Malaria Parasite Metabolic Pathways

Clinical and Immunological Aspects in Cerebral Malaria this review mainly discusses our understanding of immune mechanisms in the light of the most recent research findings. Remarkably, the newly proposed CD8+ T celldriven pathophysiological aspects within the central nervous system are summarized, giving fir

Model of eEF2 Activation by Hgh1, Cns1, and Hsp90 The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast, but its structure and function remained unknown. Cns1 is important for maintaining translation elongatio

Parasite genes important for egress to complete its complex life cycle and to allow for both amplification and transmission. the major pathways and proteins involved in the egress events during the Plasmodium life cycle—merozoite and gametocyte egress out of red blood cells, sporozoite egre

Parasite genes important for egress to complete its complex life cycle and to allow for both amplification and transmission. the major pathways and proteins involved in the egress events during the Plasmodium life cycle—merozoite and gametocyte egress out of red blood cells, sporozoite egre

Infected erythrocytes, IgG antibodies, and IgG effector function IgG antibodies are key effector molecules in acquired immunity to Plasmodium falciparum malaria, and the PfEMP1 adhesins expressed on the surface of the in-fected erythrocytes are crucial immunological targets. The antigen specificity of these antibodies

m5C levels of transcripts in schizonts and/or gametocyte stages 5-methylcytosine (m5C) is an important epitranscriptomic modification involved in messenger RNA (mRNA) stability and translation efficiency in various biological processes. Here, we characterize the landscape of m5C mRNA modifications at single nucleotide

Protein targeting to the vacuolar translocon by HSP101 PTEX is a protein-conducting channel consisting of the pore-forming protein EXP2, the protein unfoldase HSP101, and structural component PTEX150. The mechanism of how exported proteins are specifically trafficked from the parasite’s ER following PEXEL cle

Human miRNAs response to Plasmodium falciparum infection Recent research has helped establish the relationship between microRNAs (miRNAs) and many other diseases. MiRNAs are the class of small non-coding RNAs consisting of 18-23 nucleotides in length that are evolutionarily conserved and regulate gene expressio

Gold Standard for Analyzing Malaria Drug Clinical Trials Deep-sequenced amplicons (AmpSeq) substantially increase the detectability of low-density clones and may offer a new “gold standard” for molecular correction. Pharmacological simulation of clinical trials was used to evaluate the suitability of AmpSeq for

Glycans in parasites cell cycle Different glycans on the parasite and the host cell surface play significant roles in both malaria pathogenesis and host defense mechanisms. So far, only small, truncated N- and O-glycans have been identified in Plasmodium species. In contrast, complex gl