte membrane protein 1, PfEMP1 2.05
PF3D7_0632800 erythrocyte membrane protein 1, PfEMP1 1.77
PF3D7_0900300 PIR protein rifin 1.85
PF3D7_0900700 rifin 1.82 1.35
PF3D7_1219400 erythrocyte membrane protein 1 (PfEMP1), pseudogene 1.28 0.77 0.59
PF3D7_1229400
macrophage migration inhibitory factor 0.60 0.52 0.50 5.3.2.1
PF3D7_0500800
erythrocyte membrane protein 2 mature parasite-infected erythrocyte surface antigen 0.51 0.56 0.63
PF3D7_1253000
gametocyte exported protein 1 gametocyte erythrocyte cytosolic protein 0.59 0.49 0.45
PF3D7_1371800 Plasmodium exported protein, unknown function 0.25 0.22 0.20
PF3D7_1352900 fam-f protein Plasmodium exported protein, unknown function 0.72 0.37 0.29
PF3D7_1301700
cx3cl1-binding protein 2, gametocyte exported protein 7, GEXP7 0.53 0.28
PF3D7_0730800 Plasmodium exported protein, unknown function 0.59 0.43
PF3D7_0731200 Plasmodium exported protein, unknown function 0.49 0.33
PF3D7_0731700 Plasmodium exported protein (hyp9), unknown function 0.67 0.57 0.67
PF3D7_0710500 conserved Plasmodium protein, unknown function 0.55 0.61 0.61
PF3D7_0702000 Plasmodium exported protein (hyp12), unknown function 0.61 0.38
PF3D7_0702100 Plasmodium exported protein (PHISTb), unknown function, pseudogene 2.56
PF3D7_0830600 Plasmodium exported protein (PHISTc), unknown function 0.71 0.54
PF3D7_0726100 Plasmodium exported protein, unknown function 1.33 0.67 0.57
PF3D7_0830900 Plasmodium exported protein, unknown function 1.33 1.85 1.71
PF3D7_0830500 tryptophan/threonine-rich antigen sporozoite and liver stage tryptophan-rich protein, putative 0.53 0.38
PF3D7_0830300 sporozoite invasion-associated protein 2 0.61 0.52
PF3D7_1001300
Plasmodium exported protein (PHISTa), unknown function 0.69 0.46 0.39
PF3D7_1001700 Plasmodium exported protein (PHISTc), unknown function 0.72 0.43
PF3D7_1001800 Plasmodium exported protein (PHISTc), unknown function 0.69 0.47
PF3D7_1001900
Plasmodium exported protein (hyp16), unknown function 0.57
PF3D7_1002000 Plasmodium exported protein (hyp2), unknown function 0.29
PF3D7_1002100
EMP1-trafficking protein 1.18 0.43 0.26
PF3D7_1016300
glycophorin binding protein 0.66 0.48 0.45
PF3D7_1016800 Plasmodium exported protein (PHISTc), unknown function 1.33 0.68 0.43
PF3D7_1102300 Plasmodium exported protein, unknown function 2.45
PF3D7_1102500
gametocyte exported protein 2 Plasmodium exported protein (PHISTb), unknown function 0.61 0.57
PF3D7_1102900 Plasmodium exported protein (hyp11), unknown function 0.38
PF3D7_1148700
Plasmodium exported protein (PHISTc), unknown function gametocyte exported protein 12 1.47 0.77 0.50
PF3D7_1148800 Plasmodium exported protein (hyp11), unknown function 0.56 0.45
PF3D7_1148900 Plasmodium exported protein, unknown function 0.64 0.42
PF3D7_1149100 Plasmodium exported protein, unknown function 0.31 0.40 0.41
PF3D7_1301200 glycophorin binding protein 0.55
PF3D7_1302100
gamete antigen 27/25 0.82 0.32 0.25
PF3D7_1301400
Plasmodium exported protein (hyp12), unknown function 0.66 0.49
PF3D7_1301800 surface-associated interspersed protein 13.1 (SURFIN 13.1), pseudogene 0.61 0.41
PF3D7_1476200
Plasmodium exported protein (PHISTb), unknown function 0.62 0.48
PF3D7_1476300 Plasmodium exported protein (PHISTb), unknown function 0.43
PF3D7_1478600 EMP1-trafficking protein 1.84 1.41 1.22
PF3D7_0102300
Plasmodium exported protein, unknown function 0.30 0.35 0.37
PF3D7_0113000
glutamic acid-rich protein 0.57 0.53 0.46
PF3D7_0113300
Plasmodium exported protein (hyp1), unknown function 0.73 0.54
PF3D7_0113900
Plasmodium exported protein (hyp8) 0.74 0.47
PF3D7_0202100 liver stage associated protein 2 Plasmodium exported protein (PHISTc), unknown function 0.68 0.57
PF3D7_0202200
EMP1-trafficking protein 0.60 0.39
