S-nitrosylated proteins
Wang L, Delahunty C, Prieto JH, Rahlfs S, Jortzik E, Yates Iii JR, Becker K. Protein S-nitrosylation in Plasmodium falciparum. Antioxid Redox Signal. 2013 Nov 20. [Epub ahead of print] PMID: 24256207
Process PfID Annotation Nitrosylation site Transcript EC#
8906 Replication and DNA metabolism PF3D7_0305600
AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative
4.2.99.18
9115 PF3D7_1362200
RuvB-like helicase 3
3.6.4.12
8994 PF3D7_0904800 replication protein A1, small fragment
27503 Transcription and RNA metabolism PF3D7_1426100 transcription factor btf3, putative
8982 PF3D7_0817900
high mobility group protein B2
9131 PF3D7_1417800
DNA replication licensing factor MCM2
3.6.4.12
9083 PF3D7_1239200
transcription factor with AP2 domain(s) K.NEEVNYIINEVDSSNDCK.N
27561 PF3D7_1007700
AP2 domain transcription transcription factor AP2-I
24006 PF3D7_0613800
AP2 domain transcription factor, putative
9026 PF3D7_1014600 transcriptional coactivator ADA2 K.INENECTSNDIEEDIK.S
8932 PF3D7_0517400 FACT complex subunit SPT16, putative
9095 PF3D7_1325000 U6 snRNA-associated Sm-like protein LSm6, putative
9043 PF3D7_1107300
polyadenylate-binding protein-interacting protein 1, putative K.SIDALTENENNKNDAECSDSTTVK.N K.SCVSSLGVETNMK.N
29799 PF3D7_1224300
polyadenylate-binding protein 1, putative K.FCFINYADAESAK.N
9031 PF3D7_1022400
serine/arginine-rich splicing factor 4
8917 PF3D7_0321600 ATP-dependent RNA helicase ddx42, putative
3.6.4.13
9000 PF3D7_0917600
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative R.NTVSEECTYSTNER.T
3.6.4.13
15688 PF3D7_1006800
G-strand-binding protein 2
9009 PF3D7_0929200 RNA-binding protein, putative
8985 PF3D7_0823200 RNA-binding protein, putative
29882 PF3D7_0923900 polyadenylate-binding protein 2, putative
8977 PF3D7_0812500 RNA-binding protein, putative
25574 PF3D7_1002400 transformer-2 protein homolog beta, putative
8944 PF3D7_0605100 KH domain-containing protein, putative
8999 PF3D7_0916700 RNA-binding protein musashi, putative K.CNEAVASSPSTR.R
9112 PF3D7_1359400
Cugbp Elav-like family member 1
9093 PF3D7_1321700 splicing factor 1
8902 PF3D7_0209800
ATP-dependent RNA helicase UAP56 K.YVLISCDINNEIK.E R.ICSTEIYGDAFLSK.T
3.6.4.13
25651 PF3D7_0602200 MYND-type zinc finger protein, putative
8987 Translation PF3D7_0826700
receptor for activated c kinase
8910 PF3D7_0307100 40S ribosomal protein S12, putative K.LITTLCAEK.N
8978 PF3D7_0813900 40S ribosomal protein S16, putative
9064 PF3D7_1144000 40S ribosomal protein S21
9033 PF3D7_1026800
40S ribosomal protein S2
9124 PF3D7_1408600 40S ribosomal protein S8e, putative
8912 PF3D7_0309600
60S acidic ribosomal protein P2
8931 PF3D7_0517000 60S ribosomal protein L12, putative
9116 PF3D7_1365900
ubiquitin-60S ribosomal protein L40
9058 PF3D7_1130200
60S ribosomal protein P0
33918 PF3D7_1244800 translation machinery-associated protein 46, putative
