Co-inhibition of S-adenosylmethionine decarboxylase/ornithine decarboxylase effect on gene expression
van Brummelen AC, Olszewski KL, Wilinski D, Llinás M, Louw AI, Birkholtz LM. Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory  mechanisms by transcriptome, proteome, and metabolome analyses. J Biol Chem. 2009 284(7):4635-46 PMID: 19073607
over expressed; all others are down regulated
Functional category PfID Annotation 19 hrs 27 hrs 34 hrs EC# Transcript
41470 Replication and DNA metabolism PF3D7_1335500 DNA replication complex gins protein, putative 1.78
41389 PF3D7_1107400
DNA repair protein RAD51 0.49 0.59 0.61
41390 PF3D7_1111100 replication factor C subunit 5, putative 0.51 0.48 0.56
41391 PF3D7_1112600 ATPase, putative 1.71
41457 PF3D7_1317100 DNA replication licensing factor MCM4 0.46 0.61 0.74
41482 PF3D7_1355100
DNA replication licensing factor MCM6 0.55 0.69 0.85
41496 PF3D7_1408400 FANCJ-like helicase, putative 0.59 0.69 0.76 3.6.4.12
41499 PF3D7_1411400
plastid replication-repair enzyme 0.49 0.50 0.57 2.7.7.7
41506 PF3D7_1427500
DNA mismatch repair protein MSH2, putative 0.57 0.61 0.73
41511 PF3D7_1433500
DNA topoisomerase 2 1.34 0.76 0.58 5.99.1.3
41531 PF3D7_1463200
replication factor C subunit 3, putative 0.50 0.61 0.62
41164 PF3D7_0105900 3'-5' exonuclease, putative 0.66 0.56 0.68 3.1.11.1
41178 PF3D7_0203900
5'-3' exonuclease, putative 0.54 3.1.16.1
41190 PF3D7_0219600
replication factor c subunit 1 0.50 0.74 0.83
41550 ?PF3D7_1477000 replication protein A1, large subunit 0.53 0.41 0.42
41236 PF3D7_0513600
deoxyribodipyrimidine photo-lyase, putative 0.56 0.61 0.65 4.1.99.3
41264 PF3D7_0630300 DNA polymerase epsilon catalytic subunit A, putative 0.59 0.67 2.7.7.7
41312 PF3D7_0904800 replication protein A1, small fragment 0.55 0.77
41318 PF3D7_0910900 DNA primase large subunit, putative 0.56 0.64 0.82 2.7.7.6
41436 PF3D7_1234300 DNA polymerase epsilon subunit B, putative 0.46 2.7.7.7
41370 PF3D7_1031300 SAE2 domain-containing protein, putative 1.73 1.97 2.13
41257 PF3D7_0613800 AP2 domain transcription factor, putative 1.87 1.40 1.44
41319 PF3D7_0914800 GINS complex subunit Psf3, putative 0.56 0.77
41430 PF3D7_1222400
AP2 domain transcription factor 0.59
41486 PF3D7_1361900
proliferating cell nuclear antigen 1 0.31 0.42 0.54
41515 Transcription and RNA metabolism PF3D7_1439500 oocyst rupture protein 2, putative 2.06
41214 PF3D7_0408900
tRNA N6-adenosine threonylcarbamoyltransferase 0.41 0.50 0.55 2.6.99.4
41439 PF3D7_1239200 transcription factor with AP2 domain(s) 0.70
41552 PF3D7_1126000
threonine--tRNA ligase 1.69 1.29 6.1.1.3
0.71 0.27 0.27
0.41 0.47 0.59
41484 PF3D7_1360900 RNA-binding protein, putative 0.53 0.62 0.77
41291 PF3D7_0810600 ATP-dependent RNA helicase dbp1, putative 0.57 0.65 3.6.4.13
41349 PF3D7_1004400 RNA-binding protein, putative 0.57
41350 PF3D7_1006100 CCR4-NOT transcription complex subunit 5, putative 0.60 0.57
41388 PF3D7_1107100 nucleic acid binding protein, putative 1.69
41455 PF3D7_1310700
PhIL1-interacting protein PhIP 1.94 0.63 0.52
41483 PF3D7_1355800 splicing factor 3B subunit 5, putative 0.68 0.57
41497 PF3D7_1409800 CUGBP Elav-like family member 2 0.74 1.32 1.72
41551 PF3D7_1418800 ncRNA 1.64 1.80 1.92
41179 PF3D7_0205700 RNA-binding protein, putative 1.71
41240 PF3D7_0518700 mRNA-binding protein PUF1 1.91
41247 PF3D7_0525000 zinc finger protein, putative 1.29 1.70
