Malaria Parasite Metabolic Pathways

Temporal regulation of Rap Signaling by the small G-protein Rap is under tight regulation by its GEFs and GAPs. These are multi-domain proteins that are themselves controlled by distinct upstream pathways, and thus couple diffe

P. falciparum proteins with no orthologs in H. sapiens P. falciparum and H. sapiens belong to 2 different phylogenetic origin. Pf proteins that have no orthologs in Hs emphasize the features of parasitic life and provide a long list of unique targets for

Synopsis of medicinal plants used in the management of malaria in Kenya This review attempts to compile phytotherapeutical information on antimalarial plants in Kenya based on electronic data. A comprehensive web search was conducted in multidisciplinary databases, and a

Nonprotein-coding transcriptome Nonprotein-coding RNAs (npcRNAs) represent an important class of regulatory molecules that act in many cellular pathways. Here, we describe the experimental identification and validation of the small

a-acetylated N-termini of parasite proteins One-tenth of the early gametocyte-enriched proteome is constituted of putatively exported proteins, here named PfGEXPs (P. falciparum gametocyte-exported proteins). N-terminal processing and N-acetyla

Mechanisms by which antibodies participate in the clearance of P. falciparum-infected red blood cells Eliciting reliable and effective immu-nity against Plasmodium falciparum parasites remains an elusive goal inmalaria control. A naturally occur-ring human antibody response to aparasite antigen that

Parasite Histones Are Toxic to Brain Endothelium and Link Blood Barrier Breakdown and Thrombosis in Cerebral Malaria circulating extracellular histones, equally of host and parasite origin, are significantly elevated in CM patients. Higher histone levels are associated with brain swelling on magnetic resonance imagi

The Clp complex is a master regulator of apicoplast biology Most apicoplast proteins are encoded by the nuclear genome and it is unclear how the plastid proteome is regulated. Here, we study an apicoplast-localized caseinolytic-protease (Clp) system and how it