8945 PF3D7_0607000 translation initiation factor IF-2, putative
25643 PF3D7_0319600 elongation factor 1-delta, putative
9108 PF3D7_1357100 elongation factor 1-alpha
8997 PF3D7_0913200 elongation factor 1-beta
9098 PF3D7_1338300 elongation factor 1-gamma, putative
9148 PF3D7_1451100
elongation factor 2 R.ETVTEESTITCLGK.S
9157 PF3D7_1468700
eukaryotic initiation factor 4A helicase 45
3.6.4.12
9068 PF3D7_1204300
eukaryotic translation initiation factor 5A K.SVLVSVLSACGQEK.I K.YEDICPTSHNMDVPVVK.R
9127 PF3D7_1410600 eukaryotic translation initiation factor 2 subunit gamma, putative
8965 PF3D7_0716800
eukaryotic translation initiation factor 3 subunit I, putative
9017 PF3D7_1007900 eukaryotic translation initiation factor 3 subunit d, putative
9069 PF3D7_1206200 eukaryotic translation initiation factor 3 subunit C, putative
8980 PF3D7_0815600 eukaryotic translation initiation factor 3 subunit G, putative
9111 PF3D7_1358500 zinc finger protein, putative
9027 PF3D7_1015200
cysteine--tRNA ligase, putative
6.1.1.16
9102 PF3D7_1349200 glutamate--tRNA ligase, putative
6.1.1.17
9133 PF3D7_1420400
glycine--tRNA ligase
6.1.1.14
9096 PF3D7_1332900
isoleucine--tRNA ligase, putative
6.1.1.5
8954 PF3D7_0622800
leucine--tRNA ligase, putative
6.1.1.4
9103 PF3D7_1350100
lysine--tRNA ligase
6.1.1.6
9040 PF3D7_1034900
methionine--tRNA ligase
6.1.1.10
9041 PF3D7_1104000
phenylalanine--tRNA ligase beta subunit
6.1.1.20
8966 PF3D7_0717700
serine--tRNA ligase, putative
6.1.1.11
9143 PF3D7_1442300
tRNA import protein tRIP
9139 Protein post-translational modification PF3D7_1436300
translocon component PTEX150
9057 PF3D7_1129100
parasitophorous vacuolar protein 1
9008 PF3D7_0926100 protein kinase, putative
2.7.11.1
9063 PF3D7_1138500
protein phosphatase 2C protein phosphatase PPM2
3.1.3.16
8972 PF3D7_0805700
serine/threonine protein kinase, FIKK family
2.7.11.1
9106 PF3D7_1355500
serine/threonine protein phosphatase 5
3.1.3.16
8957 Hitones and their modifications PF3D7_0624600
iswi chromatin-remodeling complex atpase
3.6.4.12
8916 PF3D7_0320900
H2A.Z
8948 PF3D7_0610400
histone H3
9042 PF3D7_1105000
histone H4
8979 PF3D7_0814200
DNA/RNA-binding protein Alba 1 R.CGSTVITDQYVSGQDNSEHVVQEK.T
9014 PF3D7_1006200
DNA/RNA-binding protein Alba 3
9101 PF3D7_1346300
DNA/RNA-binding protein Alba 2
9105 PF3D7_1355100
DNA replication licensing factor MCM6
8961 PF3D7_0705400 DNA replication licensing factor MCM7
8937 PF3D7_0527000 DNA replication licensing factor MCM3, putative
1.3.3.6
9092 PF3D7_1317100 DNA replication licensing factor MCM4
9070 PF3D7_1211700 DNA replication licensing factor MCM5, putative
9114 PF3D7_1361900
proliferating cell nuclear antigen 1
8986 PF3D7_0823300
histone acetyltransferase GCN5
2.3.1.48
8897 Mitosis and chromosome assembly PF3D7_0107000
centrin-1
9147 PF3D7_1446600
centrin-2
9035 PF3D7_1027700
centrin-3
8900 PF3D7_0110700
chromatin assembly factor 1 subunit c, putative; caf1c; rbap48
