Malaria therapies in the context of the Plasmodium parasite lifecycle
Recent antimalarial drug discovery has been a race to produce new medicines that overcome emerging drug resistance, whilst considering safety and improving dosing convenience. Discovery efforts have yielded a variety of new molecules, many with novel mode
30/09/2023
Artemisinin mode of action
ATS simultaneously interferes with ? redox homeostasis, ? lipid metabolism, and ? protein synthesis in P. falciparum to exert antimalarial effects by targeting several essential proteins.
26/09/2023
Antimalarial checkpoints in housekeeping pathways of the apicoplast
Antibiotics that target prokaryotic translation have been demonstrated to exhibit antimalarial activity. The RNA polymerase of plastids is highly sensitive to rifampicin, and the in vitro and in vivo antimalarial activity of rifampicin suggests that the d
21/09/2023
FP2a trafficking pathway to the food vacuole
To cross the parasite-encasing parasitophorous vacuole membrane, exported proteins utilise a channel-forming protein complex termed the Plasmodium translocon of exported proteins (PTEX). PTEX is obligatory for parasite survival, both in vitro and in vivo,
The Maurer's clefts Dynamics
Reorganization of cell organelle-deprived host red blood cells by the apicomplexan malaria parasite Plasmodium falciparum enables their cytoadherence to endothelial cells that line the microvasculature. This increases the time red blood cells infected wit
07/09/2023
lncRNA functions
In mammals show that approximately 85% of the DNA sequences have RNA products, for which the length greater than 200 nucleotides (nt) is called long non-coding RNAs (lncRNA). LncRNAs now have been shown to play important epigenetic regulatory roles in key
06/09/2023
glutamine metabolism
Glutamine is required for carbamoyl phosphate and cytidine triphosphate (CTP) synthesis in the de novo pyrimidine pathway of malaria parasite catalyzed by cytosolic carbamoyl phosphate synthetase II and CTP synthetase, respectively. Although the parasite
29/08/2023
Nuclear organization
In eukaryotes, nuclear compartmentalization, including three-dimensional folding of the genome and physical separation of proteins in compartments or condensates, regulates mutually exclusive gene expression and chromosomal translocations. In this Review,
13/08/2023
Apicoplast-targeting drugs
after its discovery, the apicoplast was found to host the target pathways of some known antimalarial drugs, which motivated efforts for further research into its biological functions and biogenesis. Initially, many apicoplast inhibitions were found to res