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Non-redundant malarial structures in the Protein Data Bank (PDB) |
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Guy AJ, Irani V, Beeson JG, Webb B, Sali A, Richards JS, Ramsland PA.Proteome-wide mapping of immune features onto Plasmodium protein three-dimensional structures. Sci Rep. 2018 8(1):4355. PMID: 29531293 |
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PfID |
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Annotation |
PDB Ids |
Ligands |
EC# |
Transcript |
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PF3D7_0729200 |
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1-cys peroxiredoxin |
1XIY |
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1.11.1.15 |
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PF3D7_0628000 |
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6-pyruvoyltetrahydropterin synthase |
1Y13 |
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Biopterin |
4.2.3.12 |
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PF3D7_1477800 |
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acyl-CoA binding protein |
1HBK |
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PF3D7_1354500 |
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adenylosuccinate synthetase |
1P98 |
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6.3.4.4 |
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PF3D7_1133400 |
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apical membrane antigen 1 |
1HN6 |
1Z40 |
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PF3D7_1323000 |
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beta-hydroxyacyl-ACP dehydratase |
1Z6B |
1ZHG |
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Cacodylate |
4.2.1.59 |
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PF3D7_0615500 |
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cdc2-related protein kinase 5 |
1V0P |
1V0O |
1OB3 |
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Purvalanol B, Indirubin-5-Sulphonate |
2.7.11.22 |
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PF3D7_0307400 |
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ATP-dependent Clp protease proteolytic subunit |
2F6I |
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3.4.21.92 |
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PF3D7_0322000 |
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peptidyl-prolyl cis-trans isomerase |
1QNH |
1QNG |
2FU0 |
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Cyclosporin A |
5.2.1.8 |
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PF3D7_0417200 |
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bifunctional dihydrofolate reductase-thymidylate synthase |
1J3J |
1J3I |
1J3K |
3DG8 |
3QGT |
3DGA |
3JSU |
Pyrimethamine, NADPH , dUMP, WR99210, NADPH dihydro-nicotneamide-adenine-dinucleotide phosphate, 5-(4-chlorophenyl)-6-ethyl-pyrimidine-2,4-diamine, 2-(N-morpholino)ethanesulfonic acid, N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide CP7 |
1.5.1.3 |
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PF3D7_0603300 |
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dihydroorotate dehydrogenase |
1TV5 |
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orotic acid, FMN, (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide; 3,6,9,12,15-pentaoxatricosan-1-ol |
1.3.5.2 |
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PF3D7_1415800 |
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ribosomal RNA small subunit methyltransferase a1 |
2H1R |
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2.1.1.183 |
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PF3D7_1127100 |
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deoxyuridine 5'-triphosphate nucleotidohydrolase dUTP pyrophosphatase |
1VYQ |
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2 ,3-deoxy-3-fluoro-5-o-trityluridine |
3.6.1.23 |
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PF3D7_1213600 |
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dynein light chain 1, putative |
5WOF |
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PF3D7_0615100 |
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enoyl-acyl carrier reductase |
1NHG |
1NHW |
1VRW |
1ZSN |
1NNU |
1ZW1 |
1ZXL |
Triclosan, NAD+, 5-chloro-2-(2-chloro-4-nitro-phenoxy)phenol, 2-(4-amino-2-chloro-phenoxy)-5-chloro-phenol,2-[(2,4-dichlorophenyl)amino]phenol, 5-chloro-2-(2,4-dichlorophenoxy)pheno |
1.3.1.9 |
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PF3D7_1115700 |
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cysteine proteinase falcipain 2a falcipain 2 |
1YVB |
2GHU |
3BPF |
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E64 |
3.4.22.- |
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PF3D7_1115400 |
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cysteine proteinase falcipain 3 |
3BWK |
3BPM |
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N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide, SO4 |
3.4.22.- |
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PF3D7_1318100 |
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ferredoxin, putative |
1IUE |
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PF3D7_0814900 |
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superoxide dismutase [Fe] |
2AWP |
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1.15.1.1 |