9078 PF3D7_1224500 histone chaperone ASF1
9032 PF3D7_1023900
SNF2 helicase, putative chromodomain-helicase-DNA-binding protein 1 homolog, putative
3.6.4.12
9003 PF3D7_0919000
nucleosome assembly protein
9067 PF3D7_1203700
nucleosome assembly protein
23664 Carbohydrate metabolism PF3D7_0915400
ATP-dependent 6-phosphofructokinase K.SLGCMSELQTSR.L
2.7.1.11
9029 PF3D7_1015900
enolase
4.2.1.11
9145 PF3D7_1444800
fructose-bisphosphate aldolase
4.1.2.13
9138 PF3D7_1436000 glucose-6-phosphate isomerase
5.3.1.9
9154 PF3D7_1462800
glyceraldehyde-3-phosphate dehydrogenase
1.2.1.12
8956 PF3D7_0624000
hexokinase
2.7.1.1
9094 PF3D7_1324900
L-lactate dehydrogenase
1.1.1.27
9006 PF3D7_0922500
phosphoglycerate kinase
2.7.2.3
9054 PF3D7_1120100
phosphoglycerate mutase, putative
5.4.2.11
8958 PF3D7_0626800
pyruvate kinase
2.7.1.40
9142 PF3D7_1439900
triosephosphate isomerase
5.3.1.1
9151 PF3D7_1454700
6-phosphogluconate dehydrogenase, decarboxylating, putative
1.1.1.44
9149 PF3D7_1453800
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
1.1.1.49
8949 PF3D7_0610800
transketolase
2.2.1.1
8920 PF3D7_0406400
cytosolic glyoxalase II
3.1.2.6
8905 PF3D7_0303700
lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex
2.3.1.168
25543 PF3D7_1216200 glycerol-3-phosphate dehydrogenase [NAD+], putative
1.1.1.8
8920 PF3D7_0406400
cytosolic glyoxalase II
3.1.2.6
8905 PF3D7_0303700
lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex
2.3.1.168
8969 PF3D7_0801800
mannose-6-phosphate isomerase, putative
5.3.1.8
8934 Amino acid metabolism PF3D7_0520900
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase R.GTYEDTGMVNCVDVIYK.N
3.3.1.1
8947 PF3D7_0608800
ornithine aminotransferase
2.6.1.13
9038 PF3D7_1033100
S-adenosylmethionine decarboxylase/ornithine decarboxylase
4.1.1.17
9005 PF3D7_0922200
S-adenosylmethionine synthetase K.VSIDEQSPDIAQCVHENR.S
2.5.1.6
8970 PF3D7_0802000
glutamate dehydrogenase, putative
1.4.1.2
9129 PF3D7_1416500
NADP-specific glutamate dehydrogenase
1.4.1.4
25835 PF3D7_1357900 pyrroline-5-carboxylate reductase, putative K.YTVMNAVEAACEK.S
1.5.1.2
9004 Lipid metabolism PF3D7_0920800
inosine-5'-monophosphate dehydrogenase
1.1.1.205
8960 PF3D7_0704400 phosphoinositide-binding protein, putative
8936 PF3D7_0525100
acyl-CoA synthetase
6.2.1.3
9055 PF3D7_1124600
ethanolamine kinase
2.7.1.82
9037 PF3D7_1031200
MORN repeat-containing protein 1
2.7.1.68
8928 PF3D7_0511800
inositol-3-phosphate synthase
5.5.1.4
9120 PF3D7_1403900 serine/threonine protein phosphatase cpped1
3.1.3.2
8899 PF3D7_0110600
phosphatidylinositol-4-phosphate 5-kinase
2.7.1.68
9099 PF3D7_1343000
phosphoethanolamine N-methyltransferase
2.1.1.103
9020 Nucleotide metabolism PF3D7_1008900
adenylate kinase
2.7.4.3
9036 PF3D7_1029600
adenosine deaminase
3.5.4.4
9024 PF3D7_1012400
hypoxanthine-guanine phosphoribosyltransferase
2.4.2.8
9025 PF3D7_1012600
