Latest Updates

Last update: 03/08/2021

  • 03/08/2021

    RNA of unknown function or non coding The genomes of large multicellular eukaryotes are mostly comprised of non-protein coding DNA. Although there has been much agreement that a small fraction of these genomes has important biological functions, there has been much debate as to whether the re
  • 15/07/2021

    Cerebral Malaria and Protein S-Nitrosylation The pathological mechanism of CM involves multimechanism interactions, including low nitric oxide (NO) bioavailability. Low NO bioavailability in the brain is due to numerous factors including the strong binding of free heme to NO, hemolysis leading to hy
  • 04/07/2021

    The apical complex and the fusion events required for rhoptry discharge the first description of the molecular machinery used for motility and invasion, revealing a crucial role for two different secretory organelles, micronemes and rhoptries. Rhoptry proteins are injected directly into the host cytoplasm not only to promote
  • 02/07/2021

    uORF-mediated translational regulation in the asexual stage This review provides a comprehensive summary of studies that show uORF-mediated gene regulation in these parasites and highlights examples of clinically and physiologically relevant genes, including var2csa in P. falciparum, and ApiAT1 in T. gondii, that
  • 27/06/2021

    Divergent composition of the respiratory chain complexes we apply complexome profiling to map the inventory of protein complexes across the pathogenic asexual blood stages and the transmissible gametocyte stages of Plasmodium falciparum. We identify remarkably divergent composition and clade-specific additions
  • 21/06/2021

    RNA Structurome The differential accumulation of RNA secondary structures in coding and noncoding transcripts from the asexual developmental cycle in P. falciparum in human red blood cells. Our comprehensive analysis that combined high-throughput nuclease mapping of RNA
  • 16/06/2021

    Ultrastructure of the axoneme/flagellum The malarial parasites assemble flagella exclusively during the formation of the male gamete in the midgut of the female mosquito vector. The observation of gamete formation ex vivo reported by Laveran was seminal to the discovery of the parasite itself.
  • 16/06/2021

    Assembly of a signaling complex during RBC invasion Proximity of PKA to a substrate is necessary for substrate phosphorylation, but the P. falciparum genome encodes few recognizable A-kinase anchor proteins (AKAPs), suggesting the importance of PKA-regulatory subunit myristylation and membrane association
  • 02/06/2021

    The neddylation pathway Ubiquitin-conjugating enzyme E2 M (UBE2M) and ubiquitin-conjugating enzyme E2 F (UBE2F) are the two NEDD8conjugating enzymes of the neddylation pathway that take part in posttranslational modifcation and change the activity of target proteins. The activit
  • 31/05/2021

    Function of Sortilin in the regulated secretory pathway The inner membrane complex and the apical secretory organelles are defining features of apicomplexan parasites. Despite their critical roles, the mechanisms behind the biogenesis of these structures in the malaria parasite Plasmodium falciparum are still
  • 26/05/2021

    Plants used to treat malaria in Latin America Over 1,000 plant species have been used to treat malaria in Latin America, of which over 600 species were cited only once. The genera with the highest number of antimalarial species were Aspidosperma, Solanum, Piper, Croton and Aristolochia. In terms of g
  • 20/05/2021

    The SNARE conformational cycle during vesicle docking and fusion The molecular machinery of Plasmodium required to mediate the timely fusion of vesicles with the plasma membrane is not yet well investigated and this represents a knowledge gap that needs to be filled to fully understand RBC egress. It is known from othe
  • 15/05/2021

    Essential Exportome PEXEL-ome and PNEP-ome Exported proteins in P. falciparum can be roughly divided into two main groups based on the presence or absence of the Plasmodium export element or PEXEL motif (also known as vacuolartranslocation sequence/host targeting motif). The PEXEL motif consists o
  • 10/05/2021

    Rhoptry fusion and antigen secretion key aspect of the complex life cycle of Plasmodium parasites is the invasion of the parasite into its host cell, which is mediated by secretory organelles. The largest of these organelles, the rhoptry, undergoes rapid and profound physiological chang
  • 09/05/2021

    The basal complex The actomyosin contractile ring is a key feature of eukaryotic cytokinesis, conserved across many eukaryotic kingdoms. Recent research into the cell biology of the divergent eukaryotic clade Apicomplexa has revealed a contractile ring structure required f