PF3D7_0212600
secreted protein with altered thrombospondin repeat domain 0.63 0.52
PF3D7_0219700
gametocyte exported protein 20 Plasmodium exported protein (PHISTc), unknown function 0.48 0.32
PF3D7_0220300 Plasmodium exported protein, unknown function 1.42 1.90 2.06
PF3D7_0221200 Plasmodium exported protein (hyp15), unknown function 0.52 0.65 0.75
PF3D7_0301700
Plasmodium exported protein, unknown function 1.29 1.72
PF3D7_0301800 Plasmodium exported protein, unknown function 0.52 0.48
PF3D7_0312900 hypothetical protein 0.39 0.40
PF3D7_0401800
Plasmodium exported protein (PHISTb), unknown function 0.60 0.49 0.61
PF3D7_0424000
Plasmodium exported protein (PHISTc), unknown function 2.07 1.53 1.33
PF3D7_0424600
plasmodium exported protein (phistb) 0.57 0.59
PF3D7_0424900 Plasmodium exported protein (PHISTa), unknown function 0.73 0.48
PF3D7_0513700 secreted ookinete protein, putative 6-cysteine protein 0.60 0.53
PF3D7_0523900 merc domain-containing protein, putative 1.23 0.78 0.58
PF3D7_0532500 Plasmodium exported protein, unknown function 2.93 2.57 1.85
PF3D7_0532600 Plasmodium exported protein, unknown function 1.83 2.23
PF3D7_0901700 Plasmodium exported protein (hyp5), unknown function 0.47
PF3D7_0902700 Plasmodium exported protein (PHISTb), unknown function, pseudogene; MEC domain-containing protein 1.32 1.70
PF3D7_0935600 gametocytogenesis-implicated protein 0.48 0.34
PF3D7_0935900
ring-exported protein 1 1.40 0.58 0.31
PF3D7_0936000
ring-exported protein 2 0.59 0.33
PF3D7_0936300
ring-exported protein 3 0.54 0.32
PF3D7_0936600
Plasmodium exported protein (PHISTc), unknown function gametocyte exported protein 5 0.68 0.56
PF3D7_0936900 Plasmodium exported protein (PHISTb), unknown function, pseudogene 0.57
PF3D7_1201200 Plasmodium exported protein (PHISTa-like), unknown function 0.48 0.33
PF3D7_1226900
parasitophorous vacuolar protein 2 1.46 1.79
PF3D7_1240100 early transcribed membrane protein 12 0.71 0.48
PF3D7_1252700
Plasmodium exported protein (PHISTb), unknown function 0.58 0.64 0.68
PF3D7_1253300 Plasmodium exported protein (PHISTa), unknown function, pseudogene 0.61 0.44
Invasion and motility PF3D7_1008700
tubulin beta chain 0.54 0.62 0.76
PF3D7_0103800 actin-related protein arp1, putative 0.50 0.58
PF3D7_0319400 kinesin-8x 0.68 0.58 0.76
PF3D7_0503400
actin-depolymerizing factor 1 0.56 0.44 0.50
PF3D7_0503600
myosin B 0.44 0.47
PF3D7_0627200 myosin light chain, putative 0.59
PF3D7_0903700
alpha tubulin 1 0.53 0.58 0.66
PF3D7_0905300
dynein heavy chain, putative 0.44
PF3D7_0932200
profilin 0.46 0.50
PF3D7_1213600
dynein light chain 1, putative 0.48 0.64 0.74
PF3D7_1219000
formin 2 1.43 1.74 1.90
PF3D7_1227500 protein soc2, putative 1.80
PF3D7_1251200
coronin 0.70 0.51
PF3D7_1035400
merozoite surface protein 3 1.81 0.74 0.75
PF3D7_1035500
merozoite surface protein 6 1.73 0.83
PF3D7_1334600
MSP7-like protein 1.95
PF3D7_1335100
merozoite surface protein 7 1.75 1.22
PF3D7_1410400
rhoptry-associated protein 1 0.56 0.58
PF3D7_0206800
merozoite surface protein 2 1.71 0.68 0.67
PF3D7_0905400
high molecular weight rhoptry protein 3 0.55 0.76
PF3D7_0930300
merozoite surface protein 1 1.29 0.63 0.58
PF3D7_1361800 glideosome-associated connector 1.93
PF3D7_0722200
rhoptry-associated leucine zipper-like protein 1 1.82
PF3D7_0805200 IMC-associated apicomplexan protein, putative gamete release protein, putative 1.63 0.46 0.33
PF3D7_1003600
inner membrane complex protein 1c, putative 1.68
PF3D7_1035200
S-antigen 0.47 0.61
PF3D7_1118700
myosin light chain B 1.97
PF3D7_1334500
MSP7-like protein 0.38 0.52 0.58
PF3D7_1334700
MSP7-like protein 0.62 0.46
PF3D7_1341500 inner membrane complex suture component, putative 0.46 0.47
PF3D7_0109000