GMP synthase [glutamine-hydrolyzing]
6.3.5.2
9089 PF3D7_1308200
carbamoyl phosphate synthetase K.VTINNSNNSISNNENVETNLNCVSER.A
6.3.5.5
33995 PF3D7_1410200
CTP synthase
6.3.4.2
9117 PF3D7_1366500
nucleoside diphosphate kinase
2.7.4.6
8930 PF3D7_0513300
purine nucleoside phosphorylase
2.4.2.1
9140 PF3D7_1437200
ribonucleoside-diphosphate reductase large subunit, putative
1.17.4.1
8971 Cellular redox homeostasis PF3D7_0802200
1-cys peroxiredoxin K.CCILPSVDNADLPK.L
1.11.1.15
8908 PF3D7_0306300
glutaredoxin 1
1.8.4.2
9072 PF3D7_1212000
glutathione peroxidase-like thioredoxin peroxidase
1.11.1.9
9132 PF3D7_1419800
glutathione reductase
1.8.1.7
9141 PF3D7_1438900
thioredoxin peroxidase 1
1.11.1.15
9152 PF3D7_1457200
thioredoxin 1
9002 PF3D7_0918900
gamma-glutamylcysteine synthetase
6.3.2.2
30535 Biosynthesis of cofactors PF3D7_0627500
protein DJ-1
8923 PF3D7_0417200
bifunctional dihydrofolate reductase-thymidylate synthase
1.5.1.3
9080 PF3D7_1235600
serine hydroxymethyltransferase
2.1.2.1
8952 PF3D7_0621200
pyridoxine biosynthesis protein PDX1
9010 Invasion and motility PF3D7_0929400
high molecular weight rhoptry protein 2
8995 PF3D7_0905400
high molecular weight rhoptry protein 3
9034 PF3D7_1027300
peroxiredoxin merozoite capping protein 1
1.11.1.15
9011 PF3D7_0930300
merozoite surface protein 1
25721 PF3D7_1466900 conserved plasmodium protein, unknown function
8962 PF3D7_0707300
rhoptry-associated membrane antigen
9126 PF3D7_1410400
rhoptry-associated protein 1
9134 PF3D7_1420700
surface protein P113
8955 PF3D7_0623100 nuclear polyadenylated rna-binding protein nab2
9085 PF3D7_1246200
actin I
9128 PF3D7_1412500
actin II
8990 PF3D7_0903700
alpha tubulin 1 R.CVFVDLEPTVVDEVR.T
9012 PF3D7_0932200
profilin
9019 PF3D7_1008700
tubulin beta chain
9073 Chaperones PF3D7_1215300
10 kDa chaperonin
8907 PF3D7_0306200
activator of Hsp90 ATPase, AHA1
9056 PF3D7_1124700
GrpE protein homolog, mitochondrial, putative
9097 PF3D7_1333000
20 kDa chaperonin K.FSPFSNESCEFTYQNAK.Y
8940 PF3D7_0528700
peptidyl-prolyl cis-trans isomerase
5.2.1.8
9158 PF3D7_1473200 DnaJ protein, putative R.NQEEGSTNCSNVVEEEMTLEK.C
9088 PF3D7_1307200 DnaJ protein, putative
9075 PF3D7_1222300
endoplasmin, putative
23434 PF3D7_1247400
peptidyl-prolyl cis-trans isomerase fkbp
5.2.1.8
8903 PF3D7_0213100
protein SIS1
9028 PF3D7_1015600
heat shock protein 60
9001 PF3D7_0917900
PfHsp70-2
8984 PF3D7_0818900
PfHsp70-1
9062 PF3D7_1134000
PfHsp70-3
9100 PF3D7_1344200
PfHsp70-y
8963 PF3D7_0708400
heat shock protein 90
9052 PF3D7_1118200 heat shock protein 90, putative
9144 PF3D7_1443900
heat shock protein 90, putative
8939 PF3D7_0527500
Hsc70-interacting protein R.DCTEALNLNIDSANAYK.V
9137 PF3D7_1434300
Hsp70/Hsp90 organizing protein
8964 PF3D7_0708800
PfHsp70-z
8953 PF3D7_0621800 nascent polypeptide-associated complex subunit alpha, putative
8918 PF3D7_0322000
peptidyl-prolyl cis-trans isomerase K.RSVVITDCGEL.