41316 PF3D7_0909800
small nuclear ribonucleoprotein Sm D3, putative 2.24 1.73
41442 PF3D7_1244000 glucose inhibited division protein a homologue, putative 0.48 0.56 0.74
snRNA-1 1.77
41454 PF3D7_1307900 tripartite motif protein, putative 2.05
41357 PF3D7_1015500 nucleotidyltransferase, putative 0.52
41371 PF3D7_1032900
RNA polymerase II-associated protein 1, putative 0.59
41395 PF3D7_1117600
peptidyl-tRNA hydrolase ICT1, putative 0.52 3.1.1.29
41477 PF3D7_1350900 AP2 domain transcription factor AP2-O4, putative 1.80
41536 PF3D7_1469800 mediator of RNA polymerase II transcription subunit 21 0.48 0.60 0.61
41162 PF3D7_0105200
RAP01 0.52 1.28
41179 PF3D7_0205700 RNA-binding protein, putative 2.00 1.56
41200 PF3D7_0308100 zinc finger protein, putative 2.26
41252 PF3D7_0604800 RAP protein, putative 0.47
41424 PF3D7_1212300 WD repeat-containing protein, putative 0.56 0.80
41435 PF3D7_1234100
bromodomain protein 5 1.81 1.60 1.62
41255 Translation PF3D7_0611600
basal complex transmembrane protein 1 0.57 0.62
41487 PF3D7_1365100
ribosomal protein s17, mitochondrial, mtrps17 1.68
41276 PF3D7_0715600 GTP-binding translation elongation factor tu family protein, putative 0.54 0.76 0.81
41279 PF3D7_0719700 40S ribosomal protein S10, putative 1.89 1.60
41347 PF3D7_1003500 40S ribosomal protein S20e, putative 2.25 2.30
41376 PF3D7_1034900
methionine--tRNA ligase 0.58 0.59 0.66 6.1.1.10
41394 PF3D7_1117500
tyrosine--tRNA ligase 0.56 0.72 6.1.1.1
41412 PF3D7_1144000 40S ribosomal protein S21 1.77 2.04 1.67
41452 PF3D7_1302800 40S ribosomal protein S7, putative 1.53 1.84 1.84
41464 PF3D7_1331800 60S ribosomal protein L23, putative 1.97 1.79
41475 PF3D7_1342000 40S ribosomal protein S6 1.51 1.79 1.69
41504 PF3D7_1421200 40S ribosomal protein S25 1.82 2.38 1.79
41505 PF3D7_1424400 60S ribosomal protein L7-3, putative 1.83 1.72
41529 PF3D7_1460700 60S ribosomal protein L27 2.10 1.73
41183 PF3D7_0210100.1 1.72 1.55 1.43
41201 PF3D7_0312800 60S ribosomal protein L26, putative 2.00 1.76
41209 PF3D7_0322900 40S ribosomal protein S3A, putative 1.75
41230 PF3D7_0503800 60S ribosomal protein L31 1.82
41326 PF3D7_0925300
proline--tRNA ligase, putative 0.56 6.1.1.15
41403 PF3D7_1125800 kelch domain-containing protein, putative 0.58 0.69
41176 PF3D7_0202400
translation-enhancing factor 1.68 2.54 3.32
41246 PF3D7_0524400 ribosome-interacting GTPase 1, putative 2.30 1.71
41527 Post translational modifications PF3D7_1455200 methyltransferase aamt 0.35 0.44 0.47 2.1.1.201
41358 PF3D7_1015600
heat shock protein 60 0.55 0.80
41398 PF3D7_1120900
heat shock factor-binding protein 1 0.57 0.64 0.67
41411 PF3D7_1143200 DnaJ protein, putative 1.76 1.84 2.20
41418 PF3D7_1149200
ring-infected erythrocyte surface antigen 0.39 0.33
41491 PF3D7_1401100 DnaJ protein, putative 0.44 0.37
41157 PF3D7_0102200
ring-infected erythrocyte surface antigen 1.68 0.34 0.26
41172 PF3D7_0201700 DnaJ protein, putative 1.94 0.62 0.37
41244 PF3D7_0523400 DnaJ protein, putative 1.67 1.69
41434 PF3D7_1232100
60 kDa chaperonin 0.51 0.80
41290 PF3D7_0809600 peptidase family C50, putative separase, putative 0.64 0.58 0.61 3.4.22.49
41392 PF3D7_1113400 ubiquitin domain-containing protein DSK2, putative 1.89 2.10
41481 PF3D7_1353800 proteasome subunit alpha type-4, putative 0.55 0.78 3.4.25.1
41492 PF3D7_1401300
proline aminopeptidase 1.92 1.67 1.31 3.4.11.5
