|
The ART proteome |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Ismail HM, Barton V, Phanchana M, Charoensutthivarakul S, Wong MH, Hemingway J, Biagini GA, O'Neill PM, Ward SA. Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2080-5. PMID: 26858419 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Assay confidence |
PfID |
|
|
Annotation |
EC# |
Transript |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22950 |
High Confidence |
PF3D7_0930300 |
 |
 |
merozoite surface protein 1 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22945 |
|
PF3D7_0818900 |
|
|
PfHsp70-1 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22947 |
|
PF3D7_0917900 |
|
|
PfHsp70-2 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22966 |
|
PF3D7_1311900 |
|
|
V-type proton ATPase catalytic subunit A |
3.6.3.14 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22969 |
|
PF3D7_1357000 |
|
|
elongation factor 1-alpha |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22938 |
|
PF3D7_0608800 |
|
|
ornithine aminotransferase |
2.6.1.13 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22964 |
|
PF3D7_1246200 |
|
|
actin I |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22960 |
|
PF3D7_1130200 |
|
|
60S ribosomal protein P0 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22967 |
|
PF3D7_1324900 |
|
|
L-lactate dehydrogenase |
1.1.1.27 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22932 |
|
PF3D7_0322900 |
|
|
40S ribosomal protein S3A, putative |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22958 |
|
PF3D7_1117700 |
|
|
GTP-binding nuclear protein RAN/TC4 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22955 |
|
PF3D7_1026800 |
|
|
40S ribosomal protein S2 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22952 |
|
PF3D7_1012400 |
|
|
hypoxanthine-guanine phosphoribosyltransferase |
2.4.2.8 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22942 |
|
PF3D7_0711000 |
|
|
AAA family ATPase, CDC48 subfamily |
3.6.4.6 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22965 |
|
PF3D7_1311800 |
|
|
M1-family alanyl aminopeptidase |
3.4.11.2 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22972 |
|
PF3D7_1408000 |
|
|
plasmepsin II |
3.4.23.39 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22961 |
|
PF3D7_1136500 |
|
|
casein kinase 1 |
2.7.11.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22977 |
|
PFC10_API0030 |
|
|
apicoplast ribosomal protein S12 (rps12) |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22939 |
|
PF3D7_0617800 |
|
|
histone H2A |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22935 |
|
PF3D7_0503400 |
|
|
actin-depolymerizing factor 1 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22931 |
|
PF3D7_0309600 |
|
|
60S acidic ribosomal protein P2 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22937 |
Medium Confidence |
PF3D7_0523000 |
|
|
multidrug resistance protein 1. MDR1, IP3 receptor |
3.6.3.44 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22929 |
|
PF3D7_0102200 |
|
|
ring-infected erythrocyte surface antigen |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22930 |
|
PF3D7_0308200 |
|
|
T-complex protein 1 subunit eta |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22940 |
|
PF3D7_0624000 |
|
|
hexokinase |
2.7.1.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22933 |
|
PF3D7_0406100 |
|
|
V-type proton ATPase subunit B |
3.6.3.14 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22936 |
|
PF3D7_0520900 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22953 |
|
PF3D7_1015900 |
|
|
enolase |
4.2.1.11 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22949 |
|
PF3D7_0922500 |
|
|
phosphoglycerate kinase |
2.7.2.3 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22959 |
|
PF3D7_1121600 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22944 |
|
PF3D7_0731500 |
|
|
erythrocyte binding antigen-175 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22962 |
|
PF3D7_1228600 |
|
|
merozoite surface protein 9 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22976 |
|
PF3D7_1444800 |
|
|
fructose-bisphosphate aldolase |
4.1.2.13 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22970 |
|
PF3D7_1361900 |
|
|
proliferating cell nuclear antigen 1 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22952 |
|
PF3D7_1012400 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22943 |
|
PF3D7_0729900 |
|
|
dynein heavy chain, putative |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22957 |
|
PF3D7_1116700 |
|
|
dipeptidyl aminopeptidase 1 cathepsin C, homolog |
3.4.14.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22963 |
|
PF3D7_1232100 |
|
|
60 kDa chaperonin |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22934 |
|
PF3D7_0417200 |
|
|
bifunctional dihydrofolate reductase-thymidylate synthase |
1.5.1.3 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22974 |
|
PF3D7_1436000 |
|
|
glucose-6-phosphate isomerase |
5.3.1.9 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22946 |
|
PF3D7_0903700 |
|
|
alpha tubulin 1 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22968 |
|
PF3D7_1354500 |
|
|
adenylosuccinate synthetase |
6.3.4.4 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22951 |
|
PF3D7_1008700 |
|
|
tubulin beta chain |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22971 |
|
PF3D7_1405600 |
|
|
ribonucleoside-diphosphate reductase small chain, putative |
1.17.4.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 25719 |
|
PF3D7_1427900 |
|
|
leucine-rich repeat protein |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22950 |
|
PF3D7_0930300 |
|
|
merozoite surface protein 1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22948 |
|
PF3D7_0919000 |
|
|
nucleosome assembly protein |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22975 |
|
PF3D7_1439900 |
|
|
triosephosphate isomerase |
5.3.1.1 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22956 |
|
PF3D7_1035200 |
|
|
S-antigen |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22941 |
|
PF3D7_0708400 |
|
|
heat shock protein 90 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 22954 |
|
PF3D7_1020900 |
|
|
ADP-ribosylation factor 1 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|