5.2.1.8
9048 PF3D7_1115600
peptidyl-prolyl cis-trans isomerase
5.2.1.8
9130 PF3D7_1416900 prefoldin subunit 2, putative
20781 PF3D7_0512000
prefoldin subunit 6
8992 PF3D7_0904500 prefoldin subunit 4, putative
8988 PF3D7_0827900
protein disulfide isomerase
5.3.4.1
9087 PF3D7_1304500 small heat shock protein, putative
8915 PF3D7_0320300 T-complex protein 1 subunit epsilon
8909 PF3D7_0306800 T-complex protein 1 subunit beta
9109 PF3D7_1357800
T-complex protein 1 subunit delta, tcp-1-delta
9060 PF3D7_1132200 T-complex protein 1 subunit alpha
8911 PF3D7_0308200 T-complex protein 1 subunit eta
8898 PF3D7_0109400
tubulin-specific chaperone a, putative
9150 Proteolysis / hemoglobin degradation PF3D7_1454400
aminopeptidase P
3.4.11.9
9050 PF3D7_1116700
dipeptidyl aminopeptidase 1 cathepsin C, homolog K.TSPNLTTCGSSQPNK.N
3.4.14.1
9049 PF3D7_1115700
cysteine proteinase falcipain 2a falcipain 2
3.4.22.-
9046 PF3D7_1115300
falcipain 2' cysteine proteinase falcipain 2b K.LITLSEQELVDCSFK.N
3.4.22.-
9047 PF3D7_1115400
cysteine proteinase falcipain 3
3.4.22.-
9113 PF3D7_1360800
falcilysin
3.4.24.-
8996 PF3D7_0911900
inhibitor of cysteine proteases falstatin
9053 PF3D7_1118300 insulinase, putative
3.4.24.56
9146 PF3D7_1446200
M17 leucyl aminopeptidase
3.4.11.1
9090 PF3D7_1311800
M1-family alanyl aminopeptidase
3.4.11.2
9122 PF3D7_1408000
plasmepsin II
3.4.23.39
9123 PF3D7_1408100
plasmepsin III histo-aspartic protease
3.4.23.-
23514 Ubiquitin-dependent protein catabolic process PF3D7_0413600
26S protease regulatory subunit 6B, putative; 26S proteasome AAA-ATPase subunit RPT3
3.6.4.8
9018 PF3D7_1008400
26S protease regulatory subunit 4, putative
3.6.4.8
9059 PF3D7_1130400
26S protease regulatory subunit 6A, putative R.ACASQTNATFLK.L
3.6.4.8
9155 PF3D7_1466300 26S proteasome regulatory subunit RPN2, putative
3.4.25.1
8951 PF3D7_0619400
cell division cycle protein 48 homologue, putative K.TAGFSGADLAELCQR.A
9022 PF3D7_1011700 DNA repair protein RAD23, putative K.ESIDNICAMGFEK.E
9071 PF3D7_1211800 polyubiquitin
8913 PF3D7_0317800 26s proteasome non-atpase regulatory subunit 9, putative
9119 PF3D7_1368100 26S proteasome regulatory subunit RPN11, putative
8946 PF3D7_0608500 proteasome subunit alpha type-2, putative
3.4.25.1
8974 PF3D7_0807800 26S proteasome regulatory subunit RPN10, putative
8968 PF3D7_0727400
proteasome subunit alpha type-5, putative
3.4.25.1
8933 PF3D7_0518300
proteasome subunit beta type-1, putative
3.4.25.1
9104 PF3D7_1353900 proteasome subunit alpha type-7, putative
3.4.25.1
9159 PF3D7_1474800 proteasome subunit alpha type-1, putative
3.4.25.1
9118 PF3D7_1367000 suppressor of kinetochore protein 1, putative
8926 PF3D7_0505800
small ubiquitin-related modifier
8922 PF3D7_0413900 ubiquitin carboxyl-terminal hydrolase 13, putative
3.4.19.12