41513 PF3D7_1436800 ATP-dependent Clp protease proteolytic subunit 0.56 0.60 0.63 3.4.21.92
41523 PF3D7_1446200
M17 leucyl aminopeptidase 0.76 0.66 0.57 3.4.11.1
41537 PF3D7_1470900
proteasome subunit beta type-2, putative 1.70 1.80 3.4.25.1
41211 PF3D7_0404700
dipeptidyl aminopeptidase 3 0.59 0.60 3.4.14.4
41243 PF3D7_0521300 zinc finger protein, putative 2.15 1.86
41262 PF3D7_0628100
hect domain-containing protein 1, putative 2.01 6.3.2.19
41310 PF3D7_0902800
serine repeat antigen 9 0.52 0.47 0.58 3.4.22.2
41423 PF3D7_1211800 polyubiquitin 0.80 1.50 2.10
41204 PF3D7_0314700
ring finger protein rnf1 1.81 1.63 1.87
41462 PF3D7_1331300
signal peptidase complex catalytic subunit SEC11 0.59 0.66 0.73 3.4.21.89
41271 PF3D7_0704500 serine/threonine protein kinase, putative 2.05 1.56 2.7.11.1
41380 PF3D7_1039000
serine/threonine protein kinase, FIKK family 0.65 0.55 2.7.11.1
41393 PF3D7_1114700
cyclin-dependent-like kinase clk3 0.57 2.7.11.1
41399 PF3D7_1121300
tyrosine kinase-like protein 2.30 1.71 1.61 2.7.10.2
41518 PF3D7_1441300 serine/threonine protein kinase, putative 1.34 0.27 0.24 2.7.11.1
41521 PF3D7_1444200
EF-hand calcium-binding domain-containing protein, putative 1.85
41533 PF3D7_1466100 protein phosphatase containing kelch-like domains 0.71 0.57 0.64
41159 PF3D7_0102600
serine/threonine protein kinase, FIKK family 2.47 1.81 2.7.11.1
41187 PF3D7_0213400
protein kinase 7 0.75 0.58 0.72 2.7.11.1
41221 PF3D7_0424500
serine/threonine protein kinase, FIKK family 0.76 0.49 2.7.11.1
41223 PF3D7_0424700
serine/threonine protein kinase, FIKK family 1.69 1.23 2.7.11.1
41226 PF3D7_0501400 interspersed repeat antigen 0.58 0.34
41238 PF3D7_0513800
ras-related protein Rab-1A 0.31 3.6.5.2
41259 PF3D7_0623800
tyrosine kinase-like protein, putative 0.69 0.58 2.7.10.2
41307 PF3D7_0902000
serine/threonine protein kinase, FIKK family 0.57 0.54 0.48 2.7.11.1
41308 PF3D7_0902500
serine/threonine protein kinase, FIKK family 0.70 0.49 2.7.11.1
41438 PF3D7_1238900
protein kinase 2 1.69 2.26 2.7.11.1
41413 PF3D7_1147500
protein farnesyltransferase subunit beta 1.63 1.69 2.5.1.58
41500 PF3D7_1412800
peptide N-myristoyltransferase glycylpeptide N-tetradecanoyltransferase 0.66 0.59 2.3.1.97
41437 PF3D7_1238700 BTB/POZ domain-containing protein, putative 0.57 1.44
41463 PF3D7_1331600 3-hydroxyacyl-coa dehydratase deh 0.40 0.43 3.1.3.48
41490 PF3D7_1372200 histidine-rich protein III 0.59
41289 PF3D7_0808300 ubiquitin regulatory protein, putative 2.10
41297 PF3D7_0823400 alpha/beta hydrolase, putative 0.57 0.49
41292 PF3D7_0812220
GTP-binding protein YihA3 0.45
41270 PF3D7_0702300 sporozoite threonine and asparagine-rich protein 0.52
41407 PF3D7_1133700 FHA domain-containing protein, putative 0.60 0.35
41480 PF3D7_1353200
membrane associated histidine-rich protein 2 0.53 0.31
41495 PF3D7_1406400
pentatricopeptide repeat domain-containing protein 1 0.57 0.63
41507 PF3D7_1427900 leucine-rich repeat protein 0.41 0.51 0.57
41182 PF3D7_0209700 RING zinc finger protein, putative 1.75 1.38
41192 PF3D7_0220000 liver stage antigen 3 0.59 0.48
41203 PF3D7_0314300 DER1-like protein 0.70 0.57 0.68
41325 PF3D7_0924200 heptatricopeptide repeat-containing protein, putative 1.83 1.32
41421 PF3D7_1205600 tetratricopeptide repeat protein, putative 0.52 0.62 0.71
41441 PF3D7_1243900
double C2-like domain-containing protein 1.94 1.28
41372 Amino acid metabolism PF3D7_1033100