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PF3D7_1444800 |
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fructose-bisphosphate aldolase |
1A5C |
2EPH |
2PC4 |
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4.1.2.13 |
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PF3D7_1416500 |
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NADP-specific glutamate dehydrogenase |
2BMA |
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1.4.1.4 |
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PF3D7_1419800 |
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glutathione reductase |
1ONF |
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FAD |
1.8.1.7 |
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PF3D7_1419300 |
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glutathione S-transferase |
1PA3 |
1Q4J |
1OKT |
2AAW |
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S-Hexyl-Gsh, hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol, (2S,3S)-butane-1,2,3,4-tetrol |
2.5.1.18 |
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PF3D7_1462800 |
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glyceraldehyde-3-phosphate dehydrogenase |
1YWG |
2B4R |
2B4T |
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NAD+, glycerol, 4-(2-azanylethyl)benzenesulfonyl fluoride |
1.2.1.12 |
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PF3D7_1216200 |
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glycerol-3-phosphate dehydrogenase [NAD+], putative |
1YJ8 |
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1.1.1.8 |
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PF3D7_0928900 |
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guanylate kinase |
1Z6G |
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4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid, SO4 |
2.7.4.8 |
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PF3D7_1351100 |
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conserved protein, unknown function |
1ZSO |
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PF3D7_1012400 |
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hypoxanthine-guanine phosphoribosyltransferase |
1CJB |
1U5A |
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[(2R,3R,4S,5S)-3,4-dihydroxy-5-(4-oxo-3,5-dihydropyrrolo[4,5-d]pyrimidin-7-yl)pyrrolidin-2-yl]methyl dihydrogen phosphate, Pyrophosphate 2-, [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl dihydrogen phosphate |
2.4.2.8 |
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PF3D7_1324900 |
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L-lactate dehydrogenase |
1LDG |
1CET |
1CEQ |
2X8L |
1T26 |
IT24 |
1T2D |
NADH,Oxamate, Chloroquine, 4-Hydroxy-1,2,5-Thiadiazole-3-Carboxylic Acid, 3-Hydroxyisoxazole-4-Carboxylic Acid, NAD+, 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid, 2,6-dicarboxynaphthalene, naphthalene-2,6-disulfonic acid, 3,7-dihydroxynaphthalene-2-carbo |
1.1.1.27 |
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1T2C |
1U4O |
1U5C |
1T2E |
1XIV |
1T25 |
2A94 |
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2X8L |
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PF3D7_0930300 |
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merozoite surface protein 1 |
`1OB1 |
2FLG |
1CEJ |
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dimethylarsinate |
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PF3D7_1035400 |
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merozoite surface protein 3 |
1PSM |
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PF3D7_1366500 |
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nucleoside diphosphate kinase |
1XIQ |
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2.7.4.6 |
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PF3D7_0922900 |
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3-oxoacyl-[acyl-carrier-protein] reductase |
2C07 |
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SO4 |
1.1.1.35 |
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PF3D7_0922500 |
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phosphoglycerate kinase |
1LTK |
3OZ7 |
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AMP, Glycerol, SO4 |
2.7.2.3 |
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PF3D7_1120100 |
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phosphoglycerate mutase, putative |
1XQ9 |
3KKK |
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SCN |
5.4.2.11 |
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PF3D7_1408000 |
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plasmepsin II |
2IGY |
2IGX |
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5-pentyl-N-[[4-(4-piperidin-1-ylcarbonylphenyl)phenyl]methyl]-N-[1-(pyridin-2-ylmethyl)piperidin-4-yl]pyridine-2-carboxamide, N-[1-(3-methylbutyl)piperidin-4-yl]-N-[[4-(methyl-pyridin-4-yl-amino)phenyl]methyl]-4-pentyl-benzamide |
3.4.23.39 |
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PF3D7_1407800 |
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plasmepsin IV |
1LS5 |
5I70 |
5JOD |
2ANL |
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Peptstatin A, Inhibitor Rs370, Statine analog, Inhibitor Rs367, Inhibitor Eh58, JE2 |
3.4.23.- |
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PF3D7_1302100 |
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gamete antigen 27/25 |
1N81 |