9153 PF3D7_1460400
ubiquitin carboxyl-terminal hydrolase isozyme L3
3.4.19.12
8938 PF3D7_0527100
ubiquitin-conjugating enzyme E2 13
6.3.2.19
23837 PF3D7_1356300 ubiquitin-conjugating enzyme E2, putative
2.3.2.23
8975 PF3D7_0808300 ubiquitin regulatory protein, putative
8993 PF3D7_0904600 ubiquitin specific protease, putative
3.4.19.12
9121 Protein traffic PF3D7_1407800
plasmepsin IV
3.4.23.-
8901 PF3D7_0207600
serine repeat antigen 5
3.4.22.-
8991 PF3D7_0904100 AP-4 complex subunit epsilon, putative
9044 PF3D7_1108600
endoplasmic reticulum-resident calcium binding protein
9051 PF3D7_1117700
GTP-binding nuclear protein RAN/TC4
8976 PF3D7_0812400
karyopherin alpha
8935 PF3D7_0524000 karyopherin beta
8973 PF3D7_0807300
ras-related protein Rab-18
3.6.5.2
8989 PF3D7_0903200
ras-related protein RAB7
3.6.5.2
20868 PF3D7_0419600 ran-specific GTPase-activating protein 1, putative K.VVANHYIYPNESYCK.L
9030 PF3D7_1016300
glycophorin binding protein
9023 PF3D7_1011800
PRE-binding protein
8927 PF3D7_0511000
translationally-controlled tumor protein homolog K.DVFTNDEVCSDSYVQQDPFEVPEFR.E
9079 PF3D7_1229400
macrophage migration inhibitory factor
5.3.2.1
8925 PF3D7_0500800
erythrocyte membrane protein 2 mature parasite-infected erythrocyte surface antigen
9021 PF3D7_1010700 dolichyl-phosphate-mannose-protein mannosyltransferase, putative 2.4.1.109
9065 PF3D7_1149000
antigen 332, DBL-like protein
8941 PF3D7_0532100
early transcribed membrane protein 5
9066 PF3D7_1201000
Plasmodium exported protein (PHISTb), unknown function
8942 PF3D7_0532300
Plasmodium exported protein (PHISTb), unknown function
23472 Signal transduction PF3D7_0817300 conserved Plasmodium protein, unknown function, asparagine-rich antigen
24026 PF3D7_1110400 RNA-binding protein, putative
8983 PF3D7_0818200
14-3-3 protein K.EASNCAQEAYQK.A
9136 PF3D7_1434200
calmodulin
20883 PF3D7_0722400 OBG-like ATPase 1, putative
9076 PF3D7_1223100
cAMP-dependent protein kinase regulatory subunit
2.7.11.11
8904 Miscellaneous PF3D7_0220000 liver stage antigen 3
9082 PF3D7_1236100 clustered-asparagine-rich protein
9039 PF3D7_1033400
haloacid dehalogenase-like hydrolase
3.8.1.-
15096 PF3D7_1311900
V-type proton ATPase catalytic subunit A
3.6.3.14
8919 PF3D7_0406100
V-type proton ATPase subunit B
3.6.3.14
15097 PF3D7_1235700
ATP synthase subunit beta, mitochondrial
3.6.3.14
9061 PF3D7_1132300
nucleic acid binding protein, putative
S-nitrosylation (SNO) sites were assigned by the characteristic mass shift (+415.20 Da) of the peptides observed in the MS/MS data due to irreversible S-biotinylation of cysteine residues (formerly S-nitrosylated), indicated by the biotinylation reagent (EZ-Link Iodoacetyl-PEG2-Biotin) used in our biotin switch assay.
Online articles related to S-nitrosylated proteins retrieved from PubMed