photosensitized INA-labeled protein PHIL1 0.61 0.46
PF3D7_0214900
rhoptry neck protein 6 1.73
PF3D7_0515700
glideosome-associated protein 40, putative 0.48 0.54
PF3D7_0525800
inner membrane complex protein 1g, putative 1.41 0.68 0.59
PF3D7_0906910 tubulin-specific chaperone, putative 1.29 1.72 1.59
PF3D7_0918000
glideosome-associated protein 50 secreted acid phosphatase 0.68 0.59 0.76 3.1.3.2
Organellar functions mal_mito_3
apocytochrome b (cyb) 0.71 0.51 0.55
mal_mito_2 COX 1 cytochrome c oxidase subunit I 0.58 0.65 1.9.3.1
mal_mito_1
COX3 cytochrome c oxidase subunit 3 0.72 0.51 0.62 1.9.3.1
PF3D7_0715500
ATP synthase subunit epsilon, mitochondrial, putative 0.55 0.62 0.58 3.6.3.14
PF3D7_1140100 V-type proton ATPase subunit F, putative 0.56 3.6.3.14
PF3D7_1320800
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.57 0.68 2.3.1.61
PF3D7_1341900
V-type proton ATPase subunit D, putative 1.88 1.72 3.6.3.14
PF3D7_0519300
protoheme ix farnesyltransferase COX10 0.57 0.77 2.5.1.B36
PF3D7_1441700
mitochondrial inner membrane protease atp23, putative 0.39
PF3D7_1474100 ribosomal protein L20, mitochondrial, putative 0.39 0.46 0.52
PF3D7_0932600 apicoplast ribosomal protein S6, putative 1.75
PF3D7_1339500 ribosomal protein L49, mitochondrial, putative 0.44
PF3D7_1447300 mitochondrial ribosomal protein S14 precursor, putative 0.77 0.58 0.52
PF3D7_1463800 ribosomal protein S6, mitochondrial, putative 0.58
PF3D7_0918200 50S ribosomal protein L3, apicoplast, putative 0.60 0.58 0.62
PFC10_API0036 apicoplast ribosomal protein L14 0.47
PFC10_API0030 apicoplast ribosomal protein S12 (rps12) 0.59 0.60
PFC10_API0039 ribosomal protein S3, putative (rps3) 0.59 0.74
PFC10_API0035 apicoplast ribosomal protein S8 (rps8) 0.58 0.73
PF3D7_1010300
succinate dehydrogenase subunit 4, putative 0.56 0.41 1.3.5.1
PF3D7_1012300
cytochrome b-c1 complex subunit 7, putative 0.32 0.32 1.10.2.2
PF3D7_1022300
ZIP domain-containing protein, putative, ZIPCO 0.52
PF3D7_1123700 ribosomal protein l37, mitochondrial, putative 0.49 0.54 0.56
PF3D7_1305100
protein AMR3 0.45
PF3D7_1434800 mitochondrial acidic protein MAM33, putative 0.47 0.78
PF3D7_1445300 ribosomal protein S29, mitochondrial, putative 0.50 0.59
PF3D7_0406500 NYN domain-containing protein, putative 1.26 0.64 0.57
PF3D7_0416600 prohibitin-like protein phbl, putative 0.59 0.65 0.69
Transport PF3D7_0824400
nucleoside transporter 2, NT2 0.35 0.55 0.65
PF3D7_0715900
zinc transporter, putative 0.47 0.42 0.46
PF3D7_0816200
vacuolar protein sorting-associated protein 2, putative 1.86
PF3D7_1120300 CorA-like Mg2+ transporter protein, putative, MIT1 0.61 0.57 0.62
PF3D7_0112200
multidrug resistance-associated protein 1 MRP1 0.57 0.77 3.6.3.44
PF3D7_0209600 transporter, putative 0.57 0.65
PF3D7_0302600
ABC transporter B family member 4, putative, ABCB4 0.53 0.73
PF3D7_0505300 UDP-n-acetylglucosamine transporter, putative 2.01 0.72
PF3D7_0508300
triose phosphate transporter, TPT 0.52 0.79
PF3D7_0715800
drug/metabolite transporter dmt1, putative, DMT1 0.51
PF3D7_1029400 LEM3/CDC50 family protein, putative 1.54 1.94 1.89
PF3D7_1440800
major facilitator superfamily domain-containing protein, MFS6 0.56 0.65 0.77
PF3D7_1469400 nucleoside transporter 3, putative, NT3 1.69 1.85
PF3D7_0104800
apicomplexan amino acid transporter apiat8, putative 0.59 0.70 0.75
PF3D7_0212000 GDP-fructose:GMP antiporter, putative 0.68 0.46 0.49
PF3D7_0212800 multidrug efflux pump, putative, MATE 0.58
PF3D7_0910100 exportin-T 0.56
129 conserved plasmodium protein, unknown function
Online articles related to Co-inhibition of S-adenosylmethionine decarboxylase/ornithine decarboxylase effect on gene expression retrieved from PubMed

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