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PF3D7_0513300 |
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purine nucleoside phosphorylase |
2BSX |
1Q1G |
1SQ6 |
1NW4 |
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Inosine, propan-2-ol, 7-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(methylsulfanylmethyl)pyrrolidin-1-ium-2-yl]-3,5-dihydropyrrolo[2,3-e]pyrimidin-4-one, SO4 |
2.4.2.1 |
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PF3D7_1247400 |
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peptidyl-prolyl cis-trans isomerase fkbp |
2FBN |
2VN1 |
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5.2.1.8 |
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PF3D7_0907900 |
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peptide deformylase |
1JYM |
1RQC |
1RL4 |
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CO,(2R-2-{[formyl(hydroxy)amino]methyl}hexaoic acd; (2S)-N-[(2S)-6-amino-1-oxo-1-phenylazanyl-hexan-2-yl]-2-[[2-[(2S)-2-[[(2S)-6-amino-1-oxo-1-phenylazanyl-hexan-2-yl]carbamoyl]hexyl]hydrazinyl]methyl]hexanamide |
3.5.1.88 |
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PF3D7_1443900 |
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heat shock protein 90, putative |
1Y6Z |
3IED |
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AMP phosphoramidate |
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PF3D7_1144900 |
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ras-related protein Rab-6 |
1D5C |
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GDP, Mg2+ |
3.6.5.2 |
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PF3D7_0514600 |
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ribose-5-phosphate isomerase |
2F8M |
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Phosphate |
5.3.1.6 |
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PF3D7_1219900 |
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ribulose-phosphate 3-epimerase, putative |
1TQX |
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SO4, Zinc |
5.1.3.1 |
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PF3D7_1457200 |
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thioredoxin 1 |
1SYR |
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PF3D7_0318800 |
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triosephosphate isomerase, putative |
1LYX |
1LZO |
1M7O |
1M7P |
1O5X |
1LZO |
1VGA |
2-Phosphoglycolic acid, Glycerol-3-Phosphate, 2-Phosphoglycolic acid, 3-Phosphoglyceric acid, 2-phosphoglycerate |
5.3.1.1 |
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1WOA |
1WOB |
1YDV |
2VFD |
2VFE |
2VFF |
2VFG |
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2VFH |
2VFI |
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PF3D7_1345500 |
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ubiquitin-conjugating enzyme E2 |
2H2Y |
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6.3.2.19 |
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PF3D7_0923800 |
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thioredoxin reductase |
4J57 |
4J56 |
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FAD; GLYCEROL; Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex |
1.8.1.9 |
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PF3D7_1457200 |
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thioredoxin 1 |
4J57 |
4J56 |
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FAD; GLYCEROL; Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex |
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PF3D7_1345100 |
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thioredoxin 2 |
2C0D |
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PF3D7_0608800 |
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ornithine aminotransferase |
3NTJ |
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SO4 |
2.6.1.13 |
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PF3D7_1454700 |
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6-phosphogluconate dehydrogenase, decarboxylating, putative |
6FQZ |
6FQY |
6FQX |
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6-Phosphogluconc acid; triethylene glycol; di(hydroxyethyl)ether; glycerol; NADP; 1,2-ethanediol |
1.1.1.44 |
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PF3D7_1327600 |
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nicotinamide/nicotinic acid mononucleotide adenylyltransferase |
5LM3 |
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2.7.7.18 |
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PF3D7_1430700 |
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NADP-specific glutamate dehydrogenase |
3R3J |
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1.4.1.4 |
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PF3D7_1436300 |
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translocon component PTEX150 |
6E10 |
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Phosphothiophosphoric acid-adenylate ester |
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PF3D7_0807500 |
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proteasome subunit alpha type-6, putative |
6MUW |
6MUV |
6MUX |
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3.4.25.1 |
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80S Ribosom by Wong: 3JBN, but thats cryo.. |
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3JBN |
3JBO |
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